NXT2

Summary

NXT2 (nuclear transport factor 2 like export factor 2, HGNC:18151) is a protein-coding gene on chromosome Xq23, encoding NTF2-related export protein 2 (Q9NPJ8). Regulator of protein export for NES-containing proteins.

The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Source: NCBI Gene 55916 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 43 total — 2 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_001242617

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18151
Approved symbol	NXT2
Name	nuclear transport factor 2 like export factor 2
Location	Xq23
Locus type	gene with protein product
Status	Approved
Aliases	P15-2
Ensembl gene	ENSG00000101888
Ensembl biotype	protein_coding
OMIM	300320
Entrez	55916

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000218004, ENST00000372103, ENST00000372106, ENST00000372107, ENST00000911614, ENST00000911615, ENST00000956986, ENST00000956987

RefSeq mRNA: 3 — MANE Select: NM_001242617 NM_001242617, NM_001242618, NM_018698

CCDS: CCDS14546, CCDS56605, CCDS56606

Canonical transcript exons

ENST00000372106 — 4 exons

Exon	Start	End
ENSE00000674537	109541475	109541619
ENSE00001456923	109542507	109544698
ENSE00001456924	109536844	109537021
ENSE00003624149	109538045	109538131

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 94.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2331 / max 177.2784, expressed in 1663 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
197244	4.7375	1476
197241	1.9720	1161
197239	0.5273	69
197240	0.4090	139
197243	0.1748	55
197242	0.1317	32
197245	0.1206	48
197246	0.1110	47
197238	0.0493	16

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hair follicle	UBERON:0002073	94.31	gold quality
oocyte	CL:0000023	92.42	gold quality
secondary oocyte	CL:0000655	91.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.50	gold quality
upper leg skin	UBERON:0004262	90.02	gold quality
amniotic fluid	UBERON:0000173	89.08	gold quality
palpebral conjunctiva	UBERON:0001812	88.99	gold quality
esophagus squamous epithelium	UBERON:0006920	88.70	gold quality
sperm	CL:0000019	88.44	gold quality
choroid plexus epithelium	UBERON:0003911	88.39	gold quality
monocyte	CL:0000576	87.96	gold quality
mononuclear cell	CL:0000842	87.92	gold quality
male germ cell	CL:0000015	87.88	gold quality
squamous epithelium	UBERON:0006914	87.72	gold quality
epithelium of nasopharynx	UBERON:0001951	87.65	gold quality
nasopharynx	UBERON:0001728	87.64	gold quality
leukocyte	CL:0000738	87.63	gold quality
nephron tubule	UBERON:0001231	87.11	gold quality
cervix squamous epithelium	UBERON:0006922	87.10	silver quality
germinal epithelium of ovary	UBERON:0001304	87.02	gold quality
bone marrow	UBERON:0002371	86.78	gold quality
gingival epithelium	UBERON:0001949	86.47	gold quality
gingiva	UBERON:0001828	86.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.18	gold quality
skin of hip	UBERON:0001554	85.95	gold quality
epithelium of esophagus	UBERON:0001976	85.92	gold quality
bronchial epithelial cell	CL:0002328	84.83	gold quality
placenta	UBERON:0001987	84.77	gold quality
calcaneal tendon	UBERON:0003701	84.46	gold quality
periodontal ligament	UBERON:0008266	84.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.24
E-GEOD-100618	no	277.66

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

116 targeting NXT2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-12136	99.98	72.81	5713
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-557	99.96	70.01	1640

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nxt2	ENSDARG00000061527
mus_musculus	Nxt2	ENSMUSG00000042271
rattus_norvegicus	Nxt2	ENSRNOG00000019168
drosophila_melanogaster	Nxt1	FBGN0028411
caenorhabditis_elegans	nxt-1	WBGENE00003836

Paralogs (2): NUTF2 (ENSG00000102898), NXT1 (ENSG00000132661)

Protein

Protein identifiers

NTF2-related export protein 2 — Q9NPJ8 (reviewed: Q9NPJ8)

Alternative names: Protein p15-2

All UniProt accessions (1): Q9NPJ8

UniProt curated annotations — full annotation on UniProt →

Function. Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.

