OR10A4

Summary

OR10A4 (olfactory receptor family 10 subfamily A member 4, HGNC:15130) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 10A4 (Q9H209). Odorant receptor (Potential). It is a selective cancer dependency (DepMap: 10.1% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 283297 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 50 total
• Cancer dependency (DepMap): dependent in 10.1% of screened cell lines
• MANE Select transcript: NM_207186

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15130
Approved symbol	OR10A4
Name	olfactory receptor family 10 subfamily A member 4
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000170782
Ensembl biotype	protein_coding
Entrez	283297

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000379829

RefSeq mRNA: 1 — MANE Select: NM_207186 NM_207186

CCDS: CCDS7774

Canonical transcript exons

ENST00000379829 — 1 exons

Exon	Start	End
ENSE00001482659	6876625	6877619

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 79.97.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.97	gold quality
bone marrow cell	CL:0002092	58.38	silver quality
colonic epithelium	UBERON:0000397	41.81	gold quality
corpus callosum	UBERON:0002336	40.53	silver quality
tonsil	UBERON:0002372	37.95	gold quality
skeletal muscle tissue	UBERON:0001134	36.77	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
sural nerve	UBERON:0015488	36.15	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
mucosa of stomach	UBERON:0001199	33.84	gold quality
muscle tissue	UBERON:0002385	33.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.85	gold quality
liver	UBERON:0002107	29.75	gold quality
leukocyte	CL:0000738	29.65	gold quality
prefrontal cortex	UBERON:0000451	29.57	gold quality
lymph node	UBERON:0000029	28.96	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.89	silver quality
primary visual cortex	UBERON:0002436	27.76	gold quality
adrenal tissue	UBERON:0018303	27.55	gold quality
superior frontal gyrus	UBERON:0002661	27.26	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
uterine cervix	UBERON:0000002	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
myometrium	UBERON:0001296	25.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 10.1% of screened cell lines.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10a4	ENSMUSG00000073897
rattus_norvegicus	Or10a4	ENSRNOG00000077023

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10A4 — Q9H209 (reviewed: Q9H209)

Alternative names: HP2, Olfactory receptor-like protein JCG5

All UniProt accessions (1): Q9H209

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor (Potential). May be involved in taste perception.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in the tongue.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_997069* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H209-F1	88.56	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 36 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_NEUROGENESIS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOBP_CELL_PROJECTION_ORGANIZATION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_AXON_DEVELOPMENT, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOBP_CELL_MORPHOGENESIS

GO Biological Process (5): axon guidance (GO:0007411), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
axonogenesis	1
neuron projection guidance	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

238 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A4	OTOL1	A6NHN0	533
OR10A4	TAS2R4	Q9NYW5	478
OR10A4	GARIN3	Q8TC56	431
OR10A4	ZNF215	Q9UL58	423
OR10A4	TAS2R60	P59551	380
OR10A4	TMEM248	Q9NWD8	377
OR10A4	ZNF214	Q9UL59	351
OR10A4	OAZ2	O95190	343
OR10A4	ATP1B4	Q9UN42	315
OR10A4	GRM2	Q14416	311
OR10A4	AIMP2	Q13155	308
OR10A4	TAS2R46	P59540	307
OR10A4	STX10	O60499	290
OR10A4	GIMAP8	Q8ND71	289
OR10A4	NKAP	Q8N5F7	285

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR10A4	LRRC73	psi-mi:“MI:0914”(association)	0.350

BioGRID (5): KIAA1549 (Affinity Capture-MS), LRRC73 (Affinity Capture-MS), LRRC52 (Affinity Capture-MS), GADL1 (Affinity Capture-MS), HSPA1A (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

397 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6876723:GCTC:G	donor_gain	0.9000
11:6876937:G:GT	donor_gain	0.8900
11:6877288:T:A	acceptor_gain	0.7900
11:6876675:A:AG	donor_gain	0.7100
11:6876676:G:GG	donor_gain	0.7100
11:6877342:C:G	donor_gain	0.7000
11:6876652:T:G	donor_gain	0.6800
11:6877407:A:AG	acceptor_gain	0.6800
11:6877408:G:GG	acceptor_gain	0.6800
11:6877408:GCACT:G	acceptor_gain	0.6700
11:6877485:ACAGT:A	acceptor_gain	0.6700
11:6877487:A:AG	acceptor_gain	0.6700
11:6877488:G:GG	acceptor_gain	0.6700
11:6876950:G:GT	donor_gain	0.6600
11:6877295:G:A	acceptor_gain	0.6600
11:6876950:GAT:G	donor_gain	0.6500
11:6877403:CTATA:C	acceptor_loss	0.6500
11:6877404:TATA:T	acceptor_loss	0.6500
11:6877405:ATAG:A	acceptor_loss	0.6500
11:6877406:TA:T	acceptor_loss	0.6500
11:6877407:A:AC	acceptor_loss	0.6500
11:6876680:A:G	donor_gain	0.6400
11:6876861:A:G	donor_gain	0.6400
11:6877016:C:G	donor_gain	0.6400
11:6877408:GC:G	acceptor_gain	0.6400
11:6877285:T:A	acceptor_gain	0.6300
11:6877294:T:TA	acceptor_gain	0.6300
11:6877487:AGT:A	acceptor_gain	0.6200
11:6877488:GTG:G	acceptor_gain	0.6200
11:6876712:C:CG	donor_gain	0.6100

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6877152:T:C	F169L	0.873
11:6877154:T:A	F169L	0.873
11:6877154:T:G	F169L	0.873
11:6876681:T:C	F12L	0.843
11:6876683:T:A	F12L	0.843
11:6876683:T:G	F12L	0.843
11:6877140:T:C	F165L	0.810
11:6877142:C:A	F165L	0.810
11:6877142:C:G	F165L	0.810
11:6877233:T:C	F196L	0.807
11:6877235:T:A	F196L	0.807
11:6877235:T:G	F196L	0.807
11:6877182:T:C	F179L	0.759
11:6877184:C:A	F179L	0.759
11:6877184:C:G	F179L	0.759
11:6876696:T:C	F17L	0.754
11:6876698:C:A	F17L	0.754
11:6876698:C:G	F17L	0.754
11:6877179:T:C	F178L	0.742
11:6877181:C:A	F178L	0.742
11:6877181:C:G	F178L	0.742
11:6876867:T:C	F74L	0.730
11:6876869:C:A	F74L	0.730
11:6876869:C:G	F74L	0.730
11:6877401:T:C	F252L	0.712
11:6877403:C:A	F252L	0.712
11:6877403:C:G	F252L	0.712
11:6876732:T:C	F29L	0.699
11:6876734:T:A	F29L	0.699
11:6876734:T:G	F29L	0.699

dbSNP variants (sampled 300 via entrez): RS1000983356 (11:6875966 T>C,G), RS1001034278 (11:6875711 A>C,G), RS1001176962 (11:6874876 T>A,C,G), RS1002223397 (11:6876131 C>T), RS1002439547 (11:6876365 C>T), RS1002719219 (11:6877701 C>T), RS1004259945 (11:6875829 A>T), RS1005295827 (11:6875226 G>A), RS1005672560 (11:6874834 T>C), RS1006253129 (11:6876954 T>C,G), RS1006678068 (11:6877256 C>T), RS1006730342 (11:6877001 C>G,T), RS1008396766 (11:6877973 T>A), RS1009745069 (11:6876338 T>G), RS1010208534 (11:6875974 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004691_20	Huntington’s disease progression	2.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	1
Lead	affects methylation	1
Valproic Acid	decreases methylation	1
Asbestos, Crocidolite	affects expression	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.