NUDT7

Summary

NUDT7 (nudix hydrolase 7, HGNC:8054) is a protein-coding gene on chromosome 16q23.1, encoding Peroxisomal coenzyme A diphosphatase NUDT7 (P0C024). Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4’-phosphopantetheine and adenosine 3’,5’-bisphosphate.

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.

Source: NCBI Gene 283927 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_001105663

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8054
Approved symbol	NUDT7
Name	nudix hydrolase 7
Location	16q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000140876
Ensembl biotype	protein_coding
OMIM	609231
Entrez	283927

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000268533, ENST00000437314, ENST00000563839, ENST00000564031, ENST00000564085, ENST00000568787, ENST00000613075, ENST00000904198, ENST00000904199, ENST00000904200, ENST00000904201, ENST00000931007, ENST00000931008

RefSeq mRNA: 4 — MANE Select: NM_001105663 NM_001105663, NM_001243657, NM_001243660, NM_001243661

CCDS: CCDS42195, CCDS58479, CCDS58480, CCDS73916

Canonical transcript exons

ENST00000268533 — 4 exons

Exon	Start	End
ENSE00000945476	77735828	77735986
ENSE00001302871	77725431	77725584
ENSE00001478137	77722514	77722617
ENSE00002626155	77741582	77742260

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 93.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.8913 / max 116.4647, expressed in 1540 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155071	5.4131	1501
155070	0.4782	263

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	93.93	gold quality
right lobe of liver	UBERON:0001114	93.82	gold quality
secondary oocyte	CL:0000655	93.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.51	gold quality
oocyte	CL:0000023	92.34	gold quality
heart right ventricle	UBERON:0002080	91.09	gold quality
apex of heart	UBERON:0002098	90.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.63	gold quality
heart left ventricle	UBERON:0002084	90.61	gold quality
right adrenal gland	UBERON:0001233	90.56	gold quality
cardiac ventricle	UBERON:0002082	90.39	gold quality
liver	UBERON:0002107	90.20	gold quality
right adrenal gland cortex	UBERON:0035827	90.16	gold quality
left adrenal gland	UBERON:0001234	89.43	gold quality
right atrium auricular region	UBERON:0006631	89.27	gold quality
left adrenal gland cortex	UBERON:0035825	89.19	gold quality
heart	UBERON:0000948	88.85	gold quality
cardiac atrium	UBERON:0002081	88.77	gold quality
myocardium	UBERON:0002349	88.61	gold quality
adrenal cortex	UBERON:0001235	87.91	gold quality
adrenal gland	UBERON:0002369	87.00	gold quality
bronchial epithelial cell	CL:0002328	86.94	gold quality
cardiac muscle of right atrium	UBERON:0003379	86.34	gold quality
descending thoracic aorta	UBERON:0002345	85.34	gold quality
popliteal artery	UBERON:0002250	85.25	gold quality
tibial artery	UBERON:0007610	85.25	gold quality
islet of Langerhans	UBERON:0000006	85.00	gold quality
bronchus	UBERON:0002185	84.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.80	gold quality
rectum	UBERON:0001052	84.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting NUDT7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-6809-5P	99.13	68.45	1223
HSA-MIR-1228-3P	99.00	66.53	857
HSA-MIR-6074	98.89	69.64	2187
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-455-5P	98.74	67.31	795
HSA-MIR-6818-3P	98.56	68.23	1307
HSA-MIR-1262	98.17	66.52	757
HSA-MIR-4701-3P	98.17	66.25	788
HSA-MIR-6736-5P	98.17	66.43	760
HSA-MIR-1279	97.83	67.50	1898
HSA-MIR-9851-5P	97.57	67.49	1067
HSA-MIR-509-3-5P	97.21	67.74	1517
HSA-MIR-509-5P	97.21	67.90	1512
HSA-MIR-4418	97.04	67.16	1372
HSA-MIR-4296	96.35	63.55	1233

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	nudt7	ENSDARG00000070387
mus_musculus	Nudt7	ENSMUSG00000031767
rattus_norvegicus	Nudt7	ENSRNOG00000011976

Protein

Protein identifiers

Peroxisomal coenzyme A diphosphatase NUDT7 — P0C024 (reviewed: P0C024)

Alternative names: Nucleoside diphosphate-linked moiety X motif 7

All UniProt accessions (4): P0C024, A0A087WVP7, H3BMZ7, H3BRQ8

UniProt curated annotations — full annotation on UniProt →

Function. Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4’-phosphopantetheine and adenosine 3’,5’-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5’-triphosphates, nucleoside 5’-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5’-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.

Subunit / interactions. Monomer.

Subcellular location. Peroxisome.

Tissue specificity. Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.

Activity regulation. Inhibited by fluoride.

