NUP50-DT

Summary

NUP50-DT (NUP50 divergent transcript, HGNC:50502) is a long non-coding RNA gene on chromosome 22q13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50502
Approved symbol	NUP50-DT
Name	NUP50 divergent transcript
Location	22q13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226328
Ensembl biotype	lncRNA
Entrez	100506714
RNAcentral	URS000075C062 — lncRNA, 1338 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000426282, ENST00000432502, ENST00000609284, ENST00000665704, ENST00000702308, ENST00000816418, ENST00000816419, ENST00000816420, ENST00000816421, ENST00000816422, ENST00000816423, ENST00000816424, ENST00000816425, ENST00000816426, ENST00000816427, ENST00000816428, ENST00000816429, ENST00000816430, ENST00000816431, ENST00000816432

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426282 — 3 exons

Exon	Start	End
ENSE00002526386	45138824	45138916
ENSE00004219202	45133020	45134797
ENSE00004219207	45163577	45163800

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 86.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2740 / max 50.1962, expressed in 1780 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194557	5.0310	1714
194556	2.2853	1257
194555	0.6316	346
194554	0.3261	145

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	86.45	gold quality
sperm	CL:0000019	86.14	silver quality
leukocyte	CL:0000738	86.09	gold quality
cortical plate	UBERON:0005343	85.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.18	gold quality
lower esophagus mucosa	UBERON:0035834	85.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.59	gold quality
anterior cingulate cortex	UBERON:0009835	83.29	gold quality
right frontal lobe	UBERON:0002810	82.97	gold quality
stromal cell of endometrium	CL:0002255	82.93	gold quality
skin of leg	UBERON:0001511	82.56	gold quality
right lobe of liver	UBERON:0001114	81.76	gold quality
esophagus mucosa	UBERON:0002469	81.54	gold quality
granulocyte	CL:0000094	81.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.48	gold quality
right adrenal gland cortex	UBERON:0035827	81.43	gold quality
body of stomach	UBERON:0001161	81.20	gold quality
spleen	UBERON:0002106	81.00	gold quality
skin of abdomen	UBERON:0001416	80.80	gold quality
apex of heart	UBERON:0002098	80.77	gold quality
right adrenal gland	UBERON:0001233	80.74	gold quality
gastrocnemius	UBERON:0001388	80.70	gold quality
muscle of leg	UBERON:0001383	80.27	gold quality
left adrenal gland cortex	UBERON:0035825	80.25	gold quality
hypothalamus	UBERON:0001898	80.05	gold quality
left adrenal gland	UBERON:0001234	80.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.99	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.83	gold quality
cerebellar hemisphere	UBERON:0002245	79.82	gold quality
cerebellar cortex	UBERON:0002129	79.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• detects accession CR626620 which mapped to this locus as differentially expressed in the cortex (PMID:23377288)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.