OR10A6

Summary

OR10A6 (olfactory receptor family 10 subfamily A member 6 (gene/pseudogene), HGNC:15132) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 10A6 (Q8NH74). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 390093 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 80 total
• MANE Select transcript: NM_001004461

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15132
Approved symbol	OR10A6
Name	olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000279000
Ensembl biotype	protein_coding
Entrez	390093

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641238, ENST00000642108

RefSeq mRNA: 2 — MANE Select: NM_001004461 NM_001004461, NM_001389574

Canonical transcript exons

ENST00000622207 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 46.63.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	46.63	gold quality
zone of skin	UBERON:0000014	44.76	gold quality
skin of abdomen	UBERON:0001416	42.10	gold quality
colonic epithelium	UBERON:0000397	41.73	gold quality
sural nerve	UBERON:0015488	40.89	gold quality
ventricular zone	UBERON:0003053	39.85	gold quality
placenta	UBERON:0001987	37.28	gold quality
bone marrow	UBERON:0002371	37.15	gold quality
leukocyte	CL:0000738	36.59	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
monocyte	CL:0000576	36.43	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
muscle tissue	UBERON:0002385	35.30	gold quality
skeletal muscle tissue	UBERON:0001134	34.79	gold quality
tonsil	UBERON:0002372	34.47	gold quality
ascending aorta	UBERON:0001496	34.28	silver quality
adrenal tissue	UBERON:0018303	34.26	gold quality
descending thoracic aorta	UBERON:0002345	33.20	gold quality
liver	UBERON:0002107	33.17	gold quality
primary visual cortex	UBERON:0002436	32.96	gold quality
fallopian tube	UBERON:0003889	32.94	gold quality
smooth muscle tissue	UBERON:0001135	32.60	gold quality
endometrium	UBERON:0001295	32.55	gold quality
prostate gland	UBERON:0002367	32.54	silver quality
calcaneal tendon	UBERON:0003701	32.37	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
kidney	UBERON:0002113	31.95	gold quality
fundus of stomach	UBERON:0001160	31.71	gold quality
right uterine tube	UBERON:0001302	31.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10A6 — Q8NH74 (reviewed: Q8NH74)

Alternative names: Olfactory receptor OR11-96

All UniProt accessions (2): A0A126GVN8, Q8NH74

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001004461, NP_001376503 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH74-F1	86.42	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_DN, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

118 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A6	TMEM229A	B2RXF0	475
OR10A6	GNG8	Q9UK08	412
OR10A6	GNG13	Q9P2W3	399
OR10A6	VN1R1	Q9GZP7	399
OR10A6	TAS2R42	Q7RTR8	397
OR10A6	TRIM48	Q8IWZ4	392
OR10A6	TMEM181	Q9P2C4	375
OR10A6	RTP2	Q5QGT7	353
OR10A6	RTP1	P59025	350
OR10A6	GNGT2	O14610	348
OR10A6	OR2AG2	A6NM03	334
OR10A6	GNAL	P38405	325
OR10A6	CNGA2	Q16280	320
OR10A6	TAS2R14	Q9NYV8	309
OR10A6	OR11H4	Q8NGC9	307

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	76
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

260 predictions. Top by Δscore:

Variant	Effect	Δscore
11:7928040:A:T	acceptor_gain	0.7700
11:7928025:A:T	acceptor_gain	0.7600
11:7928015:C:CT	acceptor_gain	0.7300
11:7928007:A:AC	acceptor_gain	0.7200
11:7928039:C:CT	acceptor_gain	0.7200
11:7928004:CGAA:C	acceptor_gain	0.7100
11:7928016:A:T	acceptor_gain	0.7100
11:7928642:G:C	donor_gain	0.7100
11:7927989:A:C	acceptor_gain	0.7000
11:7927997:CAGAA:C	acceptor_gain	0.7000
11:7928009:G:C	acceptor_gain	0.6900
11:7928413:C:CT	donor_gain	0.6900
11:7928640:CAG:C	donor_gain	0.6900
11:7927998:A:T	acceptor_gain	0.6800
11:7928658:T:A	donor_gain	0.6700
11:7928020:G:GC	acceptor_gain	0.6600
11:7928020:G:C	acceptor_gain	0.6400
11:7928024:C:CT	acceptor_gain	0.6400
11:7928005:G:T	acceptor_gain	0.6200
11:7928002:C:CC	acceptor_gain	0.6100
11:7928414:C:CT	donor_gain	0.6000
11:7928631:TCA:T	donor_gain	0.6000
11:7928009:G:GC	acceptor_gain	0.5800
11:7928028:A:T	acceptor_gain	0.5800
11:7928451:AGGT:A	donor_gain	0.5700
11:7928638:CACAG:C	donor_gain	0.5700
11:7927816:G:GC	acceptor_gain	0.5500
11:7928000:AA:A	acceptor_gain	0.5500
11:7928007:A:C	acceptor_gain	0.5500
11:7927860:G:T	acceptor_gain	0.5400

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000379557 (11:7928893 C>A,T), RS1000496708 (11:7930033 TTTTG>T), RS1000797339 (11:7924675 C>T), RS1000932117 (11:7925576 T>C,G), RS1001364905 (11:7925767 A>G), RS1002085868 (11:7926009 C>T), RS1002168169 (11:7924796 C>T), RS1002258314 (11:7930788 C>A,T), RS1002351964 (11:7929407 A>T), RS1002487751 (11:7929219 C>T), RS1002585458 (11:7925044 G>T), RS1003355271 (11:7928280 T>A), RS1004068639 (11:7931527 A>T), RS1004143319 (11:7924684 A>G,T), RS1004480534 (11:7925600 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST007603_10	Smoking initiation	8.000000e-09
GCST008810_94	Smoking initiation (ever regular vs never regular)	1.000000e-08
GCST010135_39	Oily fish consumption	1.000000e-08
GCST010140_29	Pork consumption	1.000000e-08
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55
GCST011703_1	Smoking initiation	9.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005670	smoking initiation
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Lactic Acid	decreases expression	1
Permethrin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.