Subunit / interactions. Associates with NXF1, NXF2, NXF3 and NXF5.

Subcellular location. Nucleus. Cytoplasm.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NPJ8-1	1, A, p15-2a	yes
Q9NPJ8-3	3
Q9NPJ8-4	4, B, p15-2b

RefSeq proteins (3): NP_001229546, NP_001229547, NP_061168 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002075	NTF2_dom	Domain
IPR018222	Nuclear_transport_factor_2_euk	Domain
IPR032710	NTF2-like_dom_sf	Homologous_superfamily
IPR045875	NTF2	Family

Pfam: PF02136

UniProt features (4 total): splice variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NPJ8-F1	94.35	0.88

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 200 (showing top): CCAWYNNGAAR_UNKNOWN, BROWNE_HCMV_INFECTION_16HR_UP, GOBP_NUCLEAR_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP, KESHELAVA_MULTIPLE_DRUG_RESISTANCE, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, SCHLOSSER_SERUM_RESPONSE_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, POU3F2_02, SENESE_HDAC1_TARGETS_UP, CUI_TCF21_TARGETS_2_DN, BROWNE_HCMV_INFECTION_10HR_UP

GO Biological Process (5): mRNA export from nucleus (GO:0006406), protein transport (GO:0015031), poly(A)+ mRNA export from nucleus (GO:0016973), nucleocytoplasmic transport (GO:0006913), mRNA transport (GO:0051028)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), nuclear RNA export factor complex (GO:0042272), nuclear pore central transport channel (GO:0044613), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	2
nuclear protein-containing complex	2
RNA export from nucleus	1
gene expression	1
mRNA transport	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
mRNA export from nucleus	1
nuclear transport	1
RNA transport	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
nuclear pore	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

758 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NXT2	NUTF2	P13662	879
NXT2	NXF2B	Q9GZY0	857
NXT2	NXF3	Q9H4D5	842
NXT2	NXF1	Q9UBU9	827
NXT2	KCNE5	Q9UJ90	793
NXT2	AMMECR1	Q9Y4X0	768
NXT2	NUP62	P37198	723
NXT2	TNPO2	O14787	712
NXT2	ENY2	Q9NPA8	711
NXT2	NUP153	P49790	693
NXT2	GUCY2F	P51841	684
NXT2	NXF5	Q9H1B4	671
NXT2	NUP214	P35658	669
NXT2	HNRNPUL1	Q9BUJ2	650
NXT2	NSL1	Q96IY1	643

IntAct

60 interactions, top by confidence:

A	B	Type	Score
NXF3	NXT2	psi-mi:“MI:0915”(physical association)	0.890
NXT2	NXF3	psi-mi:“MI:0915”(physical association)	0.890
CUL5	SOCS2	psi-mi:“MI:0914”(association)	0.880
NXF1	NXT2	psi-mi:“MI:0914”(association)	0.790
NXT2	CCDC102B	psi-mi:“MI:0915”(physical association)	0.560
NXT2	PTPN3	psi-mi:“MI:0915”(physical association)	0.560
TRIM23	NXT2	psi-mi:“MI:0915”(physical association)	0.560
REL	NXT2	psi-mi:“MI:0915”(physical association)	0.560
NXT2	GOLGA2	psi-mi:“MI:0915”(physical association)	0.560
NXT2	USP54	psi-mi:“MI:0915”(physical association)	0.560
NXT2	LNX1	psi-mi:“MI:0915”(physical association)	0.560
NXT2	CEP63	psi-mi:“MI:0915”(physical association)	0.560
SSBP3	NXT2	psi-mi:“MI:0915”(physical association)	0.560
HEL-S-30	NXT2	psi-mi:“MI:0915”(physical association)	0.560
CCDC102B	NXT2	psi-mi:“MI:0915”(physical association)	0.560
PTPN3	NXT2	psi-mi:“MI:0915”(physical association)	0.560
NXT2	TRIM23	psi-mi:“MI:0915”(physical association)	0.560
LNX1	NXT2	psi-mi:“MI:0915”(physical association)	0.560
CEP63	NXT2	psi-mi:“MI:0915”(physical association)	0.560
NXT2	HEL-S-30	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (64): NXT2 (Two-hybrid), NXT2 (Two-hybrid), NXT2 (Two-hybrid), NXT2 (Two-hybrid), NXT2 (Two-hybrid), NXT2 (Two-hybrid), NXF3 (Two-hybrid), CCDC102B (Two-hybrid), CEP63 (Two-hybrid), LNX1 (Two-hybrid), USP54 (Two-hybrid), NXF3 (Two-hybrid), NXT2 (Synthetic Growth Defect), NXT2 (Two-hybrid), NXF3 (Two-hybrid)

