OR10AC1

Summary

OR10AC1 (olfactory receptor family 10 subfamily AC member 1 (gene/pseudogene), HGNC:14758) is a protein-coding gene on chromosome 7q35, encoding Olfactory receptor 10AC1 (Q8NH08). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 392133 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14758
Approved symbol	OR10AC1
Name	olfactory receptor family 10 subfamily AC member 1 (gene/pseudogene)
Location	7q35
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176510
Ensembl biotype	protein_coding
Entrez	392133

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000439431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439431 — 3 exons

Exon	Start	End
ENSE00001684683	143509256	143511933
ENSE00003812729	143519395	143519469
ENSE00003813153	143513740	143513884

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 48.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0236 / max 6.0265, expressed in 5 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86677	0.0151	4
86676	0.0085	1

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	48.07	gold quality
primary visual cortex	UBERON:0002436	46.40	silver quality
superior frontal gyrus	UBERON:0002661	44.97	silver quality
bone marrow cell	CL:0002092	44.88	gold quality
colonic epithelium	UBERON:0000397	44.88	gold quality
ventricular zone	UBERON:0003053	44.21	gold quality
frontal cortex	UBERON:0001870	43.42	gold quality
sural nerve	UBERON:0015488	43.07	gold quality
stromal cell of endometrium	CL:0002255	42.53	silver quality
cerebral cortex	UBERON:0000956	40.65	silver quality
ganglionic eminence	UBERON:0004023	38.81	gold quality
anterior cingulate cortex	UBERON:0009835	38.53	silver quality
bone marrow	UBERON:0002371	38.35	gold quality
blood	UBERON:0000178	37.65	gold quality
placenta	UBERON:0001987	36.82	silver quality
brain	UBERON:0000955	36.69	silver quality
cerebellum	UBERON:0002037	35.98	gold quality
granulocyte	CL:0000094	35.90	gold quality
cerebellar cortex	UBERON:0002129	35.83	gold quality
monocyte	CL:0000576	35.55	gold quality
cerebellar hemisphere	UBERON:0002245	35.55	gold quality
leukocyte	CL:0000738	35.37	gold quality
putamen	UBERON:0001874	34.90	gold quality
skeletal muscle tissue	UBERON:0001134	34.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	34.80	gold quality
mucosa of transverse colon	UBERON:0004991	34.00	gold quality
lymph node	UBERON:0000029	33.92	gold quality
endocervix	UBERON:0000458	33.69	silver quality
right lung	UBERON:0002167	33.25	gold quality
descending thoracic aorta	UBERON:0002345	32.87	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-111727	yes	54.02
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Olfactory receptor 10AC1 — Q8NH08 (reviewed: Q8NH08)

Alternative names: Olfactory receptor OR7-5

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Polymorphism. A stop codon due to a single nucleotide insertion in the gene coding for this protein at position Ile-90 is responsible for functional diversity thus producing a pseudogene.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH08-F1	83.26	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr7q35, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, HES2_TARGET_GENES, KMT2D_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (1): detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (1): plasma membrane (GO:0005886)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NMU1, O88628, P0C7T3, P47888, P47893, Q5JQS5, Q6IF63, Q6W049, Q8NGC4, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGI1, Q8NGI3, Q8NGJ8, Q8NGJ9, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NGN2, Q8NGR3, Q8NGR4, Q8NGR6, Q8NGT2, Q8NGU4, Q8NH06, Q8NH08, Q8NH53, Q8NH54, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH63

Diamond homologs: A4D2G3, A6NF89, A6NH00, O43749, O43869, O76001, O76002, O95221, P0C629, P23266, P23270, P23274, P23275, P30954, P30955, P34984, P34986, P58181, P59922, Q13606, Q5JQS5, Q5TZ20, Q60880, Q60883, Q60894, Q62007, Q6IF00, Q6IF99, Q6IFH4, Q6UXT6, Q8N127, Q8N628, Q8NG75, Q8NG76, Q8NG85, Q8NGA6, Q8NGC0, Q8NGE5, Q8NGF6, Q8NGI7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

96 predictions. Top by Δscore:

Variant	Effect	Δscore
7:143511683:C:CT	donor_gain	0.9200
7:143511684:C:CT	donor_gain	0.8400
7:143511680:C:CT	donor_gain	0.8200
7:143511681:C:CT	donor_gain	0.7200
7:143511391:C:CT	acceptor_gain	0.6600
7:143511194:G:A	donor_gain	0.5500
7:143511124:A:AC	donor_gain	0.5200
7:143511125:C:CC	donor_gain	0.5200
7:143511680:CCA:C	donor_gain	0.5200
7:143511681:CAC:C	donor_gain	0.5200
7:143511323:G:C	donor_gain	0.4600
7:143511391:C:T	acceptor_gain	0.4200
7:143511120:ACGT:A	donor_loss	0.3900
7:143511121:CGTA:C	donor_loss	0.3900
7:143511122:GTA:G	donor_loss	0.3900
7:143511123:TACA:T	donor_loss	0.3900
7:143511124:A:AG	donor_loss	0.3900
7:143511125:C:CA	donor_loss	0.3900
7:143511119:CACG:C	donor_loss	0.3800
7:143511590:CAT:C	donor_gain	0.3800
7:143511118:GCAC:G	donor_loss	0.3600
7:143511160:C:CC	acceptor_gain	0.3600
7:143511393:C:CT	acceptor_gain	0.3600
7:143511533:G:C	donor_gain	0.3600
7:143511122:G:C	acceptor_gain	0.3500
7:143511142:CGTAG:C	acceptor_gain	0.3500
7:143511244:C:CT	acceptor_gain	0.3400
7:143511350:CGCCG:C	acceptor_gain	0.3400
7:143511162:G:GA	donor_gain	0.3300
7:143511266:C:CT	donor_gain	0.3300

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1003010252 (7:143512924 T>C), RS1003800996 (7:143510408 T>C,G), RS1004270110 (7:143511314 G>A,C,T), RS1004974208 (7:143510753 G>A), RS1005518008 (7:143511459 G>A), RS1005584319 (7:143513356 C>G,T), RS1005615224 (7:143513613 T>C), RS1006975454 (7:143512094 GTCC>G), RS1007029459 (7:143511809 C>A,T), RS1007308497 (7:143510871 C>T), RS1007806228 (7:143512476 G>A,T), RS1008809089 (7:143513686 A>G), RS1008838699 (7:143513851 T>A), RS1010835803 (7:143511092 G>C), RS1011767071 (7:143512128 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	decreases phosphorylation	1
sodium arsenite	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.