NUTF2

Summary

NUTF2 (nuclear transport factor 2, HGNC:13722) is a protein-coding gene on chromosome 16q22.1, encoding Nuclear transport factor 2 (P61970). Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. It is a common-essential gene (DepMap: required in 99.3% of cancer cell lines).

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62.

Source: NCBI Gene 10204 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 10 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 99.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_005796

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13722
Approved symbol	NUTF2
Name	nuclear transport factor 2
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	NTF2, PP15
Ensembl gene	ENSG00000102898
Ensembl biotype	protein_coding
OMIM	605813
Entrez	10204

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 25 protein_coding, 1 retained_intron

ENST00000219169, ENST00000567105, ENST00000568233, ENST00000568390, ENST00000568396, ENST00000569436, ENST00000570026, ENST00000587481, ENST00000700610, ENST00000700611, ENST00000700612, ENST00000700613, ENST00000700614, ENST00000700615, ENST00000899783, ENST00000899784, ENST00000899785, ENST00000899786, ENST00000899787, ENST00000939627, ENST00000939628, ENST00000939629, ENST00000939630, ENST00000939631, ENST00000939632, ENST00000969121

RefSeq mRNA: 5 — MANE Select: NM_005796 NM_001322038, NM_001322039, NM_001322040, NM_001322041, NM_005796

CCDS: CCDS10848

Canonical transcript exons

ENST00000219169 — 5 exons

Exon	Start	End
ENSE00001047772	67846933	67846985
ENSE00003601795	67868340	67868411
ENSE00003651473	67865102	67865229
ENSE00003980331	67870800	67872567
ENSE00003980332	67868501	67868599

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 97.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 190.4099 / max 809.1524, expressed in 1828 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154683	166.1076	1825
154684	12.8740	1780
154682	9.4450	1792
154685	1.4328	915
154681	0.5505	323

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ascending aorta	UBERON:0001496	97.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.25	gold quality
thoracic aorta	UBERON:0001515	97.24	gold quality
popliteal artery	UBERON:0002250	97.18	gold quality
tibial artery	UBERON:0007610	97.18	gold quality
aorta	UBERON:0000947	97.12	gold quality
left coronary artery	UBERON:0001626	97.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.99	gold quality
descending thoracic aorta	UBERON:0002345	96.96	gold quality
artery	UBERON:0001637	96.95	gold quality
right coronary artery	UBERON:0001625	96.93	gold quality
anterior cingulate cortex	UBERON:0009835	96.78	gold quality
stromal cell of endometrium	CL:0002255	96.76	gold quality
embryo	UBERON:0000922	96.70	gold quality
ganglionic eminence	UBERON:0004023	96.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.57	gold quality
lower esophagus	UBERON:0013473	96.56	gold quality
hypothalamus	UBERON:0001898	96.49	gold quality
amygdala	UBERON:0001876	96.48	gold quality
coronary artery	UBERON:0001621	96.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.44	gold quality
ventricular zone	UBERON:0003053	96.39	gold quality
monocyte	CL:0000576	96.26	gold quality
smooth muscle tissue	UBERON:0001135	96.26	gold quality
leukocyte	CL:0000738	96.21	gold quality
gastrocnemius	UBERON:0001388	96.21	gold quality
right adrenal gland cortex	UBERON:0035827	96.20	gold quality
skin of abdomen	UBERON:0001416	96.19	gold quality
right atrium auricular region	UBERON:0006631	96.19	gold quality
body of uterus	UBERON:0009853	96.19	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7303	no	826.32
E-MTAB-8060	no	143.55
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC

miRNA regulators (miRDB)

56 targeting NUTF2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-3156-3P	99.76	66.72	939
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-1287-3P	99.63	66.93	492
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-891B	99.59	69.81	1083
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-18A-3P	99.56	65.68	1092
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-12131	99.48	68.72	1673

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 9)

