OAZ1

Summary

OAZ1 (ornithine decarboxylase antizyme 1, HGNC:8095) is a protein-coding gene on chromosome 19p13.3, encoding Ornithine decarboxylase antizyme 1 (P54368). Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Source: NCBI Gene 4946 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 3 total
• Druggable target: yes

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8095
Approved symbol	OAZ1
Name	ornithine decarboxylase antizyme 1
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	AZI, MGC138338, AZ1
Ensembl gene	ENSG00000104904
Ensembl biotype	protein_coding
OMIM	601579
Entrez	4946

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 7 retained_intron, 7 protein_coding, 6 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

ENST00000581150, ENST00000582888, ENST00000586054, ENST00000588673, ENST00000589361, ENST00000589739, ENST00000590943, ENST00000592727, ENST00000592787, ENST00000593012, ENST00000602676, ENST00000718416, ENST00000718417, ENST00000718418, ENST00000718419, ENST00000718420, ENST00000718421, ENST00000718422, ENST00000718423, ENST00000718424, ENST00000718425, ENST00000718426, ENST00000718427

RefSeq mRNA: 2 — MANE Select: None NM_001301020, NM_004152

CCDS: CCDS58639, CCDS77214

Canonical transcript exons

ENST00000581150 — 4 exons

Exon	Start	End
ENSE00001282935	2269520	2269744
ENSE00002695659	2271385	2271954
ENSE00002708908	2272972	2273221
ENSE00003694400	2272735	2272820

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.9915 / max 135.1089, expressed in 1728 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173070	2.5983	963
173075	2.0841	1101
173074	1.4201	929
173071	0.3260	139
173073	0.2893	97
173072	0.2736	123

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pons	UBERON:0000988	99.91	gold quality
blood	UBERON:0000178	99.89	gold quality
pylorus	UBERON:0001166	99.87	gold quality
monocyte	CL:0000576	99.86	gold quality
mononuclear cell	CL:0000842	99.86	gold quality
renal medulla	UBERON:0000362	99.86	gold quality
cardia of stomach	UBERON:0001162	99.86	gold quality
parietal lobe	UBERON:0001872	99.86	gold quality
substantia nigra pars compacta	UBERON:0001965	99.86	gold quality
postcentral gyrus	UBERON:0002581	99.86	gold quality
adult organism	UBERON:0007023	99.86	gold quality
superior vestibular nucleus	UBERON:0007227	99.86	gold quality
parotid gland	UBERON:0001831	99.85	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.85	gold quality
trabecular bone tissue	UBERON:0002483	99.85	gold quality
leukocyte	CL:0000738	99.84	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.84	gold quality
synovial joint	UBERON:0002217	99.83	gold quality
ventral tegmental area	UBERON:0002691	99.83	gold quality
vena cava	UBERON:0004087	99.83	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.83	gold quality
superior frontal gyrus	UBERON:0002661	99.82	gold quality
dorsal root ganglion	UBERON:0000044	99.81	gold quality
trigeminal ganglion	UBERON:0001675	99.81	gold quality
epithelium of nasopharynx	UBERON:0001951	99.81	gold quality
pericardium	UBERON:0002407	99.81	gold quality
lateral globus pallidus	UBERON:0002476	99.81	gold quality
superior surface of tongue	UBERON:0007371	99.81	gold quality
lower lobe of lung	UBERON:0008949	99.81	gold quality
entorhinal cortex	UBERON:0002728	99.79	gold quality

Single-cell (SCXA)

Detected in 31 experiment(s), a significant marker in 20.

Experiment	Marker?	Max mean expression
E-GEOD-149689	yes	11172.09
E-HCAD-9	yes	2377.95
E-HCAD-4	yes	272.88
E-HCAD-1	yes	114.98
E-CURD-122	yes	81.96
E-MTAB-6701	yes	73.66
E-GEOD-135922	yes	59.24
E-CURD-88	yes	55.20
E-MTAB-8410	yes	53.68
E-HCAD-10	yes	48.82
E-MTAB-10553	yes	42.53
E-MTAB-9467	yes	40.42
E-MTAB-8142	yes	35.93
E-CURD-46	yes	34.43
E-MTAB-10287	yes	28.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

