NSG1

Summary

NSG1 (neuronal vesicle trafficking associated 1, HGNC:18790) is a protein-coding gene on chromosome 4p16.3, encoding Neuronal vesicle trafficking-associated protein 1 (P42857). Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway.

Predicted to enable clathrin light chain binding activity. Involved in apoptotic process. Located in endoplasmic reticulum.

Source: NCBI Gene 27065 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 7 total
• MANE Select transcript: NM_014392

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18790
Approved symbol	NSG1
Name	neuronal vesicle trafficking associated 1
Location	4p16.3
Locus type	gene with protein product
Status	Approved
Aliases	P21, D4S234E, NEEP21
Ensembl gene	ENSG00000168824
Ensembl biotype	protein_coding
OMIM	607645
Entrez	27065

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 16 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000397958, ENST00000421177, ENST00000433139, ENST00000450293, ENST00000504171, ENST00000504347, ENST00000505246, ENST00000506380, ENST00000513555, ENST00000513829, ENST00000621129, ENST00000889808, ENST00000889809, ENST00000889810, ENST00000930399, ENST00000930400, ENST00000930401, ENST00000930402, ENST00000963790

RefSeq mRNA: 6 — MANE Select: NM_014392 NM_001040101, NM_001287763, NM_001287764, NM_001382227, NM_001382228, NM_014392

CCDS: CCDS3376, CCDS93472

Canonical transcript exons

ENST00000621129 — 5 exons

Exon	Start	End
ENSE00001161904	4409573	4409683
ENSE00001161909	4391475	4391591
ENSE00001161930	4387604	4387758
ENSE00001704112	4417235	4419058
ENSE00003933910	4387102	4387173

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 99.52.

FANTOM5 (CAGE): breadth broad, TPM avg 14.8437 / max 445.2521, expressed in 766 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46742	9.4468	694
46735	3.3339	475
46734	0.6123	230
46737	0.4548	196
46738	0.2999	159
46740	0.2225	117
46741	0.1880	99
46739	0.1840	106
46736	0.1016	55

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.52	gold quality
cortical plate	UBERON:0005343	99.48	gold quality
endothelial cell	CL:0000115	99.30	gold quality
middle temporal gyrus	UBERON:0002771	99.22	gold quality
ganglionic eminence	UBERON:0004023	98.69	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.52	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.41	gold quality
pons	UBERON:0000988	98.39	gold quality
oocyte	CL:0000023	97.92	gold quality
pituitary gland	UBERON:0000007	97.70	gold quality
superior vestibular nucleus	UBERON:0007227	97.29	gold quality
adenohypophysis	UBERON:0002196	96.95	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.92	gold quality
substantia nigra pars compacta	UBERON:0001965	96.76	gold quality
cerebellar cortex	UBERON:0002129	96.29	gold quality
cerebellar hemisphere	UBERON:0002245	96.28	gold quality
cerebellum	UBERON:0002037	96.04	gold quality
gingival epithelium	UBERON:0001949	95.70	gold quality
skin of leg	UBERON:0001511	95.57	gold quality
gingiva	UBERON:0001828	95.57	gold quality
germinal epithelium of ovary	UBERON:0001304	95.53	gold quality
hypothalamus	UBERON:0001898	95.49	gold quality
skin of abdomen	UBERON:0001416	95.39	gold quality
primary visual cortex	UBERON:0002436	95.36	gold quality
nucleus accumbens	UBERON:0001882	95.12	gold quality
zone of skin	UBERON:0000014	95.02	gold quality
lateral globus pallidus	UBERON:0002476	94.99	gold quality
substantia nigra pars reticulata	UBERON:0001966	94.83	gold quality
embryo	UBERON:0000922	94.51	gold quality
right frontal lobe	UBERON:0002810	94.37	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-MTAB-9906	yes	734.23
E-ANND-5	yes	599.27
E-GEOD-93593	yes	590.04
E-HCAD-5	yes	48.48
E-MTAB-8142	yes	19.03
E-GEOD-137537	yes	15.04
E-HCAD-25	yes	11.93
E-MTAB-5061	yes	11.28
E-ANND-3	yes	10.98
E-MTAB-9154	no	1073.88
E-ENAD-20	no	579.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

129 targeting NSG1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-32-5P	99.98	75.21	1964

Literature-anchored findings (GeneRIF, showing 5)

