OR10A2

Summary

OR10A2 (olfactory receptor family 10 subfamily A member 2, HGNC:8161) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 10A2 (Q9H208). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 341276 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 50 total
• MANE Select transcript: NM_001004460

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8161
Approved symbol	OR10A2
Name	olfactory receptor family 10 subfamily A member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	OST363
Ensembl gene	ENSG00000170790
Ensembl biotype	protein_coding
Entrez	341276

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641461

RefSeq mRNA: 1 — MANE Select: NM_001004460 NM_001004460

CCDS: CCDS31415

Canonical transcript exons

ENST00000641461 — 2 exons

Exon	Start	End
ENSE00003812383	6863057	6863351
ENSE00003813412	6869623	6874717

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 78.95.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.95	gold quality
colonic epithelium	UBERON:0000397	60.40	gold quality
bone marrow cell	CL:0002092	59.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	50.75	gold quality
stromal cell of endometrium	CL:0002255	49.32	gold quality
bone marrow	UBERON:0002371	47.01	gold quality
primary visual cortex	UBERON:0002436	45.99	silver quality
tonsil	UBERON:0002372	41.89	gold quality
superior frontal gyrus	UBERON:0002661	41.78	gold quality
ganglionic eminence	UBERON:0004023	38.72	gold quality
skeletal muscle tissue	UBERON:0001134	37.83	gold quality
calcaneal tendon	UBERON:0003701	36.92	gold quality
lower esophagus mucosa	UBERON:0035834	36.90	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
cortex of kidney	UBERON:0001225	36.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	35.81	gold quality
muscle tissue	UBERON:0002385	35.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.36	gold quality
liver	UBERON:0002107	34.96	gold quality
endometrium	UBERON:0001295	34.95	gold quality
monocyte	CL:0000576	34.70	gold quality
leukocyte	CL:0000738	34.53	gold quality
mucosa of transverse colon	UBERON:0004991	34.27	gold quality
adrenal tissue	UBERON:0018303	33.34	gold quality
Brodmann (1909) area 9	UBERON:0013540	33.29	gold quality
kidney	UBERON:0002113	32.87	gold quality
nucleus accumbens	UBERON:0001882	32.37	gold quality
caudate nucleus	UBERON:0001873	32.14	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	31.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.84

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10a2	ENSMUSG00000049674
mus_musculus	Or10a5	ENSMUSG00000073898
rattus_norvegicus	Or10a5	ENSRNOG00000087790
rattus_norvegicus	Or10a2	ENSRNOG00000090546

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10A2 — Q9H208 (reviewed: Q9H208)

Alternative names: HP4, Olfactory receptor OR11-86

All UniProt accessions (1): Q9H208

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004460* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 5, sequence conflict 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H208-F1	86.46	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 84–176

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, WP_GPCRS_OTHER, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

160 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A2	GOLT1A	Q6ZVE7	530
OR10A2	VN1R4	Q7Z5H5	518
OR10A2	DLEU7	Q6UYE1	502
OR10A2	VN1R2	Q8NFZ6	481
OR10A2	VN1R1	Q9GZP7	431
OR10A2	HDHD3	Q9BSH5	417
OR10A2	MRGPRX2	Q96LB1	402
OR10A2	TAS2R13	Q9NYV9	395
OR10A2	TAS2R5	Q9NYW4	368
OR10A2	TAS2R31	P59538	367
OR10A2	TAS2R50	P59544	367
OR10A2	SUMF2	Q8NBJ7	359
OR10A2	TAS2R10	Q9NYW0	358
OR10A2	TAS2R4	Q9NYW5	348
OR10A2	ZNF717	Q9BY31	348
OR10A2	TAS2R43	P59537	348

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O43749, O76001, O76002, O76100, O95006, P0DMU2, P23266, P23269, P23272, P23274, P30953, P30955, P58173, P59922, P70526, Q13607, Q15619, Q60890, Q6UXT6, Q8N148, Q8N628, Q8NGA6, Q8NGL2, Q8NGS0, Q8NGS2, Q8NGX8, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NH04, Q8VGI1, Q8VGK5, Q8VGR9, Q95156, Q96R09, Q96R47, Q96R48, Q96R84, Q9GZK6