48 targeting OAZ1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4306	99.72	70.50	3630

Literature-anchored findings (GeneRIF, showing 22)

• Human AZI is capable of acting as a general inhibitor for all members of the antizyme family. (PMID:15355308)
• Special polymorphism haplotype of OAZ gene is associated with Chinese systemic lupus erythematosus. OAZ may suggest a new pathway for lupus. (PMID:15476163)
• This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. (PMID:15670771)
• OAZ can alter the intensity and duration of the BMP4 stimulus through Smad6 (PMID:16373339)
• Ornithine decarboxylase antizyme 1 enhances the ability of UM1 human oral squamous cancer cells to repair DNA double-strand breaks by the nonhomologous end-joining pathway. (PMID:17630775)
• Identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. (PMID:17761941)
• Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme (PMID:18089576)
• Data suggest that residue 331 may play a major role in the dimerization of AZI, and the mutating Ser-331 to Tyr in AZI (AZI-S331Y) caused a shift from a monomer configuration to a dimer. (PMID:19635796)
• These data together demonstrate the existence of a c-Jun-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress. (PMID:20185758)
• Data show that OAZ promotes the removal of Mps1 from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1. (PMID:20861309)
• the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities (PMID:21552531)
• AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. (PMID:21931692)
• This study demomistrated that H3K4me3 modification plays an important role in up regulation of AOAZ1 in prefrontal cortex. (PMID:22008221)
• In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 is activated, leading to the inhibition of global protein synthesis and increased AZ1 synthesis via a cap-independent mechanism. (PMID:22157018)
• Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders. (PMID:23260169)
• To further understand its functions in CML pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development. (PMID:24192781)
• the effects of AZ on cell growth are independent of polyamines. (PMID:24930035)
• Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells. (PMID:25318549)
• Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). (PMID:26305948)
• Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines. (PMID:32181810)
• EPLIN-beta is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration. (PMID:37325974)
• antizyme expression requires programmed, ribosomal frameshifting (PMID:7813017)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	oaz1a	ENSDARG00000071403
mus_musculus	Oaz1	ENSMUSG00000035242
rattus_norvegicus	Oaz1	ENSRNOG00000019459

Paralogs (2): OAZ3 (ENSG00000143450), OAZ2 (ENSG00000180304)

Protein

Protein identifiers

Ornithine decarboxylase antizyme 1 — P54368 (reviewed: P54368)

All UniProt accessions (5): P54368, J3QQY4, K7EPM6, K7ERW1, Q2M222

UniProt curated annotations — full annotation on UniProt →

Function. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.

Subunit / interactions. Interacts with ODC1 and thereby sterically blocks ODC homodimerization. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1. Interacts with FAM171A1.

Induction. Induced by a ribosomal frameshifting mechanism in response to increased levels of intracellular polyamines.

Similarity. Belongs to the ODC antizyme family.

Isoforms (1)

UniProt ID	Names	Canonical?
P54368-1	1	yes

RefSeq proteins (2): NP_001287949, NP_004143 (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002993	ODC_AZ	Family
IPR016181	Acyl_CoA_acyltransferase	Homologous_superfamily
IPR038581	ODC_AZ_sf	Homologous_superfamily

Pfam: PF02100

UniProt features (20 total): strand 9, sequence variant 5, helix 2, chain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
4ZGY	X-RAY DIFFRACTION	2.63
5BWA	X-RAY DIFFRACTION	3.2
4ZGZ	X-RAY DIFFRACTION	5.81

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P54368-F1	74.98	0.47

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)
R-HSA-351202	Metabolism of polyamines

MSigDB gene sets: 204 (showing top): GOBP_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, ENK_UV_RESPONSE_KERATINOCYTE_UP, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT, MORF_UBE2I, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, HSIAO_HOUSEKEEPING_GENES, THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN, KYNG_DNA_DAMAGE_DN, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT, GOBP_POLYAMINE_METABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_TRANSPORT

GO Biological Process (6): polyamine biosynthetic process (GO:0006596), positive regulation of protein catabolic process (GO:0045732), viral translational frameshifting (GO:0075523), positive regulation of intracellular protein transport (GO:0090316), negative regulation of polyamine transmembrane transport (GO:1902268), biogenic amine metabolic process (GO:0006576)