Similarity. Belongs to the Nudix hydrolase family. PCD1 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
P0C024-1	1	yes
P0C024-2	2
P0C024-3	3

RefSeq proteins (4): NP_001099133, NP_001230586, NP_001230589, NP_001230590 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000059	NUDIX_hydrolase_NudL_CS	Conserved_site
IPR000086	NUDIX_hydrolase_dom	Domain
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily
IPR045121	CoAse	Family

Pfam: PF00293

Catalyzed reactions (Rhea), 12 shown:

• butanoyl-CoA + H2O = S-butanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:49976)
• hexanoyl-CoA + H2O = hexanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:49980)
• octanoyl-CoA + H2O = S-octanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50016)
• decanoyl-CoA + H2O = decanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50020)
• dodecanoyl-CoA + H2O = S-dodecanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50024)
• tetradecanoyl-CoA + H2O = tetradecanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50028)
• choloyl-CoA + H2O = S-choloyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50036)
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:50040)
• CoA + H2O = (R)-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:64988)
• acetyl-CoA + H2O = S-acetyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:64992)
• propanoyl-CoA + H2O = propanoyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:67464)
• malonyl-CoA + H2O = malonyl-4’-phosphopantetheine + adenosine 3’,5’-bisphosphate + 2 H(+) (RHEA:67468)

UniProt features (34 total): strand 11, helix 6, turn 4, splice variant 3, sequence variant 2, short sequence motif 2, binding site 2, chain 1, domain 1, site 1, modified residue 1

Structure

Experimental structures (PDB)

38 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
5QHH	X-RAY DIFFRACTION	1.52
5QGS	X-RAY DIFFRACTION	1.55
5QH0	X-RAY DIFFRACTION	1.57
5QHA	X-RAY DIFFRACTION	1.57
5QHB	X-RAY DIFFRACTION	1.57
5QGV	X-RAY DIFFRACTION	1.59
5QGX	X-RAY DIFFRACTION	1.61
5QGZ	X-RAY DIFFRACTION	1.65
5QH1	X-RAY DIFFRACTION	1.65
5QH3	X-RAY DIFFRACTION	1.65
5QH4	X-RAY DIFFRACTION	1.67
5QHF	X-RAY DIFFRACTION	1.67
5QGU	X-RAY DIFFRACTION	1.71
5QGY	X-RAY DIFFRACTION	1.72
5QH9	X-RAY DIFFRACTION	1.72
5QH2	X-RAY DIFFRACTION	1.74
5QH7	X-RAY DIFFRACTION	1.74
5QHE	X-RAY DIFFRACTION	1.74
5QH8	X-RAY DIFFRACTION	1.75
5QGK	X-RAY DIFFRACTION	1.81
5QGH	X-RAY DIFFRACTION	1.82
5QGO	X-RAY DIFFRACTION	1.82
5QH5	X-RAY DIFFRACTION	1.85
5QGG	X-RAY DIFFRACTION	1.91
5QHG	X-RAY DIFFRACTION	1.92
5QGW	X-RAY DIFFRACTION	1.94
5QGI	X-RAY DIFFRACTION	1.95
5QGJ	X-RAY DIFFRACTION	1.95
5QGN	X-RAY DIFFRACTION	1.95
5QGQ	X-RAY DIFFRACTION	1.95

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C024-F1	94.23	0.87

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 66 (important for coenzyme a binding)

Ligand- & substrate-binding residues (2): 92; 96

Post-translational modifications (1): 20

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-390918	Peroxisomal lipid metabolism
R-HSA-9033241	Peroxisomal protein import

MSigDB gene sets: 150 (showing top): GOBP_FATTY_ACID_CATABOLIC_PROCESS, GOBP_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS, FISCHER_G1_S_CELL_CYCLE, GOBP_COENZYME_A_METABOLIC_PROCESS, GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_ACETYL_COA_METABOLIC_PROCESS, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_FATTY_ACYL_COA_METABOLIC_PROCESS, GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS, MARTINEZ_RB1_TARGETS_DN, GOBP_AMIDE_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_CATABOLIC_PROCESS

GO Biological Process (10): nucleoside diphosphate metabolic process (GO:0009132), coenzyme A catabolic process (GO:0015938), medium-chain fatty-acyl-CoA catabolic process (GO:0036114), butyryl-CoA catabolic process (GO:0044580), acetyl-CoA catabolic process (GO:0046356), brown fat cell differentiation (GO:0050873), succinyl-CoA catabolic process (GO:1901289), propionyl-CoA metabolic process (GO:1902858), propionyl-CoA catabolic process (GO:1902859), malonyl-CoA catabolic process (GO:2001294)

