ODF2L

Summary

ODF2L (outer dense fiber of sperm tails 2 like, HGNC:29225) is a protein-coding gene on chromosome 1p22.3, encoding Protein BCAP (Q9ULJ1). Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.

Involved in negative regulation of cilium assembly. Located in centriolar satellite and ciliary basal body.

Source: NCBI Gene 57489 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 121 total
• MANE Select transcript: NM_001366781

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29225
Approved symbol	ODF2L
Name	outer dense fiber of sperm tails 2 like
Location	1p22.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1229
Ensembl gene	ENSG00000122417
Ensembl biotype	protein_coding
OMIM	620130
Entrez	57489

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 21 protein_coding, 9 nonsense_mediated_decay, 9 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000294678, ENST00000317336, ENST00000359242, ENST00000370566, ENST00000394733, ENST00000460698, ENST00000462648, ENST00000463933, ENST00000472144, ENST00000472368, ENST00000473792, ENST00000476054, ENST00000478286, ENST00000479890, ENST00000480440, ENST00000486215, ENST00000486557, ENST00000488879, ENST00000496592, ENST00000524695, ENST00000531412, ENST00000534092, ENST00000696297, ENST00000696298, ENST00000696299, ENST00000696300, ENST00000696301, ENST00000696302, ENST00000696303, ENST00000696304, ENST00000696309, ENST00000696310, ENST00000907312, ENST00000926630, ENST00000926631, ENST00000926632, ENST00000926633, ENST00000926634, ENST00000926635, ENST00000945042, ENST00000945043

RefSeq mRNA: 35 — MANE Select: NM_001366781 NM_001007022, NM_001184765, NM_001184766, NM_001366779, NM_001366781, NM_001366782, NM_001366783, NM_001366784, NM_001395519, NM_001395520, NM_001395521, NM_001395522, NM_001395523, NM_001395524, NM_001395525, NM_001395526, NM_001395527, NM_001395528, NM_001395529, NM_001395530, NM_001395531, NM_001395532, NM_001395533, NM_001395534, NM_001395535, NM_001395536, NM_001395537, NM_001395538, NM_001395539, NM_001395540, NM_001395541, NM_001395542, NM_001395543, NM_001395544, NM_020729

CCDS: CCDS30763, CCDS41354, CCDS53339, CCDS90996, CCDS90997

Canonical transcript exons

ENST00000460698 — 17 exons

Exon	Start	End
ENSE00001799773	86356444	86356602
ENSE00002154347	86346837	86348878
ENSE00003460792	86372431	86372540
ENSE00003481411	86352859	86352984
ENSE00003499910	86358787	86358891
ENSE00003510980	86384676	86384801
ENSE00003526906	86376233	86376418
ENSE00003534410	86382242	86382358
ENSE00003544617	86383134	86383196
ENSE00003552451	86360426	86360536
ENSE00003559909	86354530	86354692
ENSE00003581703	86371018	86371153
ENSE00003623212	86382931	86383002
ENSE00003623534	86385458	86385590
ENSE00003674265	86354774	86354859
ENSE00003966867	86386915	86387086
ENSE00003966868	86396033	86396323

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 98.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.1195 / max 329.8220, expressed in 1764 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13104	19.5913	1758
13103	1.1292	588
13101	0.2597	128
13102	0.1392	40

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.38	gold quality
calcaneal tendon	UBERON:0003701	96.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.33	gold quality
sural nerve	UBERON:0015488	94.94	gold quality
adenohypophysis	UBERON:0002196	94.88	gold quality
adrenal tissue	UBERON:0018303	94.33	gold quality
right lobe of thyroid gland	UBERON:0001119	93.99	gold quality
left lobe of thyroid gland	UBERON:0001120	93.74	gold quality
oviduct epithelium	UBERON:0004804	93.62	gold quality
spleen	UBERON:0002106	93.59	gold quality
right lung	UBERON:0002167	93.45	gold quality
bronchial epithelial cell	CL:0002328	93.43	gold quality
omental fat pad	UBERON:0010414	93.20	gold quality
peritoneum	UBERON:0002358	93.14	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.06	gold quality
left ovary	UBERON:0002119	92.88	gold quality
rectum	UBERON:0001052	92.87	gold quality
right ovary	UBERON:0002118	92.87	gold quality
thyroid gland	UBERON:0002046	92.85	gold quality
body of uterus	UBERON:0009853	92.52	gold quality
upper lobe of left lung	UBERON:0008952	92.44	gold quality
tibial nerve	UBERON:0001323	92.39	gold quality
pituitary gland	UBERON:0000007	92.38	gold quality
left uterine tube	UBERON:0001303	92.35	gold quality
left adrenal gland cortex	UBERON:0035825	92.35	gold quality
endocervix	UBERON:0000458	92.31	gold quality
transverse colon	UBERON:0001157	92.16	gold quality
metanephros cortex	UBERON:0010533	92.15	gold quality
bronchus	UBERON:0002185	92.13	gold quality
left adrenal gland	UBERON:0001234	92.07	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-CURD-46	yes	66.23
E-CURD-88	yes	53.11
E-GEOD-130148	yes	12.69
E-CURD-114	yes	11.84
E-ANND-3	yes	10.69
E-CURD-112	yes	4.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

