NXF3

Summary

NXF3 (nuclear RNA export factor 3, HGNC:8073) is a protein-coding gene on chromosome Xq22.1, encoding Nuclear RNA export factor 3 (Q9H4D5). May function as a tissue-specific nuclear mRNA export factor.

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

Source: NCBI Gene 56000 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 90 total — 1 likely-pathogenic
• MANE Select transcript: NM_022052

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8073
Approved symbol	NXF3
Name	nuclear RNA export factor 3
Location	Xq22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000147206
Ensembl biotype	protein_coding
OMIM	300316
Entrez	56000

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 retained_intron, 2 protein_coding

ENST00000395065, ENST00000427570, ENST00000460791, ENST00000468528, ENST00000470724, ENST00000494300, ENST00000497850

RefSeq mRNA: 1 — MANE Select: NM_022052 NM_022052

CCDS: CCDS14503

Canonical transcript exons

ENST00000395065 — 20 exons

Exon	Start	End
ENSE00001783547	103092996	103093143
ENSE00001912793	103075810	103076000
ENSE00003471696	103078560	103078632
ENSE00003474166	103083398	103083502
ENSE00003476296	103083609	103083692
ENSE00003478249	103079584	103079642
ENSE00003505253	103082255	103082364
ENSE00003510257	103079221	103079263
ENSE00003517111	103076241	103076301
ENSE00003519085	103079359	103079474
ENSE00003528133	103077614	103077746
ENSE00003532374	103080576	103080612
ENSE00003547767	103080148	103080216
ENSE00003579059	103083004	103083073
ENSE00003592386	103084342	103084495
ENSE00003635699	103084715	103084883
ENSE00003641549	103082760	103082848
ENSE00003651526	103080013	103080068
ENSE00003674047	103079763	103079870
ENSE00003689762	103083193	103083273

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 99.39.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.1299 / max 115.2604, expressed in 172 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199980	1.1299	172

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	99.39	gold quality
right testis	UBERON:0004534	99.19	gold quality
left testis	UBERON:0004533	99.04	gold quality
testis	UBERON:0000473	95.77	gold quality
gall bladder	UBERON:0002110	91.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.21	gold quality
right lung	UBERON:0002167	80.61	gold quality
upper lobe of left lung	UBERON:0008952	79.64	gold quality
left uterine tube	UBERON:0001303	78.23	gold quality
upper lobe of lung	UBERON:0008948	78.19	gold quality
fallopian tube	UBERON:0003889	76.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.20	gold quality
buccal mucosa cell	CL:0002336	72.72	gold quality
male germ cell	CL:0000015	72.59	silver quality
right adrenal gland cortex	UBERON:0035827	72.21	gold quality
adult organism	UBERON:0007023	72.09	gold quality
small intestine	UBERON:0002108	71.57	gold quality
diaphragm	UBERON:0001103	71.25	gold quality
right adrenal gland	UBERON:0001233	71.16	gold quality
right lobe of liver	UBERON:0001114	71.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.22	gold quality
sperm	CL:0000019	70.16	silver quality
pancreatic ductal cell	CL:0002079	70.07	silver quality
monocyte	CL:0000576	69.75	gold quality
left adrenal gland	UBERON:0001234	69.64	gold quality
rectum	UBERON:0001052	69.60	gold quality
mononuclear cell	CL:0000842	69.57	gold quality
left adrenal gland cortex	UBERON:0035825	69.27	gold quality
lung	UBERON:0002048	68.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.21

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting NXF3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-4704-3P	98.28	69.33	1300
HSA-MIR-12120	98.05	68.44	1768
HSA-MIR-146B-3P	97.83	65.29	782
HSA-MIR-6508-3P	96.73	65.48	576
HSA-MIR-635	96.00	65.54	687
HSA-MIR-6774-5P	95.94	65.18	722
HSA-MIR-6835-5P	95.81	64.27	500

Literature-anchored findings (GeneRIF, showing 1)

• observations collectively demonstrate that AF119895 modulates the repression of NXF3 by binding to miR-6508-3p (PMID:29274323)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	nxf1b	ENSDARG00000055076
danio_rerio	nxf1a	ENSDARG00000086017
mus_musculus	Nxf3	ENSMUSG00000057000
rattus_norvegicus	Nxf3	ENSRNOG00000028751
drosophila_melanogaster	nxf4	FBGN0051501
caenorhabditis_elegans		WBGENE00003834
caenorhabditis_elegans		WBGENE00003835