ESM2 similar proteins: A6QNX3, B2GV77, P09851, P20936, P50904, P61970, P61971, P61972, Q1JP79, Q29425, Q2KI42, Q2KIW0, Q2TBL9, Q32KP9, Q3UNA4, Q4R4K5, Q4R5H6, Q5E9J4, Q5F415, Q5FVJ7, Q5R8G4, Q5R8I6, Q5RB36, Q5RES2, Q5RKN4, Q5ZLH0, Q6PC62, Q8BG32, Q8BUH1, Q8IUI8, Q8K0F1, Q8MJJ1, Q92747, Q93034, Q99PD4, Q9CQC8, Q9CZQ9, Q9D5V5, Q9DAI2, Q9ES56

Diamond homologs: A6QNX3, B2GV77, Q2KIW0, Q3UNA4, Q5ZLH0, Q9NPJ8, Q9QZV9, Q9UKK6, Q9V3H8, Q9U757, Q9XJ54, Q10100, Q9C7F5, Q9FZK4, Q6FRC6, Q75AA5

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
NXT2	“form complex”	“NXF2-NXT2 mRNA nuclear export factor complex”	binding
NXT2	“form complex”	“NXF5-NXT2 mRNA nuclear export factor complex”	binding
NXT2	“form complex”	“NXF3-NXT2 mRNA nuclear export factor complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	1
Uncertain significance	3
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
3602633	Single allele	Pathogenic
442321	GRCh37/hg19 Xp11.21-q28(chrX:57511767-155233731)x3	Pathogenic
3235106	NM_001242617.2(NXT2):c.189dup (p.Asp64Ter)	Likely pathogenic

SpliceAI

433 predictions. Top by Δscore:

Variant	Effect	Δscore
X:109541471:TTA:T	acceptor_loss	1.0000
X:109541472:TA:T	acceptor_loss	1.0000
X:109541473:A:AG	acceptor_gain	1.0000
X:109541474:G:GG	acceptor_gain	1.0000
X:109541474:G:GT	acceptor_loss	1.0000
X:109541474:GGC:G	acceptor_gain	1.0000
X:109542494:A:AG	acceptor_gain	1.0000
X:109542494:AAT:A	acceptor_gain	1.0000
X:109542494:AATGT:A	acceptor_gain	1.0000
X:109542495:ATGT:A	acceptor_gain	1.0000
X:109542496:T:A	acceptor_gain	1.0000
X:109542498:T:TA	acceptor_gain	1.0000
X:109537019:CTGG:C	donor_loss	0.9900
X:109537020:TGGTG:T	donor_loss	0.9900
X:109537021:GGT:G	donor_loss	0.9900
X:109537022:G:GG	donor_gain	0.9900
X:109537023:TGAG:T	donor_loss	0.9900
X:109537024:GAGT:G	donor_loss	0.9900
X:109541473:AG:A	acceptor_gain	0.9900
X:109541474:GG:G	acceptor_gain	0.9900
X:109541474:GGCA:G	acceptor_gain	0.9900
X:109541578:G:GG	donor_gain	0.9900
X:109541620:G:GC	donor_loss	0.9900
X:109541621:T:A	donor_loss	0.9900
X:109542495:A:G	acceptor_gain	0.9900
X:109542495:AT:A	acceptor_gain	0.9900
X:109542495:ATGTG:A	acceptor_gain	0.9900
X:109542499:G:A	acceptor_gain	0.9900
X:109542502:T:TA	acceptor_gain	0.9900
X:109542505:A:AG	acceptor_gain	0.9900

