OOSP2

Summary

OOSP2 (oocyte secreted protein 2, HGNC:26699) is a protein-coding gene on chromosome 11q12.1, encoding Oocyte-secreted protein 2 (Q86WS3). Involved in oocyte maturation.

Involved in oocyte maturation. Located in cytoplasm.

Source: NCBI Gene 219990 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 13 total
• MANE Select transcript: NM_173801

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26699
Approved symbol	OOSP2
Name	oocyte secreted protein 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ36198, OOSP2A
Ensembl gene	ENSG00000149507
Ensembl biotype	protein_coding
OMIM	620263
Entrez	219990

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 retained_intron

ENST00000278855, ENST00000527395, ENST00000532905

RefSeq mRNA: 1 — MANE Select: NM_173801 NM_173801

CCDS: CCDS7979

Canonical transcript exons

ENST00000278855 — 4 exons

Exon	Start	End
ENSE00000990945	60044671	60044774
ENSE00001266550	60046944	60048044
ENSE00001266556	60040409	60040523
ENSE00003667382	60043469	60043647

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 87.06.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1274 / max 99.3196, expressed in 14 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
114425	0.1274	14

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	87.06	gold quality
left testis	UBERON:0004533	85.72	gold quality
testis	UBERON:0000473	85.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.41	gold quality
vermiform appendix	UBERON:0001154	37.99	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
granulocyte	CL:0000094	36.16	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
fundus of stomach	UBERON:0001160	33.88	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	32.97	silver quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
prefrontal cortex	UBERON:0000451	30.73	gold quality
right uterine tube	UBERON:0001302	29.95	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.35	gold quality
right ovary	UBERON:0002118	29.10	gold quality
liver	UBERON:0002107	29.09	gold quality
monocyte	CL:0000576	28.93	silver quality
blood	UBERON:0000178	28.90	gold quality
lymph node	UBERON:0000029	28.86	gold quality
islet of Langerhans	UBERON:0000006	28.01	gold quality
endometrium	UBERON:0001295	27.29	gold quality
tonsil	UBERON:0002372	27.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

62 targeting OOSP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-4658	99.77	64.94	514
HSA-MIR-6790-5P	99.77	65.24	505
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-26A-1-3P	99.64	66.81	788
HSA-MIR-26A-2-3P	99.64	66.82	786
HSA-MIR-142-5P	99.48	70.92	2416

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Oosp2	ENSMUSG00000055895

Paralogs (2): PLAC1 (ENSG00000170965), OOSP1 (ENSG00000284873)

Protein

Protein identifiers

Oocyte-secreted protein 2 — Q86WS3 (reviewed: Q86WS3)

Alternative names: Placenta-specific 1-like protein, Protein TMEM122

All UniProt accessions (3): Q86WS3, A0A0A0MTE3, A0A140VJR6

UniProt curated annotations — full annotation on UniProt →

Function. Involved in oocyte maturation.

Subcellular location. Secreted. Cytoplasm.

Tissue specificity. Highly expressed in oocytes.

Similarity. Belongs to the PLAC1 family.

RefSeq proteins (1): NP_776162* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033222	PLAC1_fam	Family

UniProt features (3 total): signal peptide 1, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86WS3-F1	78.39	0.47

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 56 (showing top): GOBP_OOGENESIS, GOBP_ANATOMICAL_STRUCTURE_MATURATION, GOBP_CELL_MATURATION, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_OOCYTE_MATURATION, GOBP_OOCYTE_DIFFERENTIATION, GOBP_FEMALE_GAMETE_GENERATION, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN, HMGA1_TARGET_GENES, MIR4262, MIR1468_3P, MIR181A_5P_MIR181B_5P, MIR181D_5P, MIR181C_5P

GO Biological Process (1): oocyte maturation (GO:0001556)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): extracellular region (GO:0005576), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
developmental process involved in reproduction	1
cell maturation	1
oocyte development	1
binding	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

302 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OOSP2	OOSP3	A0A2R8YFM6	769
OOSP2	MS4A18	Q3C1V0	664
OOSP2	OOSP4B	A0A2R8Y4Y8	622
OOSP2	MS4A5	Q9H3V2	550
OOSP2	EPCIP	Q9NYP8	434
OOSP2	FAM149B1	Q96BN6	409
OOSP2	ZP3	P21754	400
OOSP2	MS4A14	Q96JA4	377
OOSP2	C1orf159	Q96HA4	376
OOSP2	ZP1	P60852	371
OOSP2	NLRP5	P59047	370
OOSP2	OOSP1	A8MZH6	368
OOSP2	ASTL	Q6HA08	363
OOSP2	ING3	Q9NXR8	344
OOSP2	MS4A3	Q96HJ5	342

IntAct

16 interactions, top by confidence:

A	B	Type	Score
OOSP2	PSEN1	psi-mi:“MI:0915”(physical association)	0.560
SNCA	OOSP2	psi-mi:“MI:0915”(physical association)	0.560
HTT	OOSP2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (1): OOSP2 (Two-hybrid)

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A8MZH6, Q2Q0J1, Q4FZG8, Q86WS3, Q925U0, Q9JI83, A0A2R8Y4Y8, A0A2R8YFM6, Q4V7E2, Q9HBJ0, A0A2R8YFL7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

13 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	12
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

500 predictions. Top by Δscore:

Variant	Effect	Δscore
11:60043467:A:AG	acceptor_gain	1.0000
11:60043468:G:GG	acceptor_gain	1.0000
11:60040520:CATGG:C	donor_loss	0.9900
11:60040521:ATGG:A	donor_loss	0.9900
11:60040522:TGG:T	donor_loss	0.9900
11:60040523:GGT:G	donor_loss	0.9900
11:60040524:GTAA:G	donor_loss	0.9900
11:60040525:T:G	donor_loss	0.9900
11:60043467:AGT:A	acceptor_gain	0.9900
11:60043468:GT:G	acceptor_gain	0.9900
11:60043468:GTG:G	acceptor_gain	0.9900
11:60043646:GG:G	donor_gain	0.9900
11:60043647:GG:G	donor_gain	0.9900
11:60040679:G:GT	donor_gain	0.9800
11:60043468:GTGA:G	acceptor_gain	0.9800
11:60043468:GTGAA:G	acceptor_gain	0.9800
11:60045288:A:AG	acceptor_gain	0.9800
11:60045295:T:TA	acceptor_gain	0.9800
11:60040524:G:GG	donor_gain	0.9700
11:60041024:C:G	donor_gain	0.9700
11:60044670:GGTA:G	acceptor_gain	0.9700
11:60040682:G:GT	donor_gain	0.9400
11:60043463:CCACA:C	acceptor_loss	0.9400
11:60043464:CACAG:C	acceptor_loss	0.9400
11:60043465:ACAG:A	acceptor_loss	0.9400
11:60043466:C:CG	acceptor_loss	0.9400
11:60043468:G:C	acceptor_loss	0.9400
11:60045289:A:G	acceptor_gain	0.9400
11:60040506:GTGC:G	donor_gain	0.9300
11:60040507:TGCT:T	donor_gain	0.9300

AlphaMissense

1033 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:60043610:T:C	F69S	0.994
11:60043553:A:T	E50V	0.986
11:60043556:T:C	L51S	0.986
11:60043609:T:C	F69L	0.985
11:60043610:T:G	F69C	0.985
11:60043611:T:A	F69L	0.985
11:60043611:T:G	F69L	0.985
11:60043637:T:C	I78T	0.985
11:60044761:T:C	C112R	0.981
11:60043630:T:A	C76S	0.979
11:60043631:G:C	C76S	0.979
11:60043573:T:A	C57S	0.978
11:60043573:T:C	C57R	0.978
11:60043574:G:C	C57S	0.978
11:60044761:T:A	C112S	0.977
11:60044762:G:C	C112S	0.977
11:60043565:G:A	G54E	0.975
11:60043565:G:T	G54V	0.972
11:60043630:T:C	C76R	0.972
11:60043631:G:A	C76Y	0.972
11:60043637:T:G	I78S	0.971
11:60043632:T:G	C76W	0.969
11:60044756:T:C	L110S	0.966
11:60043553:A:C	E50A	0.964
11:60043553:A:G	E50G	0.964
11:60044713:T:C	F96L	0.964
11:60044715:T:A	F96L	0.964
11:60044715:T:G	F96L	0.964
11:60044763:T:G	C112W	0.964
11:60043502:T:A	V33D	0.963

dbSNP variants (sampled 300 via entrez): RS1000227634 (11:60041161 CTTTATGGTTTCTT>C), RS1000294196 (11:60041222 T>A), RS1000336891 (11:60044880 A>G), RS1000363815 (11:60047536 T>G), RS1000414618 (11:60047798 T>C), RS1000700792 (11:60046011 A>G,T), RS1000718201 (11:60040162 T>A,C), RS1000752521 (11:60046272 A>G), RS1000803433 (11:60046654 T>C), RS1001666224 (11:60043763 G>T), RS1001717064 (11:60044096 C>A,T), RS1001793218 (11:60039250 C>A,T), RS1001796717 (11:60040603 T>C), RS1002666098 (11:60042387 C>T), RS1002811117 (11:60045433 T>C)

Disease associations

OMIM: gene MIM:620263 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	2
CGP 52608	affects binding, increases reaction	1
MT19c compound	decreases expression	1
Arsenic	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.