NUDT10

Summary

NUDT10 (nudix hydrolase 10, HGNC:17621) is a protein-coding gene on chromosome Xp11.22, encoding Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (Q8NFP7). Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction.

This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5’ UTR, have been found for this gene.

Source: NCBI Gene 170685 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 15 total
• Druggable target: yes
• MANE Select transcript: NM_001304963

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17621
Approved symbol	NUDT10
Name	nudix hydrolase 10
Location	Xp11.22
Locus type	gene with protein product
Status	Approved
Aliases	DIPP3a, hDIPP3alpha
Ensembl gene	ENSG00000122824
Ensembl biotype	protein_coding
OMIM	300527
Entrez	170685

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000356450, ENST00000376006

RefSeq mRNA: 2 — MANE Select: NM_001304963 NM_001304963, NM_153183

CCDS: CCDS35278

Canonical transcript exons

ENST00000356450 — 2 exons

Exon	Start	End
ENSE00001469102	51332822	51333459
ENSE00001469113	51336239	51337525

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 91.20.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1711 / max 124.0915, expressed in 646 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196360	1.9093	471
196361	0.6126	326
209684	0.4040	227
196358	0.1722	103
196359	0.0729	27

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	91.20	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.39	gold quality
ganglionic eminence	UBERON:0004023	87.37	gold quality
right testis	UBERON:0004534	87.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.91	gold quality
testis	UBERON:0000473	85.50	gold quality
left testis	UBERON:0004533	85.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	84.76	gold quality
prefrontal cortex	UBERON:0000451	84.40	gold quality
right ovary	UBERON:0002118	83.95	gold quality
ventricular zone	UBERON:0003053	83.78	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.05	gold quality
left ovary	UBERON:0002119	82.90	gold quality
anterior cingulate cortex	UBERON:0009835	82.72	gold quality
seminal vesicle	UBERON:0000998	82.59	gold quality
hypothalamus	UBERON:0001898	82.33	gold quality
neocortex	UBERON:0001950	81.35	gold quality
frontal cortex	UBERON:0001870	81.17	gold quality
ovary	UBERON:0000992	80.38	gold quality
right frontal lobe	UBERON:0002810	80.35	gold quality
nucleus accumbens	UBERON:0001882	80.01	gold quality
cerebral cortex	UBERON:0000956	79.37	gold quality
amygdala	UBERON:0001876	79.07	gold quality
pancreatic ductal cell	CL:0002079	78.14	silver quality
prostate gland	UBERON:0002367	77.46	gold quality
forebrain	UBERON:0001890	76.52	gold quality
brain	UBERON:0000955	75.89	gold quality
Brodmann (1909) area 46	UBERON:0006483	75.51	gold quality
caudate nucleus	UBERON:0001873	75.50	gold quality
myometrium	UBERON:0001296	75.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting NUDT10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3671	99.90	73.04	3897
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-18A-3P	99.56	65.68	1092
HSA-MIR-4753-5P	99.54	68.51	1356
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-4480	99.42	66.02	735
HSA-MIR-5683	99.36	68.59	2083
HSA-MIR-6088	99.29	68.45	1284
HSA-MIR-3160-5P	99.28	69.07	1938
HSA-MIR-3973	99.20	69.19	1990
HSA-MIR-2054	99.20	68.89	1699
HSA-MIR-6071	99.16	67.77	1780

Literature-anchored findings (GeneRIF, showing 3)

• The NUDT10 gene, located on chromosome X, is preferentially expressed in the testis (PMID:12105228)
• Cloning and characterisation of NUDT10 as a diadenosine polyphosphate-metabolising Nudix hydrolase. (PMID:12121577)
• Clinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer. (PMID:34696672)

Cross-species orthologs

0 orthologs

Paralogs (4): NUDT4 (ENSG00000173598), NUDT4B (ENSG00000177144), NUDT11 (ENSG00000196368), NUDT3 (ENSG00000272325)

Protein

Protein identifiers

Diphosphoinositol polyphosphate phosphohydrolase 3-alpha — Q8NFP7 (reviewed: Q8NFP7)

Alternative names: Diadenosine 5’,5’’’-P1,P6-hexaphosphate hydrolase 3-alpha, Diadenosine hexaphosphate hydrolase (AMP-forming), Nucleoside diphosphate-linked moiety X motif 10, hAps2

All UniProt accessions (1): Q8NFP7

UniProt curated annotations — full annotation on UniProt →

Function. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Subcellular location. Cytoplasm.