GO Molecular Function (8): magnesium ion binding (GO:0000287), coenzyme A diphosphatase activity (GO:0010945), manganese ion binding (GO:0030145), snoRNA binding (GO:0030515), RNA binding (GO:0003723), hydrolase activity (GO:0016787), hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818), metal ion binding (GO:0046872)

GO Cellular Component (3): peroxisome (GO:0005777), peroxisomal matrix (GO:0005782), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Fatty acid metabolism	1
Protein localization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
sulfur compound catabolic process	4
purine-containing compound catabolic process	4
nucleoside phosphate catabolic process	4
fatty-acyl-CoA catabolic process	3
nucleoside phosphate metabolic process	1
coenzyme A metabolic process	1
medium-chain fatty-acyl-CoA metabolic process	1
fatty acid catabolic process	1
acetyl-CoA metabolic process	1
fat cell differentiation	1
succinyl-CoA metabolic process	1
fatty-acyl-CoA metabolic process	1
propionyl-CoA metabolic process	1
malonyl-CoA metabolic process	1
metal ion binding	1
pyrophosphatase activity	1
transition metal ion binding	1
RNA binding	1
nucleic acid binding	1
catalytic activity	1
hydrolase activity, acting on acid anhydrides	1
cation binding	1
microbody	1
peroxisome	1
microbody lumen	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1139 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUDT7	NUDT19	A8MXV4	736
NUDT7	NUDT12	Q9BQG2	679
NUDT7	NUDT13	Q86X67	611
NUDT7	NUDT2	P50583	564
NUDT7	NUDT5	Q9UKK9	557
NUDT7	NUDT22	Q9BRQ3	544
NUDT7	NUDT15	Q9NV35	536
NUDT7	NUDT17	P0C025	506
NUDT7	NUDT4B	A0A024RBG1	501
NUDT7	PRADC1	Q9BSG0	490
NUDT7	NUDT18	Q6ZVK8	476
NUDT7	NUDT6	P53370	468
NUDT7	NUDT3	O95989	464
NUDT7	CCDC18	Q5T9S5	464
NUDT7	PANK1	Q8TE04	463

IntAct

2 interactions, top by confidence:

A	B	Type	Score
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350

BioGRID (2): NUDT7 (Affinity Capture-MS), NUDT7 (Protein-peptide)

ESM2 similar proteins: A2WYE9, A7T395, B7PXE3, F4HX15, F4IAE9, F4JLK2, O13717, O22060, O22243, O22951, O22993, O23461, O45830, O59761, P0C024, P31928, P34305, Q02331, Q0JGK4, Q12524, Q1EHT7, Q1PCQ8, Q23236, Q43845, Q4V8V2, Q5I3B2, Q5RDX4, Q5S7T7, Q67WN8, Q6ATJ8, Q6P158, Q6QN12, Q6ZHZ1, Q8GYB1, Q8L6H7, Q8L7W2, Q8RY24, Q92813, Q944S1, Q99MY2

Diamond homologs: A1ABY1, A1JMC0, A4TKD0, A4WBH1, A6TAY4, A7FJ95, A7MKE8, A7ZMT6, A8A110, A8AFP5, A9MVU1, A9R5X2, B1J0S5, B1JP41, B1LD60, B1XH80, B2K0H0, B2U449, B4SUL8, B4TKF7, B4TXZ6, B5BHD1, B5F3R6, B5FTK8, B5R2U5, B5XQ60, B5YQV4, B6IBP0, B7L6U1, B7LPN4, B7M287, B7MBL9, B7MVU2, B7NBF9, B7NSW2, B7USI8, C0Q309, C4ZZG9, O22951, P0A2K9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

822 predictions. Top by Δscore:

Variant	Effect	Δscore
16:77725429:A:AG	acceptor_gain	1.0000
16:77725430:G:GG	acceptor_gain	1.0000
16:77735951:G:GT	donor_gain	1.0000
16:77741580:A:AG	acceptor_gain	1.0000
16:77741581:G:GG	acceptor_gain	1.0000
16:77741581:GACA:G	acceptor_gain	1.0000
16:77722613:GTCAG:G	donor_gain	0.9900
16:77722614:TCAGG:T	donor_loss	0.9900
16:77722615:CAGG:C	donor_loss	0.9900
16:77722616:AGGTA:A	donor_loss	0.9900
16:77722617:GG:G	donor_loss	0.9900
16:77722618:G:A	donor_loss	0.9900
16:77722619:T:A	donor_loss	0.9900
16:77725417:T:TA	acceptor_loss	0.9900
16:77725426:TTTA:T	acceptor_loss	0.9900
16:77725428:TA:T	acceptor_loss	0.9900
16:77725430:GAAAC:G	acceptor_gain	0.9900
16:77725580:AGAAG:A	donor_loss	0.9900
16:77725582:AAGG:A	donor_loss	0.9900
16:77725583:AGG:A	donor_loss	0.9900
16:77725585:G:T	donor_loss	0.9900
16:77725586:T:G	donor_loss	0.9900
16:77735924:G:GT	donor_gain	0.9900
16:77735949:TGG:T	donor_gain	0.9900
16:77741573:T:A	acceptor_gain	0.9900
16:77741581:GA:G	acceptor_gain	0.9900
16:77741581:GAC:G	acceptor_gain	0.9900
16:77725428:TAGAA:T	acceptor_gain	0.9800
16:77725429:AGAAA:A	acceptor_gain	0.9800
16:77725430:GAAA:G	acceptor_gain	0.9800

