NUDT11

Summary

NUDT11 (nudix hydrolase 11, HGNC:18011) is a protein-coding gene on chromosome Xp11.22, encoding Diphosphoinositol polyphosphate phosphohydrolase 3-beta (Q96G61). Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction.

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).

Source: NCBI Gene 55190 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 15 total
• Druggable target: yes
• MANE Select transcript: NM_018159

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18011
Approved symbol	NUDT11
Name	nudix hydrolase 11
Location	Xp11.22
Locus type	gene with protein product
Status	Approved
Aliases	DIPP3b, FLJ10628, hDIPP3beta
Ensembl gene	ENSG00000196368
Ensembl biotype	protein_coding
OMIM	300528
Entrez	55190

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000375992

RefSeq mRNA: 1 — MANE Select: NM_018159 NM_018159

CCDS: CCDS43952

Canonical transcript exons

ENST00000375992 — 2 exons

Exon	Start	End
ENSE00001469078	51490011	51491749
ENSE00001469091	51495951	51496592

Expression profiles

Bgee: expression breadth ubiquitous, 220 present calls, max score 96.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.1216 / max 91.3983, expressed in 1125 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199304	2.2501	911
199303	2.2418	955
199306	1.1843	376
199305	0.4454	253

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	96.02	gold quality
orbitofrontal cortex	UBERON:0004167	94.59	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.65	gold quality
embryo	UBERON:0000922	93.53	gold quality
ganglionic eminence	UBERON:0004023	93.51	gold quality
middle temporal gyrus	UBERON:0002771	93.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.97	gold quality
right testis	UBERON:0004534	90.61	gold quality
superior frontal gyrus	UBERON:0002661	90.44	gold quality
oocyte	CL:0000023	90.22	gold quality
secondary oocyte	CL:0000655	89.73	gold quality
ventricular zone	UBERON:0003053	89.68	gold quality
testis	UBERON:0000473	89.53	gold quality
left testis	UBERON:0004533	89.30	gold quality
Brodmann (1909) area 46	UBERON:0006483	88.88	gold quality
nucleus accumbens	UBERON:0001882	88.82	gold quality
cauda epididymis	UBERON:0004360	88.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	88.11	gold quality
entorhinal cortex	UBERON:0002728	88.07	gold quality
prefrontal cortex	UBERON:0000451	87.96	gold quality
postcentral gyrus	UBERON:0002581	87.91	gold quality
hypothalamus	UBERON:0001898	87.23	gold quality
adult organism	UBERON:0007023	87.16	gold quality
frontal cortex	UBERON:0001870	87.00	gold quality
neocortex	UBERON:0001950	86.98	gold quality
anterior cingulate cortex	UBERON:0009835	86.76	gold quality
cingulate cortex	UBERON:0003027	86.73	gold quality
parietal lobe	UBERON:0001872	86.64	gold quality
cerebral cortex	UBERON:0000956	86.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	29.18
E-ANND-3	no	2.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

96 targeting NUDT11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867

Literature-anchored findings (GeneRIF, showing 3)

• The NUDT11 gene, located on chromosome X, is preferentially expressed in the testis (PMID:12105228)
• Cloning and characterisation of NUDT11 as a diadenosine polyphosphate-metabolising Nudix hydrolase. (PMID:12121577)
• NUDT11, HNF1B, and SLC22A3 genes have roles in prostate cancer pathogenesis (PMID:22730461)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Nudt10	ENSMUSG00000073293
mus_musculus	Nudt11	ENSMUSG00000073295
rattus_norvegicus	LOC134484128	ENSRNOG00000046053
rattus_norvegicus		ENSRNOG00000080376

Paralogs (4): NUDT10 (ENSG00000122824), NUDT4 (ENSG00000173598), NUDT4B (ENSG00000177144), NUDT3 (ENSG00000272325)

Protein

Protein identifiers

Diphosphoinositol polyphosphate phosphohydrolase 3-beta — Q96G61 (reviewed: Q96G61)

Alternative names: Diadenosine 5’,5’’’-P1,P6-hexaphosphate hydrolase 3-beta, Diadenosine hexaphosphate hydrolase (AMP-forming), Nucleoside diphosphate-linked moiety X motif 11, hAps1

All UniProt accessions (1): Q96G61

UniProt curated annotations — full annotation on UniProt →

Function. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Subcellular location. Cytoplasm.

Tissue specificity. Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.

Cofactor. Binds 3 Mg(2+) or Mn(2+) ions per subunit. Mn(2+) may be the true cofactor in vivo.

Similarity. Belongs to the Nudix hydrolase family. DIPP subfamily.

