NUDCD1

Summary

NUDCD1 (NudC domain containing 1, HGNC:24306) is a protein-coding gene on chromosome 8q23.1, encoding NudC domain-containing protein 1 (Q96RS6).

Predicted to be involved in immune system process. Located in cytosol and nucleoplasm.

Source: NCBI Gene 84955 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 99 total
• MANE Select transcript: NM_032869

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24306
Approved symbol	NUDCD1
Name	NudC domain containing 1
Location	8q23.1
Locus type	gene with protein product
Status	Approved
Aliases	CML66, FLJ14991
Ensembl gene	ENSG00000120526
Ensembl biotype	protein_coding
OMIM	606109
Entrez	84955

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 10 protein_coding, 4 retained_intron, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000239690, ENST00000427660, ENST00000519607, ENST00000521439, ENST00000676569, ENST00000676990, ENST00000677182, ENST00000677737, ENST00000678094, ENST00000678168, ENST00000679027, ENST00000931096, ENST00000931097, ENST00000931098, ENST00000931099, ENST00000931100, ENST00000931101, ENST00000967053

RefSeq mRNA: 2 — MANE Select: NM_032869 NM_001128211, NM_032869

CCDS: CCDS47910, CCDS6312

Canonical transcript exons

ENST00000239690 — 10 exons

Exon	Start	End
ENSE00000981104	109322309	109322463
ENSE00000981118	109240919	109243301
ENSE00002119265	109333893	109334087
ENSE00003477644	109296384	109296569
ENSE00003480265	109245322	109245481
ENSE00003500043	109275352	109275496
ENSE00003537264	109293344	109293524
ENSE00003579066	109280968	109281172
ENSE00003599321	109289751	109289933
ENSE00003605839	109271005	109271130

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 99.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9605 / max 354.6034, expressed in 1796 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94408	23.5660	1796
94407	0.3944	187

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.09	gold quality
oocyte	CL:0000023	93.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.49	gold quality
calcaneal tendon	UBERON:0003701	87.91	gold quality
germinal epithelium of ovary	UBERON:0001304	87.89	gold quality
cartilage tissue	UBERON:0002418	87.69	gold quality
tibialis anterior	UBERON:0001385	87.54	silver quality
cardiac muscle of right atrium	UBERON:0003379	87.31	gold quality
ventricular zone	UBERON:0003053	86.41	gold quality
islet of Langerhans	UBERON:0000006	86.30	gold quality
myocardium	UBERON:0002349	86.17	silver quality
ganglionic eminence	UBERON:0004023	85.95	gold quality
embryo	UBERON:0000922	85.94	gold quality
kidney epithelium	UBERON:0004819	85.35	gold quality
cortical plate	UBERON:0005343	85.35	gold quality
sperm	CL:0000019	85.33	gold quality
deltoid	UBERON:0001476	85.15	gold quality
pericardium	UBERON:0002407	85.05	gold quality
smooth muscle tissue	UBERON:0001135	84.74	gold quality
omental fat pad	UBERON:0010414	84.32	gold quality
peritoneum	UBERON:0002358	84.31	gold quality
cauda epididymis	UBERON:0004360	84.28	gold quality
adrenal tissue	UBERON:0018303	84.07	gold quality
placenta	UBERON:0001987	83.63	gold quality
ileal mucosa	UBERON:0000331	83.49	gold quality
stromal cell of endometrium	CL:0002255	83.47	gold quality
adipose tissue of abdominal region	UBERON:0007808	83.47	gold quality
vermiform appendix	UBERON:0001154	83.29	gold quality
lymph node	UBERON:0000029	83.14	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.04
E-MTAB-6524	no	116.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

97 targeting NUDCD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-5682	99.89	72.56	1005
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548AJ-5P	99.78	71.12	3085

Literature-anchored findings (GeneRIF, showing 10)