AlphaMissense

1551 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:77735914:A:C	E92D	0.987
16:77735914:A:T	E92D	0.987
16:77735915:G:C	A93P	0.987
16:77741666:T:C	F145L	0.981
16:77741668:C:A	F145L	0.981
16:77741668:C:G	F145L	0.981
16:77735926:A:C	E96D	0.979
16:77735926:A:T	E96D	0.979
16:77735854:C:G	C72W	0.978
16:77735910:G:C	R91P	0.977
16:77735904:C:A	A89D	0.975
16:77741820:C:A	A196E	0.974
16:77741688:T:C	F152S	0.973
16:77735856:T:C	F73S	0.972
16:77741756:T:C	F175L	0.972
16:77741758:T:A	F175L	0.972
16:77741758:T:G	F175L	0.972
16:77735913:A:T	E92V	0.968
16:77741667:T:C	F145S	0.968
16:77735859:C:A	P74H	0.967
16:77735852:T:C	C72R	0.964
16:77741861:T:C	F210L	0.963
16:77741863:T:A	F210L	0.963
16:77741863:T:G	F210L	0.963
16:77735853:G:A	C72Y	0.962
16:77741610:G:A	G126D	0.959
16:77735862:G:A	G75E	0.958
16:77735924:G:C	E96Q	0.958
16:77741627:T:C	F132L	0.958
16:77741629:C:A	F132L	0.958

dbSNP variants (sampled 300 via entrez): RS1000091522 (16:77731307 G>C), RS1000391549 (16:77721203 G>C), RS1000518870 (16:77720943 C>A,T), RS1000569351 (16:77726023 C>A,T), RS1000637796 (16:77725115 C>A,G), RS1000761487 (16:77723896 A>G), RS1000995692 (16:77720757 A>T), RS1001226351 (16:77737753 C>G,T), RS1001279134 (16:77742605 G>A), RS1001547922 (16:77733807 G>A), RS1001630682 (16:77740874 G>A,T), RS1001637270 (16:77728878 C>T), RS1001686160 (16:77735784 A>G), RS1001874489 (16:77729992 G>A,C), RS1001981341 (16:77734518 G>A,C)

Disease associations

OMIM: gene MIM:609231 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001762_826	Obesity-related traits	7.000000e-06
GCST005170_34	Intraocular pressure	3.000000e-14
GCST005580_124	Intraocular pressure	2.000000e-27
GCST005580_204	Intraocular pressure	1.000000e-25
GCST007001_10	Cerebrospinal AB1-42 levels in normal cognition	2.000000e-07
GCST010683_4	Graft survival time in renal transplantation (donor effect)	2.000000e-07
GCST90011770_75	Glaucoma (primary open-angle)	7.000000e-13

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0005199	renal transplant outcome measurement
EFO:0007892	donor genotype effect measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Hydrolases & Lipases

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
NUDT7-COV-1	Inhibition	5.96	pIC50

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases expression	5
trichostatin A	decreases expression, affects cotreatment	3
Benzo(a)pyrene	decreases expression	3
methylmercuric chloride	decreases expression	2
Acetaminophen	decreases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Cisplatin	affects expression, affects cotreatment, increases expression	2
Estradiol	affects cotreatment, decreases expression	2
Nickel	decreases expression	2
Tretinoin	decreases expression	2
Cyclosporine	decreases expression	2
dicrotophos	decreases expression	1
urushiol	decreases expression	1
sodium arsenate	decreases expression, increases abundance	1
sulforaphane	decreases expression	1
nickel sulfate	increases expression	1
Am 580	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Rosiglitazone	decreases expression	1
Temozolomide	decreases expression	1
Decitabine	affects expression	1
Arsenic Trioxide	decreases expression	1
Vorinostat	increases expression	1
Air Pollutants, Occupational	affects expression	1
Arsenic	decreases expression, increases abundance	1
Calcitriol	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TB44	HAP1 NUDT7 (-) 1	Cancer cell line	Male
CVCL_TB45	HAP1 NUDT7 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.