• A nuclear pore binding site was studied on a mutated NTF2 protein. (PMID:15522285)
• Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG. (PMID:18266911)
• NTF2 is a potential mediator of retinal vasculature integrity. (PMID:19404486)
• Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation. (PMID:21195711)
• Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells. (PMID:22880006)
• Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules. (PMID:26823604)
• These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase. (PMID:29017749)
• DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins. (PMID:34324340)
• Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression. (PMID:34880267)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	nutf2	ENSDARG00000056531
mus_musculus	Nutf2	ENSMUSG00000008450
mus_musculus	Nutf2-ps1	ENSMUSG00000071497
rattus_norvegicus	Nutf2l1	ENSRNOG00000018945
rattus_norvegicus	AABR07018058.1	ENSRNOG00000057750
drosophila_melanogaster	Ntf-2	FBGN0031145
drosophila_melanogaster	Ntf-2r	FBGN0032680
caenorhabditis_elegans	ran-4	WBGENE00004305

Paralogs (2): NXT2 (ENSG00000101888), NXT1 (ENSG00000132661)

Protein

Protein identifiers

Nuclear transport factor 2 — P61970 (reviewed: P61970)

Alternative names: Placental protein 15

All UniProt accessions (7): P61970, A0A8V8TPY3, A0A8V8TR25, A0A8V8TR28, A0A8V8TRD3, B4DEQ2, H3BRV9

UniProt curated annotations — full annotation on UniProt →

Function. Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Subunit / interactions. Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import.

Subcellular location. Cytoplasm. Cytosol. Nucleus outer membrane. Nucleus. Nuclear pore complex. Nucleus inner membrane. Nucleoplasm.

RefSeq proteins (5): NP_001308967, NP_001308968, NP_001308969, NP_001308970, NP_005787* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002075	NTF2_dom	Domain
IPR018222	Nuclear_transport_factor_2_euk	Domain
IPR032710	NTF2-like_dom_sf	Homologous_superfamily
IPR045875	NTF2	Family

Pfam: PF02136

UniProt features (14 total): strand 6, helix 3, mutagenesis site 2, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1GY5	X-RAY DIFFRACTION	2.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P61970-F1	95.29	0.93

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 4

Mutagenesis-validated functional residues (2):

Position	Phenotype
42	no effect on localization to the nucleoplasm.
124	no effect on localization to the nucleoplasm.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 209 (showing top): MYAATNNNNNNNGGC_UNKNOWN, E2F_Q4_01, chr16q22, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, KAAB_FAILED_HEART_ATRIUM_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, RACCACAR_AML_Q6, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOMF_GTPASE_BINDING, GGAMTNNNNNTCCY_UNKNOWN, CAGCTG_AP4_Q5, PUJANA_CHEK2_PCC_NETWORK, GOBP_NUCLEAR_TRANSPORT, AAACCAC_MIR140

GO Biological Process (6): protein import into nucleus (GO:0006606), protein export from nucleus (GO:0006611), mRNA transport (GO:0051028), protein localization to nuclear pore (GO:0090204), nucleocytoplasmic transport (GO:0006913), protein transport (GO:0015031)

GO Molecular Function (5): structural constituent of nuclear pore (GO:0017056), small GTPase binding (GO:0031267), identical protein binding (GO:0042802), nuclear import signal receptor activity (GO:0061608), protein binding (GO:0005515)

GO Cellular Component (11): nuclear inner membrane (GO:0005637), nuclear outer membrane (GO:0005640), nucleoplasm (GO:0005654), cytosol (GO:0005829), nuclear membrane (GO:0031965), nuclear pore central transport channel (GO:0044613), extracellular exosome (GO:0070062), nucleus (GO:0005634), nuclear pore (GO:0005643), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
intracellular protein transport	2
import into nucleus	2
nuclear pore	2
nuclear membrane	2
nuclear envelope	2
nuclear protein-containing complex	2
protein localization to nucleus	1
establishment of protein localization to organelle	1
nuclear export	1
RNA transport	1
protein localization to nuclear envelope	1
nuclear transport	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
structural molecule activity	1
nucleocytoplasmic transport	1
GTPase binding	1
protein binding	1
nucleocytoplasmic carrier activity	1
binding	1
organelle inner membrane	1
organelle outer membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
nuclear lumen	1
cytoplasm	1
nucleus	1
organelle membrane	1
extracellular vesicle	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