Tissue specificity. Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.

Cofactor. Binds 3 Mg(2+) or Mn(2+) ions per subunit. Mn(2+) may be the true cofactor in vivo.

Similarity. Belongs to the Nudix hydrolase family. DIPP subfamily.

RefSeq proteins (2): NP_001291892, NP_694853 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000086	NUDIX_hydrolase_dom	Domain
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily
IPR020084	NUDIX_hydrolase_CS	Conserved_site
IPR047198	DDP-like_NUDIX	Domain

Pfam: PF00293

Enzyme classification (BRENDA):

• EC 3.6.1.60 — diadenosine hexaphosphate hydrolase (AMP-forming) (BRENDA: 3 organisms, 19 substrates, 9 inhibitors, 9 Km, 9 kcat entries)

Substrate kinetics (BRENDA)

2 substrates with measured Km, best-characterized 2. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
P1,P5-BIS(5’-ADENOSYL)PENTAPHOSPHATE	0.0077–0.05	6
P1,P6-BIS(5’-ADENOSYL)HEXAPHOSPHATE	0.0059–0.61	3

Catalyzed reactions (Rhea), 2 shown:

• P(1),P(6)-bis(5’-adenosyl) hexaphosphate + H2O = adenosine 5’-pentaphosphate + AMP + 2 H(+) (RHEA:32047)
• P(1),P(5)-bis(5’-adenosyl) pentaphosphate + H2O = adenosine 5’-tetraphosphate + AMP + 2 H(+) (RHEA:32051)

UniProt features (30 total): binding site 10, strand 8, helix 4, sequence conflict 2, chain 1, domain 1, region of interest 1, short sequence motif 1, compositionally biased region 1, active site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3MCF	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NFP7-F1	89.80	0.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 68 (proton acceptor)

Ligand- & substrate-binding residues (10): 65; 65; 69; 89–91; 115; 133; 9; 17–19; 38–40; 49

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol

MSigDB gene sets: 64 (showing top): AP1_01, TGCGCANK_UNKNOWN, GOBP_INOSITOL_PHOSPHATE_METABOLIC_PROCESS, GOBP_POLYOL_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS, TGANTCA_AP1_C, NRF2_Q4, GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS, WHN_B, GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS

GO Biological Process (4): diphosphoinositol polyphosphate metabolic process (GO:0071543), diadenosine pentaphosphate catabolic process (GO:1901907), diadenosine hexaphosphate catabolic process (GO:1901909), adenosine 5’-(hexahydrogen pentaphosphate) catabolic process (GO:1901911)

GO Molecular Function (8): endopolyphosphatase activity (GO:0000298), diphosphoinositol-polyphosphate diphosphatase activity (GO:0008486), bis(5’-adenosyl)-hexaphosphatase activity (GO:0034431), bis(5’-adenosyl)-pentaphosphatase activity (GO:0034432), metal ion binding (GO:0046872), protein binding (GO:0005515), pyrophosphatase activity (GO:0016462), hydrolase activity (GO:0016787)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Inositol phosphate metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
pyrophosphatase activity	4
diadenosine polyphosphate catabolic process	2
cellular anatomical structure	2
inositol phosphate metabolic process	1
purine ribonucleotide catabolic process	1
cation binding	1
binding	1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

770 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUDT10	AIRE	O43918	833
NUDT10	TOR1A	O14656	774
NUDT10	TNFRSF25	P78507	751
NUDT10	MICB	P79525	666
NUDT10	PTPN22	Q9Y2R2	629
NUDT10	TNFRSF10A	O00220	626
NUDT10	Q5Y7H0	Q5Y7H0	534
NUDT10	HLA-B	P01889	503
NUDT10	HLA-DRA	P01903	426
NUDT10	RASSF1	Q9NS23	422
NUDT10	TG	P01266	371
NUDT10	TPO	P07202	371
NUDT10	NUDT22	Q9BRQ3	367
NUDT10	POMC	P01189	366
NUDT10	NUDT17	P0C025	330

IntAct

28 interactions, top by confidence:

A	B	Type	Score
RNASEH2C	RNASEH2A	psi-mi:“MI:0914”(association)	0.640
NUDT10	SNAPC5	psi-mi:“MI:0915”(physical association)	0.560
NUDT10	TCF4	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	NUDT10	psi-mi:“MI:0915”(physical association)	0.560
SNAPC5	NUDT10	psi-mi:“MI:0915”(physical association)	0.560
TCF4	NUDT10	psi-mi:“MI:0915”(physical association)	0.560
NUDT10	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
NUDT10	PDLIM7	psi-mi:“MI:0915”(physical association)	0.560
REL	NUDT10	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	NUDT10	psi-mi:“MI:0915”(physical association)	0.560
NUDT10	TRIM8	psi-mi:“MI:0915”(physical association)	0.560
NUDT10	NUDT4B	psi-mi:“MI:0914”(association)	0.500
NUDT10	NUDT4B	psi-mi:“MI:0915”(physical association)	0.500
NUDT3	NUDT10	psi-mi:“MI:0914”(association)	0.350
NUDT10	TRIM8	psi-mi:“MI:0915”(physical association)	0.000
NUDT10	PDLIM7	psi-mi:“MI:0915”(physical association)	0.000
NUDT10	REL	psi-mi:“MI:0915”(physical association)	0.000
NUDT10	HSF2BP	psi-mi:“MI:0915”(physical association)	0.000
ddhA	NUDT10	psi-mi:“MI:0915”(physical association)	0.000
RASSF1	NUDT10	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (20): NUDT10 (Two-hybrid), NUDT10 (Two-hybrid), NUDT10 (Two-hybrid), NUDT10 (Affinity Capture-MS), NUDT10 (Affinity Capture-MS), NUDT10 (Affinity Capture-MS), HSF2BP (Two-hybrid), REL (Two-hybrid), TRIM8 (Two-hybrid), PDLIM7 (Two-hybrid), NUDT10 (Affinity Capture-MS), NUDT10 (Affinity Capture-MS), NUDT4 (Affinity Capture-MS), NUDT10 (Affinity Capture-MS), HNRNPLL (Affinity Capture-MS)

ESM2 similar proteins: A0A024RBG1, A2VE79, A3KMI0, A7E320, B0R160, B6CHA3, F4JLK2, F6UA42, O22951, O45830, O59761, O95989, P0C027, P0C028, P32271, Q08C92, Q09790, Q566C7, Q58CW0, Q5RAF0, Q5RDX4, Q5U243, Q6NPD7, Q6P5D3, Q7TMI3, Q7TPK1, Q7YTB0, Q8BJM7, Q8CIG3, Q8L7W2, Q8NB78, Q8NFP7, Q8R2U6, Q8VDF2, Q8VHT6, Q91WU5, Q96G61, Q96PU4, Q96T88, Q99321

Diamond homologs: A0A024RBG1, A2VE79, O95989, P0C027, P0C028, P53370, P70563, P96590, Q09790, Q52K88, Q566C7, Q58CW0, Q5RAF0, Q8CH40, Q8NFP7, Q8R2U6, Q8VY81, Q93ZY7, Q96G61, Q99321, Q99MY2, Q9JI46, Q9LE73, Q9LHK1, Q9LQU5, Q9NZJ9, Q9ZU95, Q9RVK2, A1AA28, A4FUG7, A7ZKS4, A7ZZ89, B1IUD3, B1LI09, B1XA44, P0AEI6, P0AEI7, P0AEI8, P0AEI9, P0C025

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

15 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

386 predictions. Top by Δscore:

Variant	Effect	Δscore
X:51333460:G:GG	donor_gain	0.9900
X:51336233:TTTTA:T	acceptor_loss	0.9900
X:51336234:TTTA:T	acceptor_loss	0.9900
X:51336237:A:AG	acceptor_gain	0.9800
X:51336238:G:GG	acceptor_gain	0.9800
X:51336238:GGT:G	acceptor_gain	0.9800
X:51333447:A:G	donor_gain	0.9700
X:51333398:C:G	donor_gain	0.9600
X:51333458:TA:T	donor_gain	0.9600
X:51336227:TTTTC:T	acceptor_loss	0.9600
X:51336228:TTTCT:T	acceptor_loss	0.9600
X:51336229:TTCTT:T	acceptor_loss	0.9600
X:51336230:TCTTT:T	acceptor_loss	0.9600
X:51336231:CTTTT:C	acceptor_loss	0.9600
X:51336232:TTTTT:T	acceptor_loss	0.9600
X:51333455:CCCTA:C	donor_gain	0.9500
X:51333457:CTA:C	donor_gain	0.9500
X:51336225:ATTTT:A	acceptor_loss	0.9500
X:51336226:TTTTT:T	acceptor_loss	0.9500
X:51333071:G:GG	donor_gain	0.9400
X:51333456:CCTA:C	donor_gain	0.9400
X:51333458:TAGTA:T	donor_loss	0.9300
X:51333459:AG:A	donor_loss	0.9300
X:51333460:G:GA	donor_loss	0.9300
X:51333461:TAT:T	donor_loss	0.9300
X:51333240:GAAC:G	donor_gain	0.9200
X:51333349:TCTCC:T	donor_gain	0.9200
X:51333420:G:GT	donor_gain	0.9200
X:51332368:G:GG	donor_gain	0.9100
X:51336238:GGTGA:G	acceptor_gain	0.8900