RefSeq proteins (1): NP_060629* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000086	NUDIX_hydrolase_dom	Domain
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily
IPR020084	NUDIX_hydrolase_CS	Conserved_site
IPR047198	DDP-like_NUDIX	Domain

Pfam: PF00293

Enzyme classification (BRENDA):

• EC 3.6.1.52 — diphosphoinositol-polyphosphate diphosphatase (BRENDA: 7 organisms, 75 substrates, 14 inhibitors, 14 Km, 20 kcat entries)
• EC 3.6.1.60 — diadenosine hexaphosphate hydrolase (AMP-forming) (BRENDA: 3 organisms, 19 substrates, 9 inhibitors, 9 Km, 9 kcat entries)

Substrate kinetics (BRENDA)

16 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
DIPHOSPHOINOSITOL PENTAKISPHOSPHATE	—	6
P1,P5-BIS(5’-ADENOSYL)PENTAPHOSPHATE	0.0077–0.05	6
P1,P6-BIS(5’-ADENOSYL)HEXAPHOSPHATE	0.0059–0.61	3
4-NITROPHENYL PHOSPHATE	3	1
5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE	0.035	1
5-PHOSPHO-D-RIBOSYL 1-DIPHOSPHATE	0.13	1
ADENOSINE TETRAPHOSPHATE	0.004	1
BISDIPHOSPHOINOSITOL TETRAKISPHOSPHATE	—	1
DIADENOSINE 5’,5’’’-P1,P6-HEXAPHOSPHATE	0.018	1
GUANOSINE TETRAPHOSPHATE	0.011	1
1,5-BIS-DIPHOSPHOINOSITOL 2,3,4,6-TETRAKISPHOSPH	—	0
1-DIPHOSPHOINOSITOL 2,3,4,5,6-PENTAKISPHOSPHATE	—	0
2-DIPHOSPHOINOSITOL 1,3,4,5,6-PENTAKISPHOSPHATE	—	0
4-DIPHOSPHOINOSITOL 1,2,3,5,6-PENTAKISPHOSPHATE	—	0
5-DIPHOSPHOINOSITOL 1,2,3,4,6-PENTAKISPHOSPHATE	—	0

Catalyzed reactions (Rhea), 2 shown:

• P(1),P(6)-bis(5’-adenosyl) hexaphosphate + H2O = adenosine 5’-pentaphosphate + AMP + 2 H(+) (RHEA:32047)
• P(1),P(5)-bis(5’-adenosyl) pentaphosphate + H2O = adenosine 5’-tetraphosphate + AMP + 2 H(+) (RHEA:32051)

UniProt features (17 total): binding site 10, chain 1, domain 1, sequence variant 1, region of interest 1, short sequence motif 1, compositionally biased region 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96G61-F1	89.37	0.79

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 68 (proton acceptor)

Ligand- & substrate-binding residues (10): 65; 65; 69; 89–91; 115; 133; 9; 17–19; 38–40; 49

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol

MSigDB gene sets: 140 (showing top): AP1_01, TGCGCANK_UNKNOWN, GOBP_INOSITOL_PHOSPHATE_METABOLIC_PROCESS, GOBP_POLYOL_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS, TGANTCA_AP1_C, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, NRF2_Q4, GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS, WHN_B, GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS

GO Biological Process (4): diphosphoinositol polyphosphate metabolic process (GO:0071543), diadenosine pentaphosphate catabolic process (GO:1901907), diadenosine hexaphosphate catabolic process (GO:1901909), adenosine 5’-(hexahydrogen pentaphosphate) catabolic process (GO:1901911)

GO Molecular Function (8): endopolyphosphatase activity (GO:0000298), diphosphoinositol-polyphosphate diphosphatase activity (GO:0008486), bis(5’-adenosyl)-hexaphosphatase activity (GO:0034431), bis(5’-adenosyl)-pentaphosphatase activity (GO:0034432), metal ion binding (GO:0046872), protein binding (GO:0005515), pyrophosphatase activity (GO:0016462), hydrolase activity (GO:0016787)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Inositol phosphate metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
pyrophosphatase activity	4
diadenosine polyphosphate catabolic process	2
cellular anatomical structure	2
inositol phosphate metabolic process	1
purine ribonucleotide catabolic process	1
cation binding	1
binding	1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

