OOSP3

Summary

OOSP3 (oocyte secreted protein family member 3, HGNC:53903) is a protein-coding gene on chromosome 11q12.1, encoding Oocyte-secreted protein 3 (A0A2R8YFM6).

Predicted to be located in extracellular region.

Source: NCBI Gene 112577461 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395255

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53903
Approved symbol	OOSP3
Name	oocyte secreted protein family member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000285231
Ensembl biotype	protein_coding
OMIM	621112
Entrez	112577461

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000646438

RefSeq mRNA: 1 — MANE Select: NM_001395255 NM_001395255

CCDS: CCDS91477

Canonical transcript exons

ENST00000646438 — 5 exons

Exon	Start	End
ENSE00003816263	59894079	59894176
ENSE00003822383	59895502	59895652
ENSE00003822736	59880261	59880439
ENSE00003978200	59896133	59896483
ENSE00003978201	59878782	59878881

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 84.20.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.20	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.56	gold quality
blood	UBERON:0000178	54.22	gold quality
cortical plate	UBERON:0005343	41.05	silver quality
stromal cell of endometrium	CL:0002255	40.60	silver quality
bone marrow cell	CL:0002092	38.74	gold quality
endometrium	UBERON:0001295	38.69	silver quality
superior frontal gyrus	UBERON:0002661	37.90	silver quality
mucosa of transverse colon	UBERON:0004991	37.56	silver quality
spleen	UBERON:0002106	37.37	gold quality
skeletal muscle tissue	UBERON:0001134	37.35	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
body of stomach	UBERON:0001161	36.92	gold quality
muscle tissue	UBERON:0002385	36.52	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
stomach	UBERON:0000945	35.56	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
gastrocnemius	UBERON:0001388	35.44	silver quality
muscle of leg	UBERON:0001383	35.19	silver quality
cortex of kidney	UBERON:0001225	35.18	gold quality
duodenum	UBERON:0002114	35.12	gold quality
kidney	UBERON:0002113	35.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	34.44	silver quality
rectum	UBERON:0001052	34.29	silver quality
adult mammalian kidney	UBERON:0000082	33.98	silver quality
islet of Langerhans	UBERON:0000006	33.26	gold quality
prefrontal cortex	UBERON:0000451	32.97	silver quality
fundus of stomach	UBERON:0001160	32.54	gold quality
primary visual cortex	UBERON:0002436	32.44	silver quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Oocyte-secreted protein 3 — A0A2R8YFM6 (reviewed: A0A2R8YFM6)

All UniProt accessions (1): A0A2R8YFM6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the PLAC1 family.

RefSeq proteins (1): NP_001382184* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033222	PLAC1_fam	Family

UniProt features (8 total): glycosylation site 6, signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A2R8YFM6-F1	66.28	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (6): 64, 130, 148, 151, 165, 178

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr11q12

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

54 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OOSP3	OOSP2	Q86WS3	769
OOSP3	OOSP1	A8MZH6	583
OOSP3	DEPDC7	Q96QD5	339
OOSP3	NUTM1	Q86Y26	296
OOSP3	ASTL	Q6HA08	278
OOSP3	NEU1	Q99519	252
OOSP3	BTG4	Q9NY30	244
OOSP3	CNOT6L	Q96LI5	211
OOSP3	ZP1	P60852	204
OOSP3	NLRP5	P59047	203
OOSP3	CNOT8	Q9UFF9	202
OOSP3	CNOT7	Q9UIV1	201
OOSP3	CNOT6	Q9ULM6	201
OOSP3	SHB	Q15464	200
OOSP3	PADI6	Q6TGC4	199

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A0A2R8YFM6, Q2Q0J1, Q4FZG8, Q4V7E2, Q9JI83, A0A2R8YFL7, A8MZH6, Q925U0, A0A2R8Y4Y8, Q86WS3, Q9HBJ0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1252 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:59880402:T:C	F72S	0.994
11:59880401:T:C	F72L	0.990
11:59880403:T:A	F72L	0.990
11:59880403:T:G	F72L	0.990
11:59880422:T:A	C79S	0.986
11:59880423:G:C	C79S	0.986
11:59880402:T:G	F72C	0.984
11:59880365:T:A	C60S	0.983
11:59880366:G:C	C60S	0.983
11:59880288:T:C	F34S	0.982
11:59880356:G:A	G57R	0.979
11:59880356:G:C	G57R	0.979
11:59880365:T:C	C60R	0.979
11:59880357:G:T	G57V	0.978
11:59880422:T:C	C79R	0.975
11:59880272:T:A	C29S	0.974
11:59880273:G:C	C29S	0.974
11:59880288:T:G	F34C	0.974
11:59880357:G:A	G57E	0.974
11:59880350:T:C	S55P	0.973
11:59894106:T:C	S94P	0.972
11:59894163:T:A	C113S	0.972
11:59894164:G:C	C113S	0.972
11:59894113:T:A	L96H	0.968
11:59880429:T:C	I81T	0.967
11:59880407:T:G	Y74D	0.965
11:59894163:T:C	C113R	0.964
11:59894165:T:G	C113W	0.963
11:59880429:T:G	I81S	0.961
11:59894158:T:C	L111S	0.961

dbSNP variants (sampled 300 via entrez): RS1000188111 (11:59881156 C>G,T), RS1000288917 (11:59896379 A>G), RS1000574114 (11:59896055 A>T), RS1000782771 (11:59892377 A>G), RS1000930355 (11:59879318 T>C), RS1000988606 (11:59885868 T>A), RS1001203828 (11:59876996 G>A), RS1001471417 (11:59885618 A>G), RS1001998393 (11:59884509 C>T), RS1002060948 (11:59878442 G>A,C), RS1002127507 (11:59880410 C>A,G,T), RS1002182576 (11:59891108 T>G), RS1002325207 (11:59878088 G>T), RS1002452234 (11:59892283 T>A), RS1002674491 (11:59890473 T>C)

Disease associations

OMIM: gene MIM:621112 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.