AlphaMissense

945 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:109541514:T:A	W48R	0.999
X:109541514:T:C	W48R	0.999
X:109541521:G:A	G50E	0.999
X:109541614:T:A	V81D	0.999
X:109542540:T:A	V94D	0.999
X:109542552:G:A	G98E	0.999
X:109542594:A:C	Q112P	0.999
X:109542638:T:A	W127R	0.999
X:109542638:T:C	W127R	0.999
X:109542663:G:C	R135P	0.999
X:109538081:G:C	A18P	0.998
X:109538102:T:G	Y25D	0.998
X:109541521:G:T	G50V	0.998
X:109541577:A:C	S69R	0.998
X:109541579:T:A	S69R	0.998
X:109541579:T:G	S69R	0.998
X:109542534:T:A	V92D	0.998
X:109542537:T:C	L93P	0.998
X:109542600:T:C	F114S	0.998
X:109542606:T:C	L116P	0.998
X:109542662:C:A	R135S	0.998
X:109538082:C:A	A18D	0.997
X:109538090:T:C	F21L	0.997
X:109538092:T:A	F21L	0.997
X:109538092:T:G	F21L	0.997
X:109538128:A:C	R33S	0.997
X:109538128:A:T	R33S	0.997
X:109541490:T:G	Y40D	0.997
X:109541516:G:C	W48C	0.997
X:109541516:G:T	W48C	0.997

dbSNP variants (sampled 300 via entrez): RS1000139108 (X:109537304 C>T), RS1000298598 (X:109540024 G>A,C), RS1001050667 (X:109539874 T>C,G), RS1001627280 (X:109538704 C>T), RS1001923401 (X:109540411 T>A), RS1002469408 (X:109540478 C>G), RS1002733175 (X:109535704 A>C,G), RS1003568471 (X:109533946 C>A,T), RS1003600784 (X:109542925 A>G,T), RS1003631913 (X:109543242 T>A), RS1003645565 (X:109535404 A>T), RS1004518163 (X:109537953 GT>G), RS1004652602 (X:109538587 G>A,T), RS1005139636 (X:109543738 G>A), RS1005279248 (X:109536411 G>A)

Disease associations

OMIM: gene MIM:300320 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): male infertility (MONDO:0005372)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
versicolorin A	increases expression	1
cadmium sulfate	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
jinfukang	decreases expression	1
Decitabine	increases expression	1
Zoledronic Acid	increases expression	1
Vorinostat	increases expression	1
Azacitidine	increases expression	1
Benzo(a)pyrene	affects methylation	1
Copper	affects binding, decreases expression	1
Disulfiram	affects binding, decreases expression	1
Hydrogen Peroxide	affects expression	1
Methylcholanthrene	affects binding, increases reaction	1
Piroxicam	increases expression	1
Tretinoin	increases expression	1
Valproic Acid	affects expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2FC	HAP1 NXT2 (-) 1	Cancer cell line	Male
CVCL_E2FD	HAP1 NXT2 (-) 2	Cancer cell line	Male
CVCL_E2FE	HAP1 NXT2 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

125 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
NCT07402759	PHASE3	ACTIVE_NOT_RECRUITING	Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
NCT01880086	PHASE2	COMPLETED	Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
NCT02061384	PHASE2	COMPLETED	RA-2 13-cis Retinoic Acid (Isotretinoin)
NCT02421887	PHASE2	COMPLETED	Males, Antioxidants, and Infertility Trial
NCT05200663	PHASE2	UNKNOWN	Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
NCT05290558	PHASE2	ACTIVE_NOT_RECRUITING	The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
NCT06091969	PHASE2	NOT_YET_RECRUITING	Supplementation for Male Subfertility
NCT01595308	PHASE1	COMPLETED	A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers
NCT02122211	PHASE1	COMPLETED	Choline Dehydrogenase and Sperm Function: Effects of Betaine
NCT02575924	PHASE1	UNKNOWN	Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
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