NUDT9

Summary

NUDT9 (nudix hydrolase 9, HGNC:8056) is a protein-coding gene on chromosome 4q22.1, encoding ADP-ribose pyrophosphatase (Q9BW91). Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’-phosphate.

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 53343 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 56 total
• Druggable target: yes
• MANE Select transcript: NM_024047

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8056
Approved symbol	NUDT9
Name	nudix hydrolase 9
Location	4q22.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC3037
Ensembl gene	ENSG00000170502
Ensembl biotype	protein_coding
OMIM	606022
Entrez	53343

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 12 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000302174, ENST00000440591, ENST00000473942, ENST00000502933, ENST00000512216, ENST00000514227, ENST00000514345, ENST00000515371, ENST00000851358, ENST00000851359, ENST00000851360, ENST00000851361, ENST00000925580, ENST00000925581, ENST00000965707, ENST00000965708

RefSeq mRNA: 3 — MANE Select: NM_024047 NM_001248011, NM_024047, NM_198038

CCDS: CCDS3620, CCDS3621

Canonical transcript exons

ENST00000302174 — 8 exons

Exon	Start	End
ENSE00001135449	87422573	87423012
ENSE00001175718	87454371	87454455
ENSE00001175744	87441829	87441915
ENSE00001175754	87438277	87438372
ENSE00001556821	87457843	87459455
ENSE00003560776	87449142	87449253
ENSE00003619603	87434981	87435220
ENSE00003653419	87451589	87451735

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 96.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.0063 / max 215.3042, expressed in 1799 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48730	11.8563	1782
48735	2.6644	1360
48731	1.1949	729
48733	0.6885	425
48734	0.3297	143
48732	0.2726	84

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	96.88	gold quality
body of pancreas	UBERON:0001150	95.54	gold quality
pancreas	UBERON:0001264	95.15	gold quality
middle temporal gyrus	UBERON:0002771	95.08	gold quality
duodenum	UBERON:0002114	94.41	gold quality
parotid gland	UBERON:0001831	93.35	gold quality
right adrenal gland	UBERON:0001233	92.58	gold quality
right adrenal gland cortex	UBERON:0035827	92.53	gold quality
rectum	UBERON:0001052	92.51	gold quality
jejunal mucosa	UBERON:0000399	92.48	gold quality
left adrenal gland	UBERON:0001234	92.46	gold quality
adrenal gland	UBERON:0002369	92.19	gold quality
choroid plexus epithelium	UBERON:0003911	92.07	gold quality
renal glomerulus	UBERON:0000074	92.02	gold quality
left adrenal gland cortex	UBERON:0035825	91.99	gold quality
nephron tubule	UBERON:0001231	91.98	gold quality
metanephric glomerulus	UBERON:0004736	91.98	gold quality
adrenal cortex	UBERON:0001235	91.77	gold quality
adrenal tissue	UBERON:0018303	91.77	gold quality
visceral pleura	UBERON:0002401	91.70	gold quality
tendon of biceps brachii	UBERON:0008188	91.69	gold quality
mucosa of transverse colon	UBERON:0004991	91.56	gold quality
esophagus squamous epithelium	UBERON:0006920	91.39	gold quality
endocervix	UBERON:0000458	91.36	gold quality
body of uterus	UBERON:0009853	91.32	gold quality
kidney epithelium	UBERON:0004819	91.30	gold quality
metanephros	UBERON:0000081	91.29	gold quality
ectocervix	UBERON:0012249	91.25	gold quality
prefrontal cortex	UBERON:0000451	91.22	gold quality
tibia	UBERON:0000979	91.16	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	8.86
E-ANND-3	yes	7.98
E-GEOD-83139	no	3.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting NUDT9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-627-3P	99.90	71.42	3316
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-4804-3P	99.65	67.78	866
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-4762-3P	99.43	69.72	2363
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-4652-3P	99.33	70.02	2742
HSA-MIR-1244	99.33	68.38	832
HSA-MIR-892C-5P	99.16	70.56	2116

Literature-anchored findings (GeneRIF, showing 8)