• An alternative promoter (CML66-S short isoform) has been identified in combination with alternative splicing as a novel mechanism for regulation of the epitope generation of a self-tumor antigen. (PMID:14688378)
• CML66 may play an oncogenic role in ways of favoring tumor cells proliferation, invasion and metastasis-associated with multiple pathways. (PMID:18534745)
• study identified a novel gene, OVA66, which was expressed significantly higher in cancer patients than normal controls; IgG level against OVA66 was significantly elevated in the serum of cancer patients from different histological types of cancer [OVA66] (PMID:18754882)
• the different NudCD1 isoforms have unique interacting partners, with the first isoform binding to a putative RNA helicase named DHX15 involved in mRNA splicing. (PMID:29021621)
• NudCD1 significantly increased in renal cell carcinoma and was positively correlated with cell proliferation, migration, and invasion (PMID:29461594)
• OVA66 overexpression in the cancer cell lines promoted VEGF secretion, tumour growth and angiogenesis in vitro and in vivo (PMID:30833190)
• NudCD1 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells through the Activation of IGF1R-ERK1/2. (PMID:32634806)
• Analysis of NudCD1 and NF-kappaBeta in the early detection and course evaluation of renal cancer. (PMID:33336728)
• NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways. (PMID:36104662)
• Identifying the role of NUDCD1 in human tumors from clinical and molecular mechanisms: a study based on comprehensive bioinformatics and experimental validation. (PMID:37338527)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nudcd1	ENSDARG00000036158
mus_musculus	Nudcd1	ENSMUSG00000038736
rattus_norvegicus	Nudcd1	ENSRNOG00000024929
drosophila_melanogaster	CG10347	FBGN0030342
caenorhabditis_elegans	C44E4.5	WBGENE00016654

Protein

Protein identifiers

NudC domain-containing protein 1 — Q96RS6 (reviewed: Q96RS6)

Alternative names: Chronic myelogenous leukemia tumor antigen 66, Tumor antigen CML66

All UniProt accessions (5): Q96RS6, A0A7I2V457, A0A7I2V4C4, E5RGX7, E5RHQ3

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cytoplasm. Nucleus Cytoplasm Cytoplasm. Nucleus.

Tissue specificity. Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells.

Miscellaneous. Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96RS6-1	1, CML66-L	yes
Q96RS6-2	2, CML66-S
Q96RS6-3	3

RefSeq proteins (2): NP_001121683, NP_116258* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007052	CS_dom	Domain
IPR008978	HSP20-like_chaperone	Homologous_superfamily
IPR037895	NUDCD1	Family

Pfam: PF04969

UniProt features (13 total): sequence variant 4, splice variant 4, modified residue 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RS6-F1	86.41	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 8, 388

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 161 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, COUP_01, WEI_MYCN_TARGETS_WITH_E_BOX, NF1_Q6_01, HNF4_DR1_Q3, DODD_NASOPHARYNGEAL_CARCINOMA_UP, TGGNNNNNNKCCAR_UNKNOWN, DOUGLAS_BMI1_TARGETS_UP, ZHANG_BREAST_CANCER_PROGENITORS_UP, NFE2_01, NUYTTEN_EZH2_TARGETS_DN, MARSON_BOUND_BY_E2F4_UNSTIMULATED, STAT1_02

GO Biological Process (1): immune system process (GO:0002376)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), cytosol (GO:0005829), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
biological_process	1
binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1224 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUDCD1	ENY2	Q9NPA8	706
NUDCD1	NUDCD2	Q8WVJ2	590
NUDCD1	EBAG9	O00559	541
NUDCD1	NUDCD3	Q8IVD9	506
NUDCD1	NUDC	Q9Y266	505
NUDCD1	EXOSC5	Q9NQT4	475
NUDCD1	C8orf33	Q9H7E9	445
NUDCD1	TMEM186	Q96B77	434
NUDCD1	ZMAT5	Q9UDW3	429
NUDCD1	ZNF189	O75820	409
NUDCD1	AFTPH	Q6ULP2	392
NUDCD1	RSRC2	Q7L4I2	378
NUDCD1	MRPL50	Q8N5N7	374
NUDCD1	ZNF222	Q9UK12	370
NUDCD1	ZNF623	O75123	366

IntAct

38 interactions, top by confidence:

A	B	Type	Score
DHX38	PPP4C	psi-mi:“MI:0914”(association)	0.730
DHX38	NUDCD1	psi-mi:“MI:0915”(physical association)	0.710
COPG1	NUDCD1	psi-mi:“MI:0915”(physical association)	0.710
DHX8	AHCYL1	psi-mi:“MI:0914”(association)	0.640
COPG1	COPE	psi-mi:“MI:0914”(association)	0.640
DHX38	PPP4R3A	psi-mi:“MI:0914”(association)	0.640
DHX38	DHX16	psi-mi:“MI:0914”(association)	0.630
NUDCD1	COPB1	psi-mi:“MI:0915”(physical association)	0.620
DHX32	POLRMT	psi-mi:“MI:0914”(association)	0.530
ABCF2	AHCYL1	psi-mi:“MI:0914”(association)	0.530
NUDCD1		psi-mi:“MI:0915”(physical association)	0.400
NUDCD1	DHX8	psi-mi:“MI:0915”(physical association)	0.400
NUDCD1	DHX16	psi-mi:“MI:0915”(physical association)	0.400
ARAF	NUDCD1	psi-mi:“MI:0915”(physical association)	0.400
NUDCD1	COPG2	psi-mi:“MI:0915”(physical association)	0.400
NUDCD1	AKT3	psi-mi:“MI:0915”(physical association)	0.400
NXF1	NUDCD1	psi-mi:“MI:0915”(physical association)	0.400
NUDCD1	TUBAL3	psi-mi:“MI:0914”(association)	0.350
DHX15	BBX	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
USP36	STK25	psi-mi:“MI:0914”(association)	0.350
COPA	ESYT2	psi-mi:“MI:0914”(association)	0.350
COPB2	ESYT2	psi-mi:“MI:0914”(association)	0.350
COPE	ESYT2	psi-mi:“MI:0914”(association)	0.350
COPG1	ATL3	psi-mi:“MI:0914”(association)	0.350
COPG2	ILVBL	psi-mi:“MI:0914”(association)	0.350
COPZ1	ATL3	psi-mi:“MI:0914”(association)	0.350

BioGRID (110): NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Affinity Capture-MS), NUDCD1 (Proximity Label-MS), NUDCD1 (Proximity Label-MS), NUDCD1 (Proximity Label-MS), NUDCD1 (Proximity Label-MS)

ESM2 similar proteins: A1KXW8, A6QL50, E1BGQ2, H0Y354, O94955, P47224, Q08326, Q0IIH8, Q1JQA1, Q1RMS8, Q1RMZ1, Q2TBU5, Q3T1H6, Q4R372, Q4R528, Q4R9C4, Q5F480, Q5F4A1, Q5I0G3, Q5RCQ0, Q5RFG8, Q5TFE4, Q5TYM5, Q641X7, Q6L9T8, Q6PIP5, Q7L622, Q7Z6J8, Q7ZX59, Q86X60, Q8BFZ8, Q8BKW4, Q8BM85, Q8BX13, Q8CEL2, Q8N5C7, Q8N635, Q8NHU2, Q8TCF1, Q8TCJ0

Diamond homologs: Q28IB1, Q503C8, Q6PIP5, Q7T0S2, Q96RS6, Q54M64, Q9VVA6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 38 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-dependent Golgi-to-ER retrograde traffic	8	34.1×	6e-09
COPI-mediated anterograde transport	8	33.8×	6e-09

GO biological processes:

GO term	Partners	Fold	FDR
intra-Golgi vesicle-mediated transport	7	111.7×	4e-11
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	5	51.1×	4e-06
endoplasmic reticulum to Golgi vesicle-mediated transport	6	24.7×	9e-06
mRNA splicing, via spliceosome	5	13.9×	1e-03
intracellular protein transport	6	11.8×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

99 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	75
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2390 predictions. Top by Δscore:

