OOSP4A

Summary

OOSP4A (oocyte secreted protein family member 4A, HGNC:53904) is a protein-coding gene on chromosome 11q12.1, encoding Oocyte-secreted protein 4A (A0A2R8YFL7).

Predicted to be located in extracellular region.

Source: NCBI Gene 112577462 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395277

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53904
Approved symbol	OOSP4A
Name	oocyte secreted protein family member 4A
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000285010
Ensembl biotype	protein_coding
Entrez	112577462

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000645590

RefSeq mRNA: 1 — MANE Select: NM_001395277 NM_001395277

CCDS: CCDS91479

Canonical transcript exons

ENST00000643613 — 0 exons

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 42.87.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	42.87	gold quality
metanephros cortex	UBERON:0010533	42.40	gold quality
cortical plate	UBERON:0005343	41.70	gold quality
adult mammalian kidney	UBERON:0000082	39.61	gold quality
anterior cingulate cortex	UBERON:0009835	38.59	gold quality
cortex of kidney	UBERON:0001225	38.38	gold quality
right frontal lobe	UBERON:0002810	38.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	37.68	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cerebral cortex	UBERON:0000956	37.00	gold quality
kidney	UBERON:0002113	36.91	gold quality
frontal cortex	UBERON:0001870	36.61	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
endometrium	UBERON:0001295	36.21	silver quality
bone marrow cell	CL:0002092	36.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	36.04	gold quality
islet of Langerhans	UBERON:0000006	35.98	gold quality
prefrontal cortex	UBERON:0000451	35.98	gold quality
Ammon’s horn	UBERON:0001954	35.73	gold quality
spleen	UBERON:0002106	35.56	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
vermiform appendix	UBERON:0001154	35.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	35.00	silver quality
cerebellar cortex	UBERON:0002129	34.56	silver quality
cerebellar hemisphere	UBERON:0002245	34.49	silver quality
cerebellum	UBERON:0002037	34.40	silver quality
right uterine tube	UBERON:0001302	34.21	gold quality
substantia nigra	UBERON:0002038	33.98	gold quality
primary visual cortex	UBERON:0002436	33.85	gold quality
superior frontal gyrus	UBERON:0002661	33.71	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Oocyte-secreted protein 4A — A0A2R8YFL7 (reviewed: A0A2R8YFL7)

All UniProt accessions (1): A0A2R8YFL7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the PLAC1 family.

RefSeq proteins (1): NP_001382206* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033222	PLAC1_fam	Family

UniProt features (3 total): signal peptide 1, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A2R8YFL7-F1	70.78	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 128

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr11q12

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A0A2R8YFL7, Q2Q0J1, Q9HBJ0, A0A2R8YFM6, A8MZH6, Q925U0, Q4FZG8, Q4V7E2, Q86WS3, Q9JI83

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000124571 (11:59968912 T>G), RS1001183350 (11:59963613 T>G), RS1002125771 (11:59968856 G>C), RS1003673282 (11:59965048 T>A), RS1004518469 (11:59964525 A>C,G), RS1004895165 (11:59965129 CG>C,CGGG), RS1005177811 (11:59964125 G>A,T), RS1005509285 (11:59962482 T>A), RS1005931406 (11:59963082 T>C), RS1006147990 (11:59969964 C>T), RS1006191534 (11:59962894 C>A,G), RS1006225309 (11:59968720 A>G), RS1006531018 (11:59970265 A>G), RS1007392409 (11:59968271 C>T), RS1007676199 (11:59962280 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.