OCIAD2

Summary

OCIAD2 (OCIA domain containing 2, HGNC:28685) is a protein-coding gene on chromosome 4p11, encoding OCIA domain-containing protein 2 (Q56VL3). Has an essential role in the assembly of mitochondrial respiratory chain complex III.

Predicted to be involved in endocytosis; hematopoietic stem cell homeostasis; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within response to bacterium. Located in mitochondrion.

Source: NCBI Gene 132299 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 47 total
• Druggable target: yes
• MANE Select transcript: NM_001014446

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28685
Approved symbol	OCIAD2
Name	OCIA domain containing 2
Location	4p11
Locus type	gene with protein product
Status	Approved
Aliases	MGC45416
Ensembl gene	ENSG00000145247
Ensembl biotype	protein_coding
OMIM	619633
Entrez	132299

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 18 protein_coding, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000273860, ENST00000381464, ENST00000506226, ENST00000508069, ENST00000508632, ENST00000510159, ENST00000512087, ENST00000514155, ENST00000514576, ENST00000620187, ENST00000899075, ENST00000899076, ENST00000899077, ENST00000899078, ENST00000899079, ENST00000899080, ENST00000899081, ENST00000899082, ENST00000928706, ENST00000928707, ENST00000928708, ENST00000928709, ENST00000928710, ENST00000928711

RefSeq mRNA: 4 — MANE Select: NM_001014446 NM_001014446, NM_001286773, NM_001286774, NM_152398

CCDS: CCDS33981, CCDS3485

Canonical transcript exons

ENST00000508632 — 7 exons

Exon	Start	End
ENSE00002026887	48906658	48906774
ENSE00002043035	48885019	48885565
ENSE00003560566	48899829	48899925
ENSE00003612706	48897804	48897857
ENSE00003648025	48892772	48892889
ENSE00003658343	48904484	48904611
ENSE00003784162	48894006	48894053

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 99.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.0882 / max 370.2458, expressed in 1633 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52094	22.3691	1603
52095	2.3367	1028
52096	0.3824	192

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	99.21	gold quality
ileal mucosa	UBERON:0000331	98.97	gold quality
ganglionic eminence	UBERON:0004023	98.65	gold quality
embryo	UBERON:0000922	98.64	gold quality
cortical plate	UBERON:0005343	98.44	gold quality
duodenum	UBERON:0002114	98.06	gold quality
adult mammalian kidney	UBERON:0000082	97.37	gold quality
cortex of kidney	UBERON:0001225	96.87	gold quality
islet of Langerhans	UBERON:0000006	96.83	gold quality
renal medulla	UBERON:0000362	96.83	gold quality
jejunal mucosa	UBERON:0000399	96.81	gold quality
mucosa of transverse colon	UBERON:0004991	96.66	gold quality
kidney	UBERON:0002113	96.46	gold quality
epithelial cell of pancreas	CL:0000083	96.36	gold quality
pancreatic ductal cell	CL:0002079	96.31	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.75	gold quality
nasal cavity epithelium	UBERON:0005384	95.70	gold quality
oviduct epithelium	UBERON:0004804	95.67	gold quality
rectum	UBERON:0001052	95.51	gold quality
right lobe of liver	UBERON:0001114	95.45	gold quality
thymus	UBERON:0002370	95.36	gold quality
liver	UBERON:0002107	95.16	gold quality
pituitary gland	UBERON:0000007	94.43	gold quality
colonic mucosa	UBERON:0000317	94.43	gold quality
caput epididymis	UBERON:0004358	94.38	gold quality
gall bladder	UBERON:0002110	94.18	gold quality
metanephros cortex	UBERON:0010533	94.08	gold quality
nasal cavity mucosa	UBERON:0001826	94.01	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.99	gold quality
corpus epididymis	UBERON:0004359	93.77	gold quality

Single-cell (SCXA)

Detected in 15 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-HCAD-15	yes	910.63
E-MTAB-8271	yes	218.25
E-HCAD-4	yes	147.20
E-MTAB-10287	yes	46.91
E-HCAD-10	yes	29.16
E-MTAB-8410	yes	23.91
E-HCAD-5	yes	20.19
E-MTAB-10042	yes	15.33
E-CURD-114	yes	9.17
E-CURD-112	yes	8.19
E-MTAB-6108	no	548.69
E-GEOD-124858	no	274.96
E-MTAB-10018	no	256.92
E-CURD-120	no	7.45
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting OCIAD2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-6739-3P	99.22	68.84	1843
HSA-MIR-6847-5P	97.93	66.74	1808
HSA-MIR-12127	97.93	66.67	793
HSA-MIR-375-3P	97.91	65.12	483
HSA-MIR-4257	97.86	68.05	1190
HSA-MIR-4287	97.55	67.24	1247

