OCM2

Summary

OCM2 (oncomodulin 2, HGNC:34396) is a protein-coding gene on chromosome 7q21.3, encoding Oncomodulin-2 (P0CE71).

This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins.

Source: NCBI Gene 4951 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_006188

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34396
Approved symbol	OCM2
Name	oncomodulin 2
Location	7q21.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000135175
Ensembl biotype	protein_coding
OMIM	620522
Entrez	4951

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000257627, ENST00000473987

RefSeq mRNA: 1 — MANE Select: NM_006188 NM_006188

CCDS: CCDS5653

Canonical transcript exons

ENST00000257627 — 4 exons

Exon	Start	End
ENSE00001788818	97990044	97990196
ENSE00003553931	97987047	97987156
ENSE00003628323	97988416	97988548
ENSE00003978289	97984687	97984983

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 90.92.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.35	gold quality
colonic epithelium	UBERON:0000397	41.93	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
bone marrow	UBERON:0002371	35.64	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
prefrontal cortex	UBERON:0000451	33.72	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
tonsil	UBERON:0002372	32.72	gold quality
placenta	UBERON:0001987	32.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
primary visual cortex	UBERON:0002436	31.49	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
lymph node	UBERON:0000029	30.83	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
blood	UBERON:0000178	29.76	gold quality
frontal cortex	UBERON:0001870	29.56	gold quality
monocyte	CL:0000576	29.11	silver quality
leukocyte	CL:0000738	28.97	silver quality
duodenum	UBERON:0002114	28.14	gold quality
anterior cingulate cortex	UBERON:0009835	27.99	gold quality
skin of abdomen	UBERON:0001416	27.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	27.79	silver quality
zone of skin	UBERON:0000014	27.74	gold quality
superior frontal gyrus	UBERON:0002661	27.59	gold quality
cerebral cortex	UBERON:0000956	27.52	gold quality
skin of leg	UBERON:0001511	27.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EGR1, HIF1A

miRNA regulators (miRDB)

26 targeting OCM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-328-5P	99.08	64.65	1000
HSA-MIR-6885-5P	98.71	64.33	902
HSA-MIR-4317	98.49	67.09	987
HSA-MIR-1262	98.17	66.52	757
HSA-MIR-4701-3P	98.17	66.25	788
HSA-MIR-6736-5P	98.17	66.43	760
HSA-MIR-6757-5P	98.08	65.50	724
HSA-MIR-4665-5P	97.91	67.69	1536
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-6514-3P	97.52	66.50	808
HSA-MIR-509-3-5P	97.21	67.74	1517
HSA-MIR-509-5P	97.21	67.90	1512
HSA-MIR-4418	97.04	67.16	1372
HSA-MIR-12128	96.67	66.98	1471
HSA-MIR-6866-5P	96.64	68.06	624
HSA-MIR-6790-3P	88.15	62.55	113

Literature-anchored findings (GeneRIF, showing 1)

• This study deministrated that Parvalbumin-immunoreactive neurons in the human claustrum. (PMID:23832597)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	pvalb5	ENSDARG00000032836
mus_musculus	Ocm	ENSMUSG00000029618
rattus_norvegicus	Ocm	ENSRNOG00000001031

Paralogs (2): PVALB (ENSG00000100362), OCM (ENSG00000122543)

Protein

Protein identifiers

Oncomodulin-2 — P0CE71 (reviewed: P0CE71)

All UniProt accessions (1): P0CE71

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the parvalbumin family.

RefSeq proteins (1): NP_006179* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002048	EF_hand_dom	Domain
IPR008080	Parvalbumin	Family
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site

Pfam: PF13499

UniProt features (13 total): binding site 10, domain 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CE71-F1	91.63	0.82

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (10): 95; 97; 102; 52; 54; 56; 58; 63; 91; 93

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 42 (showing top): MIR298, MIR3158_5P, MIR509_5P, MIR509_3_5P, MIR12128, MIR4418, MIR4701_3P, MIR1262, MIR6736_5P, MIR6866_5P, GSE1448_ANTI_VALPHA2_VS_VBETA5_DP_THYMOCYTE_UP, GSE22886_NAIVE_CD8_TCELL_VS_NKCELL_UP, GSE24634_TREG_VS_TCONV_POST_DAY5_IL4_CONVERSION_DN, GSE25087_FETAL_VS_ADULT_TREG_DN, GSE26928_NAIVE_VS_EFF_MEMORY_CD4_TCELL_UP

GO Biological Process (0):

GO Molecular Function (2): calcium ion binding (GO:0005509), metal ion binding (GO:0046872)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metal ion binding	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1365 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OCM2	SLC26A5	P58743	903
OCM2	PITPNM1	O00562	864
OCM2	GFI1	Q99684	758
OCM2	STRC	Q7RTU9	535
OCM2	ADCY6	O43306	512
OCM2	OTOF	Q9HC10	496
OCM2	POU4F3	Q15319	455
OCM2	TMC1	Q8TDI8	437
OCM2	MINAR2	P59773	435
OCM2	PAIP2B	Q9ULR5	426
OCM2	ATP1B3	P54709	425
OCM2	ATOH1	Q92858	410
OCM2	SLC1A1	P43005	363
OCM2	TMC2	Q8TDI7	360
OCM2	KCNA10	Q16322	359

IntAct

8 interactions, top by confidence:

A	B	Type	Score
MED12	MED14	psi-mi:“MI:0914”(association)	0.640
OCM2	ZMYM6	psi-mi:“MI:0915”(physical association)	0.400
OCM2	TERF1	psi-mi:“MI:0915”(physical association)	0.370
OCM2	TERF2	psi-mi:“MI:0915”(physical association)	0.370
OCM2	TERF2IP	psi-mi:“MI:0915”(physical association)	0.370
ARFGAP2	OCM2	psi-mi:“MI:0914”(association)	0.350
ZNF708	OCM2	psi-mi:“MI:0914”(association)	0.350

