OMP

Summary

OMP (olfactory marker protein, HGNC:8136) is a protein-coding gene on chromosome 11q13.5, encoding Olfactory marker protein (P47874). May act as a modulator of the olfactory signal-transduction cascade.

Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade.

Source: NCBI Gene 4975 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_006189

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8136
Approved symbol	OMP
Name	olfactory marker protein
Location	11q13.5
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000254550
Ensembl biotype	protein_coding
OMIM	164340
Entrez	4975

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000529803

RefSeq mRNA: 1 — MANE Select: NM_006189 NM_006189

CCDS: CCDS53682

Canonical transcript exons

ENST00000529803 — 1 exons

Exon	Start	End
ENSE00002199725	77102840	77103331

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 75.48.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vastus lateralis	UBERON:0001379	75.48	gold quality
mucosa of transverse colon	UBERON:0004991	72.95	gold quality
duodenum	UBERON:0002114	68.35	gold quality
lower esophagus mucosa	UBERON:0035834	67.82	gold quality
right lobe of liver	UBERON:0001114	66.46	gold quality
rectum	UBERON:0001052	65.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.47	gold quality
transverse colon	UBERON:0001157	63.21	gold quality
liver	UBERON:0002107	58.49	gold quality
small intestine	UBERON:0002108	57.76	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.20	gold quality
colonic epithelium	UBERON:0000397	56.40	gold quality
gall bladder	UBERON:0002110	54.01	gold quality
intestine	UBERON:0000160	53.67	gold quality
esophagus mucosa	UBERON:0002469	53.46	gold quality
colon	UBERON:0001155	52.65	gold quality
left adrenal gland cortex	UBERON:0035825	51.71	gold quality
bone marrow	UBERON:0002371	50.57	gold quality
body of stomach	UBERON:0001161	50.22	gold quality
left adrenal gland	UBERON:0001234	49.93	gold quality
smooth muscle tissue	UBERON:0001135	49.78	gold quality
stomach	UBERON:0000945	49.41	gold quality
apex of heart	UBERON:0002098	49.31	gold quality
urinary bladder	UBERON:0001255	48.55	gold quality
adult mammalian kidney	UBERON:0000082	48.45	gold quality
adrenal gland	UBERON:0002369	47.12	gold quality
right coronary artery	UBERON:0001625	46.79	gold quality
right adrenal gland cortex	UBERON:0035827	46.74	gold quality
ectocervix	UBERON:0012249	46.67	gold quality
fundus of stomach	UBERON:0001160	46.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EBF1, NEUROD1, NFIC, TOX

Literature-anchored findings (GeneRIF, showing 3)

• Olfactory marker protein captures cAMP produced via Galphas-protein-coupled receptor activation. (PMID:32703433)
• Olfactory marker protein is unlikely to be cleaved by calpain 5. (PMID:36309704)
• Olfactory marker protein contains a leucine-rich domain in the Omega-loop important for nuclear export. (PMID:36333725)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ompb	ENSDARG00000032380
danio_rerio	ompa	ENSDARG00000105218
mus_musculus	Omp	ENSMUSG00000074006

Protein

Protein identifiers

Olfactory marker protein — P47874 (reviewed: P47874)

Alternative names: Olfactory neuronal-specific protein

All UniProt accessions (1): P47874

UniProt curated annotations — full annotation on UniProt →

Function. May act as a modulator of the olfactory signal-transduction cascade.

Subunit / interactions. Interacts with BEX1 and BEX2.

Subcellular location. Cytoplasm.

Tissue specificity. Uniquely associated with mature olfactory receptor neurons.

Similarity. Belongs to the olfactory marker protein family.