Literature-anchored findings (GeneRIF, showing 10)

• Like OCIAD1, OCIAD2 is a cancer-related protein and its expression level increases during the course of malignant progression and is thought to be a very useful marker for evaluating the malignancy of ovarian mucinous tumors. (PMID:22726067)
• OCIAD2 also increased the interaction of nicastrin with C99 and stimulated APP processing via gamma-secretase activation, but did not affect Notch processing (PMID:24270855)
• it well explained the mechanism of TGFbeta induced OCIAD2 expression in cancer microenvironment, therefore providing an important clue for the future functional analysis of OCIAD2 in tumor pathogenesis. (PMID:24949437)
• these data indicate that reduced expression of OCIAD2 by DNA hypermethylation plays an important role in hepatocellular carcinoma tumor growth and invasion. (PMID:28911005)
• Our results suggest that OCIAD2 could be a useful prognostic biomarker of lung adenocarcinoma (PMID:30320419)
• Cellular OCIAD2 protein is a proviral factor for hepatitis C virus replication. (PMID:34371038)
• Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma. (PMID:34628698)
• Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. (PMID:35080992)
• Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome. (PMID:35920378)
• OCIAD2 promotes pancreatic cancer progression through the AKT signaling pathway. (PMID:38944166)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	ociad2	ENSDARG00000052336
mus_musculus	Ociad2	ENSMUSG00000029153
rattus_norvegicus	Ociad2	ENSRNOG00000002196
drosophila_melanogaster	asrij	FBGN0034793

Paralogs (1): OCIAD1 (ENSG00000109180)

Protein

Protein identifiers

OCIA domain-containing protein 2 — Q56VL3 (reviewed: Q56VL3)

Alternative names: Ovarian carcinoma immunoreactive antigen-like protein

All UniProt accessions (3): D6RD77, Q56VL3, J3KPI9

UniProt curated annotations — full annotation on UniProt →

Function. Has an essential role in the assembly of mitochondrial respiratory chain complex III. Is also required for STAT3 activation and plays a role in cell migration.

Subunit / interactions. Interacts (via OCIA domain) with OCIAD1/ASRIJ and STAT3.

Subcellular location. Endosome. Mitochondrion. Mitochondrion inner membrane.

Isoforms (2)

UniProt ID	Names	Canonical?
Q56VL3-1	1	yes
Q56VL3-2	2

RefSeq proteins (4): NP_001014446, NP_001273702, NP_001273703, NP_689611 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009764	OCIA_dom	Domain
IPR040187	OCAD1/2	Family

Pfam: PF07051

UniProt features (6 total): chain 1, domain 1, region of interest 1, modified residue 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q56VL3-F1	57.29	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY, GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_VIA_JAK_STAT, BRUECKNER_TARGETS_OF_MIRLET7A3_DN, GOBP_CYTOCHROME_COMPLEX_ASSEMBLY, KOYAMA_SEMA3B_TARGETS_UP, GOCC_MITOCHONDRIAL_ENVELOPE, chr4p11, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GOBP_IMPORT_INTO_CELL, GOBP_ENDOCYTOSIS, OSMAN_BLADDER_CANCER_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP

GO Biological Process (6): endocytosis (GO:0006897), response to bacterium (GO:0009617), cell migration (GO:0016477), mitochondrial respiratory chain complex III assembly (GO:0034551), positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427), hematopoietic stem cell homeostasis (GO:0061484)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), lysosome (GO:0005764), endosome (GO:0005768), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
intracellular membrane-bounded organelle	2
endomembrane system	2
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
response to other organism	1
cell motility	1
mitochondrion	1
respiratory chain complex III assembly	1
mitochondrial respiratory chain complex assembly	1
cell surface receptor signaling pathway via JAK-STAT	1
regulation of receptor signaling pathway via JAK-STAT	1
positive regulation of receptor signaling pathway via STAT	1
homeostasis of number of cells	1
binding	1
organelle inner membrane	1
mitochondrial membrane	1
lytic vacuole	1
cytoplasmic vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