168 interactions, top by confidence:

A	B	Type	Score
RAN	NUTF2	psi-mi:“MI:0915”(physical association)	0.890
NUTF2	RAN	psi-mi:“MI:0407”(direct interaction)	0.890
RAN	NUP153	psi-mi:“MI:0914”(association)	0.790
NUP62	NUTF2	psi-mi:“MI:0915”(physical association)	0.780
NUTF2	NUP62	psi-mi:“MI:0915”(physical association)	0.780
NUTF2	NUTF2	psi-mi:“MI:0915”(physical association)	0.670
NUTF2	NUTF2	psi-mi:“MI:0407”(direct interaction)	0.670
CDKN1B	KPNA3	psi-mi:“MI:0915”(physical association)	0.580
NUTF2	SPATC1L	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	BRWD1	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	YAF2	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	THAP3	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	TLE5	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	LENG1	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	CHCHD3	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	KHDC4	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	TEX35	psi-mi:“MI:0915”(physical association)	0.560
NUTF2	ZMAT2	psi-mi:“MI:0915”(physical association)	0.560
NUTF2		psi-mi:“MI:0915”(physical association)	0.560

BioGRID (152): NUTF2 (Two-hybrid), NUTF2 (Two-hybrid), NUP62 (Two-hybrid), NUTF2 (Affinity Capture-RNA), NUTF2 (Affinity Capture-RNA), NUTF2 (Affinity Capture-RNA), NUP62 (Reconstituted Complex), AP2A1 (Co-fractionation), AP2A2 (Co-fractionation), APOA1BP (Co-fractionation), CTH (Co-fractionation), GPX4 (Co-fractionation), HINT1 (Co-fractionation), NUTF2 (Co-fractionation), NUTF2 (Co-fractionation)

ESM2 similar proteins: A6QNX3, B2GV77, P09851, P20936, P50904, P61970, P61971, P61972, Q1JP79, Q29425, Q2KI42, Q2KIW0, Q2TBL9, Q32KP9, Q3UNA4, Q4R4K5, Q4R5H6, Q5E9J4, Q5F415, Q5FVJ7, Q5R8G4, Q5R8I6, Q5RB36, Q5RES2, Q5RKN4, Q5ZLH0, Q6PC62, Q8BG32, Q8BUH1, Q8IUI8, Q8K0F1, Q8MJJ1, Q92747, Q93034, Q99PD4, Q9CQC8, Q9CZQ9, Q9D5V5, Q9DAI2, Q9ES56

Diamond homologs: O42242, P33331, P61970, P61971, P61972, P87102, Q10100, Q21735, Q32KP9, Q5R8G4, Q6BWC0, Q6CC82, Q6CQX4, Q6FRC6, Q75AA5, Q8NJ52, Q96VN3, Q9C7F5, Q9FZK4, Q9P926, Q9XJ54, Q86HW7, P0CAN8, Q9FME2, Q5ZLH0, P97855, Q13283, Q32LC7, Q5RB87, Q9V3H8, O94260, Q9U757, B2GV77, Q3UNA4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
NUTF2	“up-regulates activity”	NUP62	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 63 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
NEP/NS2 Interacts with the Cellular Export Machinery	5	44.4×	1e-05
Nuclear import of Rev protein	5	43.1×	1e-05
Rev-mediated nuclear export of HIV RNA	5	40.7×	1e-05
NS1 Mediated Effects on Host Pathways	5	36.6×	2e-05
SUMOylation of DNA replication proteins	5	31.8×	2e-05
tRNA processing in the nucleus	5	25.2×	7e-05
ISG15 antiviral mechanism	5	19.3×	1e-04
HCMV Late Events	5	12.6×	5e-04

GO biological processes:

GO term	Partners	Fold	FDR
protein import into nucleus	6	17.3×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

10 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

688 predictions. Top by Δscore:

