OPN1MW3

Summary

OPN1MW3 (opsin 1, medium wave sensitive 3, HGNC:51831) is a protein-coding gene on chromosome Xq28, encoding Medium-wave-sensitive opsin 3 (P0DN78). Visual pigments are the light-absorbing molecules that mediate vision.

Enables identical protein binding activity and photoreceptor activity. Involved in positive regulation of cytokinesis. Located in plasma membrane.

Source: NCBI Gene 101060233 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001330067

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51831
Approved symbol	OPN1MW3
Name	opsin 1, medium wave sensitive 3
Location	Xq28
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000269433
Ensembl biotype	protein_coding
Entrez	101060233

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000599405

RefSeq mRNA: 1 — MANE Select: NM_001330067 NM_001330067

CCDS: CCDS83509

Canonical transcript exons

ENST00000599405 — 6 exons

Exon	Start	End
ENSE00002978841	154268352	154268591
ENSE00003007601	154262712	154263008
ENSE00003162556	154264996	154265164
ENSE00003208384	154266632	154266797
ENSE00003978220	154257582	154257731
ENSE00003978221	154270874	154271090

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 40.19.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	40.19	gold quality
sural nerve	UBERON:0015488	37.72	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.96	gold quality
granulocyte	CL:0000094	34.00	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
blood	UBERON:0000178	29.25	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.97	gold quality
lymph node	UBERON:0000029	28.66	gold quality
duodenum	UBERON:0002114	28.14	gold quality
leukocyte	CL:0000738	27.17	gold quality
tonsil	UBERON:0002372	27.05	gold quality
monocyte	CL:0000576	26.62	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
right coronary artery	UBERON:0001625	26.23	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.06	gold quality
right lobe of liver	UBERON:0001114	24.75	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	opn1lw2	ENSDARG00000044861
danio_rerio	opn1lw1	ENSDARG00000044862
mus_musculus	Opn1mw	ENSMUSG00000031394
rattus_norvegicus	Opn1mw	ENSRNOG00000051529

Paralogs (9): OPN3 (ENSG00000054277), OPN1LW (ENSG00000102076), OPN4 (ENSG00000122375), OPN5 (ENSG00000124818), OPN1SW (ENSG00000128617), RHO (ENSG00000163914), OPN1MW2 (ENSG00000166160), RRH (ENSG00000180245), OPN1MW (ENSG00000268221)

Protein

Protein identifiers

Medium-wave-sensitive opsin 3 — P0DN78 (reviewed: P0DN78)

Alternative names: Green cone photoreceptor pigment, Green-sensitive opsin, opsin 1 cone pigments medium-wave-sensitive 3

All UniProt accessions (1): P0DN78

UniProt curated annotations — full annotation on UniProt →

Function. Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Subcellular location. Cell membrane.

Post-translational modifications. N-glycosylated. O-glycosylated. Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Similarity. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

RefSeq proteins (1): NP_001316996* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000378	Opsin_red/grn	Family
IPR001760	Opsin	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR027430	Retinal_BS	Binding_site
IPR050125	GPCR_opsins	Family

Pfam: PF00001

UniProt features (21 total): topological domain 8, transmembrane region 7, region of interest 2, chain 1, modified residue 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DN78-F1	83.05	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 312

Disulfide bonds (1): 126–203

Glycosylation sites (1): 34

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 40 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, GOBP_PHOTOTRANSDUCTION, GOBP_CYTOKINESIS, GOBP_POSITIVE_REGULATION_OF_CELL_DIVISION, GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS, GOBP_REGULATION_OF_CYTOKINESIS, GOBP_POSITIVE_REGULATION_OF_CYTOKINESIS, GOBP_REGULATION_OF_CELL_DIVISION, GOBP_RESPONSE_TO_RADIATION, GOBP_DETECTION_OF_LIGHT_STIMULUS, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_DETECTION_OF_ABIOTIC_STIMULUS, GOBP_DETECTION_OF_STIMULUS