1066 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUDT11	EHBP1	Q8NDI1	819
NUDT11	STYXL1	Q9Y6J8	646
NUDT11	KLK3	P07288	607
NUDT11	MSMB	P08118	579
NUDT11	NXF3	Q9H4D5	504
NUDT11	SLC22A3	O75751	489
NUDT11	UHMK1	Q8TAS1	489
NUDT11	LMTK2	Q8IWU2	479
NUDT11	CTAG2	O75638	471
NUDT11	NUDT1	P36639	462
NUDT11	NUDT12	Q9BQG2	460
NUDT11	SSU72	Q9NP77	447
NUDT11	BRD10	Q5HYC2	439
NUDT11	TRIM39	Q9HCM9	434
NUDT11	NUDT14	O95848	433

IntAct

8 interactions, top by confidence:

A	B	Type	Score
NUDT11	DDIT4L	psi-mi:“MI:0915”(physical association)	0.560
DDIT4L	NUDT11	psi-mi:“MI:0915”(physical association)	0.560
MAD2L2		psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
ANKLE2	NUDT4B	psi-mi:“MI:0914”(association)	0.350
TRAF6	NUDT11	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): NUDT11 (Affinity Capture-MS), NUDT11 (Affinity Capture-MS), NUDT11 (Affinity Capture-RNA), NUDT11 (Affinity Capture-MS), NUDT11 (Affinity Capture-MS), NUDT11 (Proximity Label-MS), NUDT11 (Affinity Capture-MS)

ESM2 similar proteins: A0A024RBG1, A2VE79, A3KMI0, A7E320, B0R160, B6CHA3, F4JLK2, F6UA42, O22951, O45830, O59761, O95989, P0C027, P0C028, P32271, Q08C92, Q09790, Q566C7, Q58CW0, Q5RAF0, Q5RDX4, Q5U243, Q6NPD7, Q6P5D3, Q7TMI3, Q7TPK1, Q7YTB0, Q8BJM7, Q8CIG3, Q8L7W2, Q8NB78, Q8NFP7, Q8R2U6, Q8VDF2, Q8VHT6, Q91WU5, Q96G61, Q96PU4, Q96T88, Q99321

Diamond homologs: A0A024RBG1, A2VE79, O95989, P0C027, P0C028, P53370, P70563, P96590, Q09790, Q52K88, Q566C7, Q58CW0, Q5RAF0, Q8CH40, Q8NFP7, Q8R2U6, Q8VY81, Q93ZY7, Q96G61, Q99321, Q99MY2, Q9JI46, Q9LE73, Q9LHK1, Q9LQU5, Q9NZJ9, Q9ZU95, Q9RVK2, P32091, P59659, P13420, Q6NPD7, Q75UV1, Q8L7W2, Q94B74, Q9SJC4, Q9SJC6, Q9SU14, F1P963, O45830

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

15 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	6
Likely benign	1
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

390 predictions. Top by Δscore:

Variant	Effect	Δscore
X:51491750:C:T	acceptor_loss	1.0000
X:51491751:T:C	acceptor_loss	1.0000
X:51491746:TCAT:T	acceptor_gain	0.9900
X:51491747:CAT:C	acceptor_gain	0.9900
X:51491747:CATC:C	acceptor_gain	0.9900
X:51491750:C:CC	acceptor_gain	0.9900
X:51495949:A:AC	donor_gain	0.9900
X:51495950:C:CC	donor_gain	0.9900
X:51491745:TTCAT:T	acceptor_gain	0.9800
X:51491746:TCATC:T	acceptor_gain	0.9800
X:51491747:CATCT:C	acceptor_gain	0.9800
X:51491748:AT:A	acceptor_gain	0.9800
X:51491748:ATCT:A	acceptor_gain	0.9800
X:51491749:TCTG:T	acceptor_gain	0.9800
X:51495950:CTA:C	donor_gain	0.9700
X:51496338:A:AC	donor_gain	0.9700
X:51496339:C:CC	donor_gain	0.9700
X:51491750:C:G	acceptor_gain	0.9600
X:51495950:CTAGG:C	donor_gain	0.9600
X:51495963:T:C	donor_gain	0.9600
X:51496166:CGTT:C	donor_gain	0.9600
X:51495950:CT:C	donor_gain	0.9500
X:51496012:G:C	donor_gain	0.9500
X:51495945:ACAT:A	donor_loss	0.9300
X:51495947:ATAC:A	donor_loss	0.9300
X:51495948:TA:T	donor_loss	0.9300
X:51495949:A:AT	donor_loss	0.9300
X:51495950:C:A	donor_loss	0.9300
X:51495950:CTAG:C	donor_gain	0.9300
X:51495989:T:TA	donor_gain	0.9300