BioGRID (7): ZMYM6 (Affinity Capture-MS), OCM2 (Affinity Capture-MS), OCM2 (Affinity Capture-MS), OCM2 (Affinity Capture-MS), OCM2 (Two-hybrid), OCM2 (Two-hybrid), OCM2 (Two-hybrid)

ESM2 similar proteins: A0A1B0GWK0, O01305, O35508, P02613, P02615, P02616, P02624, P02626, P02627, P02629, P02630, P02631, P02637, P04109, P04110, P04111, P04573, P05941, P09485, P0CE71, P0CE72, P13833, P15844, P18087, P19753, P21788, P25027, P30187, P30563, P34368, P41045, P43305, P51434, P51879, P80026, P80050, P80079, P80080, P82978, Q03975

Diamond homologs: A0A1B0GWK0, A0A3F2YLV2, A0A7M4EAX1, D3GME4, O35508, O49717, P02614, P02615, P02616, P02617, P02618, P02619, P02620, P02621, P02622, P02623, P02624, P02625, P02626, P02627, P02628, P02629, P02630, P02631, P05939, P05940, P05941, P09227, P0CE71, P0CE72, P18087, P19753, P20472, P30563, P32848, P43305, P51434, P51879, P56503, P59747

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

575 predictions. Top by Δscore:

Variant	Effect	Δscore
7:97987045:AC:A	donor_gain	1.0000
7:97987046:CC:C	donor_gain	1.0000
7:97987046:CCCT:C	donor_gain	1.0000
7:97988414:A:AC	donor_gain	1.0000
7:97988415:C:CT	donor_gain	1.0000
7:97988418:A:AC	donor_gain	1.0000
7:97988418:AAG:A	donor_gain	1.0000
7:97988418:AAGCT:A	donor_gain	1.0000
7:97987032:CA:C	donor_gain	0.9900
7:97987040:GACAT:G	donor_loss	0.9900
7:97987042:CAT:C	donor_loss	0.9900
7:97987044:T:TA	donor_loss	0.9900
7:97987045:A:AC	donor_gain	0.9900
7:97987045:ACCCT:A	donor_loss	0.9900
7:97987046:C:CC	donor_gain	0.9900
7:97988415:CTT:C	donor_gain	0.9900
7:97988415:CTTA:C	donor_gain	0.9900
7:97988419:A:C	donor_gain	0.9900
7:97988545:GGGTC:G	acceptor_gain	0.9900
7:97988546:GGTCT:G	acceptor_gain	0.9900
7:97988547:GTCT:G	acceptor_gain	0.9900
7:97988549:C:CC	acceptor_gain	0.9900
7:97990052:T:A	donor_gain	0.9900
7:97987152:AAAAC:A	acceptor_gain	0.9800
7:97987157:C:CA	acceptor_loss	0.9800
7:97987158:T:C	acceptor_loss	0.9800
7:97988410:G:C	donor_gain	0.9800
7:97988415:CT:C	donor_gain	0.9800
7:97988415:CTTAA:C	donor_gain	0.9800
7:97988548:TCT:T	acceptor_gain	0.9800

AlphaMissense

736 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:97988466:G:C	F48L	0.995
7:97988466:G:T	F48L	0.995
7:97988468:A:G	F48L	0.995
7:97984980:A:G	F103S	0.993
7:97987080:C:G	D91H	0.991
7:97988419:A:G	L64P	0.991
7:97984979:G:C	F103L	0.990
7:97984979:G:T	F103L	0.990
7:97984981:A:G	F103L	0.990
7:97988456:C:G	D52H	0.990
7:97988467:A:G	F48S	0.990
7:97988455:T:A	D52V	0.989
7:97988521:A:G	F30S	0.989
7:97988520:G:C	F30L	0.988
7:97988520:G:T	F30L	0.988
7:97988522:A:G	F30L	0.988
7:97987079:T:A	D91V	0.987
7:97987079:T:G	D91A	0.987
7:97988455:T:G	D52A	0.987
7:97984980:A:C	F103C	0.986
7:97987094:A:G	L86S	0.985
7:97988419:A:T	L64H	0.985
7:97987138:A:C	F71L	0.984
7:97987138:A:T	F71L	0.984
7:97987140:A:G	F71L	0.984
7:97988434:A:G	L59P	0.984
7:97988442:G:C	S56R	0.984
7:97988442:G:T	S56R	0.984
7:97988444:T:G	S56R	0.984
7:97987058:A:T	I98N	0.983

dbSNP variants (sampled 300 via entrez): RS1000349617 (7:97984943 C>T), RS1001241628 (7:97989399 T>G), RS1003530452 (7:97988308 C>G,T), RS1007389807 (7:97991748 A>T), RS1007609165 (7:97985766 A>C), RS1008054172 (7:97988986 A>G), RS1008075966 (7:97985359 C>T), RS1008279193 (7:97992062 A>C), RS1008562584 (7:97984644 G>C), RS1009031376 (7:97984413 GA>G), RS1010343607 (7:97984453 C>T), RS1010910150 (7:97990625 A>T), RS1011577503 (7:97987979 G>A), RS1011860582 (7:97989639 C>T), RS1014303245 (7:97991356 T>C)

Disease associations

OMIM: gene MIM:620522 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001099_14	Sudden cardiac arrest	2.000000e-06
GCST006922_15	Regular attendance at a religious group	9.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004278	sudden cardiac arrest
EFO:0009592	social interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression	1
Folic Acid	decreases expression	1
Valproic Acid	increases methylation	1
Asbestos, Serpentine	increases methylation	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.