OCIAD1

Summary

OCIAD1 (OCIA domain containing 1, HGNC:16074) is a protein-coding gene on chromosome 4p11, encoding OCIA domain-containing protein 1 (Q9NX40). Maintains stem cell potency.

Predicted to be involved in several processes, including hematopoietic stem cell homeostasis; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of stem cell differentiation. Located in membrane and mitochondrion.

Source: NCBI Gene 54940 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 56 total
• Druggable target: yes
• MANE Select transcript: NM_017830

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16074
Approved symbol	OCIAD1
Name	OCIA domain containing 1
Location	4p11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20455, TPA018, OCIA, Asrij
Ensembl gene	ENSG00000109180
Ensembl biotype	protein_coding
OMIM	619596
Entrez	54940

Gene structure

Transcript identifiers

Ensembl transcripts: 78 — 73 protein_coding, 2 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000264312, ENST00000381473, ENST00000396448, ENST00000425583, ENST00000444354, ENST00000502972, ENST00000503016, ENST00000504654, ENST00000505922, ENST00000506801, ENST00000507210, ENST00000507546, ENST00000508293, ENST00000508329, ENST00000508996, ENST00000509122, ENST00000509164, ENST00000509246, ENST00000509664, ENST00000509963, ENST00000510824, ENST00000511102, ENST00000511662, ENST00000512236, ENST00000512981, ENST00000513391, ENST00000513641, ENST00000514981, ENST00000861192, ENST00000861193, ENST00000861194, ENST00000861195, ENST00000861196, ENST00000861197, ENST00000861198, ENST00000861199, ENST00000861200, ENST00000861201, ENST00000861202, ENST00000861203, ENST00000861204, ENST00000861205, ENST00000861206, ENST00000861207, ENST00000861208, ENST00000861209, ENST00000861210, ENST00000861211, ENST00000861212, ENST00000861213, ENST00000861214, ENST00000861215, ENST00000861216, ENST00000861217, ENST00000861218, ENST00000861219, ENST00000861220, ENST00000861221, ENST00000932595, ENST00000932596, ENST00000932597, ENST00000932598, ENST00000932599, ENST00000932600, ENST00000932601, ENST00000932602, ENST00000932603, ENST00000932604, ENST00000932605, ENST00000932606, ENST00000932607, ENST00000932608, ENST00000932609, ENST00000965896, ENST00000965897, ENST00000965898, ENST00000965899, ENST00000965900

RefSeq mRNA: 6 — MANE Select: NM_017830 NM_001079839, NM_001079840, NM_001079841, NM_001079842, NM_001168254, NM_017830

CCDS: CCDS3484, CCDS43228, CCDS47052

Canonical transcript exons

ENST00000264312 — 9 exons

Exon	Start	End
ENSE00001288338	48851806	48851975
ENSE00003474760	48833401	48833481
ENSE00003489810	48860725	48861815
ENSE00003516132	48849947	48850082
ENSE00003555010	48832620	48832682
ENSE00003633633	48842636	48842689
ENSE00003784626	48857213	48857365
ENSE00003788962	48848399	48848446
ENSE00003904594	48831088	48831249

Expression profiles

Bgee: expression breadth ubiquitous, 264 present calls, max score 99.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 108.7265 / max 1193.9401, expressed in 1827 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47587	43.9024	1819
47588	30.9362	1814
47594	16.9106	1794
47589	6.6157	1734
47592	1.9814	1096
47586	1.6980	1034
47590	1.5714	1166
47596	1.5235	870
47595	1.1782	736
47597	0.8581	569

Top tissues by expression

264 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	99.91	gold quality
endothelial cell	CL:0000115	99.55	gold quality
renal medulla	UBERON:0000362	99.42	gold quality
cardia of stomach	UBERON:0001162	99.40	gold quality
kidney epithelium	UBERON:0004819	99.37	gold quality
ventral tegmental area	UBERON:0002691	99.31	gold quality
cardiac muscle of right atrium	UBERON:0003379	99.31	gold quality
pylorus	UBERON:0001166	99.30	gold quality
lateral globus pallidus	UBERON:0002476	99.30	gold quality
nipple	UBERON:0002030	99.29	gold quality
cerebellar vermis	UBERON:0004720	99.25	gold quality
parietal lobe	UBERON:0001872	99.24	gold quality
islet of Langerhans	UBERON:0000006	99.23	gold quality
postcentral gyrus	UBERON:0002581	99.23	gold quality
superior surface of tongue	UBERON:0007371	99.20	gold quality
Brodmann (1909) area 46	UBERON:0006483	99.19	gold quality
ileal mucosa	UBERON:0000331	99.18	gold quality
medulla oblongata	UBERON:0001896	99.17	gold quality
trachea	UBERON:0003126	99.17	gold quality
upper arm skin	UBERON:0004263	99.16	gold quality
left ventricle myocardium	UBERON:0006566	99.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.15	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.14	gold quality
superior frontal gyrus	UBERON:0002661	99.14	gold quality
trigeminal ganglion	UBERON:0001675	99.13	gold quality
inferior vagus X ganglion	UBERON:0005363	99.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	99.11	gold quality
prefrontal cortex	UBERON:0000451	99.10	gold quality
tibialis anterior	UBERON:0001385	99.10	gold quality
dorsal plus ventral thalamus	UBERON:0001897	99.08	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-124858	no	257.57
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

