NUTM2B-AS1

Summary

NUTM2B-AS1 (NUTM2B antisense RNA 1, HGNC:51204) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51204
Approved symbol	NUTM2B-AS1
Name	NUTM2B antisense RNA 1
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225484
Ensembl biotype	lncRNA
OMIM	618639
Entrez	101060691
RNAcentral	URS0000759C3A — lncRNA, 1331 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 88 — 88 lncRNA

ENST00000419697, ENST00000430963, ENST00000477192, ENST00000483080, ENST00000484794, ENST00000488805, ENST00000495430, ENST00000496359, ENST00000596088, ENST00000600376, ENST00000601369, ENST00000610681, ENST00000619625, ENST00000653620, ENST00000658528, ENST00000659471, ENST00000661316, ENST00000662025, ENST00000665716, ENST00000669121, ENST00000670682, ENST00000671459, ENST00000807165, ENST00000807166, ENST00000807167, ENST00000807168, ENST00000807169, ENST00000807170, ENST00000807171, ENST00000807172, ENST00000807173, ENST00000807174, ENST00000807175, ENST00000807176, ENST00000807177, ENST00000807178, ENST00000807179, ENST00000807180, ENST00000807181, ENST00000807182, ENST00000807183, ENST00000807184, ENST00000807185, ENST00000807186, ENST00000807187, ENST00000807188, ENST00000807189, ENST00000807190, ENST00000807191, ENST00000807192, ENST00000807193, ENST00000807194, ENST00000807195, ENST00000807196, ENST00000807197, ENST00000807198, ENST00000807199, ENST00000807200, ENST00000807201, ENST00000807202, ENST00000807203, ENST00000807204, ENST00000807205, ENST00000807206, ENST00000807207, ENST00000807208, ENST00000807209, ENST00000807210, ENST00000807211, ENST00000807212, ENST00000807213, ENST00000807214, ENST00000807215, ENST00000807216, ENST00000807217, ENST00000807218, ENST00000807219, ENST00000807220, ENST00000807221, ENST00000807222, ENST00000807223, ENST00000807224, ENST00000807225, ENST00000807226, ENST00000807227, ENST00000807228, ENST00000807229, ENST00000807230

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419697 — 2 exons

Exon	Start	End
ENSE00001717028	79814613	79814654
ENSE00001774632	79804057	79804527

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 95.30.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5061 / max 17.6263, expressed in 281 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110315	0.5061	281

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	95.30	gold quality
bone marrow cell	CL:0002092	90.82	gold quality
calcaneal tendon	UBERON:0003701	90.74	gold quality
lower esophagus mucosa	UBERON:0035834	89.33	gold quality
metanephros cortex	UBERON:0010533	88.33	gold quality
minor salivary gland	UBERON:0001830	88.30	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.20	gold quality
left testis	UBERON:0004533	88.14	gold quality
right lobe of liver	UBERON:0001114	88.12	gold quality
skin of abdomen	UBERON:0001416	88.11	gold quality
body of pancreas	UBERON:0001150	88.10	gold quality
adrenal tissue	UBERON:0018303	88.05	gold quality
right lung	UBERON:0002167	88.04	gold quality
omental fat pad	UBERON:0010414	87.98	gold quality
peritoneum	UBERON:0002358	87.90	gold quality
mucosa of transverse colon	UBERON:0004991	87.74	gold quality
left lobe of thyroid gland	UBERON:0001120	87.68	gold quality
upper lobe of left lung	UBERON:0008952	87.67	gold quality
sural nerve	UBERON:0015488	87.65	gold quality
body of uterus	UBERON:0009853	87.44	gold quality
tibial nerve	UBERON:0001323	87.30	gold quality
monocyte	CL:0000576	87.29	gold quality
leukocyte	CL:0000738	87.22	gold quality
right atrium auricular region	UBERON:0006631	87.21	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.16	gold quality
skin of leg	UBERON:0001511	87.02	gold quality
left ovary	UBERON:0002119	86.96	gold quality
left coronary artery	UBERON:0001626	86.85	gold quality
right testis	UBERON:0004534	86.81	gold quality
right ovary	UBERON:0002118	86.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Non-coding CGG repeat expansion in LOC642361/NUTM2B-AS1 is associated with a phenotype of oculopharyngodistal myopathy. (PMID:37923380)
• CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy. (PMID:38159879)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.