OR10A5

Summary

OR10A5 (olfactory receptor family 10 subfamily A member 5, HGNC:15131) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 10A5 (Q9H207). Odorant receptor (Potential).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 144124 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_178168

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15131
Approved symbol	OR10A5
Name	olfactory receptor family 10 subfamily A member 5
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	OR11-403, JCG6
Ensembl gene	ENSG00000166363
Ensembl biotype	protein_coding
OMIM	608493
Entrez	144124

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000299454

RefSeq mRNA: 1 — MANE Select: NM_178168 NM_178168

CCDS: CCDS7773

Canonical transcript exons

ENST00000299454 — 1 exons

Exon	Start	End
ENSE00004472047	6845683	6846636

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 84.26.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.26	gold quality
bone marrow cell	CL:0002092	53.92	silver quality
colonic epithelium	UBERON:0000397	42.80	gold quality
bone marrow	UBERON:0002371	40.81	gold quality
sural nerve	UBERON:0015488	38.92	gold quality
tonsil	UBERON:0002372	37.32	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
corpus callosum	UBERON:0002336	36.21	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
mucosa of stomach	UBERON:0001199	33.17	gold quality
calcaneal tendon	UBERON:0003701	32.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	30.54	gold quality
liver	UBERON:0002107	30.19	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.74	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.78	gold quality
lymph node	UBERON:0000029	27.57	gold quality
placenta	UBERON:0001987	27.54	gold quality
superior frontal gyrus	UBERON:0002661	27.10	gold quality
leukocyte	CL:0000738	27.00	gold quality
monocyte	CL:0000576	26.94	gold quality
blood	UBERON:0000178	26.69	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.13

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10a2	ENSMUSG00000049674
mus_musculus	Or10a5	ENSMUSG00000073898
rattus_norvegicus	Or10a5	ENSRNOG00000087790
rattus_norvegicus	Or10a2	ENSRNOG00000090546

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10A5 — Q9H207 (reviewed: Q9H207)

Alternative names: HP3, Olfactory receptor 10A1, Olfactory receptor 11-403, Olfactory receptor-like protein JCG6

All UniProt accessions (2): A0A126GWR0, Q9H207

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor (Potential). May be involved in taste perception.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in the tongue.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_835462* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence conflict 4, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H207-F1	89.20	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 38 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, TGACCTY_ERR1_Q2, TCF11_01, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, TGACCTTG_SF1_Q6, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, YATGNWAAT_OCT_C, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, OCT_Q6, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY

GO Biological Process (4): sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

204 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A5	PGAP2	Q9UHJ9	543
OR10A5	TUB	P50607	431
OR10A5	PIGW	Q7Z7B1	425
OR10A5	TAS2R60	P59551	419
OR10A5	TMEM248	Q9NWD8	418
OR10A5	ZNF117	Q03924	398
OR10A5	ATP1B4	Q9UN42	352
OR10A5	VPS37C	A5D8V6	349
OR10A5	CARD18	P57730	348
OR10A5	H2AC14	Q99878	348
OR10A5	STX10	O60499	321
OR10A5	CSHL1	Q14406	313
OR10A5	NXNL1	Q96CM4	310
OR10A5	SLFNL1	Q499Z3	297
OR10A5	TNP2	Q05952	294

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10A5 (Affinity Capture-MS)

ESM2 similar proteins: A6ND48, B2RN74, O60412, O76099, O76100, P23271, P23272, P34982, P37068, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8N349, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGC1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGQ3, Q8NGR1, Q8NGS2, Q8NGW1, Q8NGZ0, Q8NH07, Q8NH80, Q8NH92, Q8NHA4, Q8VEY3, Q8VFR8, Q95157

