OOSP4B

Summary

OOSP4B (oocyte secreted protein family member 4B, HGNC:53905) is a protein-coding gene on chromosome 11q12.1, encoding Oocyte-secreted protein 4B (A0A2R8Y4Y8).

Predicted to be located in extracellular region.

Source: NCBI Gene 107987155 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395278

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53905
Approved symbol	OOSP4B
Name	oocyte secreted protein family member 4B
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000255393
Ensembl biotype	protein_coding
Entrez	107987155

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 1 retained_intron, 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000534388, ENST00000642343, ENST00000644647

RefSeq mRNA: 1 — MANE Select: NM_001395278 NM_001395278

Canonical transcript exons

ENST00000642343 — 5 exons

Exon	Start	End
ENSE00003818260	60024908	60025005
ENSE00003824211	60029782	60029929
ENSE00003825000	60023880	60024061
ENSE00003829753	60030802	60031095
ENSE00003830179	60017181	60017413

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 81.41.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.41	gold quality
bone marrow cell	CL:0002092	39.06	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow	UBERON:0002371	35.87	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.38	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
endometrium	UBERON:0001295	33.23	silver quality
right testis	UBERON:0004534	32.95	silver quality
monocyte	CL:0000576	32.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
testis	UBERON:0000473	30.15	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.19	gold quality
left testis	UBERON:0004533	29.07	silver quality
liver	UBERON:0002107	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.90	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.22	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-110499	no	3.85
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Oocyte-secreted protein 4B — A0A2R8Y4Y8 (reviewed: A0A2R8Y4Y8)

All UniProt accessions (1): A0A2R8Y4Y8

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the PLAC1 family.

RefSeq proteins (1): NP_001382207* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR033222	PLAC1_fam	Family

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A2R8Y4Y8-F1	72.93	0.44

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr11q12

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

24 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OOSP4B	MS4A5	Q9H3V2	695
OOSP4B	OOSP2	Q86WS3	622
OOSP4B	MS4A14	Q96JA4	620
OOSP4B	MS4A12	Q9NXJ0	507
OOSP4B	MS4A6E	Q96DS6	479
OOSP4B	MS4A4E	Q96PG1	446
OOSP4B	MS4A6A	Q9H2W1	351
OOSP4B	MS4A4A	Q96JQ5	348
OOSP4B	MS4A2	Q01362	297
OOSP4B	MS4A1	P08984	270
OOSP4B	TREML2	Q5T2D2	202
OOSP4B	FDX1	P10109	167

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A0A2R8Y4Y8, A0A2R8YFL7, A0A2R8YFM6, A0A8J1K1A4, A6MFL5, A6MFL6, A6MFL7, A6NHS7, A8MZH6, F8RKW5, G5E8D7, O54767, O77726, O88393, P17219, P20239, P26342, P34128, P35054, P42099, P47983, P47984, P70041, Q03167, Q05996, Q07G34, Q14CH0, Q1W7Q6, Q2Q0J1, Q3HXY1, Q3HXY2, Q3HXY3, Q3HXY4, Q3HXY5, Q3HXY6, Q3HXY8, Q3HXZ1, Q4FZG8

Diamond homologs: A0A2R8Y4Y8, Q4FZG8, A0A2R8YFM6, A8MZH6, Q4V7E2, Q86WS3, Q9HBJ0, Q9JI83

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1065 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:60024023:T:C	F56L	0.982
11:60024025:T:A	F56L	0.982
11:60024025:T:G	F56L	0.982
11:60023936:T:C	F27L	0.927
11:60023938:T:A	F27L	0.927
11:60023938:T:G	F27L	0.927
11:60024024:T:G	F56C	0.926
11:60024980:T:C	F93L	0.926
11:60024982:T:A	F93L	0.926
11:60024982:T:G	F93L	0.926
11:60024024:T:C	F56S	0.917
11:60024911:T:C	F70L	0.916
11:60024913:C:A	F70L	0.916
11:60024913:C:G	F70L	0.916
11:60023908:G:C	W17C	0.902
11:60023908:G:T	W17C	0.902
11:60024992:T:C	C97R	0.885
11:60024945:T:C	I81T	0.879
11:60024994:C:G	C97W	0.879
11:60024992:T:A	C97S	0.869
11:60024993:G:C	C97S	0.869
11:60024995:T:C	F98L	0.867
11:60024997:T:A	F98L	0.867
11:60024997:T:G	F98L	0.867
11:60023906:T:A	W17R	0.853
11:60023906:T:C	W17R	0.853
11:60024020:G:C	A55P	0.852
11:60023997:C:T	T47I	0.849
11:60024993:G:A	C97Y	0.849
11:60024011:T:C	F52L	0.840

dbSNP variants (sampled 300 via entrez): RS1001156168 (11:60017093 G>C), RS1001244992 (11:60028212 C>A,T), RS1001894200 (11:60015934 A>T), RS1001960571 (11:60017648 G>T), RS1002275458 (11:60027425 G>A,T), RS1002326926 (11:60016218 A>C), RS1002403324 (11:60021042 T>C), RS1002435940 (11:60021411 G>A), RS1002709416 (11:60020311 C>A,G), RS1002757088 (11:60027804 G>A), RS1002771549 (11:60020404 G>A), RS1002915203 (11:60018331 G>T), RS1002946157 (11:60018559 G>A), RS1003104283 (11:60022853 G>A,T), RS1003200822 (11:60024352 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.