NUTM2A-AS1

Summary

NUTM2A-AS1 (NUTM2A antisense RNA 1, HGNC:45161) is a long non-coding RNA gene on chromosome 10q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45161
Approved symbol	NUTM2A-AS1
Name	NUTM2A antisense RNA 1
Location	10q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223482
Ensembl biotype	lncRNA
Entrez	728190
RNAcentral	URS000075A46C — lncRNA, 825 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 327 — 327 lncRNA

ENST00000366446, ENST00000413722, ENST00000413961, ENST00000417860, ENST00000420424, ENST00000433530, ENST00000433920, ENST00000446751, ENST00000447424, ENST00000451940, ENST00000456104, ENST00000458739, ENST00000653080, ENST00000653238, ENST00000654503, ENST00000655272, ENST00000656123, ENST00000659257, ENST00000660454, ENST00000660726, ENST00000661845, ENST00000662586, ENST00000663113, ENST00000663644, ENST00000663683, ENST00000664664, ENST00000664997, ENST00000666515, ENST00000666844, ENST00000667520, ENST00000667985, ENST00000668225, ENST00000668676, ENST00000671543, ENST00000684884, ENST00000686013, ENST00000686862, ENST00000687141, ENST00000687827, ENST00000687925, ENST00000687947, ENST00000688214, ENST00000688257, ENST00000688790, ENST00000688926, ENST00000690287, ENST00000690598, ENST00000691822, ENST00000692417, ENST00000693252, ENST00000700831, ENST00000700855, ENST00000701072, ENST00000701080, ENST00000701110, ENST00000701133, ENST00000701382, ENST00000701799, ENST00000701896, ENST00000701903, ENST00000701968, ENST00000701973, ENST00000701988, ENST00000742028, ENST00000742029, ENST00000742030, ENST00000742031, ENST00000742032, ENST00000742033, ENST00000742034, ENST00000742035, ENST00000742036, ENST00000742037, ENST00000742038, ENST00000742039, ENST00000742040, ENST00000742041, ENST00000742042, ENST00000742043, ENST00000742045, ENST00000742046, ENST00000742047, ENST00000742048, ENST00000742049, ENST00000742050, ENST00000742051, ENST00000742052, ENST00000742053, ENST00000742054, ENST00000742055, ENST00000742056, ENST00000742057, ENST00000742058, ENST00000742059, ENST00000742060, ENST00000742061, ENST00000742062, ENST00000742063, ENST00000742064, ENST00000742065, ENST00000742066, ENST00000742067, ENST00000742068, ENST00000742069, ENST00000742070, ENST00000742071, ENST00000742072, ENST00000742073, ENST00000742074, ENST00000742075, ENST00000742076, ENST00000742077, ENST00000742078, ENST00000742079, ENST00000742080, ENST00000742081, ENST00000742082, ENST00000742083, ENST00000742084, ENST00000742085, ENST00000742086, ENST00000742087, ENST00000742088, ENST00000742089, ENST00000742090, ENST00000742091, ENST00000742092, ENST00000742093, ENST00000742094, ENST00000742095, ENST00000742096, ENST00000742097, ENST00000742098, ENST00000742099, ENST00000742100, ENST00000742101, ENST00000742102, ENST00000742103, ENST00000742104, ENST00000742105, ENST00000742106, ENST00000742107, ENST00000742108, ENST00000742109, ENST00000742110, ENST00000742111, ENST00000742112, ENST00000742113, ENST00000742114, ENST00000742115, ENST00000742116, ENST00000742117, ENST00000742118, ENST00000742119, ENST00000742120, ENST00000742121, ENST00000742122, ENST00000742123, ENST00000742124, ENST00000742125, ENST00000742126, ENST00000742127, ENST00000742128, ENST00000742129, ENST00000742130, ENST00000742131, ENST00000742132, ENST00000742133, ENST00000742134, ENST00000742135, ENST00000742136, ENST00000742137, ENST00000742138, ENST00000742139, ENST00000742140, ENST00000742141, ENST00000742142, ENST00000742143, ENST00000742144, ENST00000742145, ENST00000742146, ENST00000742147, ENST00000742148, ENST00000742149, ENST00000742150, ENST00000742151, ENST00000742152, ENST00000742153, ENST00000742154, ENST00000742155, ENST00000742156, ENST00000742157, ENST00000742158, ENST00000742159, ENST00000742160, ENST00000742161, ENST00000742162, ENST00000742163, ENST00000742164, ENST00000742165, ENST00000742166, ENST00000742167, ENST00000742168, ENST00000742169, ENST00000742170, ENST00000742171, ENST00000742172, ENST00000742173, ENST00000742174, ENST00000742175, ENST00000742176, ENST00000742177, ENST00000742178, ENST00000742179, ENST00000742180, ENST00000742181, ENST00000742182, ENST00000742183, ENST00000742184, ENST00000742185, ENST00000742186, ENST00000742187, ENST00000742188, ENST00000742189, ENST00000742190, ENST00000742191, ENST00000742192, ENST00000742193, ENST00000742194, ENST00000742195, ENST00000742196, ENST00000742197, ENST00000742198, ENST00000742199, ENST00000742200, ENST00000742201, ENST00000742202, ENST00000742203, ENST00000742204, ENST00000742205, ENST00000742206, ENST00000742207, ENST00000742208, ENST00000742209, ENST00000742210, ENST00000742211, ENST00000742212, ENST00000742213, ENST00000742214, ENST00000742215, ENST00000742216, ENST00000742217, ENST00000742218, ENST00000742219, ENST00000742220, ENST00000742221, ENST00000742222, ENST00000742223, ENST00000742224, ENST00000742225, ENST00000742226, ENST00000742227, ENST00000742228, ENST00000742229, ENST00000742230, ENST00000742231, ENST00000742232, ENST00000742233, ENST00000742234, ENST00000742235, ENST00000742236, ENST00000742237, ENST00000742238, ENST00000742239, ENST00000742240, ENST00000742241, ENST00000742242, ENST00000742243, ENST00000742244, ENST00000742245, ENST00000742246, ENST00000742247, ENST00000742248, ENST00000742249, ENST00000742250, ENST00000742251, ENST00000742252, ENST00000742253, ENST00000742254, ENST00000742255, ENST00000742256, ENST00000742257, ENST00000742258, ENST00000742259, ENST00000742260, ENST00000742261, ENST00000742262, ENST00000742263, ENST00000742264, ENST00000742265, ENST00000742266, ENST00000742267, ENST00000742268, ENST00000742269, ENST00000742270, ENST00000742271, ENST00000742272, ENST00000742273, ENST00000742274, ENST00000742275, ENST00000742276, ENST00000742277, ENST00000742278, ENST00000742279, ENST00000742280, ENST00000742281, ENST00000742282, ENST00000742283, ENST00000742284, ENST00000742285, ENST00000742286, ENST00000742287, ENST00000742288, ENST00000742289, ENST00000742290, ENST00000742291, ENST00000742292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366446 — 3 exons