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

211 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6870036:T:TA	acceptor_gain	0.9100
11:6870038:G:C	acceptor_gain	0.7600
11:6870034:TTTGG:T	acceptor_gain	0.7200
11:6870037:G:A	acceptor_gain	0.7200
11:6869741:G:GG	donor_gain	0.6900
11:6870036:TGG:T	acceptor_gain	0.6700
11:6870471:T:G	acceptor_gain	0.6600
11:6870481:A:G	acceptor_gain	0.6400
11:6870333:G:GA	donor_gain	0.6100
11:6870473:T:G	acceptor_gain	0.5900
11:6870475:T:G	acceptor_gain	0.5600
11:6870480:A:AG	acceptor_gain	0.5600
11:6870376:A:AG	acceptor_gain	0.5300
11:6869822:T:TA	acceptor_gain	0.5200
11:6870035:TTGG:T	acceptor_gain	0.5100
11:6870332:T:TA	donor_gain	0.5100
11:6870414:G:T	donor_gain	0.5100
11:6870474:A:AG	acceptor_gain	0.5000
11:6870041:T:TA	acceptor_gain	0.4900
11:6870407:C:G	donor_gain	0.4900
11:6870472:A:AG	acceptor_gain	0.4900
11:6870482:G:GG	acceptor_gain	0.4900
11:6870414:G:GT	donor_gain	0.4800
11:6870470:A:AG	acceptor_gain	0.4800
11:6870477:A:AG	acceptor_gain	0.4700
11:6870329:T:TA	donor_gain	0.4500
11:6869738:TAA:T	donor_gain	0.4300
11:6870039:A:AG	acceptor_gain	0.4300
11:6870040:G:GG	acceptor_gain	0.4300
11:6870279:C:A	donor_gain	0.4300

AlphaMissense

1973 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6870586:A:C	S278R	0.939
11:6870588:C:A	S278R	0.939
11:6870588:C:G	S278R	0.939
11:6870256:A:C	S168R	0.911
11:6870258:C:A	S168R	0.911
11:6870258:C:G	S168R	0.911
11:6870160:T:A	W136R	0.893
11:6870160:T:C	W136R	0.893
11:6870247:T:C	F165L	0.884
11:6870249:C:A	F165L	0.884
11:6870249:C:G	F165L	0.884
11:6870594:A:C	R280S	0.880
11:6870594:A:T	R280S	0.880
11:6870481:A:C	S243R	0.879
11:6870483:C:A	S243R	0.879
11:6870483:C:G	S243R	0.879
11:6870080:G:C	R109P	0.877
11:6870069:G:A	M105I	0.871
11:6870069:G:C	M105I	0.871
11:6870069:G:T	M105I	0.871
11:6870573:C:A	N273K	0.870
11:6870573:C:G	N273K	0.870
11:6870217:T:C	F155L	0.869
11:6870219:C:A	F155L	0.869
11:6870219:C:G	F155L	0.869
11:6870466:T:C	F238L	0.863
11:6870468:C:A	F238L	0.863
11:6870468:C:G	F238L	0.863
11:6870244:T:C	F164L	0.859
11:6870246:C:A	F164L	0.859

dbSNP variants (sampled 300 via entrez): RS1000214957 (11:6863735 G>A), RS1000658801 (11:6865577 T>C), RS1000719008 (11:6864043 A>G,T), RS1000974647 (11:6871263 T>C), RS1001176962 (11:6874876 T>A,C,G), RS1001586832 (11:6864766 G>C), RS1002002334 (11:6870726 T>A,C,G), RS1002155423 (11:6864291 A>C), RS1002584628 (11:6862843 G>A), RS1002718727 (11:6871852 T>C), RS1002971054 (11:6873928 T>C), RS1003109577 (11:6865242 A>C), RS1003162046 (11:6865555 C>T), RS1003533760 (11:6863844 C>A), RS1003604722 (11:6861613 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004691_20	Huntington’s disease progression	2.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1
Diethylhexyl Phthalate	decreases expression	1
Silicon Dioxide	increases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.