AlphaMissense

1059 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:51496090:A:G	W119R	1.000
X:51496090:A:T	W119R	1.000
X:51496100:C:A	R115S	1.000
X:51496100:C:G	R115S	1.000
X:51496101:C:A	R115M	1.000
X:51496101:C:G	R115T	1.000
X:51496233:C:T	G71E	1.000
X:51496088:C:A	W119C	0.999
X:51496088:C:G	W119C	0.999
X:51496124:C:A	W107C	0.999
X:51496124:C:G	W107C	0.999
X:51496126:A:G	W107R	0.999
X:51496126:A:T	W107R	0.999
X:51496152:A:G	L98P	0.999
X:51496225:C:G	G74R	0.999
X:51496225:C:T	G74R	0.999
X:51496233:C:A	G71V	0.999
X:51496237:C:G	A70P	0.999
X:51496250:C:A	E65D	0.999
X:51496250:C:G	E65D	0.999
X:51496254:C:G	R64P	0.999
X:51496302:G:T	P48Q	0.999
X:51496312:A:G	W45R	0.999
X:51496312:A:T	W45R	0.999
X:51496341:A:G	L35S	0.999
X:51496344:A:G	L34P	0.999
X:51496373:G:C	C24W	0.999
X:51496379:G:C	C22W	0.999
X:51496059:A:G	L129P	0.998
X:51496072:C:G	A125P	0.998

dbSNP variants (sampled 300 via entrez): RS1000190777 (X:51489777 G>A,C,T), RS1004595019 (X:51490549 T>C), RS1005114098 (X:51491092 C>T), RS1006383205 (X:51493181 T>G), RS1008835488 (X:51489837 C>A), RS1010500155 (X:51491729 C>T), RS1010786282 (X:51494484 T>C), RS1010864565 (X:51492219 A>G), RS1011250887 (X:51493991 T>C), RS1012921857 (X:51489718 G>C), RS1013194175 (X:51490652 G>A), RS1013309694 (X:51491356 C>T), RS1014556143 (X:51490289 A>G), RS1015083654 (X:51490550 G>A), RS1016348985 (X:51492632 C>T)

Disease associations

OMIM: gene MIM:300528 | disease phenotypes: MIM:300491

GenCC curated gene-disease

Mondo (1): epilepsy, X-linked 1, with variable learning disabilities and behavior disorders (MONDO:0010339)

Orphanet (1): X-linked epilepsy-learning disabilities-behavior disorders syndrome (Orphanet:85294)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000152_12	Prostate cancer	2.000000e-09
GCST000153_1	Prostate cancer	4.000000e-13

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C564505	Epilepsy, X-Linked, with Variable Learning Disabilities and Behavior Disorders (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4296042 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	6
sodium arsenite	increases expression, decreases expression	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression	2
Cadmium Chloride	decreases expression	2
P(1),P(5)-di(adenosine-5’-)pentaphosphate	increases metabolic processing, increases reaction, increases chemical synthesis	1
trichostatin A	increases expression	1
arsenite	affects binding, increases reaction	1
adenosine 5’-tetraphosphate	increases metabolic processing, increases chemical synthesis	1
manganese chloride	increases metabolic processing, increases reaction	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
adenosine 5’-pentaphosphate	increases chemical synthesis, increases metabolic processing	1
diadenosine 5’,5’’’’-P1,P6-hexaphosphate	increases metabolic processing, increases chemical synthesis	1
CGP 52608	affects binding, increases reaction	1
nutlin 3	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
LDN 193189	increases expression, affects cotreatment	1
Sunitinib	decreases expression	1
Adenosine Monophosphate	increases chemical synthesis, increases metabolic processing	1
Air Pollutants	decreases expression, increases abundance	1
Calcitriol	increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Succimer	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, increases expression	1
Lipopolysaccharides	increases expression, decreases reaction	1
Rotenone	decreases expression	1
Dihydrotestosterone	increases expression	1

ChEMBL screening assays

4 unique, capped per target: 2 admet, 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4259509	ADMET	Substrate activity at N-terminal His-tagged DIPP3-beta (unknown origin) expressed in Escherichia coli assessed as enzyme-mediated test compound metabolism after 20 mins in presence of Mg2+ by malachite green dye based assay	A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. — Medchemcomm
CHEMBL4259518	Binding	Stabilization of N-terminal His-tagged DIPP3-beta (unknown origin) expressed in Escherichia coli assessed as increase in melting temperature at 0.1 mM by SYPRO orange dye based DSF method	A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. — Medchemcomm

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1I2	HAP1 NUDT11 (-) 1	Cancer cell line	Male
CVCL_D1I3	HAP1 NUDT11 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.