Exon	Start	End
ENSE00002461438	87336786	87336889
ENSE00003855182	87333777	87334814
ENSE00003877425	87341337	87341527

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 95.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5027 / max 343.7137, expressed in 1780 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110432	2.8249	1557
110433	2.0311	976
110434	2.0223	1102
110435	1.6243	674

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	95.00	gold quality
sural nerve	UBERON:0015488	94.63	gold quality
bone marrow cell	CL:0002092	94.52	gold quality
calcaneal tendon	UBERON:0003701	92.87	gold quality
monocyte	CL:0000576	92.80	gold quality
leukocyte	CL:0000738	92.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.18	gold quality
right lung	UBERON:0002167	91.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.28	gold quality
upper lobe of left lung	UBERON:0008952	91.27	gold quality
adrenal tissue	UBERON:0018303	91.19	gold quality
ectocervix	UBERON:0012249	91.04	gold quality
right ovary	UBERON:0002118	90.94	gold quality
body of pancreas	UBERON:0001150	90.92	gold quality
tibial nerve	UBERON:0001323	90.89	gold quality
body of uterus	UBERON:0009853	90.88	gold quality
left ovary	UBERON:0002119	90.83	gold quality
left lobe of thyroid gland	UBERON:0001120	90.69	gold quality
omental fat pad	UBERON:0010414	90.54	gold quality
skin of abdomen	UBERON:0001416	90.52	gold quality
peritoneum	UBERON:0002358	90.41	gold quality
minor salivary gland	UBERON:0001830	90.37	gold quality
endocervix	UBERON:0000458	90.16	gold quality
rectum	UBERON:0001052	90.13	gold quality
right lobe of thyroid gland	UBERON:0001119	90.06	gold quality
skin of leg	UBERON:0001511	89.97	gold quality
popliteal artery	UBERON:0002250	89.89	gold quality
tibial artery	UBERON:0007610	89.87	gold quality
right adrenal gland cortex	UBERON:0035827	89.87	gold quality
left adrenal gland	UBERON:0001234	89.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a. (PMID:33089970)
• Long non-coding RNA NUT family member 2A-antisense RNA 1 sponges microRNA-613 to increase the resistance of gastric cancer cells to matrine through regulating oxidative stress and vascular endothelial growth factor A. (PMID:35771149)
• LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway. (PMID:36242728)
• NR1D1-transactivated lncRNA NUTM2A-AS1 promotes chemoresistance and immune evasion in neuroblastoma via inhibiting B7-H3 degradation. (PMID:38785199)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.