107 targeting ODF2L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-7845-5P	99.88	64.88	771
HSA-MIR-129-5P	99.88	70.26	3273
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-659-3P	99.85	70.69	1620
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767

Literature-anchored findings (GeneRIF, showing 1)

• ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models. (PMID:36378528)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Odf2l	ENSMUSG00000028256
rattus_norvegicus	Odf2l	ENSRNOG00000014059

Paralogs (1): ODF2 (ENSG00000136811)

Protein

Protein identifiers

Protein BCAP — Q9ULJ1 (reviewed: Q9ULJ1)

Alternative names: Basal body centriole-associated protein, Outer dense fiber protein 2-like

All UniProt accessions (13): A0A8Q3SIE2, A0A8Q3SIL9, A0A8Q3SIM3, A0A8Q3WL67, A0A8Q3WMC5, B5ME44, E9PJZ1, E9PMV9, E9PNP0, Q9ULJ1, H0YCM1, H0YD68, H0YF19

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Centriolar satellite. Cilium basal body Cytoplasm. Centriolar satellite Cytoplasm.

Tissue specificity. Mainly expressed in trachea and testis. Not detected in bone marrow, bladder, leukocytes. Only weakly detected in tongue, stomach, brain and ovaries.

Similarity. Belongs to the ODF2 family.

Isoforms (6)

UniProt ID	Names	Canonical?
Q9ULJ1-1	1, L-BCAP	yes
Q9ULJ1-2	2
Q9ULJ1-3	3
Q9ULJ1-4	4
Q9ULJ1-5	5
Q9ULJ1-6	6

RefSeq proteins (35): NP_001007023, NP_001171694, NP_001171695, NP_001353708, NP_001353710, NP_001353711, NP_001353712, NP_001353713, NP_001382448, NP_001382449, NP_001382450, NP_001382451, NP_001382452, NP_001382453, NP_001382454, NP_001382455, NP_001382456, NP_001382457, NP_001382458, NP_001382459, NP_001382460, NP_001382461, NP_001382462, NP_001382463, NP_001382464, NP_001382465, NP_001382466, NP_001382467, NP_001382468, NP_001382469, NP_001382470, NP_001382471, NP_001382472, NP_001382473, NP_065780 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026099	ODF2/BCAP	Family

UniProt features (16 total): coiled-coil region 5, splice variant 5, sequence conflict 3, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULJ1-F1	82.06	0.52

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 120 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_CILIUM_ORGANIZATION, GOCC_CENTROSOME, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP, GOBP_ORGANELLE_ASSEMBLY, PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP, GOBP_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_REGULATION_OF_CILIUM_ASSEMBLY, GOBP_CELL_PROJECTION_ORGANIZATION

GO Biological Process (2): cell projection organization (GO:0030030), negative regulation of cilium assembly (GO:1902018)

GO Molecular Function (0):

GO Cellular Component (8): centrosome (GO:0005813), centriole (GO:0005814), centriolar satellite (GO:0034451), ciliary basal body (GO:0036064), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
microtubule organizing center	3
cellular anatomical structure	3
intracellular membraneless organelle	2
cellular component organization	1
cilium assembly	1
negative regulation of plasma membrane bounded cell projection assembly	1
regulation of cilium assembly	1
negative regulation of organelle assembly	1
centriole	1
centrosome	1
cilium	1
intracellular anatomical structure	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