38 targeting OCIAD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-4721	99.26	66.05	818
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-7151-3P	99.04	69.72	2370

Literature-anchored findings (GeneRIF, showing 8)

• Over-expressed in metastatic ovarian cancer. Effect of OCIAD1 on cell adhesion may be related to its function in ovarian cancer. Possibility of OCIAD1’s role in tumor metastasis. (PMID:18328549)
• This is the first study to indicate that OCIAD1 is a key player in generating ovarian cancer recurrence. (PMID:20515946)
• OCIAD1 is a potential biomarker of thyroid carcinoma but had no significant additive effect on the risk of distant metastasis. (PMID:22081784)
• Like OCIAD1, OCIAD2 is a cancer-related protein and its expression level increases during the course of malignant progression and is thought to be a very useful marker for evaluating the malignancy of ovarian mucinous tumors. (PMID:22726067)
• high OCIAD1 levels in pancreatic ductal adenocarcinoma promoted tumor cells migration. OCIAD1 exerted its effects by regulating ATM (PMID:31221523)
• OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages. (PMID:31931285)
• OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease. (PMID:32697788)
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. (PMID:34034859)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ociad1	ENSDARG00000052334
danio_rerio		ENSDARG00000056677
mus_musculus	Ociad1	ENSMUSG00000029152
rattus_norvegicus	Ociad1	ENSRNOG00000002205
drosophila_melanogaster	asrij	FBGN0034793

Paralogs (1): OCIAD2 (ENSG00000145247)

Protein

Protein identifiers

OCIA domain-containing protein 1 — Q9NX40 (reviewed: Q9NX40)

Alternative names: Ovarian cancer immunoreactive antigen domain containing 1, Ovarian carcinoma immunoreactive antigen

All UniProt accessions (16): Q9NX40, D6R918, D6R9T5, D6RA54, D6RBC5, D6RBN5, D6RC55, D6RDI5, D6RDK1, D6RDK6, D6RF01, D6RF07, D6RG39, D6RI08, D6RIT9, D6RIV2

UniProt curated annotations — full annotation on UniProt →

Function. Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes. Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer.

Subunit / interactions. Interacts with OCIAD2. Interacts with STAT3.

Subcellular location. Endosome.

Tissue specificity. Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord.

Domain organisation. The OCIA domain is necessary and sufficient for endosomal localization.

Miscellaneous. ‘Asrij’ stands for ‘blood’ in Sanskrit as this protein is strongly expressed in blood vessels.

Similarity. Belongs to the OCIAD1 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9NX40-1	1, A	yes
Q9NX40-2	2, B
Q9NX40-3	3
Q9NX40-4	4

RefSeq proteins (6): NP_001073308, NP_001073309, NP_001073310, NP_001073311, NP_001161726, NP_060300* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009764	OCIA_dom	Domain
IPR040187	OCAD1/2	Family

Pfam: PF07051

UniProt features (13 total): modified residue 4, splice variant 3, region of interest 2, compositionally biased region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NX40-F1	65.25	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 108, 116, 123, 191

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 131 (showing top): GCM_MAP4K4, GCM_GSPT1, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_VIA_JAK_STAT, WANG_LMO4_TARGETS_DN, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, chr4p11, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GCM_NF2, GOBP_STEM_CELL_DIFFERENTIATION, GOBP_IMPORT_INTO_CELL, DANG_BOUND_BY_MYC, GOBP_ENDOCYTOSIS, GOBP_REGULATION_OF_STEM_CELL_DIFFERENTIATION, GCM_PTK2