Variant	Effect	Δscore
16:67865230:G:GG	donor_gain	1.0000
16:67868334:TTTCA:T	acceptor_loss	1.0000
16:67868335:TTCAG:T	acceptor_loss	1.0000
16:67868336:TCAG:T	acceptor_loss	1.0000
16:67868337:CAGAT:C	acceptor_loss	1.0000
16:67868338:AGAT:A	acceptor_loss	1.0000
16:67868339:G:A	acceptor_loss	1.0000
16:67868408:GTCT:G	donor_gain	1.0000
16:67868412:G:GG	donor_gain	1.0000
16:67868416:G:GG	donor_gain	1.0000
16:67868500:GA:G	acceptor_gain	1.0000
16:67868500:GAGCC:G	acceptor_gain	1.0000
16:67868598:AG:A	donor_loss	1.0000
16:67868599:GGTAA:G	donor_loss	1.0000
16:67868600:G:T	donor_loss	1.0000
16:67870797:TA:T	acceptor_loss	1.0000
16:67870798:A:AG	acceptor_gain	1.0000
16:67870798:A:C	acceptor_loss	1.0000
16:67870798:AGGC:A	acceptor_gain	1.0000
16:67870799:G:GG	acceptor_gain	1.0000
16:67870799:GGC:G	acceptor_gain	1.0000
16:67870799:GGCG:G	acceptor_gain	1.0000
16:67865191:T:G	donor_gain	0.9900
16:67868338:A:AG	acceptor_gain	0.9900
16:67868339:G:GG	acceptor_gain	0.9900
16:67868339:GATT:G	acceptor_gain	0.9900
16:67868407:TGTCT:T	donor_gain	0.9900
16:67868408:GTCTG:G	donor_gain	0.9900
16:67868409:TCT:T	donor_gain	0.9900
16:67868409:TCTGT:T	donor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000000842 (16:67853556 T>C), RS1000082581 (16:67845853 C>T), RS1000108866 (16:67856514 G>A,T), RS1000112117 (16:67860436 G>A,T), RS1000150548 (16:67863379 AGCTG>A), RS1000176513 (16:67870929 G>T), RS1000306697 (16:67870717 AT>A,ATT), RS1000362521 (16:67856957 G>A), RS1000413714 (16:67866969 A>C,G,T), RS1000482398 (16:67861592 T>C), RS1000547586 (16:67860170 G>A), RS1000748422 (16:67861967 G>C), RS1000832563 (16:67848251 C>T), RS1001193571 (16:67856490 C>A), RS1001232055 (16:67872067 G>T)

Disease associations

OMIM: gene MIM:605813 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002539_84	Schizophrenia	2.000000e-08
GCST006803_42	Schizophrenia	4.000000e-08
GCST010002_113	Refractive error	2.000000e-14

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067085 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.66	Kd	2.171	nM	CHEMBL3752910
8.66	ED50	2.171	nM	CHEMBL3752910
6.38	Kd	419.2	nM	CHEMBL5653589
6.38	ED50	419.2	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148908: Binding affinity to human NUTF2 incubated for 45 mins by Kinobead based pull down assay	kd	0.0022	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148908: Binding affinity to human NUTF2 incubated for 45 mins by Kinobead based pull down assay	kd	0.4192	uM

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	3
Valproic Acid	affects cotreatment, decreases expression, increases expression	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, decreases expression, affects cotreatment	2
Tretinoin	decreases expression	2
aristolochic acid I	increases expression	1
bisphenol F	increases expression	1
nobiletin	decreases expression, decreases reaction	1
sodium arsenate	decreases expression, decreases reaction	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
ochratoxin A	increases expression	1
tamibarotene	affects expression	1
microcystin RR	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
Arsenic	affects methylation	1
Cisplatin	increases expression	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Selenium	increases expression	1
Smoke	decreases expression	1
Theophylline	increases expression	1
Tobacco Smoke Pollution	affects expression	1
Vitamin E	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651950	Binding	Binding affinity to human NUTF2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.