OPA1-AS1

Summary

OPA1-AS1 (OPA1 antisense RNA 1, HGNC:40421) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40421
Approved symbol	OPA1-AS1
Name	OPA1 antisense RNA 1
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224855
Ensembl biotype	lncRNA
Entrez	100873941
RNAcentral	URS000075C845 — lncRNA, 513 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000433105, ENST00000444085

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433105 — 3 exons

Exon	Start	End
ENSE00001716027	193619601	193619686
ENSE00001753569	193627229	193627332
ENSE00001795494	193618609	193618910

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 83.08.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	83.08	gold quality
corpus callosum	UBERON:0002336	82.98	gold quality
bone marrow	UBERON:0002371	74.62	gold quality
adrenal tissue	UBERON:0018303	74.33	gold quality
bone marrow cell	CL:0002092	67.45	silver quality
monocyte	CL:0000576	63.06	gold quality
leukocyte	CL:0000738	62.26	gold quality
lymph node	UBERON:0000029	61.79	gold quality
endometrium	UBERON:0001295	61.76	gold quality
rectum	UBERON:0001052	60.74	gold quality
duodenum	UBERON:0002114	60.43	gold quality
liver	UBERON:0002107	59.40	gold quality
stromal cell of endometrium	CL:0002255	58.65	gold quality
blood	UBERON:0000178	58.41	gold quality
islet of Langerhans	UBERON:0000006	57.83	gold quality
muscle tissue	UBERON:0002385	57.83	gold quality
vermiform appendix	UBERON:0001154	57.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.48	gold quality
placenta	UBERON:0001987	57.23	gold quality
muscle of leg	UBERON:0001383	57.02	gold quality
tonsil	UBERON:0002372	56.70	gold quality
smooth muscle tissue	UBERON:0001135	56.60	gold quality
gall bladder	UBERON:0002110	56.41	gold quality
kidney	UBERON:0002113	56.32	gold quality
cortex of kidney	UBERON:0001225	56.02	gold quality
apex of heart	UBERON:0002098	55.31	gold quality
tibial nerve	UBERON:0001323	55.10	gold quality
adrenal gland	UBERON:0002369	54.97	gold quality
prefrontal cortex	UBERON:0000451	54.93	gold quality
stomach	UBERON:0000945	54.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.55

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.