GO Molecular Function (2): ornithine decarboxylase inhibitor activity (GO:0008073), protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of polyamines	1
Metabolism of amino acids and derivatives	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
polyamine metabolic process	1
biogenic amine biosynthetic process	1
positive regulation of catabolic process	1
protein catabolic process	1
regulation of protein catabolic process	1
positive regulation of protein metabolic process	1
viral process	1
viral translation	1
intracellular protein transport	1
positive regulation of intracellular transport	1
regulation of intracellular protein transport	1
positive regulation of protein transport	1
negative regulation of transmembrane transport	1
polyamine transmembrane transport	1
regulation of polyamine transmembrane transport	1
amine metabolic process	1
ornithine decarboxylase activity	1
enzyme inhibitor activity	1
ornithine decarboxylase regulator activity	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

1144 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OAZ1	ODC1	P11926	970
OAZ1	AZIN1	O14977	941
OAZ1	AZIN2	Q96A70	907
OAZ1	RPL27	P08526	716
OAZ1	EEF1G	P26641	672
OAZ1	ALAS1	P13196	628
OAZ1	RPL37A	P12751	593
OAZ1	SAT1	P21673	591
OAZ1	RPL19	P14118	540
OAZ1	POLR1B	Q9H9Y6	537
OAZ1	ABCF1	Q8NE71	521
OAZ1	POLR2A	P24928	506
OAZ1	GUSB	P08236	496
OAZ1	STC2	O76061	479
OAZ1	RPS29	P30054	477

IntAct

18 interactions, top by confidence:

A	B	Type	Score
AZIN1	OAZ2	psi-mi:“MI:0914”(association)	0.670
OAZ1	AZIN1	psi-mi:“MI:0914”(association)	0.640
EGFR	OAZ1	psi-mi:“MI:0915”(physical association)	0.550
AZIN2	OAZ2	psi-mi:“MI:0914”(association)	0.530
AGTR1	OAZ1	psi-mi:“MI:0915”(physical association)	0.510
OAZ1	AGTR1	psi-mi:“MI:0915”(physical association)	0.510
OAZ1	NLGN3	psi-mi:“MI:0915”(physical association)	0.370
OAZ1	HTR2B	psi-mi:“MI:0915”(physical association)	0.370
OAZ1	MYCBP2	psi-mi:“MI:0915”(physical association)	0.370
OAZ1	PIAS4	psi-mi:“MI:0915”(physical association)	0.370
AZIN1	KIF5C	psi-mi:“MI:0914”(association)	0.350
OAZ1	YWHAG	psi-mi:“MI:0914”(association)	0.350
NRIP1	OAZ1	psi-mi:“MI:0915”(physical association)	0.000
ATXN1	OAZ1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (47): TP73 (Affinity Capture-Western), OAZ1 (Affinity Capture-Western), OAZ1 (Affinity Capture-MS), AZIN1 (Reconstituted Complex), ODC1 (Reconstituted Complex), OAZ1 (Reconstituted Complex), GBE1 (Affinity Capture-MS), ODC1 (Affinity Capture-MS), UPF1 (Affinity Capture-MS), RAB7A (Affinity Capture-MS), TAF1B (Affinity Capture-MS), SRA1 (Affinity Capture-MS), CEPT1 (Affinity Capture-MS), CAMSAP2 (Affinity Capture-MS), AZIN1 (Affinity Capture-MS)

ESM2 similar proteins: A4VCH4, B4F7E8, G3V7Q0, O08608, O14795, O42148, O70585, O95190, P0C7A6, P42225, P50747, P54368, P55814, Q05AA6, Q0VGY8, Q13474, Q1LVW0, Q2KIM1, Q2KJ58, Q3TLI0, Q3UHE1, Q4KM45, Q56K12, Q5JSJ4, Q5R680, Q5VZK9, Q5XII8, Q62768, Q62769, Q6EDY6, Q6IQ26, Q6NYU2, Q6PAL8, Q6WKZ8, Q7SYD9, Q7ZXK3, Q80YV4, Q8BND4, Q8IWV8, Q8K2I9

