NUTM2G

Summary

NUTM2G (NUT family member 2G, HGNC:23449) is a protein-coding gene on chromosome 9q22.33, encoding NUT family member 2G (Q5VZR2).

At a glance

• Clinical variants (ClinVar): 160 total
• MANE Select transcript: NM_001170741

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23449
Approved symbol	NUTM2G
Name	NUT family member 2G
Location	9q22.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188152
Ensembl biotype	protein_coding
Entrez	441457

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000354649, ENST00000372322

RefSeq mRNA: 2 — MANE Select: NM_001170741 NM_001045477, NM_001170741

CCDS: CCDS43854, CCDS55329

Canonical transcript exons

ENST00000372322 — 7 exons

Exon	Start	End
ENSE00001375236	96937064	96937404
ENSE00001591367	96935328	96935456
ENSE00001684432	96931722	96932418
ENSE00001712328	96936425	96936564
ENSE00001749279	96937885	96938001
ENSE00001771206	96938364	96939416
ENSE00002275804	96928843	96929040

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 75.30.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.30	silver quality
bone marrow cell	CL:0002092	68.85	silver quality
colonic epithelium	UBERON:0000397	63.95	silver quality
stromal cell of endometrium	CL:0002255	63.91	gold quality
lower esophagus mucosa	UBERON:0035834	63.46	gold quality
bone marrow	UBERON:0002371	62.57	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.30	gold quality
monocyte	CL:0000576	61.89	gold quality
leukocyte	CL:0000738	61.63	gold quality
blood	UBERON:0000178	60.91	gold quality
skeletal muscle tissue	UBERON:0001134	59.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.23	gold quality
sural nerve	UBERON:0015488	58.19	gold quality
tonsil	UBERON:0002372	57.31	silver quality
apex of heart	UBERON:0002098	57.08	gold quality
primary visual cortex	UBERON:0002436	56.77	gold quality
granulocyte	CL:0000094	56.39	gold quality
right testis	UBERON:0004534	55.57	gold quality
left testis	UBERON:0004533	55.51	gold quality
testis	UBERON:0000473	55.21	gold quality
muscle tissue	UBERON:0002385	54.92	gold quality
cortex of kidney	UBERON:0001225	54.18	gold quality
urinary bladder	UBERON:0001255	54.14	gold quality
lymph node	UBERON:0000029	54.07	gold quality
adrenal tissue	UBERON:0018303	53.90	gold quality
esophagus mucosa	UBERON:0002469	52.74	gold quality
uterine cervix	UBERON:0000002	52.05	gold quality
endometrium	UBERON:0001295	51.62	gold quality
myometrium	UBERON:0001296	51.58	gold quality
ovary	UBERON:0000992	51.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting NUTM2G, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-4260	98.78	65.37	848
HSA-MIR-6810-5P	98.29	66.21	975
HSA-MIR-450A-2-3P	97.91	67.56	1459
HSA-MIR-1225-3P	97.29	64.60	876
HSA-MIR-4286	97.20	64.37	1587
HSA-MIR-1913	97.07	66.20	1417

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Nutm2	ENSMUSG00000071909
rattus_norvegicus	Nutm2	ENSRNOG00000027311

Paralogs (6): NUTM2F (ENSG00000130950), NUTM1 (ENSG00000184507), NUTM2A (ENSG00000184923), NUTM2B (ENSG00000188199), NUTM2D (ENSG00000214562), NUTM2E (ENSG00000228570)

Protein

Protein identifiers

NUT family member 2G — Q5VZR2 (reviewed: Q5VZR2)

All UniProt accessions (1): Q5VZR2

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the NUT family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5VZR2-1	1	yes
Q5VZR2-2	2

RefSeq proteins (2): NP_001038942, NP_001164212* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024309	NUT_N	Domain
IPR024310	NUT	Family

Pfam: PF12881

UniProt features (13 total): region of interest 5, compositionally biased region 5, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VZR2-F1	52.23	0.12

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 10 (showing top): chr9q22, MIR4728_5P, MIR6785_5P, MIR149_3P, MIR4441, MIR1200, MIR4270, MIR1291, MIR1178_3P, MIR10398_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

406 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NUTM2G	RTL9	Q8NET4	664
NUTM2G	NUGGC	Q68CJ6	625
NUTM2G	OR2T27	Q8NH04	595
NUTM2G	RALGPS1	Q5JS13	594
NUTM2G	MAP7D2	Q96T17	590
NUTM2G	ZC3H7B	Q9UGR2	531
NUTM2G	KRTAP9-1	A8MXZ3	518
NUTM2G	MCRIP1	C9JLW8	514
NUTM2G	MROH8	Q9H579	507
NUTM2G	ZNF169	Q14929	473
NUTM2G	ZNF510	Q9Y2H8	472
NUTM2G	FRG2C	A6NGY1	446
NUTM2G	CCDC134	Q9H6E4	433
NUTM2G	ING3	Q9NXR8	409
NUTM2G	TAPT1	Q6NXT6	402

IntAct

0 interactions, top by confidence:

BioGRID (1): NUTM2G (Affinity Capture-RNA)

