OR10A7

Summary

OR10A7 (olfactory receptor family 10 subfamily A member 7, HGNC:15329) is a protein-coding gene on chromosome 12q13.2, encoding Olfactory receptor 10A7 (Q8NGE5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 121364 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001005280

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15329
Approved symbol	OR10A7
Name	olfactory receptor family 10 subfamily A member 7
Location	12q13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000179919
Ensembl biotype	protein_coding
Entrez	121364

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000326258

RefSeq mRNA: 1 — MANE Select: NM_001005280 NM_001005280

CCDS: CCDS31815

Canonical transcript exons

ENST00000326258 — 1 exons

Exon	Start	End
ENSE00001288391	55221025	55221975

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 88.65.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.65	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.47	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.15	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
adrenal tissue	UBERON:0018303	29.62	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.90	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.38	gold quality
monocyte	CL:0000576	27.36	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.82	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.23	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.08	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10A7 — Q8NGE5 (reviewed: Q8NGE5)

Alternative names: Olfactory receptor OR12-6

All UniProt accessions (2): Q8NGE5, A0A126GVR3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005280* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGE5-F1	90.15	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

104 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10A7	MROH2B	Q7Z745	398
OR10A7	POLR2L	P52436	322
OR10A7	DDX11	Q96FC9	274
OR10A7	ELAPOR2	A8MWY0	247
OR10A7	ZNF804B	A4D1E1	243
OR10A7	HBE1	P02100	229
OR10A7	AZU1	P20160	222
OR10A7	SLC35F3	Q8IY50	200
OR10A7	CHTF8	P0CG13	199
OR10A7	GALK2	Q01415	198
OR10A7	COL28A1	Q2UY09	192
OR10A7	KLHL1	Q9NR64	186
OR10A7	TSBP1	Q5SRN2	176
OR10A7	CDAN1	Q8IWY9	175
OR10A7	STXBP5L	Q9Y2K9	174
OR10A7	CCDC141	Q6ZP82	174

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGD5, Q8NGE5, Q8NGE8, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

211 predictions. Top by Δscore:

Variant	Effect	Δscore
12:55221668:T:TA	acceptor_gain	0.8800
12:55221235:G:GG	donor_gain	0.7200
12:55221669:G:A	acceptor_gain	0.7200
12:55221664:ATTTT:A	acceptor_gain	0.7100
12:55221677:A:AG	acceptor_gain	0.6800
12:55221678:C:G	acceptor_gain	0.6800
12:55221679:ACCC:A	acceptor_gain	0.6500
12:55221682:C:CA	acceptor_gain	0.6300
12:55221665:T:G	acceptor_gain	0.6200
12:55221780:C:CA	acceptor_gain	0.6000
12:55221693:A:AG	acceptor_gain	0.5900
12:55221701:T:A	acceptor_gain	0.5800
12:55221779:AC:A	acceptor_gain	0.5800
12:55221047:GA:G	donor_gain	0.5700
12:55221664:A:AG	acceptor_gain	0.5700
12:55221200:T:G	donor_gain	0.5600
12:55221232:G:GT	donor_gain	0.5500
12:55221421:TCAG:T	acceptor_gain	0.5500
12:55221694:A:G	acceptor_gain	0.5400
12:55221696:A:AG	acceptor_gain	0.5400
12:55221787:GCCA:G	acceptor_gain	0.5400
12:55221680:C:G	acceptor_gain	0.5300
12:55221780:C:G	acceptor_gain	0.5300
12:55221374:T:TA	acceptor_gain	0.5200
12:55221679:A:AG	acceptor_gain	0.5200
12:55221686:T:G	acceptor_gain	0.5200
12:55221764:T:TA	acceptor_gain	0.5200
12:55221692:T:G	acceptor_gain	0.5100
12:55221422:CAGT:C	acceptor_gain	0.5000
12:55221423:A:T	acceptor_gain	0.5000

AlphaMissense

2089 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:55221790:A:C	S256R	0.953
12:55221792:T:A	S256R	0.953
12:55221792:T:G	S256R	0.953
12:55221058:T:C	F12L	0.952
12:55221060:T:A	F12L	0.952
12:55221060:T:G	F12L	0.952
12:55221775:T:C	F251L	0.951
12:55221777:C:A	F251L	0.951
12:55221777:C:G	F251L	0.951
12:55221349:A:C	S109R	0.924
12:55221351:T:A	S109R	0.924
12:55221351:T:G	S109R	0.924
12:55221526:T:C	F168L	0.921
12:55221528:C:A	F168L	0.921
12:55221528:C:G	F168L	0.921
12:55221059:T:C	F12S	0.920
12:55221553:T:C	F177L	0.907
12:55221555:T:A	F177L	0.907
12:55221555:T:G	F177L	0.907
12:55221233:A:T	E70V	0.895
12:55221389:G:C	R122P	0.893
12:55221556:T:C	F178L	0.892
12:55221558:C:A	F178L	0.892
12:55221558:C:G	F178L	0.892
12:55221241:T:C	F73L	0.888
12:55221243:C:A	F73L	0.888
12:55221243:C:G	F73L	0.888
12:55221387:T:A	D121E	0.882
12:55221387:T:G	D121E	0.882
12:55221788:C:A	A255D	0.882

dbSNP variants (sampled 300 via entrez): RS1000275885 (12:55219819 A>G), RS1000792555 (12:55219460 G>A), RS1001508281 (12:55219033 C>T), RS1002049099 (12:55221450 G>A), RS1004466526 (12:55220290 G>A), RS1005454213 (12:55222057 C>T), RS1006590857 (12:55222385 T>C), RS1006856642 (12:55222417 C>T), RS1006952938 (12:55222183 G>C), RS1008148253 (12:55221337 T>C,G), RS1009768983 (12:55221390 C>T), RS1010276528 (12:55219254 G>A,T), RS1011162273 (12:55222039 C>G,T), RS1011465311 (12:55222307 C>A), RS1012174043 (12:55221941 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002238_5	Contrast sensitivity	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005419	contrast sensitivity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.