OR10A3

Summary

OR10A3 (olfactory receptor family 10 subfamily A member 3, HGNC:8162) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 10A3 (P58181). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26496 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001003745

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8162
Approved symbol	OR10A3
Name	olfactory receptor family 10 subfamily A member 3
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	HTPCRX12, HSHTPCRX12
Ensembl gene	ENSG00000170683
Ensembl biotype	protein_coding
Entrez	26496

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000642047

RefSeq mRNA: 1 — MANE Select: NM_001003745 NM_001003745

CCDS: CCDS31421

Canonical transcript exons

ENST00000612788 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 45.17.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	45.17	gold quality
bone marrow cell	CL:0002092	43.45	gold quality
colonic epithelium	UBERON:0000397	41.88	gold quality
skin of leg	UBERON:0001511	40.35	silver quality
zone of skin	UBERON:0000014	39.79	silver quality
stromal cell of endometrium	CL:0002255	38.79	gold quality
skin of abdomen	UBERON:0001416	38.48	silver quality
ganglionic eminence	UBERON:0004023	37.18	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	36.33	gold quality
bone marrow	UBERON:0002371	35.47	gold quality
muscle tissue	UBERON:0002385	35.44	gold quality
monocyte	CL:0000576	32.91	gold quality
placenta	UBERON:0001987	32.91	silver quality
duodenum	UBERON:0002114	32.47	gold quality
leukocyte	CL:0000738	32.43	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	32.01	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	31.98	gold quality
liver	UBERON:0002107	31.72	gold quality
metanephros cortex	UBERON:0010533	31.59	gold quality
cortex of kidney	UBERON:0001225	31.57	gold quality
lymph node	UBERON:0000029	30.97	gold quality
prefrontal cortex	UBERON:0000451	30.87	gold quality
descending thoracic aorta	UBERON:0002345	30.86	gold quality
right uterine tube	UBERON:0001302	30.63	gold quality
blood	UBERON:0000178	29.96	gold quality
vermiform appendix	UBERON:0001154	29.15	gold quality
endocervix	UBERON:0000458	28.94	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-7303	no	2.91
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Activation of OR10A3 by Suberic Acid Promotes Collagen Synthesis in UVB-Irradiated Dermal Fibroblasts via the cAMP-Akt Pathway. (PMID:36552724)

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10a3	ENSMUSG00000046431
mus_musculus	Or10a3m	ENSMUSG00000056946
mus_musculus	Or10a3b	ENSMUSG00000062434
mus_musculus	Or10a3n	ENSMUSG00000066239
mus_musculus	Or10a49	ENSMUSG00000066240
mus_musculus	Or10a48	ENSMUSG00000066241
rattus_norvegicus	Or10a49	ENSRNOG00000030782
rattus_norvegicus	Or10a3	ENSRNOG00000069450
rattus_norvegicus	Or10a48	ENSRNOG00000069937
rattus_norvegicus	Or10a3c	ENSRNOG00000070494

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10A3 — P58181 (reviewed: P58181)

Alternative names: HTPCRX12, Olfactory receptor OR11-97

All UniProt accessions (2): P58181, A0A126GVZ2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001003745* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P58181-F1	88.12	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE14000_TRANSLATED_RNA_VS_MRNA_16H_LPS_DC_UP, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GSE26928_EFF_MEM_VS_CENTR_MEM_CD4_TCELL_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

174 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A3	TMEM232	C9JQI7	593
OR10A3	ACTL9	Q8TC94	573
OR10A3	C9orf43	Q8TAL5	519
OR10A3	PFDN4	Q9NQP4	479
OR10A3	ZGPAT	Q8N5A5	477
OR10A3	SLC25A46	Q96AG3	470
OR10A3	NLRP10	Q86W26	448
OR10A3	CCDC80	Q76M96	446
OR10A3	GLB1	P16278	400
OR10A3	OVOL1	O14753	400
OR10A3	DCAF4	Q8WV16	400
OR10A3	EMSY	Q7Z589	398
OR10A3	ZNF214	Q9UL59	385
OR10A3	TNFRSF6B	O95407	373
OR10A3	OLFML1	Q6UWY5	371

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NM76, P37067, P37069, P37070, P37071, P58181, Q13606, Q60884, Q60886, Q60895, Q8N127, Q8N162, Q8NGE1, Q8NGE2, Q8NGF7, Q8NGG4, Q8NGL1, Q8NGL3, Q8NGS4, Q8NGS5, Q8NGS9, Q8NGT0, Q8NH48, Q8NH51, Q8NH92, Q8NH93, Q8VEW5, Q8VEW6, Q8VF12, Q8VF66, Q8VFD0, Q8VFD1, Q8VFD3, Q8VFK2

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

217 predictions. Top by Δscore:

Variant	Effect	Δscore
11:7938862:CGAA:C	acceptor_gain	0.9300
11:7938865:A:AC	acceptor_gain	0.9200
11:7938883:A:T	acceptor_gain	0.9200
11:7938867:G:C	acceptor_gain	0.9000
11:7938865:A:C	acceptor_gain	0.8100
11:7938855:CAGAA:C	acceptor_gain	0.7400
11:7938860:C:CC	acceptor_gain	0.7400
11:7938882:C:CT	acceptor_gain	0.7400
11:7938874:A:T	acceptor_gain	0.7200
11:7939303:AAACT:A	donor_loss	0.7200
11:7939304:AACT:A	donor_loss	0.7200
11:7939305:ACTCA:A	donor_loss	0.7200
11:7939306:CTC:C	donor_loss	0.7200
11:7939307:TCA:T	donor_loss	0.7200
11:7939308:CACC:C	donor_loss	0.7200
11:7939309:A:C	donor_loss	0.7200
11:7939310:C:CG	donor_loss	0.7200
11:7938873:C:CT	acceptor_gain	0.7100
11:7939199:C:CT	acceptor_gain	0.7000
11:7939302:GAAAC:G	donor_loss	0.7000
11:7938867:G:GC	acceptor_gain	0.6900
11:7938897:C:CT	acceptor_gain	0.6700
11:7938886:A:T	acceptor_gain	0.6500
11:7938847:A:C	acceptor_gain	0.6000
11:7938863:G:T	acceptor_gain	0.6000
11:7939548:TATGG:T	donor_gain	0.6000
11:7939549:ATGGA:A	donor_gain	0.6000
11:7939200:A:T	acceptor_gain	0.5700
11:7939117:A:C	donor_gain	0.5600
11:7939309:A:AC	donor_gain	0.5600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000050091 (11:7938725 A>G), RS1000153609 (11:7941496 A>T), RS1001567605 (11:7938754 T>C), RS1002014211 (11:7939838 C>A,G), RS1002570323 (11:7937528 A>C,T), RS1002753312 (11:7942860 A>G), RS1003255613 (11:7939984 C>T), RS1003981084 (11:7939804 T>C), RS1004021961 (11:7943524 A>G), RS1004246585 (11:7937989 T>G), RS1004282745 (11:7938128 A>T), RS1004520770 (11:7943272 G>T), RS1006292690 (11:7940438 C>T), RS1006736410 (11:7938530 A>G), RS1006802158 (11:7937896 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001709_8	Atopic dermatitis	2.000000e-22
GCST010135_39	Oily fish consumption	1.000000e-08
GCST010140_29	Pork consumption	1.000000e-08
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.