GO Biological Process (8): G protein-coupled receptor signaling pathway (GO:0007186), visual perception (GO:0007601), phototransduction (GO:0007602), absorption of visible light (GO:0016038), positive regulation of cytokinesis (GO:0032467), cellular response to light stimulus (GO:0071482), signal transduction (GO:0007165), detection of visible light (GO:0009584)

GO Molecular Function (3): G protein-coupled photoreceptor activity (GO:0008020), G protein-coupled receptor activity (GO:0004930), photoreceptor activity (GO:0009881)

GO Cellular Component (4): photoreceptor outer segment (GO:0001750), plasma membrane (GO:0005886), photoreceptor disc membrane (GO:0097381), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	2
signal transduction	2
detection of light stimulus	2
cellular anatomical structure	2
sensory perception of light stimulus	1
light absorption	1
cytokinesis	1
regulation of cytokinesis	1
positive regulation of cell division	1
positive regulation of cell cycle process	1
response to light stimulus	1
cellular response to radiation	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
detection of visible light	1
photoreceptor activity	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
signaling receptor activity	1
photoreceptor cell cilium	1
membrane	1
cell periphery	1
photoreceptor outer segment	1
organelle membrane	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: O12948, O18910, O18912, O18913, O18914, O35476, O35478, O35599, O57605, O93441, O93459, P04000, P04001, P0DN77, P0DN78, P22329, P22330, P22331, P22332, P22671, P28683, P32309, P32310, P32311, P32312, P32313, P34989, P35357, P35358, P41591, P41592, P51471, P51472, P51474, P51488, P79863, P87365, P87366, P87367, Q8AYM7

Diamond homologs: O12948, O13092, O13227, O18910, O18911, O18912, O18913, O18914, O35476, O35478, O35599, O42604, O57605, O62794, O93441, O93459, P03999, P04000, P04001, P0DN77, P0DN78, P22328, P22329, P22330, P22331, P22332, P22671, P28683, P28684, P32308, P32309, P32310, P32311, P32312, P32313, P34989, P35357, P35358, P35359, P35403

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2391 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:154262881:C:A	N94K	0.999
X:154262881:C:G	N94K	0.999
X:154265115:T:A	W177R	0.999
X:154265115:T:C	W177R	0.999
X:154270874:T:C	F329L	0.999
X:154270876:T:A	F329L	0.999
X:154270876:T:G	F329L	0.999
X:154262812:T:A	N71K	0.998
X:154262812:T:G	N71K	0.998
X:154262829:C:A	A77D	0.998
X:154262874:T:A	L92Q	0.998
X:154262883:T:C	L95P	0.998
X:154262918:A:C	S107R	0.998
X:154262920:C:A	S107R	0.998
X:154262920:C:G	S107R	0.998
X:154262927:A:C	S110R	0.998
X:154262929:C:A	S110R	0.998
X:154262929:C:G	S110R	0.998
X:154265133:T:A	W183R	0.998
X:154265133:T:C	W183R	0.998
X:154265157:T:A	W191R	0.998
X:154265157:T:C	W191R	0.998
X:154266661:G:A	C203Y	0.998
X:154268544:A:C	S313R	0.998
X:154268546:T:A	S313R	0.998
X:154268546:T:G	S313R	0.998
X:154268561:C:A	N318K	0.998
X:154268561:C:G	N318K	0.998
X:154268563:C:A	P319H	0.998
X:154262799:C:A	S67Y	0.997

dbSNP variants (sampled 284 via entrez): RS138932322 (X:154257095 G>A), RS1557162880 (X:154255592 T>A), RS1557162883 (X:154255617 C>T), RS1557162885 (X:154255618 A>G), RS1557162889 (X:154255716 CAGG>C), RS1557162890 (X:154255816 A>C,G), RS1557162893 (X:154255824 C>G), RS1557162895 (X:154255825 G>A,T), RS1557162897 (X:154255826 G>A,C), RS1557162898 (X:154255827 G>A,C,T), RS1557162900 (X:154255828 G>C,T), RS1557162902 (X:154255829 G>A,C,T), RS1557162903 (X:154255830 G>A,C,T), RS1557162905 (X:154255829 G>GGT), RS1557162908 (X:154255830 GT>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.