OBI1-AS1

Summary

OBI1-AS1 (OBI1 antisense RNA 1, HGNC:42700) is a long non-coding RNA gene on chromosome 13q22.3-q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42700
Approved symbol	OBI1-AS1
Name	OBI1 antisense RNA 1
Location	13q22.3-q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.354
Ensembl gene	ENSG00000234377
Ensembl biotype	lncRNA
Entrez	100874222
RNAcentral	URS000047DB4C — lncRNA, 2418 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000430549, ENST00000444769, ENST00000560209, ENST00000560584, ENST00000605996, ENST00000606124, ENST00000606187, ENST00000606376, ENST00000606429, ENST00000606803, ENST00000607205, ENST00000607220, ENST00000607860, ENST00000607862, ENST00000701098, ENST00000739941, ENST00000739942, ENST00000739943, ENST00000739944, ENST00000739945

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430549 — 5 exons

Exon	Start	End
ENSE00001621293	78189608	78189696
ENSE00001633866	78274253	78274337
ENSE00002561387	78578477	78578663
ENSE00003701747	78054997	78055064
ENSE00003701992	78605301	78605354

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 84.94.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.9525 / max 143.5361, expressed in 91 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135534	0.8976	87
135535	0.0549	39

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.94	gold quality
caudate nucleus	UBERON:0001873	80.83	gold quality
corpus callosum	UBERON:0002336	79.74	gold quality
nucleus accumbens	UBERON:0001882	79.28	gold quality
putamen	UBERON:0001874	79.04	gold quality
amygdala	UBERON:0001876	77.23	gold quality
temporal lobe	UBERON:0001871	77.04	gold quality
substantia nigra	UBERON:0002038	76.65	gold quality
hypothalamus	UBERON:0001898	75.92	gold quality
anterior cingulate cortex	UBERON:0009835	73.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.43	gold quality
colonic epithelium	UBERON:0000397	71.79	gold quality
right frontal lobe	UBERON:0002810	71.59	gold quality
cerebral cortex	UBERON:0000956	70.96	gold quality
Ammon’s horn	UBERON:0001954	70.96	gold quality
frontal cortex	UBERON:0001870	70.81	gold quality
prefrontal cortex	UBERON:0000451	70.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.96	gold quality
brain	UBERON:0000955	69.59	gold quality
ventricular zone	UBERON:0003053	69.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.35	gold quality
superior frontal gyrus	UBERON:0002661	67.93	gold quality
primary visual cortex	UBERON:0002436	64.64	gold quality
ganglionic eminence	UBERON:0004023	61.32	gold quality
blood	UBERON:0000178	57.14	gold quality
monocyte	CL:0000576	55.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	55.37	gold quality
leukocyte	CL:0000738	55.22	gold quality
cerebellum	UBERON:0002037	54.51	gold quality
cerebellar cortex	UBERON:0002129	54.51	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	2022.41
E-HCAD-25	yes	1752.75
E-ANND-3	yes	5.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data mining of bulk and single-cell RNA sequencing introduces OBI1-AS1 as an astrocyte marker with possible role in glioma recurrence and progression. (PMID:35260196)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.