NXT1-AS1

Summary

NXT1-AS1 (NXT1 antisense RNA 1, HGNC:40734) is a long non-coding RNA gene on chromosome 20p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40734
Approved symbol	NXT1-AS1
Name	NXT1 antisense RNA 1
Location	20p11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234832
Ensembl biotype	lncRNA
Entrez	105372572
RNAcentral	URS0002A176FA — lncRNA, 837 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000442884, ENST00000610918, ENST00000716734, ENST00000716735, ENST00000716736, ENST00000716737, ENST00000782929, ENST00000782930, ENST00000782931, ENST00000782932, ENST00000782933, ENST00000782934, ENST00000782935, ENST00000782936, ENST00000782937, ENST00000782938, ENST00000782939, ENST00000782940, ENST00000782941, ENST00000782942, ENST00000782943, ENST00000782944, ENST00000782945, ENST00000782946, ENST00000782947, ENST00000782948, ENST00000782949, ENST00000782950, ENST00000782951, ENST00000782952

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442884 — 2 exons

Exon	Start	End
ENSE00001663589	23346941	23347597
ENSE00004030571	23351330	23351486

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 79.99.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3488 / max 28.0447, expressed in 132 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
186684	0.1802	60
186683	0.1686	64

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.99	silver quality
colonic epithelium	UBERON:0000397	72.28	gold quality
bone marrow cell	CL:0002092	70.75	silver quality
ganglionic eminence	UBERON:0004023	64.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.38	gold quality
monocyte	CL:0000576	62.56	gold quality
bone marrow	UBERON:0002371	62.42	gold quality
cortical plate	UBERON:0005343	61.37	gold quality
stromal cell of endometrium	CL:0002255	59.24	gold quality
granulocyte	CL:0000094	57.79	gold quality
skeletal muscle tissue	UBERON:0001134	56.25	gold quality
blood	UBERON:0000178	54.73	gold quality
calcaneal tendon	UBERON:0003701	54.30	gold quality
right adrenal gland cortex	UBERON:0035827	52.37	gold quality
gall bladder	UBERON:0002110	51.23	gold quality
islet of Langerhans	UBERON:0000006	50.72	gold quality
duodenum	UBERON:0002114	50.64	gold quality
liver	UBERON:0002107	50.62	gold quality
lymph node	UBERON:0000029	50.29	gold quality
ectocervix	UBERON:0012249	50.15	gold quality
left uterine tube	UBERON:0001303	49.93	gold quality
apex of heart	UBERON:0002098	49.88	gold quality
popliteal artery	UBERON:0002250	49.37	gold quality
tibial artery	UBERON:0007610	49.35	gold quality
muscle of leg	UBERON:0001383	49.29	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.06	gold quality
right lobe of liver	UBERON:0001114	48.97	gold quality
prefrontal cortex	UBERON:0000451	48.96	gold quality
placenta	UBERON:0001987	48.79	gold quality
tonsil	UBERON:0002372	48.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.73

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.