• Hydrolyses ADP-ribose to AMP and ribose-5-phosphate (PMID:11825615)
• analysis of the human NUDT9 gene and its potential alternative transcripts along with detailed studies of the enzymatic properties and cell biological behavior of human NUDT9 protein (PMID:12427752)
• Data report the crystal structures of NUDT9 in the presence and in the absence of the reaction product ribose 5’-phosphate. (PMID:12948489)
• parallel enzymic characterization of the specific ADP-ribose pyrophosphatase from human placenta and a recombinant NUDT9 protein expressed from a cDNA clone was carried out (PMID:16860484)
• NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium (PMID:19574167)
• ADP-ribose reactive NUDT9 NUDIX hydrolase isoforms modulate HIF-1alpha in cancer cells (PMID:30190133)
• Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9. (PMID:34189846)
• NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities. (PMID:37343711)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nudt9	ENSDARG00000087927
mus_musculus	Nudt9	ENSMUSG00000029310
rattus_norvegicus	Nudt9	ENSRNOG00000002186
drosophila_melanogaster	spd-2	FBGN0027500
caenorhabditis_elegans		WBGENE00003583

Protein

Protein identifiers

ADP-ribose pyrophosphatase — Q9BW91 (reviewed: Q9BW91)

Alternative names: ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, Nucleoside diphosphate-linked moiety X motif 9

All UniProt accessions (4): Q9BW91, D6R8Z6, D6RAW2, H7C386

UniProt curated annotations — full annotation on UniProt →

Function. Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’-phosphate. Has also a weak phosphohydrolase activity against NADH and FAD (in vitro).

Subunit / interactions. Monomer. Interacts with GLOD4.

Subcellular location. Mitochondrion Mitochondrion. Cytoplasm.

Tissue specificity. Ubiquitously expressed but isoform 1 is the most predominant isoform.

Induction. Inhibited by fluoride and N-acetyl-p-benzoquinoneimine.

Similarity. Belongs to the Nudix hydrolase family. NudF subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BW91-1	1, NUDT9alpha	yes
Q9BW91-2	2, NUDT9beta

RefSeq proteins (3): NP_001234940, NP_076952, NP_932155 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000086	NUDIX_hydrolase_dom	Domain
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily
IPR039989	NUDT9	Family

Pfam: PF00293, PF25969

Catalyzed reactions (Rhea), 1 shown:

• ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+) (RHEA:10412)

UniProt features (30 total): strand 9, helix 8, turn 4, sequence conflict 2, transit peptide 1, chain 1, domain 1, region of interest 1, short sequence motif 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
1Q33	X-RAY DIFFRACTION	1.81
1QVJ	X-RAY DIFFRACTION	1.91

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BW91-F1	85.43	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 121

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins

MSigDB gene sets: 159 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, SHEPARD_BMYB_MORPHOLINO_UP, GOBP_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS, TGCGCANK_UNKNOWN, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, WANG_RECURRENT_LIVER_CANCER_DN, MODULE_206, GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS, KEGG_PURINE_METABOLISM, GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS, chr4q22, GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS

GO Biological Process (2): ADP catabolic process (GO:0046032), nucleobase-containing small molecule metabolic process (GO:0055086)

GO Molecular Function (4): ADP-sugar pyrophosphatase activity (GO:0019144), ADP-ribose diphosphatase activity (GO:0047631), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (8): cytoplasm (GO:0005737), mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), cytosol (GO:0005829), nuclear body (GO:0016604), cell junction (GO:0030054), nuclear membrane (GO:0031965), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Purine catabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
pyrophosphatase activity	2
cytoplasm	2
purine ribonucleotide catabolic process	1
purine ribonucleoside diphosphate catabolic process	1
ADP metabolic process	1
nucleobase-containing compound metabolic process	1
small molecule metabolic process	1
binding	1
catalytic activity	1
intracellular anatomical structure	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1
nucleoplasm	1
intracellular membraneless organelle	1
nucleus	1
nuclear envelope	1
organelle membrane	1
extracellular vesicle	1

Protein interactions and networks

STRING

654 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUDT9	NUDT5	Q9UKK9	794
NUDT9	NUDT14	O95848	721
NUDT9	NUDT12	Q9BQG2	712
NUDT9	NUDT2	P50583	680
NUDT9	NUDT18	Q6ZVK8	670
NUDT9	PARG	Q86W56	655
NUDT9	NUDT22	Q9BRQ3	579
NUDT9	PTK2B	Q14289	573
NUDT9	NUDT16	Q96DE0	572
NUDT9	TRPM6	Q9BX84	523
NUDT9	ADPRS	Q9NX46	506
NUDT9	MACROD1	Q9BQ69	479
NUDT9	NUDT17	P0C025	475
NUDT9	TRPM8	Q7Z2W7	464
NUDT9	TRPM7	Q96QT4	463

IntAct

27 interactions, top by confidence:

A	B	Type	Score
SDHAF3	NDUFAB1	psi-mi:“MI:0914”(association)	0.640
GET3	GET1	psi-mi:“MI:0914”(association)	0.640
FBXO6	MAN2B1	psi-mi:“MI:0914”(association)	0.640
SDF4	ACAD11	psi-mi:“MI:0914”(association)	0.640
PBX3	NUDT9	psi-mi:“MI:0915”(physical association)	0.560
NUDT9	EPHA2	psi-mi:“MI:0915”(physical association)	0.370
APBA1	KIF2A	psi-mi:“MI:0914”(association)	0.350
SLC39A7	AIP	psi-mi:“MI:0914”(association)	0.350
LCN9	C1QL1	psi-mi:“MI:0914”(association)	0.350
CCDC32	AP2A2	psi-mi:“MI:0914”(association)	0.350
DPP6	ATP5MC1	psi-mi:“MI:0914”(association)	0.350
SLC2A2	CAPG	psi-mi:“MI:0914”(association)	0.350
NUDT9	WDR5B	psi-mi:“MI:0914”(association)	0.350
FAHD1	VWA8	psi-mi:“MI:0914”(association)	0.350
NUDT9	HARS2	psi-mi:“MI:0914”(association)	0.350
CALM1	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
DDX28	UBA6	psi-mi:“MI:0914”(association)	0.350
FBXO6	TMEM131L	psi-mi:“MI:0914”(association)	0.350
GAB2	UBA6	psi-mi:“MI:0914”(association)	0.350
MOAP1	TAF4	psi-mi:“MI:0914”(association)	0.350
MRPL49	UBA6	psi-mi:“MI:0914”(association)	0.350
NUDT9	POF1B	psi-mi:“MI:0914”(association)	0.350
SERPINA12	COQ9	psi-mi:“MI:0914”(association)	0.350
PBX3	NUDT9	psi-mi:“MI:0915”(physical association)	0.000
NUDT9	MDM2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (51): NUDT9 (Affinity Capture-MS), DUT (Co-fractionation), IMPA1 (Co-fractionation), IMPA2 (Co-fractionation), MAN2A1 (Co-fractionation), NIT1 (Co-fractionation), NUDT9 (Co-fractionation), NUDT9 (Co-fractionation), PHPT1 (Co-fractionation), WDR5B (Affinity Capture-MS), NUDT9 (Affinity Capture-MS), NUDT9 (Affinity Capture-MS), TRIM11 (Affinity Capture-MS), NUDT9 (Synthetic Lethality), NUDT9 (Co-fractionation)

ESM2 similar proteins: A0A061AE05, A0A1D8PLI2, A6QXC6, A7KAL8, B9FK36, G2XR75, I1RZ92, M7U9B9, O42641, O74516, O74927, O81395, P09880, P15496, P24521, P41888, P45350, P51820, P53070, P78820, Q00955, Q05762, Q09297, Q09580, Q10258, Q10313, Q17693, Q29RH3, Q2QRX6, Q38970, Q45EK7, Q4R4P6, Q4R7L8, Q4WM52, Q5AWA2, Q5PQ50, Q5RD76, Q5XIG0, Q6C3P4, Q6NPD7

Diamond homologs: A0A0R4IMY7, A7T1N0, A8DYE2, E9PTA2, J9SQF3, O94759, Q2TV84, Q2WEA5, Q5XIG0, Q7TN37, Q7Z2W7, Q7Z4N2, Q8BVU5, Q8R455, Q8R4D5, Q8TD43, Q91YD4, Q9BW91, Q9ESQ5, Q9HCF6, Q9JJH7, Q9NZQ8, S5UH55, Q09297, Q8CIR4, Q923J1, Q925B3, Q96QT4, Q9BX84, Q93971

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1757 predictions. Top by Δscore:

Variant	Effect	Δscore
4:87438258:ATT:A	acceptor_gain	1.0000
4:87438275:A:AG	acceptor_gain	1.0000
4:87438276:G:GC	acceptor_gain	1.0000
4:87438276:GT:G	acceptor_gain	1.0000
4:87438370:GAG:G	donor_gain	1.0000
4:87438371:AGG:A	donor_loss	1.0000
4:87438372:GGTA:G	donor_loss	1.0000
4:87438373:G:GA	donor_loss	1.0000
4:87438373:G:GG	donor_gain	1.0000
4:87441818:T:A	acceptor_gain	1.0000
4:87441825:CCA:C	acceptor_loss	1.0000
4:87441827:A:AC	acceptor_loss	1.0000
4:87441827:A:AG	acceptor_gain	1.0000
4:87441828:G:GA	acceptor_gain	1.0000
4:87441828:GA:G	acceptor_gain	1.0000
4:87441828:GAA:G	acceptor_gain	1.0000
4:87441828:GAAA:G	acceptor_gain	1.0000
4:87441828:GAAAT:G	acceptor_gain	1.0000
4:87441912:CCAGG:C	donor_loss	1.0000
4:87441913:CAGGT:C	donor_loss	1.0000
4:87441914:AGG:A	donor_loss	1.0000
4:87441915:GGTAA:G	donor_loss	1.0000
4:87441916:GTAAG:G	donor_loss	1.0000
4:87441917:T:A	donor_loss	1.0000
4:87449140:A:AG	acceptor_gain	1.0000
4:87449141:G:GG	acceptor_gain	1.0000
4:87449251:GGG:G	donor_gain	1.0000
4:87449252:GGG:G	donor_gain	1.0000
4:87449253:GGTAA:G	donor_loss	1.0000
4:87449254:G:A	donor_loss	1.0000

AlphaMissense

2312 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:87441878:T:A	W165R	0.999
4:87441878:T:C	W165R	0.999
4:87454416:T:A	W279R	0.999
4:87454416:T:C	W279R	0.999
4:87441889:T:A	N168K	0.998
4:87441889:T:G	N168K	0.998
4:87454399:G:C	R273P	0.998
4:87454403:C:A	N274K	0.998
4:87454403:C:G	N274K	0.998
4:87454413:G:C	A278P	0.998
4:87454418:G:C	W279C	0.998
4:87454418:G:T	W279C	0.998
4:87457899:T:A	W311R	0.998
4:87457899:T:C	W311R	0.998
4:87438328:A:C	R133S	0.997
4:87438328:A:T	R133S	0.997
4:87441863:G:T	G160W	0.997
4:87441864:G:A	G160E	0.997
4:87441881:G:C	G166R	0.997
4:87441882:G:A	G166D	0.997
4:87449210:T:A	V200D	0.997
4:87449223:G:C	R204S	0.997
4:87449223:G:T	R204S	0.997
4:87449239:T:A	W210R	0.997
4:87449239:T:C	W210R	0.997
4:87449242:G:C	A211P	0.997
4:87435201:T:A	W110R	0.996
4:87435201:T:C	W110R	0.996
4:87441863:G:A	G160R	0.996
4:87441863:G:C	G160R	0.996

dbSNP variants (sampled 300 via entrez): RS1000067760 (4:87447545 G>C), RS1000177029 (4:87433102 A>G), RS1000193807 (4:87430567 A>C), RS1000195347 (4:87423676 G>A), RS10002390 (4:87425517 C>T), RS1000287367 (4:87426869 C>G), RS1000310408 (4:87453681 G>A,C), RS1000392878 (4:87421492 T>C), RS1000484294 (4:87439117 G>T), RS1000582915 (4:87434882 G>A,C,T), RS1000653427 (4:87436692 T>A), RS1000707686 (4:87429931 A>G), RS1000750044 (4:87422607 A>C), RS1000863226 (4:87455344 A>C,G), RS10008963 (4:87457563 G>A)

Disease associations

OMIM: gene MIM:606022 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005316_596	Intelligence (MTAG)	2.000000e-08
GCST006585_809	Blood protein levels	2.000000e-22

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105984 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
manganese chloride	decreases reaction, increases activity, increases reaction	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
deguelin	increases expression	1
bisphenol B	increases expression	1
pyrachlostrobin	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Acetaminophen	increases expression	1
Dithiothreitol	decreases reaction, increases activity, increases reaction	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Fluorides	decreases reaction, increases activity	1
Hydrogen Peroxide	decreases reaction, increases activity, increases reaction	1
Ivermectin	decreases expression	1
Magnesium	decreases reaction, increases activity	1
Manganese	decreases reaction, increases activity, increases reaction	1
Quercetin	decreases expression	1
Magnesium Chloride	decreases reaction, increases activity	1
Cyclosporine	decreases expression	1
Acrylamide	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4008389	Binding	Inhibition of NUDT9 (unknown origin) by malachite green reagent based assay	Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. — J Med Chem

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B5KK	HAP1 NUDT9 (-) 2	Cancer cell line	Male
CVCL_DX51	HAP1 NUDT6 (-) NUDT9 (-)	Cancer cell line	Male
CVCL_XR23	HAP1 NUDT9 (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.