GO Biological Process (4): endocytosis (GO:0006897), positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427), hematopoietic stem cell homeostasis (GO:0061484), regulation of stem cell differentiation (GO:2000736)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), lysosome (GO:0005764), endosome (GO:0005768), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
intracellular membrane-bounded organelle	2
endomembrane system	2
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
cell surface receptor signaling pathway via JAK-STAT	1
regulation of receptor signaling pathway via JAK-STAT	1
positive regulation of receptor signaling pathway via STAT	1
homeostasis of number of cells	1
regulation of cell differentiation	1
stem cell differentiation	1
binding	1
lytic vacuole	1
cytoplasmic vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1052 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OCIAD1	ARF1	P10947	604
OCIAD1	DCUN1D4	Q92564	547
OCIAD1	SLAIN2	Q9P270	527
OCIAD1	C18orf32	Q8TCD1	496
OCIAD1	NFXL1	Q6ZNB6	471
OCIAD1	COX18	Q8N8Q8	449
OCIAD1	G3BP2	Q9UN86	434
OCIAD1	FRYL	O94915	416
OCIAD1	SLC35F2	Q8IXU6	399
OCIAD1	STAT3	P40763	394
OCIAD1	CWH43	Q9H720	392
OCIAD1	LRRC66	Q68CR7	389
OCIAD1	DOLPP1	Q86YN1	384
OCIAD1	TRUB2	O95900	371
OCIAD1	UQCC5	Q8WVI0	358

IntAct

157 interactions, top by confidence:

A	B	Type	Score
IFT70B	IFT56	psi-mi:“MI:0914”(association)	0.790
EXOC8	EXOC5	psi-mi:“MI:0914”(association)	0.730
SLC30A3	OCIAD1	psi-mi:“MI:0915”(physical association)	0.670
COG7	ILVBL	psi-mi:“MI:0914”(association)	0.640
ASPH	OCIAD1	psi-mi:“MI:0915”(physical association)	0.560
MMD	OCIAD1	psi-mi:“MI:0915”(physical association)	0.560
CAMLG	OCIAD1	psi-mi:“MI:0915”(physical association)	0.560
FXYD6	OCIAD1	psi-mi:“MI:0915”(physical association)	0.560
TMEM239	OCIAD1	psi-mi:“MI:0915”(physical association)	0.560
OCIAD1	FKBP7	psi-mi:“MI:0915”(physical association)	0.560
TIMMDC1	NDUFS8	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
UST	GOLIM4	psi-mi:“MI:0914”(association)	0.530
GNAS	CPT2	psi-mi:“MI:0914”(association)	0.530
SGSM1	CETN2	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
SYCE3	RER1	psi-mi:“MI:0914”(association)	0.530
UST	CANX	psi-mi:“MI:0914”(association)	0.530
SLC6A8	ILVBL	psi-mi:“MI:0914”(association)	0.530
OCIAD1	ATF7	psi-mi:“MI:0915”(physical association)	0.520
RALB	EI24	psi-mi:“MI:0914”(association)	0.510
COG4	MUL1	psi-mi:“MI:0914”(association)	0.500
HTRA2	HAX1	psi-mi:“MI:2364”(proximity)	0.420

BioGRID (549): OCIAD1 (Affinity Capture-RNA), OCIAD1 (Affinity Capture-RNA), OCIAD1 (Affinity Capture-RNA), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), OCIAD1 (Affinity Capture-RNA), PCBP1 (Co-fractionation), OCIAD1 (Proximity Label-MS), OCIAD1 (Affinity Capture-MS)

ESM2 similar proteins: A2AFR3, A6QLZ5, O08838, O94888, O95983, P0C6S7, P21580, P49418, P50478, Q05B58, Q08DU8, Q14161, Q14CM0, Q1RMZ1, Q32KN2, Q3KR37, Q3ZK22, Q497H0, Q5E948, Q5RD48, Q5REE1, Q5REY7, Q5RFL7, Q5U2M7, Q5UAK0, Q5ZIA0, Q5ZKA4, Q60769, Q66H91, Q6DC60, Q6ZPY2, Q7TQF7, Q7Z6G8, Q8BIZ1, Q8BR63, Q8BXK4, Q8IW50, Q8N108, Q8N128, Q8R3V6

Diamond homologs: A1A619, Q28GQ3, Q28X44, Q3SYY7, Q56VL3, Q5E948, Q5RD48, Q5XIG4, Q6NYD7, Q9CRD0, Q9D8W7, Q9NX40, Q9W1X9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 168 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Intra-Golgi traffic	5	11.8×	9e-03
R-HSA-425366	6	9.9×	8e-03
Mitochondrial protein import	6	9.2×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1997 predictions. Top by Δscore:

Variant	Effect	Δscore
4:48832683:G:GG	donor_gain	1.0000
4:48832694:T:G	donor_gain	1.0000
4:48832694:T:TG	donor_gain	1.0000
4:48833391:T:A	acceptor_gain	1.0000
4:48833482:G:GG	donor_gain	1.0000
4:48842634:A:AG	acceptor_gain	1.0000
4:48842635:G:GA	acceptor_gain	1.0000
4:48842635:GCT:G	acceptor_gain	1.0000
4:48842635:GCTGT:G	acceptor_gain	1.0000
4:48842688:AG:A	donor_loss	1.0000
4:48842689:GG:G	donor_loss	1.0000
4:48842690:GT:G	donor_loss	1.0000
4:48842691:T:A	donor_loss	1.0000
4:48849940:A:AG	acceptor_gain	1.0000
4:48849944:AAGTT:A	acceptor_gain	1.0000
4:48849945:A:G	acceptor_gain	1.0000
4:48860723:A:AG	acceptor_gain	1.0000
4:48860724:G:GG	acceptor_gain	1.0000
4:48831409:G:GT	donor_gain	0.9900
4:48831409:G:T	donor_gain	0.9900
4:48831430:GGGT:G	donor_gain	0.9900
4:48831431:GGTG:G	donor_gain	0.9900
4:48831444:G:T	donor_gain	0.9900
4:48832698:G:GG	donor_gain	0.9900
4:48833381:T:TA	acceptor_gain	0.9900
4:48833392:G:A	acceptor_gain	0.9900
4:48833395:A:AG	acceptor_gain	0.9900
4:48833396:A:G	acceptor_gain	0.9900
4:48833479:GAT:G	donor_gain	0.9900
4:48842630:CTATA:C	acceptor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000013523 (4:48815479 C>T), RS1000062002 (4:48861820 G>A), RS1000166126 (4:48821867 A>G), RS1000247400 (4:48819426 A>C,G), RS1000263473 (4:48828407 G>C), RS1000317831 (4:48828189 T>C), RS1000423242 (4:48834352 A>G), RS1000826100 (4:48832408 C>G,T), RS1000880229 (4:48833996 A>T), RS1000882908 (4:48838965 C>G), RS1001030992 (4:48803529 G>A), RS1001091976 (4:48845373 A>G), RS1001166279 (4:48859682 C>G), RS1001239794 (4:48859254 T>C), RS1001244185 (4:48815110 G>A)

Disease associations

OMIM: gene MIM:619596 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007267_263	Systolic blood pressure	5.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067371 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.22	Kd	6.036	nM	CHEMBL3752910
8.22	ED50	6.036	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149901: Binding affinity to human OCIAD1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0060	uM

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation	4
sodium arsenite	decreases expression, increases abundance, increases expression	2
Hydrogen Peroxide	increases expression, affects expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
alpha-pinene	increases abundance, affects cotreatment, increases expression	1
bisphenol A	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
methylparaben	increases expression	1
perfluorooctanoic acid	increases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
pentabromodiphenyl ether	increases expression	1
chloropicrin	increases expression	1
corosolic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
bisphenol B	increases expression	1
LDN 193189	decreases expression, affects cotreatment	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Vorinostat	decreases expression	1
Acrolein	increases abundance, affects cotreatment, increases expression	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	affects phosphorylation	1
Doxorubicin	increases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Formaldehyde	increases expression	1
Ivermectin	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652943	Binding	Binding affinity to human OCIAD1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

8 cell lines: 4 embryonic stem cell, 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_9S74	BJNhem20-OCIAD1-CRISPR-20	Embryonic stem cell	Female
CVCL_AB54	BJNhem20-OCIAD1-OV	Embryonic stem cell	Female
CVCL_B3D3	Abcam HEK293T OCIAD1 KO	Transformed cell line	Female
CVCL_DQ66	BJNhem20-OCIAD1-Tet-On	Embryonic stem cell	Female
CVCL_DQ69	BJNhem20-OCIAD1-CRISPR-39	Embryonic stem cell	Female
CVCL_TB57	HAP1 OCIAD1 (-) 1	Cancer cell line	Male
CVCL_XR26	HAP1 OCIAD1 (-) 2	Cancer cell line	Male
CVCL_XR27	HAP1 OCIAD1 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.