AlphaMissense

1059 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:51333309:G:C	R115T	1.000
X:51333309:G:T	R115M	1.000
X:51333310:G:C	R115S	1.000
X:51333310:G:T	R115S	1.000
X:51333031:C:G	C22W	0.999
X:51333037:C:G	C24W	0.999
X:51333066:T:C	L34P	0.999
X:51333069:T:C	L35S	0.999
X:51333098:T:A	W45R	0.999
X:51333098:T:C	W45R	0.999
X:51333108:C:A	P48Q	0.999
X:51333173:G:C	A70P	0.999
X:51333177:G:A	G71E	0.999
X:51333320:T:A	W119R	0.999
X:51333320:T:C	W119R	0.999
X:51333322:G:C	W119C	0.999
X:51333322:G:T	W119C	0.999
X:51333029:T:C	C22R	0.998
X:51333035:T:C	C24R	0.998
X:51333036:G:A	C24Y	0.998
X:51333105:T:A	V47E	0.998
X:51333111:G:A	G49D	0.998
X:51333114:G:A	G50E	0.998
X:51333150:C:A	A62E	0.998
X:51333156:G:C	R64P	0.998
X:51333160:G:C	E65D	0.998
X:51333160:G:T	E65D	0.998
X:51333169:A:C	E68D	0.998
X:51333169:A:T	E68D	0.998
X:51333177:G:T	G71V	0.998

dbSNP variants (sampled 300 via entrez): RS1000477164 (X:51334979 C>T), RS1000787477 (X:51335537 G>T), RS1004900296 (X:51337309 C>G), RS1005398968 (X:51336592 G>A), RS1009150108 (X:51335571 T>C), RS1009183664 (X:51336030 G>A), RS1011946518 (X:51334909 G>A,T), RS1013383330 (X:51336712 C>G), RS1013623642 (X:51337382 T>C), RS1015026087 (X:51336658 C>G,T), RS1015198299 (X:51336160 T>C), RS1018917657 (X:51335190 C>T), RS1018991002 (X:51335590 G>C), RS1023388654 (X:51336770 T>C,G), RS1023459049 (X:51337408 C>T)

Disease associations

OMIM: gene MIM:300527 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000152_12	Prostate cancer	2.000000e-09
GCST000153_1	Prostate cancer	4.000000e-13
GCST90000050_87	Age at first birth	1.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009101	age at first birth measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295904 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	2
kojic acid	decreases expression	1
P(1),P(5)-di(adenosine-5’-)pentaphosphate	increases metabolic processing, increases reaction, increases chemical synthesis	1
diguanosine tetraphosphate	increases metabolic processing	1
adenosine 5’-tetraphosphate	increases chemical synthesis, increases metabolic processing	1
diadenosine tetraphosphate	increases metabolic processing	1
manganese chloride	increases metabolic processing, increases reaction	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
adenosine 5’-pentaphosphate	increases chemical synthesis, increases metabolic processing	1
diadenosine 5’,5’’’’-P1,P6-hexaphosphate	increases chemical synthesis, increases metabolic processing	1
CGP 52608	affects binding, increases reaction	1
nutlin 3	affects cotreatment, increases expression	1
abrine	decreases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Adenosine Monophosphate	increases chemical synthesis, increases metabolic processing	1
Clozapine	increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Silicon Dioxide	increases expression	1
8-Bromo Cyclic Adenosine Monophosphate	decreases expression	1

ChEMBL screening assays

4 unique, capped per target: 2 admet, 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4259508	ADMET	Substrate activity at N-terminal His-tagged DIPP3-alpha (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay	A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. — Medchemcomm
CHEMBL4259517	Binding	Stabilization of N-terminal His-tagged DIPP3-alpha (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature at 0.1 mM by SYPRO orange dye based DSF method	A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. — Medchemcomm

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2EN	HAP1 NUDT10 (-) 1	Cancer cell line	Male
CVCL_E2EP	HAP1 NUDT10 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.