Diamond homologs: A1BPI0, O08608, O42148, O95190, P54368, P54369, P54370, P55814, P70112, Q56K12, Q5R680, Q9R109, Q9UMX2, Q9YI97, Q9YI98, P54361, Q95P51, O44535, Q9NHZ5, Q9NHZ6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

973 predictions. Top by Δscore:

Variant	Effect	Δscore
19:2269740:GAGAG:G	donor_gain	1.0000
19:2269741:AGAGG:A	donor_loss	1.0000
19:2269742:GAG:G	donor_gain	1.0000
19:2269743:AGGT:A	donor_loss	1.0000
19:2269743:AGGTA:A	donor_loss	1.0000
19:2269744:GGTA:G	donor_loss	1.0000
19:2269745:G:C	donor_loss	1.0000
19:2269745:G:GG	donor_gain	1.0000
19:2269746:T:G	donor_loss	1.0000
19:2271942:G:T	donor_gain	1.0000
19:2272818:GAG:G	donor_gain	1.0000
19:2272820:GGTA:G	donor_loss	1.0000
19:2270581:G:T	donor_gain	0.9900
19:2271951:ACAG:A	donor_loss	0.9900
19:2271952:CAGG:C	donor_loss	0.9900
19:2271953:AGGTG:A	donor_loss	0.9900
19:2271954:GGT:G	donor_loss	0.9900
19:2271955:G:A	donor_loss	0.9900
19:2271956:T:G	donor_loss	0.9900
19:2272821:G:GG	donor_gain	0.9900
19:2272971:GCC:G	acceptor_gain	0.9900
19:2273338:T:A	acceptor_gain	0.9900
19:2269743:AG:A	donor_gain	0.9800
19:2269744:GG:G	donor_gain	0.9800
19:2270559:G:GT	donor_gain	0.9800
19:2270581:G:GT	donor_gain	0.9800
19:2271780:A:AG	acceptor_gain	0.9800
19:2271781:G:GG	acceptor_gain	0.9800
19:2271951:ACAGG:A	donor_loss	0.9800
19:2271952:CAG:C	donor_loss	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000125788 (19:2268579 C>T), RS1000702754 (19:2273984 G>A), RS1000753675 (19:2273850 C>T), RS1000788561 (19:2271214 G>C), RS1001379209 (19:2272608 G>A,C), RS1001470952 (19:2272455 C>T), RS1001794141 (19:2270544 C>T), RS1002063347 (19:2273533 G>A), RS1002379952 (19:2269551 C>A,G,T), RS1002383762 (19:2273322 T>A), RS1002707370 (19:2269945 G>C), RS1002798937 (19:2269794 G>A,C,T), RS1003445015 (19:2267730 C>T), RS1003809057 (19:2269058 A>C,T), RS1004119323 (19:2269230 G>C,T)

Disease associations

OMIM: gene MIM:601579 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523241 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
pinosylvin	decreases expression	1
chloropicrin	decreases expression	1
deguelin	increases expression	1
2-palmitoylglycerol	increases expression	1
fenpyroximate	increases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	increases expression	1
pyrimidifen	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Doxorubicin	affects response to substance	1
Folic Acid	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Phthalic Acids	decreases methylation	1
Rotenone	increases expression	1
Selenium	increases expression	1
Smoke	decreases expression	1
Dronabinol	decreases expression	1
Tretinoin	increases expression	1
Vinblastine	affects response to substance	1
Metribolone	affects splicing	1
Antirheumatic Agents	decreases expression	1
Acrylamide	increases expression	1

ChEMBL screening assays

3 unique, capped per target: 2 binding, 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4324830	ADMET	Substrate activity at OAZ1 in human DU145 cells assessed as enzyme-mediated drug uptake at 100 uM in presence of CHX after 4 hrs by HPLC method	Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives. — J Med Chem
CHEMBL4324857	Binding	Induction of OAZ1 in human DU145 cells assessed as reduction in intracellular ODC activity at 10 uM in presence of CHX after 6 hrs by Western blot analysis relative to control	Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives. — J Med Chem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3D2	Abcam HEK293T OAZ1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.