ESM2 similar proteins: A0A096LP49, A0A8V8TNH8, A0A8V8TPE2, A1L443, A2IDD5, A5D7L8, A6NDY2, A6NIJ5, A6NNJ1, A6NNL0, A7E346, A8K0R7, A8MXJ8, A8MXZ1, B1AL46, B1ASB6, C9JSJ3, E9PGG2, O08574, P0C7V4, P0C7W8, P0C7X0, P0CG20, P0DV73, P0DV75, P0DV76, Q0VG99, Q0ZCJ7, Q149B8, Q2M3G4, Q3TQ03, Q3V0C3, Q4KLY2, Q5JXC2, Q5RCJ6, Q5SV97, Q5SW24, Q5VT03, Q5VZR2, Q6ZMY3

Diamond homologs: A1L443, A6NNL0, B1AL46, Q3V0C3, Q5VT03, Q5VZR2, Q86Y26, Q8BHP2, Q8IVF1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

160 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	148
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1327 predictions. Top by Δscore:

Variant	Effect	Δscore
9:96932419:G:GG	donor_gain	1.0000
9:96935326:A:AG	acceptor_gain	1.0000
9:96935327:G:GA	acceptor_gain	1.0000
9:96935327:GC:G	acceptor_gain	1.0000
9:96935327:GCC:G	acceptor_gain	1.0000
9:96935327:GCCC:G	acceptor_gain	1.0000
9:96935327:GCCCA:G	acceptor_gain	1.0000
9:96935345:T:TA	acceptor_gain	1.0000
9:96935452:GCAAA:G	donor_gain	1.0000
9:96935454:AAAG:A	donor_loss	1.0000
9:96935455:AA:A	donor_gain	1.0000
9:96935455:AAG:A	donor_loss	1.0000
9:96935456:AGT:A	donor_loss	1.0000
9:96935457:G:GG	donor_gain	1.0000
9:96937387:G:GT	donor_gain	1.0000
9:96937876:T:TA	acceptor_gain	1.0000
9:96937883:A:AG	acceptor_gain	1.0000
9:96937883:A:AT	acceptor_loss	1.0000
9:96937883:AG:A	acceptor_gain	1.0000
9:96937883:AGGT:A	acceptor_gain	1.0000
9:96937883:AGGTG:A	acceptor_gain	1.0000
9:96937884:G:GA	acceptor_gain	1.0000
9:96937884:GG:G	acceptor_gain	1.0000
9:96937884:GGT:G	acceptor_gain	1.0000
9:96937884:GGTG:G	acceptor_gain	1.0000
9:96937884:GGTGG:G	acceptor_gain	1.0000
9:96937978:G:GT	donor_gain	1.0000
9:96937981:G:GT	donor_gain	1.0000
9:96937982:A:T	donor_gain	1.0000
9:96937997:CCCAG:C	donor_loss	1.0000

AlphaMissense

4728 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:96936426:T:C	F282L	0.990
9:96936428:C:A	F282L	0.990
9:96936428:C:G	F282L	0.990
9:96932411:T:C	F236L	0.985
9:96932413:C:A	F236L	0.985
9:96932413:C:G	F236L	0.985
9:96935406:G:C	W264C	0.982
9:96935406:G:T	W264C	0.982
9:96936427:T:C	F282S	0.981
9:96936435:T:C	F285L	0.980
9:96936437:T:A	F285L	0.980
9:96936437:T:G	F285L	0.980
9:96935404:T:A	W264R	0.977
9:96935404:T:C	W264R	0.977
9:96935437:T:C	F275L	0.969
9:96935439:C:A	F275L	0.969
9:96935439:C:G	F275L	0.969
9:96932344:G:C	W213C	0.968
9:96932344:G:T	W213C	0.968
9:96937909:T:C	F450L	0.967
9:96937911:C:A	F450L	0.967
9:96937911:C:G	F450L	0.967
9:96932342:T:A	W213R	0.966
9:96932342:T:C	W213R	0.966
9:96932408:T:C	C235R	0.960
9:96932333:T:C	F210L	0.959
9:96932335:C:A	F210L	0.959
9:96932335:C:G	F210L	0.959
9:96932356:G:C	K217N	0.956
9:96932356:G:T	K217N	0.956

dbSNP variants (sampled 300 via entrez): RS1000340002 (9:96928627 T>C), RS1000584982 (9:96937643 G>C), RS1000700891 (9:96926877 G>A,T), RS1000940813 (9:96927182 G>C), RS1001688580 (9:96933591 C>T), RS1001707509 (9:96938038 G>A), RS1001930507 (9:96933731 C>T), RS1002317196 (9:96927333 G>A), RS1002591513 (9:96935900 C>G), RS1002988426 (9:96930527 A>C,G), RS1003357696 (9:96934436 C>T), RS1003472372 (9:96940292 G>A,C), RS1003585066 (9:96928819 C>T), RS1003600073 (9:96934700 C>T), RS1003787018 (9:96940815 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
benzo(e)pyrene	increases methylation	1
Methapyrilene	increases methylation	1
Tobacco Smoke Pollution	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.