• a novel p53-responsive gene D4S234E is accumulated in the ER and induces apoptosis in response to DNA damage. (PMID:20599942)
• These results suggest that NEEP21 may play a critical role in apoptosis as a mediator of p53. (PMID:20878061)
• NEEP21 profoundly affects the processing of beta-amyloid precursor proteins and Abeta peptide production. (PMID:21084623)
• This review focuses on two closely related, neuron-enriched endosomal proteins: NEEP21 and Calcyon which perform distinct roles in regulating receptor endocytosis, recycling, and degradation–{REVIEW} (PMID:25376768)
• miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway. (PMID:38892156)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Nsg1	ENSMUSG00000029126
rattus_norvegicus	Nsg1	ENSRNOG00000005700

Paralogs (2): CALY (ENSG00000130643), NSG2 (ENSG00000170091)

Protein

Protein identifiers

Neuronal vesicle trafficking-associated protein 1 — P42857 (reviewed: P42857)

Alternative names: Neuron-enriched endosomal protein of 21 kDa, Neuron-specific protein family member 1

All UniProt accessions (2): P42857, B2R5R8

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.

Subunit / interactions. Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12. Interacts with APP; could regulate APP processing. Interacts with FAM171A1.

Subcellular location. Membrane. Golgi apparatus. trans-Golgi network membrane. Endosome membrane. Cell projection. Dendrite. Early endosome membrane. Late endosome membrane. Lysosome lumen. Recycling endosome membrane. Cytoplasmic vesicle membrane. Golgi stack membrane. Endosome. Multivesicular body membrane. Endoplasmic reticulum membrane.

Induction. Up-regulated by TP53 after DNA damage. Up-regulated by genotoxic stress.

Similarity. Belongs to the NSG family.

Isoforms (2)

UniProt ID	Names	Canonical?
P42857-1	1	yes
P42857-2	2

RefSeq proteins (6): NP_001035190, NP_001274692, NP_001274693, NP_001369156, NP_001369157, NP_055207* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009431	NSG	Family

Pfam: PF06387

UniProt features (6 total): topological domain 2, chain 1, transmembrane region 1, region of interest 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P42857-F1	60.70	0.08

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 252 (showing top): GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_CLATHRIN_COAT_ASSEMBLY, GOBP_VESICLE_MEDIATED_TRANSPORT, BAKER_HEMATOPOESIS_STAT1_TARGETS, BAKER_HEMATOPOIESIS_STAT3_TARGETS, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, HANN_RESISTANCE_TO_BCL2_INHIBITOR_UP, GOBP_CELL_CELL_SIGNALING, MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN, GOCC_TRANS_GOLGI_NETWORK, GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY, MODULE_379, BILD_E2F3_ONCOGENIC_SIGNATURE, HUPER_BREAST_BASAL_VS_LUMINAL_UP

GO Biological Process (12): receptor recycling (GO:0001881), positive regulation of receptor recycling (GO:0001921), apoptotic process (GO:0006915), endosomal transport (GO:0016197), amyloid precursor protein metabolic process (GO:0042982), clathrin coat assembly (GO:0048268), spontaneous synaptic transmission (GO:0098814), neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887), vesicle-mediated transport in synapse (GO:0099003), neurotransmitter receptor cycle (GO:0099627), postsynaptic neurotransmitter receptor cycle (GO:0099630), regulation of long-term synaptic potentiation (GO:1900271)

GO Molecular Function (4): clathrin light chain binding (GO:0032051), ionotropic glutamate receptor binding (GO:0035255), signaling receptor binding (GO:0005102), protein binding (GO:0005515)

GO Cellular Component (27): nucleus (GO:0005634), cytoplasm (GO:0005737), endosome (GO:0005768), late endosome (GO:0005770), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020), lateral plasma membrane (GO:0016328), dendrite (GO:0030425), early endosome membrane (GO:0031901), Golgi cisterna membrane (GO:0032580), multivesicular body membrane (GO:0032585), trans-Golgi network membrane (GO:0032588), somatodendritic compartment (GO:0036477), lysosomal lumen (GO:0043202), postsynaptic membrane (GO:0045211), recycling endosome membrane (GO:0055038), postsynaptic endosome (GO:0098845), glutamatergic synapse (GO:0098978), lysosome (GO:0005764), early endosome (GO:0005769), Golgi apparatus (GO:0005794), endosome membrane (GO:0010008), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410), late endosome membrane (GO:0031902), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
postsynapse	3
organelle membrane	3
vesicle-mediated transport	2
synapse	2
intracellular membrane-bounded organelle	2
endomembrane system	2
endosome	2
endosome membrane	2
endocytosis	1
receptor metabolic process	1
receptor recycling	1
regulation of receptor recycling	1
positive regulation of macromolecule metabolic process	1
positive regulation of signaling	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
intracellular transport	1
protein metabolic process	1
protein-containing complex assembly	1
chemical synaptic transmission	1
spontaneous neurotransmitter secretion	1
intercellular transport	1
neurotransmitter receptor transport to postsynaptic membrane	1
neurotransmitter receptor transport, endosome to plasma membrane	1
neurotransmitter receptor transport	1
establishment of localization in cell	1
neurotransmitter receptor cycle	1
regulation of synaptic plasticity	1
long-term synaptic potentiation	1
clathrin binding	1
glutamate receptor binding	1
protein binding	1
binding	1
intracellular anatomical structure	1
cytoplasmic vesicle	1
cytoplasm	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