786 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OCIAD2	TIGD4	Q8IY51	519
OCIAD2	DCUN1D4	Q92564	507
OCIAD2	TMEM131L	A2VDJ0	504
OCIAD2	SMIM14	Q96QK8	489
OCIAD2	SYNPO2	Q9UMS6	472
OCIAD2	COMMD8	Q9NX08	472
OCIAD2	TBC1D30	Q9Y2I9	470
OCIAD2	RNF182	Q8N6D2	469
OCIAD2	RNF150	Q9ULK6	462
OCIAD2	NRIP3	Q9NQ35	460
OCIAD2	LHFPL2	Q6ZUX7	457
OCIAD2	GPR180	Q86V85	448
OCIAD2	ARFIP1	P53367	447
OCIAD2	PARP6	Q2NL67	447
OCIAD2	FAM120AOS	Q5T036	433

IntAct

41 interactions, top by confidence:

A	B	Type	Score
ANKH	FAM234B	psi-mi:“MI:0914”(association)	0.530
KCNIP3	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
SHFL	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
TRIP12	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
KIF20B	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
TAOK1	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
CYP3A43	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
DNAH12	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
SUPT5H	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
SIK3	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
ECEL1	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
SCIN	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
RPL17	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
FAM199X	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
SENP5	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
HPF1	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
OCIAD2	rep	psi-mi:“MI:0915”(physical association)	0.370
S100A9	OCIAD2	psi-mi:“MI:0915”(physical association)	0.370
OCIAD2		psi-mi:“MI:0915”(physical association)	0.370
	TMEM223	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
SMIM26	CNOT1	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
GPR45	VWA8	psi-mi:“MI:0914”(association)	0.350
NAAA	HAX1	psi-mi:“MI:0914”(association)	0.350
MFSD10	NDUFS8	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (83): OCIAD2 (Affinity Capture-MS), OCIAD2 (Affinity Capture-MS), OCIAD2 (PCA), OCIAD2 (Affinity Capture-MS), OCIAD2 (Affinity Capture-Western), OCIAD1 (Affinity Capture-Western), OCIAD2 (Affinity Capture-Western), STAT3 (Affinity Capture-Western), VDAC3 (Co-fractionation), OCIAD2 (Co-fractionation), OCIAD2 (Co-fractionation), OCIAD2 (Co-fractionation), OCIAD2 (Co-fractionation), SCCPDH (Co-fractionation), ACOT9 (Co-fractionation)

ESM2 similar proteins: A0A1N7SYS3, A1A619, A3LP48, A9ULX8, B0BN56, D4A2Y9, F1NVK6, F6UF99, O04326, P40508, P82908, P82925, P92204, Q02854, Q04935, Q0P5B1, Q1LVV0, Q28GQ3, Q28HF6, Q28X44, Q2UDY8, Q3SYY7, Q3V0J1, Q56VL3, Q5I030, Q5R891, Q5XI29, Q61733, Q659C4, Q66IE4, Q68EU0, Q6AZH0, Q6BI17, Q6CHT7, Q6CJX5, Q6DFB7, Q6DFJ8, Q6NYD7, Q6PFM4, Q75D23

Diamond homologs: A1A619, Q28GQ3, Q28X44, Q3SYY7, Q56VL3, Q5E948, Q5RD48, Q5XIG4, Q6NYD7, Q9CRD0, Q9D8W7, Q9NX40, Q9W1X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

984 predictions. Top by Δscore:

Variant	Effect	Δscore
4:48906653:CTCA:C	donor_loss	1.0000
4:48906654:TCACC:T	donor_loss	1.0000
4:48906655:CAC:C	donor_loss	1.0000
4:48906656:A:AT	donor_loss	1.0000
4:48906657:C:A	donor_loss	1.0000
4:48892890:C:CC	acceptor_gain	0.9900
4:48904612:C:CC	acceptor_gain	0.9900
4:48906652:GCTCA:G	donor_loss	0.9900
4:48906656:A:AC	donor_gain	0.9900
4:48906657:C:CC	donor_gain	0.9900
4:48892887:CAA:C	acceptor_gain	0.9800
4:48894004:A:AC	donor_gain	0.9800
4:48894005:C:CC	donor_gain	0.9800
4:48897122:T:TA	donor_gain	0.9800
4:48897163:AGG:A	donor_gain	0.9800
4:48906657:CCT:C	donor_gain	0.9800
4:48894005:CGTG:C	donor_gain	0.9700
4:48906656:AC:A	donor_gain	0.9700
4:48906657:CC:C	donor_gain	0.9700
4:48892886:GCAAC:G	acceptor_loss	0.9600
4:48892887:CAACT:C	acceptor_loss	0.9600
4:48892888:AAC:A	acceptor_loss	0.9600
4:48892889:AC:A	acceptor_loss	0.9600
4:48892890:C:T	acceptor_loss	0.9600
4:48892891:T:G	acceptor_loss	0.9600
4:48904486:G:A	donor_gain	0.9600
4:48906657:CCTG:C	donor_gain	0.9600
4:48906657:CCTGT:C	donor_gain	0.9600
4:48885564:GCCTA:G	acceptor_loss	0.9500
4:48885565:CCTAG:C	acceptor_loss	0.9500

AlphaMissense

999 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:48897835:G:C	S62R	0.993
4:48897835:G:T	S62R	0.993
4:48897837:T:G	S62R	0.993
4:48899855:C:G	C46S	0.976
4:48899856:A:T	C46S	0.976
4:48892838:C:G	C106S	0.968
4:48892839:A:T	C106S	0.968
4:48899842:A:C	S50R	0.968
4:48899842:A:T	S50R	0.968
4:48899844:T:G	S50R	0.968
4:48892874:C:T	G94E	0.964
4:48892883:C:T	G91D	0.964
4:48892886:G:T	A90D	0.961
4:48899856:A:G	C46R	0.961
4:48899830:T:A	R54S	0.959
4:48899830:T:G	R54S	0.959
4:48892875:C:G	G94R	0.958
4:48892875:C:T	G94R	0.958
4:48892863:C:G	G98R	0.957
4:48892863:C:T	G98R	0.957
4:48897833:A:T	M63K	0.957
4:48899839:G:C	F51L	0.957
4:48899839:G:T	F51L	0.957
4:48899841:A:G	F51L	0.957
4:48897827:A:T	V65D	0.955
4:48894013:T:A	K86N	0.953
4:48894013:T:G	K86N	0.953
4:48892862:C:T	G98E	0.952
4:48892839:A:G	C106R	0.951
4:48892868:C:T	G96D	0.951

dbSNP variants (sampled 300 via entrez): RS1000236018 (4:48908700 G>A), RS1000517012 (4:48901156 A>G), RS1000978863 (4:48884635 A>C), RS1001347907 (4:48902098 T>C), RS1001419327 (4:48908375 G>C), RS1001539987 (4:48890004 G>A), RS1002357488 (4:48889274 G>C), RS1002692959 (4:48888203 C>T), RS1002928303 (4:48901037 A>C,G), RS1003024697 (4:48900801 C>T), RS1003252414 (4:48893951 G>A,C), RS1003266996 (4:48899307 C>G), RS1003423558 (4:48906062 A>G), RS1003444115 (4:48900669 G>T), RS1003499276 (4:48907233 T>G)

Disease associations

OMIM: gene MIM:619633 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007094_157	Diastolic blood pressure	6.000000e-06
GCST007099_37	Systolic blood pressure	2.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066320 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.49	Kd	3242	nM	CHEMBL5653589
5.49	ED50	3242	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148910: Binding affinity to human OCIAD2 incubated for 45 mins by Kinobead based pull down assay	kd	3.2416	uM

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment	2
Acetaminophen	decreases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Valproic Acid	affects cotreatment, increases expression, increases methylation	2
GSK-J4	increases expression	1
methylmercuric chloride	increases expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	increases expression	1
potassium chromate(VI)	decreases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
beta-methylcholine	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
chloropicrin	increases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
belinostat	decreases expression	1
dorsomorphin	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Acrolein	increases abundance, affects cotreatment, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Carbamazepine	affects expression	1
Cisplatin	affects expression	1
Dexamethasone	affects cotreatment, decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651952	Binding	Binding affinity to human OCIAD2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C6Q6	BJNhem20-OCIAD2-CRISPR-33	Embryonic stem cell	Female
CVCL_C6Q7	BJNhem20-OCIAD2-CRISPR-40	Embryonic stem cell	Female
CVCL_C6Q8	BJNhem20-OCIAD2-OV	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.