RefSeq proteins (1): NP_006180* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009103	Olfactory_marker	Family
IPR036727	Olfactory_marker_sf	Homologous_superfamily

Pfam: PF06554

UniProt features (5 total): sequence variant 2, initiator methionine 1, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P47874-F1	94.83	0.94

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 58 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_NEUROGENESIS, chr11q13, GOBP_CELL_CELL_SIGNALING, GOBP_SYNAPTIC_SIGNALING, GOBP_SENSORY_PERCEPTION, KIM_GASTRIC_CANCER_CHEMOSENSITIVITY, NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON, GOCC_NEURON_PROJECTION, GOCC_SYNAPSE, GOCC_CELL_BODY, GOCC_SOMATODENDRITIC_COMPARTMENT, GOCC_AXON

GO Biological Process (4): signal transduction (GO:0007165), chemical synaptic transmission (GO:0007268), sensory perception of smell (GO:0007608), neurogenesis (GO:0022008)

GO Molecular Function (0):

GO Cellular Component (6): nucleus (GO:0005634), cytosol (GO:0005829), axon (GO:0030424), neuronal cell body (GO:0043025), synapse (GO:0045202), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
anterograde trans-synaptic signaling	1
sensory perception of chemical stimulus	1
nervous system development	1
cell differentiation	1
intracellular membrane-bounded organelle	1
cytoplasm	1
neuron projection	1
somatodendritic compartment	1
cell body	1
cell junction	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

600 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OMP	TMTC1	Q8IUR5	793
OMP	CNGA2	Q16280	774
OMP	GAP43	P17677	769
OMP	MYO7A	P78427	754
OMP	ADCY3	O60266	715
OMP	TH	P07101	666
OMP	GUCY2D	Q02846	631
OMP	GUCY2F	P51841	607
OMP	AVPR2	P30518	601
OMP	BEX1	Q9HBH7	583
OMP	BEX2	Q9BXY8	583
OMP	GNAO1	P09471	575
OMP	EBF1	Q9UH73	539
OMP	ANO2	Q9NQ90	531
OMP	GNAL	P38405	521

IntAct

8 interactions, top by confidence:

A	B	Type	Score
BACC1	SMARCA5	psi-mi:“MI:0914”(association)	0.530
RGS5	CST8	psi-mi:“MI:0914”(association)	0.350
LARP4	TPST2	psi-mi:“MI:0914”(association)	0.350
OMP	CST1	psi-mi:“MI:0914”(association)	0.350
CIDEB	SNCG	psi-mi:“MI:0914”(association)	0.350
OMP	GPX4	psi-mi:“MI:0914”(association)	0.350
FAM218A	OMP	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): BEX1 (Reconstituted Complex), AHNAK2 (Affinity Capture-MS), CRNN (Affinity Capture-MS), OMP (Affinity Capture-MS), OMP (Affinity Capture-MS), ZG16B (Affinity Capture-MS), AMY1C (Affinity Capture-MS), FAHD2A (Affinity Capture-MS), CST1 (Affinity Capture-MS), GPX4 (Affinity Capture-MS), OMP (Affinity Capture-MS), OMP (Affinity Capture-MS), OMP (Affinity Capture-MS)

ESM2 similar proteins: A1AI64, A2RGJ5, A3MA28, A4WGB6, A6MM39, B1MZI4, B2TVN1, B3TN54, B4YNF9, B5BJ27, B7N2M8, C0HJW7, C0HM47, C0HMC8, C0Q3J4, D7Y2H3, O03070, O52512, P04866, P0DA80, P0DA81, P17449, P24418, P27378, P36326, P47874, P55219, P55444, P63999, P64001, P86203, Q03MP9, Q03SF0, Q07860, Q07874, Q0ICV5, Q0IDJ2, Q0SZ73, Q1I0U5, Q1J4K7

Diamond homologs: P08523, P47874, Q64288

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

126 predictions. Top by Δscore:

Variant	Effect	Δscore
11:77103252:TC:T	donor_gain	0.9100
11:77103253:C:A	donor_gain	0.9000
11:77103254:AT:A	donor_gain	0.9000
11:77103305:GCC:G	donor_gain	0.8500
11:77103313:G:GA	donor_gain	0.7600
11:77103067:C:T	donor_gain	0.6600
11:77103259:C:CG	donor_gain	0.6600
11:77102960:G:GT	donor_gain	0.6400
11:77102984:GCGGA:G	donor_gain	0.6400
11:77103281:G:GT	donor_gain	0.6300
11:77103044:A:T	donor_gain	0.6100
11:77103073:C:A	donor_gain	0.6100
11:77103085:C:T	donor_gain	0.6000
11:77102988:A:AG	donor_gain	0.5700
11:77102989:G:GG	donor_gain	0.5700
11:77103048:T:TA	donor_gain	0.5100
11:77103255:T:G	donor_gain	0.5100
11:77102909:C:T	donor_gain	0.5000
11:77102947:G:GT	donor_gain	0.5000
11:77103075:C:G	donor_gain	0.5000
11:77102986:G:GT	donor_gain	0.4900
11:77103167:G:GT	donor_gain	0.4900
11:77103026:C:G	donor_gain	0.4800
11:77102908:GCAGA:G	donor_gain	0.4700
11:77102987:GAGTC:G	donor_gain	0.4700
11:77102965:G:GT	donor_gain	0.4500
11:77103031:G:GG	donor_gain	0.4500
11:77103265:CGTCA:C	donor_gain	0.4500
11:77103276:GC:G	donor_gain	0.4500
11:77103030:A:AG	donor_gain	0.4400

AlphaMissense

1064 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:77103032:T:C	F65L	0.980
11:77103034:C:A	F65L	0.980
11:77103034:C:G	F65L	0.980
11:77103098:T:A	W87R	0.979
11:77103098:T:C	W87R	0.979
11:77103124:G:A	M95I	0.979
11:77103124:G:C	M95I	0.979
11:77103124:G:T	M95I	0.979
11:77103041:T:A	W68R	0.978
11:77103041:T:C	W68R	0.978
11:77103100:G:C	W87C	0.978
11:77103100:G:T	W87C	0.978
11:77103317:T:C	F160L	0.976
11:77103319:T:A	F160L	0.976
11:77103319:T:G	F160L	0.976
11:77103008:T:C	F57L	0.968
11:77103010:C:A	F57L	0.968
11:77103010:C:G	F57L	0.968
11:77103212:T:C	F125L	0.966
11:77103214:T:A	F125L	0.966
11:77103214:T:G	F125L	0.966
11:77103245:C:A	R136S	0.965
11:77103155:T:C	F106L	0.963
11:77103157:C:A	F106L	0.963
11:77103157:C:G	F106L	0.963
11:77103043:G:C	W68C	0.961
11:77103043:G:T	W68C	0.961
11:77103072:T:A	V78D	0.961
11:77103094:G:C	Q85H	0.960
11:77103094:G:T	Q85H	0.960

dbSNP variants (sampled 300 via entrez): RS1000267923 (11:77101079 C>T), RS1002279500 (11:77103467 C>T), RS1006840813 (11:77101159 G>A,C), RS1007136996 (11:77101579 T>G), RS1008852038 (11:77103501 C>T), RS1009152190 (11:77103779 G>A), RS1010252262 (11:77102564 G>A), RS1010366750 (11:77102267 A>G), RS1014267321 (11:77101838 C>T), RS1016733477 (11:77101583 G>C), RS1017259796 (11:77101270 A>C), RS1018525889 (11:77102633 C>G), RS1020432226 (11:77102595 G>A,C), RS1020768974 (11:77103487 C>T), RS1024278201 (11:77101839 G>A)

Disease associations

OMIM: gene MIM:164340 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

10 total (human), top 10 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
(+)-JQ1 compound	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Carmustine	decreases expression	1
Hydrogen Peroxide	affects expression	1
Methotrexate	decreases expression	1
Urethane	decreases expression, increases expression	1
Asbestos, Crocidolite	affects expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.