ODC1-DT

Summary

ODC1-DT (ODC1 divergent transcript, HGNC:54070) is a long non-coding RNA gene on chromosome 2p25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54070
Approved symbol	ODC1-DT
Name	ODC1 divergent transcript
Location	2p25.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-MIF
Ensembl gene	ENSG00000257135
Ensembl biotype	lncRNA
Entrez	101929715
RNAcentral	URS000075CD89 — lncRNA, 882 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000404616, ENST00000547349, ENST00000553181, ENST00000667698, ENST00000670859, ENST00000684902, ENST00000690575, ENST00000702529, ENST00000810589, ENST00000810590, ENST00000810591, ENST00000810592, ENST00000810593, ENST00000810594, ENST00000810595, ENST00000810596, ENST00000810597, ENST00000810598, ENST00000810599, ENST00000810600, ENST00000810601, ENST00000810602

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000404616 — 4 exons

Exon	Start	End
ENSE00001549937	10453869	10454058
ENSE00001552177	10455423	10455552
ENSE00001559654	10455246	10455268
ENSE00002415926	10452319	10452469

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 87.06.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2561 / max 48.3036, expressed in 624 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18850	1.2355	620
18851	0.0205	5

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	87.06	gold quality
left testis	UBERON:0004533	80.26	gold quality
right testis	UBERON:0004534	80.13	gold quality
buccal mucosa cell	CL:0002336	79.19	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.03	gold quality
tibialis anterior	UBERON:0001385	77.97	silver quality
cardiac muscle of right atrium	UBERON:0003379	77.02	gold quality
left ventricle myocardium	UBERON:0006566	76.89	gold quality
testis	UBERON:0000473	76.82	gold quality
bone marrow cell	CL:0002092	74.26	silver quality
kidney epithelium	UBERON:0004819	73.94	gold quality
ileal mucosa	UBERON:0000331	73.13	gold quality
right lobe of liver	UBERON:0001114	71.12	gold quality
monocyte	CL:0000576	70.10	gold quality
leukocyte	CL:0000738	70.08	gold quality
sural nerve	UBERON:0015488	69.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.11	gold quality
tibial artery	UBERON:0007610	68.68	gold quality
popliteal artery	UBERON:0002250	68.67	gold quality
aorta	UBERON:0000947	67.71	gold quality
granulocyte	CL:0000094	67.70	gold quality
ventricular zone	UBERON:0003053	67.67	gold quality
descending thoracic aorta	UBERON:0002345	67.42	gold quality
cortical plate	UBERON:0005343	67.26	gold quality
ascending aorta	UBERON:0001496	66.67	gold quality
thoracic aorta	UBERON:0001515	66.58	gold quality
adenohypophysis	UBERON:0002196	66.19	gold quality
tibial nerve	UBERON:0001323	65.97	gold quality
left coronary artery	UBERON:0001626	65.50	gold quality
pituitary gland	UBERON:0000007	65.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Our data reveal the existence of a feedback loop between c-Myc and lncRNA-MIF, through which c-Myc protein stability is finely controlled. Additionally, we show that the lncRNA-MIF inhibits aerobic glycolysis and tumorigenesis by suppressing c-Myc and miR-586. (PMID:27317567)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.