Variant	Effect	Δscore
8:109245324:AAAG:A	donor_gain	1.0000
8:109264095:TAAAG:T	donor_gain	1.0000
8:109271138:C:CT	acceptor_gain	1.0000
8:109275347:CTTA:C	donor_loss	1.0000
8:109275348:TTACC:T	donor_loss	1.0000
8:109275349:TACCA:T	donor_loss	1.0000
8:109275350:A:AC	donor_gain	1.0000
8:109275350:A:AT	donor_loss	1.0000
8:109275350:AC:A	donor_gain	1.0000
8:109275351:C:CT	donor_gain	1.0000
8:109275351:CC:C	donor_gain	1.0000
8:109275351:CCA:C	donor_gain	1.0000
8:109275351:CCAG:C	donor_gain	1.0000
8:109275351:CCAGT:C	donor_gain	1.0000
8:109275492:CCAAG:C	acceptor_gain	1.0000
8:109275493:CAAGC:C	acceptor_gain	1.0000
8:109275494:AAG:A	acceptor_gain	1.0000
8:109275495:AG:A	acceptor_gain	1.0000
8:109275496:GC:G	acceptor_loss	1.0000
8:109275497:C:CC	acceptor_gain	1.0000
8:109275503:G:C	acceptor_gain	1.0000
8:109275503:G:GC	acceptor_gain	1.0000
8:109275504:T:C	acceptor_gain	1.0000
8:109275504:T:TC	acceptor_gain	1.0000
8:109275505:T:C	acceptor_gain	1.0000
8:109275505:T:TC	acceptor_gain	1.0000
8:109275509:A:AC	acceptor_gain	1.0000
8:109275509:A:C	acceptor_gain	1.0000
8:109280964:ATAC:A	donor_loss	1.0000
8:109280966:AC:A	donor_loss	1.0000

AlphaMissense

3859 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:109243295:A:T	V489D	1.000
8:109243088:C:T	G558E	0.999
8:109243203:A:C	Y520D	0.999
8:109243282:C:A	K493N	0.999
8:109243282:C:G	K493N	0.999
8:109243301:C:T	G487D	0.999
8:109245322:C:G	G487R	0.999
8:109245385:A:G	W466R	0.999
8:109245385:A:T	W466R	0.999
8:109333944:A:G	Y23H	0.999
8:109333951:G:C	F20L	0.999
8:109333951:G:T	F20L	0.999
8:109333953:A:G	F20L	0.999
8:109243055:A:G	L569P	0.998
8:109243058:A:T	V568D	0.998
8:109243089:C:G	G558R	0.998
8:109243089:C:T	G558R	0.998
8:109243133:G:T	A543D	0.998
8:109243162:T:A	R533S	0.998
8:109243162:T:G	R533S	0.998
8:109243163:C:G	R533T	0.998
8:109243299:A:G	Y488H	0.998
8:109245327:G:T	A485D	0.998
8:109245352:A:G	W477R	0.998
8:109245352:A:T	W477R	0.998
8:109333937:A:G	L25P	0.998
8:109333944:A:C	Y23D	0.998
8:109243126:C:A	Q545H	0.997
8:109243126:C:G	Q545H	0.997
8:109243235:G:T	A509D	0.997

dbSNP variants (sampled 300 via entrez): RS1000042395 (8:109309448 A>G), RS1000061467 (8:109264797 T>C), RS1000086586 (8:109320520 T>A,C), RS1000133580 (8:109258719 A>T), RS1000207530 (8:109273953 T>C), RS1000219899 (8:109265310 G>A), RS1000242247 (8:109311406 C>T), RS1000253954 (8:109265021 G>A), RS1000292040 (8:109271823 A>C,G), RS1000304063 (8:109294943 T>A,C), RS1000320738 (8:109324922 T>C), RS1000368340 (8:109276721 ATC>A), RS1000423130 (8:109318020 TA>T), RS1000449364 (8:109271511 A>C), RS1000494974 (8:109330179 G>A)

Disease associations

OMIM: gene MIM:606109 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003518_76	Daytime sleep phenotypes	2.000000e-06
GCST003542_207	Night sleep phenotypes	5.000000e-06
GCST008595_200	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)	7.000000e-09
GCST009391_2140	Metabolite levels	3.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement
EFO:0004337	intelligence
EFO:0004784	self reported educational attainment
EFO:0010384	phosphatidylcholine 38:2 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	4
methylmercuric chloride	decreases expression	3
Nickel	increases expression, decreases expression	3
trichostatin A	affects cotreatment, decreases expression	2
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation	2
Valproic Acid	affects expression, increases expression	2
Cadmium Chloride	decreases expression	2
Particulate Matter	increases abundance, decreases expression	2
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	increases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
decabromobiphenyl ether	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
coumarin	increases phosphorylation	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
nutlin 3	affects cotreatment, increases secretion	1
dorsomorphin	decreases expression, affects cotreatment	1
jinfukang	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Carbamazepine	affects expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KT84	HeLa SilenciX NUDCD1	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.