1043 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ODF2L	PRSS23	O95084	497
ODF2L	SH3GLB1	Q9Y371	489
ODF2L	PKDREJ	Q9NTG1	473
ODF2L	CBY2	Q8NA61	469
ODF2L	GRB2	P29354	445
ODF2L	UBXN11	Q5T124	437
ODF2L	PIK3R2	O00459	434
ODF2L	SPEM1	Q8N4L4	412
ODF2L	SPATA19	Q7Z5L4	407
ODF2L	SPATA9	Q9BWV2	405
ODF2L	METTL3	Q86U44	404
ODF2L	EMC9	Q9Y3B6	402
ODF2L	CABYR	O75952	397
ODF2L	DKKL1	Q9UK85	396
ODF2L	OAZ3	Q9UMX2	395

IntAct

49 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
EMILIN1	METTL15	psi-mi:“MI:0914”(association)	0.530
PPP1R13B	CCDC85C	psi-mi:“MI:0914”(association)	0.530
BORCS6	HSBP1	psi-mi:“MI:0914”(association)	0.530
ODF2	PLK1	psi-mi:“MI:0914”(association)	0.480
ODF2L	CHD4	psi-mi:“MI:0915”(physical association)	0.400
Ndc80	RRBP1	psi-mi:“MI:0915”(physical association)	0.400
ERBB2	ODF2L	psi-mi:“MI:0915”(physical association)	0.370
ODF2L	HTT	psi-mi:“MI:0915”(physical association)	0.370
S100P	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
CFAP184	TARS3	psi-mi:“MI:0914”(association)	0.350
KRT38	KRBA1	psi-mi:“MI:0914”(association)	0.350
INSYN1	CCDC85C	psi-mi:“MI:0914”(association)	0.350
ODF2L	GAPDHS	psi-mi:“MI:0914”(association)	0.350
BORCS6	UQCRQ	psi-mi:“MI:0914”(association)	0.350
BRK1	KIF5C	psi-mi:“MI:0914”(association)	0.350
CEP128	CCDC66	psi-mi:“MI:2364”(proximity)	0.270
PCM1	CCDC66	psi-mi:“MI:2364”(proximity)	0.270
ODF2	CCDC66	psi-mi:“MI:2364”(proximity)	0.270
TRAF3IP1	ODF2L	psi-mi:“MI:0915”(physical association)	0.000
NDEL1	ODF2L	psi-mi:“MI:0915”(physical association)	0.000
ppdK	ODF2L	psi-mi:“MI:0915”(physical association)	0.000
ODF2L	spo0J	psi-mi:“MI:0915”(physical association)	0.000
ODF2L		psi-mi:“MI:0915”(physical association)	0.000
cotE	ODF2L	psi-mi:“MI:0915”(physical association)	0.000
ODF2L	citT3	psi-mi:“MI:0915”(physical association)	0.000
ODF2L	lysR	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (55): ODF2L (Affinity Capture-RNA), ODF2L (Affinity Capture-MS), ODF2L (Proximity Label-MS), ODF2L (Proximity Label-MS), ODF2L (Proximity Label-MS), ODF2L (Proximity Label-MS), ODF2L (Affinity Capture-MS), ODF2L (Affinity Capture-MS), NPM2 (Affinity Capture-MS), GAPDHS (Affinity Capture-MS), ZMAT2 (Affinity Capture-MS), HACL1 (Affinity Capture-MS), ODF2L (Affinity Capture-RNA), ODF2L (Biochemical Activity), ODF2L (Proximity Label-MS)

ESM2 similar proteins: A0A0A6YYL3, A2A2Z9, A6NC57, A8MYB1, A9JSR5, A9UM82, A9ZSY0, D3ZNV2, F4K1B4, G5EBL8, H3BUK9, O14043, P34606, Q01649, Q08B20, Q0VBY1, Q19UN5, Q32L59, Q4UJ75, Q501X2, Q5CZ79, Q5M7B7, Q5SQ80, Q5TYW2, Q5VUR7, Q66HB6, Q6AY08, Q7FAD5, Q7TPV2, Q7Z7B0, Q80X59, Q811D2, Q86Y13, Q86YR6, Q8IVF6, Q8N6Q1, Q8NF67, Q8WXW3, Q95JR0, Q96AA8

Diamond homologs: Q08B20, Q0VBY1, Q5ZKK5, Q9D478, Q9ULJ1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 50 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cilium assembly	5	11.2×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

121 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	88
Likely benign	8
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2755 predictions. Top by Δscore:

Variant	Effect	Δscore
1:86354525:CATA:C	donor_loss	1.0000
1:86354526:ATAC:A	donor_loss	1.0000
1:86354527:TA:T	donor_loss	1.0000
1:86354528:A:C	donor_loss	1.0000
1:86354689:TTTT:T	acceptor_gain	1.0000
1:86354690:TTT:T	acceptor_gain	1.0000
1:86354697:T:C	acceptor_gain	1.0000
1:86354697:T:TC	acceptor_gain	1.0000
1:86354700:C:CT	acceptor_gain	1.0000
1:86354772:A:AC	donor_gain	1.0000
1:86354773:C:CC	donor_gain	1.0000
1:86354773:CT:C	donor_gain	1.0000
1:86354855:TCAAC:T	acceptor_gain	1.0000
1:86354856:CAAC:C	acceptor_gain	1.0000
1:86354856:CAACC:C	acceptor_gain	1.0000
1:86354857:AAC:A	acceptor_gain	1.0000
1:86354857:AACC:A	acceptor_loss	1.0000
1:86354858:AC:A	acceptor_gain	1.0000
1:86354859:CC:C	acceptor_gain	1.0000
1:86354859:CCTAA:C	acceptor_loss	1.0000
1:86354860:C:CC	acceptor_gain	1.0000
1:86354860:C:T	acceptor_gain	1.0000
1:86356458:C:CA	donor_gain	1.0000
1:86356472:T:TA	donor_gain	1.0000
1:86356488:T:TA	donor_gain	1.0000
1:86356489:C:A	donor_gain	1.0000
1:86356511:T:A	donor_gain	1.0000
1:86358782:CGTA:C	donor_loss	1.0000
1:86358783:GTA:G	donor_loss	1.0000
1:86358784:TA:T	donor_loss	1.0000

AlphaMissense

4328 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:86382300:A:G	L189P	0.968
1:86354561:A:G	L579P	0.961
1:86354553:C:G	A582P	0.952
1:86382303:C:G	R188P	0.951
1:86352908:A:G	L615P	0.949
1:86352920:A:G	L611P	0.947
1:86382956:A:G	L161P	0.935
1:86354780:A:G	L533P	0.924
1:86354571:C:G	A576P	0.923
1:86382998:A:G	L147P	0.917
1:86354657:A:G	L547P	0.912
1:86382343:C:G	A175P	0.912
1:86376310:C:G	A245P	0.887
1:86354624:A:G	L558P	0.886
1:86382336:C:G	R177P	0.885
1:86354556:C:G	A581P	0.880
1:86371139:A:G	L312P	0.877
1:86352929:A:G	I608T	0.867
1:86354564:T:G	Q578P	0.861
1:86354645:A:G	L551P	0.859
1:86371127:A:G	L316P	0.848
1:86358870:C:G	A426P	0.847
1:86382258:A:G	L203S	0.846
1:86376394:A:G	W217R	0.841
1:86376394:A:T	W217R	0.841
1:86356454:A:G	L503P	0.831
1:86382274:C:G	A198P	0.830
1:86382312:A:T	V185E	0.829
1:86382291:T:G	Q192P	0.810
1:86352938:T:G	Q605P	0.808

dbSNP variants (sampled 300 via entrez): RS1000017063 (1:86349038 TTTAAAA>T), RS1000043815 (1:86372860 C>G,T), RS1000278189 (1:86394658 T>C), RS1000306890 (1:86348979 T>C), RS1000416816 (1:86349488 T>C), RS1000541012 (1:86354225 A>C), RS1000622318 (1:86393118 C>T), RS1000700800 (1:86382610 T>C), RS1000837770 (1:86362976 C>T), RS1000847604 (1:86363301 C>T), RS1000940907 (1:86367992 T>C), RS1000953608 (1:86357852 T>C), RS1001018030 (1:86350561 T>C), RS1001080235 (1:86395851 C>G,T), RS1001169067 (1:86362480 G>A)

Disease associations

OMIM: gene MIM:620130 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005580_172	Intraocular pressure	1.000000e-08
GCST005580_288	Intraocular pressure	2.000000e-09
GCST006629_76	Pulse pressure	3.000000e-10
GCST009847_14	Hallux valgus	3.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, decreases methylation	3
Particulate Matter	increases abundance, increases expression, decreases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation, affects methylation, affects cotreatment	1
trichostatin A	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
torcetrapib	increases expression	1
bisphenol S	increases methylation	1
jinfukang	decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	decreases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Clorgyline	increases expression	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Ethyl Methanesulfonate	increases expression	1
Malathion	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Testosterone	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	increases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.