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

223 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6846303:G:GA	donor_gain	0.8200
11:6846377:C:G	donor_gain	0.7700
11:6846302:T:TA	donor_gain	0.7100
11:6846451:A:AG	acceptor_gain	0.7100
11:6846452:G:GG	acceptor_gain	0.7100
11:6846384:G:GT	donor_gain	0.6900
11:6846441:T:G	acceptor_gain	0.6400
11:6846452:GCCTC:G	acceptor_gain	0.6300
11:6846452:GC:G	acceptor_gain	0.6200
11:6846443:T:G	acceptor_gain	0.6000
11:6846447:TTCTA:T	acceptor_loss	0.5900
11:6846448:TCTA:T	acceptor_loss	0.5900
11:6846449:CTAG:C	acceptor_loss	0.5900
11:6846450:TAGCC:T	acceptor_loss	0.5900
11:6846451:AGCCT:A	acceptor_loss	0.5900
11:6846452:G:A	acceptor_loss	0.5900
11:6845707:A:AG	donor_gain	0.5800
11:6846384:G:T	donor_gain	0.5800
11:6846262:GCACT:G	donor_gain	0.5700
11:6846442:A:AG	acceptor_gain	0.5700
11:6846445:T:G	acceptor_gain	0.5700
11:6846290:G:GT	donor_gain	0.5600
11:6846440:A:AG	acceptor_gain	0.5500
11:6845711:G:GG	donor_gain	0.5300
11:6846452:GCCT:G	acceptor_gain	0.5300
11:6846007:G:A	acceptor_gain	0.5200
11:6846249:C:A	donor_gain	0.5200
11:6846011:T:TA	donor_gain	0.5100
11:6846012:A:AA	donor_gain	0.5100
11:6846385:A:T	donor_gain	0.5100

AlphaMissense

2080 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6846187:T:C	F169L	0.885
11:6846189:C:A	F169L	0.885
11:6846189:C:G	F169L	0.885
11:6845716:T:C	F12L	0.861
11:6845718:T:A	F12L	0.861
11:6845718:T:G	F12L	0.861
11:6846556:A:C	S292R	0.833
11:6846558:C:A	S292R	0.833
11:6846558:C:G	S292R	0.833
11:6846175:T:C	F165L	0.829
11:6846177:C:A	F165L	0.829
11:6846177:C:G	F165L	0.829
11:6846436:T:C	F252L	0.823
11:6846438:C:A	F252L	0.823
11:6846438:C:G	F252L	0.823
11:6846268:T:C	F196L	0.811
11:6846270:T:A	F196L	0.811
11:6846270:T:G	F196L	0.811
11:6845731:T:C	F17L	0.810
11:6845733:C:A	F17L	0.810
11:6845733:C:G	F17L	0.810
11:6846130:T:A	W150R	0.797
11:6846130:T:C	W150R	0.797
11:6846451:A:C	S257R	0.794
11:6846453:C:A	S257R	0.794
11:6846453:C:G	S257R	0.794
11:6846217:T:C	F179L	0.781
11:6846219:C:A	F179L	0.781
11:6846219:C:G	F179L	0.781
11:6846397:T:C	F239L	0.777

dbSNP variants (sampled 300 via entrez): RS1002436888 (11:6844045 C>A,T), RS1004094390 (11:6844837 C>G), RS1005096767 (11:6846926 C>A), RS1007868822 (11:6845208 G>A), RS1008568315 (11:6844984 A>C), RS1008829489 (11:6845054 G>A), RS1009159598 (11:6846802 T>C), RS1009253070 (11:6846920 T>G), RS1015478362 (11:6844998 T>TA), RS1015532298 (11:6845214 T>G), RS1018506385 (11:6843795 G>A), RS1019513338 (11:6845069 G>A), RS1019576452 (11:6845958 C>A), RS1021948874 (11:6846809 C>T), RS1023444636 (11:6844529 G>A,C)

Disease associations

OMIM: gene MIM:608493 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004691_20	Huntington’s disease progression	2.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
terbufos	increases methylation	1
sodium arsenite	increases expression	1
CGP 52608	affects binding, increases reaction	1
Arsenic Trioxide	increases expression	1
Benzo(a)pyrene	affects methylation	1
Fonofos	increases methylation	1
Parathion	increases methylation	1
Silicon Dioxide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.