642 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NSG1	STX18	Q9P2W9	806
NSG1	GRIP1	Q9Y3R0	783
NSG1	EVC2	Q86UK5	749
NSG1	CRMP1	Q14194	717
NSG1	EVC	P57679	639
NSG1	GRIA2	P42262	621
NSG1	GRIA1	P42261	571
NSG1	MSX1	P28360	557
NSG1	GRIPAP1	Q4V328	502
NSG1	PICK1	Q9NRD5	495
NSG1	OAZ1	P54368	442
NSG1	STX12	Q86Y82	440
NSG1	CENPH	Q9H3R5	419
NSG1	SRSF5	Q13243	403
NSG1	EEIG2	Q5T8I3	394
NSG1	TMEM128	Q5BJH2	394

IntAct

120 interactions, top by confidence:

A	B	Type	Score
NSG1	KASH5	psi-mi:“MI:0915”(physical association)	0.720
KASH5	NSG1	psi-mi:“MI:0915”(physical association)	0.720
NSG1	BSCL2	psi-mi:“MI:0915”(physical association)	0.560
BSCL2	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	TMEM139	psi-mi:“MI:0915”(physical association)	0.560
OPRM1	NSG1	psi-mi:“MI:0915”(physical association)	0.560
	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	FNDC9	psi-mi:“MI:0915”(physical association)	0.560
NSG1	SLC7A14	psi-mi:“MI:0915”(physical association)	0.560
SLC30A4	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	SPACA1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	TMEM207	psi-mi:“MI:0915”(physical association)	0.560
NSG1	TMEM52B	psi-mi:“MI:0915”(physical association)	0.560
ATP6AP2	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	KIR2DL3	psi-mi:“MI:0915”(physical association)	0.560
NSG1	PDZK1IP1	psi-mi:“MI:0915”(physical association)	0.560
EVI2B	NSG1	psi-mi:“MI:0915”(physical association)	0.560
FFAR2	NSG1	psi-mi:“MI:0915”(physical association)	0.560
FCGR2A	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	RELL2	psi-mi:“MI:0915”(physical association)	0.560
NSG1	TMX2	psi-mi:“MI:0915”(physical association)	0.560
MGST3	NSG1	psi-mi:“MI:0915”(physical association)	0.560
NSG1	BTN2A1	psi-mi:“MI:0915”(physical association)	0.560
GPR42	NSG1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (43): NSG1 (Two-hybrid), CCDC155 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid), NSG1 (Two-hybrid)

ESM2 similar proteins: A4IG66, B2RUZ4, B3DHH5, F1NVK6, F1Q930, O70367, O76024, O77770, O95772, P02683, P0C8K7, P42857, P56695, P84889, Q0P4Z1, Q15053, Q1JPG0, Q28DG6, Q2TBG9, Q4QQM5, Q4R5Q3, Q56JY4, Q5BLE2, Q5M836, Q5RF46, Q5XJS0, Q5ZKK0, Q62092, Q6GR21, Q6IQA2, Q6NRB7, Q6P606, Q7L4E1, Q7Z3D4, Q8BG50, Q8BK03, Q8BXV2, Q8IUW5, Q8K2J7, Q8NAN2

Diamond homologs: P02683, P42857, P47759, P58821, Q0VCZ0, Q3KR51, Q4R5Q3, Q5RF46, Q62092, Q8QFP1, Q9DCA7, Q9NYX4, Q9Y328

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1935 predictions. Top by Δscore:

Variant	Effect	Δscore
4:4387759:G:GA	donor_loss	1.0000
4:4387759:G:GG	donor_gain	1.0000
4:4387760:T:G	donor_loss	1.0000
4:4391460:T:TA	acceptor_gain	1.0000
4:4391467:T:A	acceptor_gain	1.0000
4:4391468:G:A	acceptor_gain	1.0000
4:4391471:TAAG:T	acceptor_loss	1.0000
4:4391472:A:AG	acceptor_gain	1.0000
4:4391472:AAG:A	acceptor_gain	1.0000
4:4391472:AAGGT:A	acceptor_gain	1.0000
4:4391473:A:G	acceptor_gain	1.0000
4:4391473:AGGT:A	acceptor_gain	1.0000
4:4391474:G:A	acceptor_gain	1.0000
4:4391474:G:GC	acceptor_loss	1.0000
4:4391474:GGTG:G	acceptor_gain	1.0000
4:4391586:TTTA:T	donor_gain	1.0000
4:4391589:AAG:A	donor_loss	1.0000
4:4391592:GTG:G	donor_loss	1.0000
4:4391593:T:G	donor_loss	1.0000
4:4409567:CCACA:C	acceptor_loss	1.0000
4:4409568:CACAG:C	acceptor_loss	1.0000
4:4409570:CA:C	acceptor_loss	1.0000
4:4409571:A:AG	acceptor_gain	1.0000
4:4409571:A:C	acceptor_loss	1.0000
4:4409572:G:GT	acceptor_gain	1.0000
4:4409572:GGTCT:G	acceptor_gain	1.0000
4:4409640:TGTAC:T	donor_gain	1.0000
4:4409681:AAG:A	donor_loss	1.0000
4:4409684:GT:G	donor_loss	1.0000
4:4409685:T:A	donor_loss	1.0000

AlphaMissense

1204 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:4409612:T:C	C96R	0.999
4:4409660:T:C	C112R	0.998
4:4417244:T:A	C123S	0.998
4:4417244:T:C	C123R	0.998
4:4417245:G:C	C123S	0.998
4:4387721:T:A	L31H	0.997
4:4409595:C:A	A90D	0.997
4:4409616:T:A	V97D	0.997
4:4409607:T:C	L94P	0.996
4:4409660:T:A	C112S	0.996
4:4409661:G:C	C112S	0.996
4:4387736:T:C	L36P	0.995
4:4409607:T:A	L94H	0.995
4:4409607:T:G	L94R	0.995
4:4409661:G:A	C112Y	0.995
4:4409662:C:G	C112W	0.995
4:4417246:C:G	C123W	0.995
4:4409586:T:A	V87D	0.994
4:4409625:T:C	L100P	0.994
4:4409628:T:A	V101D	0.994
4:4409672:T:C	F116L	0.994
4:4409674:C:A	F116L	0.994
4:4409674:C:G	F116L	0.994
4:4387693:T:C	F22L	0.993
4:4387695:C:A	F22L	0.993
4:4387695:C:G	F22L	0.993
4:4387721:T:C	L31P	0.993
4:4409598:T:C	L91P	0.993
4:4409598:T:G	L91R	0.993
4:4387709:T:C	L27P	0.992

dbSNP variants (sampled 300 via entrez): RS1000101417 (4:4416706 C>G), RS10002237 (4:4417884 C>T), RS1000245748 (4:4400245 C>T), RS1000310322 (4:4411054 C>T), RS1000457234 (4:4394648 A>T), RS1000506951 (4:4397652 G>A,C), RS1000527789 (4:4398947 T>A), RS1000580248 (4:4398726 G>A), RS1000676336 (4:4386701 G>A,T), RS1000810713 (4:4414633 C>A,T), RS1000839739 (4:4408324 T>A), RS10008550 (4:4384861 C>G,T), RS1000870988 (4:4408098 T>C), RS1000937479 (4:4386912 C>A,T), RS1001033624 (4:4409951 C>T)

Disease associations

OMIM: gene MIM:607645 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005173_80	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes	3.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004723	coronary artery calcification

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	8
Benzo(a)pyrene	affects methylation, increases expression	2
Diethylhexyl Phthalate	decreases methylation, increases abundance, decreases expression	2
Doxorubicin	increases expression	2
Estradiol	affects cotreatment, increases expression	2
Aflatoxin B1	decreases expression, increases methylation	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	decreases expression	1
propionaldehyde	increases expression	1
testosterone undecanoate	affects cotreatment, decreases expression	1
trichostatin A	increases expression	1
mono-(2-ethylhexyl)phthalate	decreases methylation, increases abundance	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
beta-methylcholine	affects expression	1
pentanal	increases expression	1
deguelin	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
nutlin 3	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Aldehydes	increases expression	1
Camptothecin	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Formaldehyde	decreases expression	1
Methapyrilene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.