Paralogs (3): NXF1 (ENSG00000162231), NXF2 (ENSG00000269405), NXF2B (ENSG00000269437)

Protein

Protein identifiers

Nuclear RNA export factor 3 — Q9H4D5 (reviewed: Q9H4D5)

Alternative names: TAP-like protein 3

All UniProt accessions (2): Q9H4D5, H0Y6A1

UniProt curated annotations — full annotation on UniProt →

Function. May function as a tissue-specific nuclear mRNA export factor.

Subunit / interactions. Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Expressed at high level in testis and at low level in a small number of tissues.

Domain organisation. Lacks C-terminal domain that mediates direct interactions with nucleoporins. Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain. The RNA-binding domain is a non-canonical RNP-type domain.

Similarity. Belongs to the NXF family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H4D5-1	1	yes
Q9H4D5-2	2

RefSeq proteins (1): NP_071335* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002075	NTF2_dom	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR015245	Tap_RNA-bd	Domain
IPR018222	Nuclear_transport_factor_2_euk	Domain
IPR030217	NXF_fam	Family
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR032710	NTF2-like_dom_sf	Homologous_superfamily
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR057125	NXF1/2/3/5-like_LRR	Domain

Pfam: PF09162, PF22602, PF24048

UniProt features (13 total): splice variant 3, domain 2, mutagenesis site 2, region of interest 2, compositionally biased region 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H4D5-F1	63.39	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (2):

Position	Phenotype
300	inactivates crm1 binding; when associated with r-302.
302	inactivates crm1 binding; when associated with r-300.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 49 (showing top): FOXD3_01, GOBP_NUCLEAR_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, AACTTT_UNKNOWN, GOBP_NUCLEAR_EXPORT, GOBP_RNA_LOCALIZATION, AGCYRWTTC_UNKNOWN, WGTTNNNNNAAA_UNKNOWN, CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN, WAGSCHAL_EHMT2_TARGETS_UP, chrXq22, GOBP_RNA_EXPORT_FROM_NUCLEUS, GOBP_MRNA_EXPORT_FROM_NUCLEUS, GOBP_POLY_A_PLUS_MRNA_EXPORT_FROM_NUCLEUS, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP

GO Biological Process (3): mRNA export from nucleus (GO:0006406), poly(A)+ mRNA export from nucleus (GO:0016973), mRNA transport (GO:0051028)

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), nuclear RNA export factor complex (GO:0042272)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular anatomical structure	2
RNA export from nucleus	1
gene expression	1
mRNA transport	1
mRNA export from nucleus	1
RNA transport	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

748 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NXF3	NXT1	Q9UKK6	983
NXF3	XPO1	O14980	922
NXF3	NUTF2	P13662	909
NXF3	NXT2	Q9NPJ8	842
NXF3	NUP214	P35658	775
NXF3	NUP62	P37198	760
NXF3	NUP153	P49790	756
NXF3	NUP98	P52948	706
NXF3	HNRNPUL1	Q9BUJ2	648
NXF3	NPAS4	Q8IUM7	623
NXF3	TNPO2	O14787	573
NXF3	DDX39B	Q13838	557
NXF3	THOC5	Q13769	507
NXF3	NUDT11	Q96G61	504
NXF3	FMR1	Q06787	493

IntAct

40 interactions, top by confidence:

A	B	Type	Score
NXF3	NXT1	psi-mi:“MI:0915”(physical association)	0.950
NXT1	NXF3	psi-mi:“MI:0915”(physical association)	0.950
NXF3	NXT2	psi-mi:“MI:0915”(physical association)	0.890
NXT2	NXF3	psi-mi:“MI:0915”(physical association)	0.890
NXF3	NXT2	psi-mi:“MI:0915”(physical association)	0.630
NXF3	SKIL	psi-mi:“MI:0915”(physical association)	0.560
SKIL	NXF3	psi-mi:“MI:0915”(physical association)	0.560
NXF3	TRIM11	psi-mi:“MI:0914”(association)	0.350
NXT2	MYO1G	psi-mi:“MI:0914”(association)	0.350
NXF3	NXT1	psi-mi:“MI:0915”(physical association)	0.000
NXT2	NXF3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): NXF3 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Two-hybrid), XPO1 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Two-hybrid), TRIM11 (Affinity Capture-MS), NXT1 (Affinity Capture-MS), NXT2 (Affinity Capture-MS), NXF3 (Two-hybrid), NXF3 (Two-hybrid), NXF3 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A494C1R9, A2AKB4, A2APT9, A6NKD2, A8MT33, B0BN44, E9PGG2, F5GYI3, O19110, O88852, P0CV98, P0CV99, P0CW00, P0CW01, Q01534, Q03386, Q0P5N2, Q12967, Q14684, Q2M329, Q3U3N0, Q5F267, Q5I0E2, Q5R5G8, Q5R866, Q5SYB0, Q5VTJ3, Q60953, Q69ZB3, Q6ZUX3, Q7TQI8, Q80VJ8, Q80VR2, Q86VY4, Q8BSI6, Q8IZJ4, Q8N831, Q8VD63, Q95LS7, Q96FG2

Diamond homologs: O35381, O88984, P49911, P58797, Q1RMS5, Q5R752, Q8ILI6, Q92688, Q99JX7, Q9GZY0, Q9H1B4, Q9H4D5, Q9U1H9, Q9UBU9, Q9XVS8, Q3SZC6

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
NXF3	“form complex”	“NXF3-NXT1 mRNA nuclear export factor complex”	binding
NXF3	“form complex”	“NXF3-NXT2 mRNA nuclear export factor complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

90 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	37
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3235107	NM_022052.2(NXF3):c.826G>T (p.Gly276Ter)	Likely pathogenic

SpliceAI

2601 predictions. Top by Δscore:

Variant	Effect	Δscore
X:103076302:C:CC	acceptor_gain	1.0000
X:103077742:ACAGA:A	acceptor_gain	1.0000
X:103077743:CAGA:C	acceptor_gain	1.0000
X:103077743:CAGAC:C	acceptor_gain	1.0000
X:103077744:AGA:A	acceptor_gain	1.0000
X:103077745:GA:G	acceptor_gain	1.0000
X:103077747:C:CC	acceptor_gain	1.0000
X:103078633:C:CC	acceptor_gain	1.0000
X:103078636:C:CT	acceptor_gain	1.0000
X:103079261:TTCC:T	acceptor_loss	1.0000
X:103079262:TCCT:T	acceptor_loss	1.0000
X:103079263:CCTG:C	acceptor_loss	1.0000
X:103079264:CTG:C	acceptor_loss	1.0000
X:103079265:T:A	acceptor_loss	1.0000
X:103079355:TCA:T	donor_loss	1.0000
X:103079356:CAC:C	donor_loss	1.0000
X:103079357:A:AC	donor_gain	1.0000
X:103079357:AC:A	donor_gain	1.0000
X:103079357:ACCGT:A	donor_gain	1.0000
X:103079358:C:CA	donor_gain	1.0000
X:103079358:CC:C	donor_gain	1.0000
X:103079358:CCG:C	donor_gain	1.0000
X:103079358:CCGT:C	donor_gain	1.0000
X:103079358:CCGTC:C	donor_gain	1.0000
X:103079470:AAGGT:A	acceptor_gain	1.0000
X:103079471:AGGT:A	acceptor_gain	1.0000
X:103079472:GGT:G	acceptor_gain	1.0000
X:103079473:GT:G	acceptor_gain	1.0000
X:103079474:TC:T	acceptor_loss	1.0000
X:103079475:C:CC	acceptor_gain	1.0000

