OOSP1

Summary

OOSP1 (oocyte secreted protein 1, HGNC:49233) is a protein-coding gene on chromosome 11q12.1, encoding Putative oocyte-secreted protein 1 homolog (A8MZH6). May be involved in cell differentiation.

Predicted to act upstream of or within blastocyst development. Predicted to be located in extracellular region.

Source: NCBI Gene 255649 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001395276

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49233
Approved symbol	OOSP1
Name	oocyte secreted protein 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284873
Ensembl biotype	protein_coding
OMIM	621111
Entrez	255649

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000644529, ENST00000646685

RefSeq mRNA: 1 — MANE Select: NM_001395276 NM_001395276

CCDS: CCDS91478

Canonical transcript exons

ENST00000645605 — 0 exons

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 84.65.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.65	gold quality
corpus callosum	UBERON:0002336	54.33	gold quality
calcaneal tendon	UBERON:0003701	46.59	gold quality
blood	UBERON:0000178	45.72	gold quality
granulocyte	CL:0000094	44.55	silver quality
adrenal tissue	UBERON:0018303	42.48	silver quality
cortical plate	UBERON:0005343	41.49	gold quality
stromal cell of endometrium	CL:0002255	40.74	silver quality
skeletal muscle tissue	UBERON:0001134	39.96	silver quality
duodenum	UBERON:0002114	39.71	gold quality
rectum	UBERON:0001052	38.68	silver quality
endometrium	UBERON:0001295	38.60	silver quality
bone marrow	UBERON:0002371	37.44	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
kidney	UBERON:0002113	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	36.10	silver quality
muscle tissue	UBERON:0002385	35.90	silver quality
superior frontal gyrus	UBERON:0002661	35.62	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
right frontal lobe	UBERON:0002810	35.47	gold quality
adult mammalian kidney	UBERON:0000082	35.45	silver quality
Brodmann (1909) area 9	UBERON:0013540	35.06	silver quality
cerebellar hemisphere	UBERON:0002245	34.91	silver quality
anterior cingulate cortex	UBERON:0009835	34.90	silver quality
cerebellar cortex	UBERON:0002129	34.81	silver quality
cerebellum	UBERON:0002037	34.75	silver quality
frontal cortex	UBERON:0001870	34.72	gold quality
prefrontal cortex	UBERON:0000451	34.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Oosp1	ENSMUSG00000041857

Paralogs (2): OOSP2 (ENSG00000149507), PLAC1 (ENSG00000170965)

Protein

Protein identifiers

Putative oocyte-secreted protein 1 homolog — A8MZH6 (reviewed: A8MZH6)

All UniProt accessions (2): A0A2R8Y634, A0A2R8YCH4

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in cell differentiation.

Subcellular location. Secreted.

Similarity. Belongs to the PLAC1 family.

RefSeq proteins (1): NP_001382205* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033222	PLAC1_fam	Family

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MZH6-F1	86.40	0.71

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 12 (showing top): WANG_TARGETS_OF_MLL_CBP_FUSION_UP, GSE13522_WT_VS_IFNG_KO_SKIN_UP, GSE7596_AKT_TRANSD_VS_CTRL_CD4_TCONV_WITH_TGFB_DN, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_UP, chr11q12, GSE3720_UNSTIM_VS_LPS_STIM_VD1_GAMMADELTA_TCELL_DN, GSE3720_LPS_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP, GSE5589_WT_VS_IL10_KO_LPS_STIM_MACROPHAGE_180MIN_DN, BOYLAN_MULTIPLE_MYELOMA_C_D_DN, GSE34217_MIR17_92_OVEREXPRESS_VS_WT_ACT_CD8_TCELL_DN, GSE40274_CTRL_VS_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, BOYLAN_MULTIPLE_MYELOMA_PCA1_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

248 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OOSP1	OOSP3	A0A2R8YFM6	583
OOSP1	ZP1	P60852	571
OOSP1	ZP3	P21754	542
OOSP1	GDF9	O60383	540
OOSP1	RFPL4A	A6NLU0	526
OOSP1	H1-8	Q8IZA3	514
OOSP1	ZP4	Q12836	507
OOSP1	MS4A18	Q3C1V0	506
OOSP1	CCDC177	Q9NQR7	470
OOSP1	BMP15	O95972	446
OOSP1	NOBOX	O60393	446
OOSP1	ZAR1	Q86SH2	436
OOSP1	ASTL	Q6HA08	433
OOSP1	ZP2	Q05996	432
OOSP1	PRR23E	Q8N813	432

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A8MZH6, Q2Q0J1, Q4FZG8, Q86WS3, Q925U0, Q9JI83, A0A2R8YFL7, A0A2R8YFM6, A0A2R8Y4Y8, Q4V7E2, Q9HBJ0, G5E8D7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000015532 (11:59949007 G>A), RS1000134920 (11:59942927 G>A,C), RS1000218963 (11:59946695 A>C,G), RS1000269575 (11:59955448 C>A,T), RS1000281350 (11:59937711 G>C), RS1000295809 (11:59957249 T>C,G), RS1000333885 (11:59950270 G>A), RS1000615563 (11:59939260 C>CA), RS1000920341 (11:59936766 C>A), RS1001133389 (11:59942963 C>T), RS1001263744 (11:59954777 G>A), RS1001384230 (11:59948254 G>A), RS1001514685 (11:59943122 T>G), RS1001673801 (11:59956858 T>C), RS1001772306 (11:59955021 T>G)

Disease associations

OMIM: gene MIM:621111 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.