AlphaMissense

3563 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:103078598:G:C	F471L	0.978
X:103078598:G:T	F471L	0.978
X:103078600:A:G	F471L	0.978
X:103084351:G:C	F114L	0.977
X:103084351:G:T	F114L	0.977
X:103084353:A:G	F114L	0.977
X:103083500:A:C	F146L	0.975
X:103083500:A:T	F146L	0.975
X:103083502:A:G	F146L	0.975
X:103080021:G:C	F348L	0.972
X:103080021:G:T	F348L	0.972
X:103080023:A:G	F348L	0.972
X:103083473:G:C	F155L	0.968
X:103083473:G:T	F155L	0.968
X:103083475:A:G	F155L	0.968
X:103083441:A:G	L166P	0.965
X:103083450:G:T	A163D	0.964
X:103078593:C:G	R473P	0.963
X:103083621:G:C	F141L	0.962
X:103083621:G:T	F141L	0.962
X:103083623:A:G	F141L	0.962
X:103083474:A:G	F155S	0.956
X:103078599:A:G	F471S	0.952
X:103083441:A:T	L166Q	0.950
X:103083501:A:G	F146S	0.947
X:103079821:A:C	Y368D	0.943
X:103079241:A:T	V453D	0.940
X:103079246:A:C	F451L	0.938
X:103079246:A:T	F451L	0.938
X:103079248:A:G	F451L	0.938

dbSNP variants (sampled 300 via entrez): RS1000142058 (X:103086421 A>T), RS1000221267 (X:103080737 G>A), RS1000356903 (X:103086755 C>G,T), RS1000444219 (X:103092017 A>AAC), RS1000772894 (X:103092584 G>A), RS1001183810 (X:103093571 T>G), RS1001247677 (X:103086367 C>T), RS1001576114 (X:103086621 A>G), RS1002213337 (X:103090363 T>G), RS1002399791 (X:103094666 T>G), RS1002586876 (X:103091337 C>T), RS1002775310 (X:103086364 T>C), RS1002884215 (X:103095053 T>C), RS1003235255 (X:103080484 A>G), RS1003307978 (X:103083921 G>C)

Disease associations

OMIM: gene MIM:300316 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): male infertility (MONDO:0005372)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006442_453	Educational attainment (years of education)	4.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004784	self reported educational attainment

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases mutagenesis	2
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
abrine	increases expression	1
Tretinoin	increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

125 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
NCT07402759	PHASE3	ACTIVE_NOT_RECRUITING	Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
NCT01880086	PHASE2	COMPLETED	Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
NCT02061384	PHASE2	COMPLETED	RA-2 13-cis Retinoic Acid (Isotretinoin)
NCT02421887	PHASE2	COMPLETED	Males, Antioxidants, and Infertility Trial
NCT05200663	PHASE2	UNKNOWN	Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
NCT05290558	PHASE2	ACTIVE_NOT_RECRUITING	The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
NCT06091969	PHASE2	NOT_YET_RECRUITING	Supplementation for Male Subfertility
NCT01595308	PHASE1	COMPLETED	A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers
NCT02122211	PHASE1	COMPLETED	Choline Dehydrogenase and Sperm Function: Effects of Betaine
NCT02575924	PHASE1	UNKNOWN	Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
NCT01304927	PHASE2/PHASE3	COMPLETED	Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
NCT02349945	PHASE2/PHASE3	COMPLETED	FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy
NCT05222841	PHASE2/PHASE3	COMPLETED	The Effectiveness of Spermotrend Food Supplement in the Treatment of Male Infertility
NCT05616598	PHASE2/PHASE3	COMPLETED	Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters
NCT02025270	PHASE1/PHASE2	COMPLETED	MSCs For Treatment of Azoospermic Patients
NCT04541459	EARLY_PHASE1	UNKNOWN	Validation of New Devices Against Ambient Electromagnetic Radiation
NCT05792813	EARLY_PHASE1	UNKNOWN	Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility
NCT06188936	EARLY_PHASE1	COMPLETED	Home Semen Analysis Tests As a Screening Tool for Fertility Patients
NCT00012480	Not specified	COMPLETED	Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm
NCT00044369	Not specified	COMPLETED	Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
NCT00119925	Not specified	UNKNOWN	‘SPRING’-Study: Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists
NCT00178516	Not specified	COMPLETED	Vitamin E and Male Infertility
NCT00315029	Not specified	COMPLETED	Patient-Centered Implementation Trial for Single Embryo Transfer
NCT00341120	Not specified	COMPLETED	Genetic Causes of Male Infertility
NCT00481403	Not specified	COMPLETED	Study of Sperm Molecular Factors Implicated in Male Fertility
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT00596739	Not specified	COMPLETED	A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery
NCT00756561	Not specified	COMPLETED	HOP-2A - Intratesticular Hormone Levels
NCT00961558	Not specified	TERMINATED	Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy
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