OR10AD1

Summary

OR10AD1 (olfactory receptor family 10 subfamily AD member 1, HGNC:14819) is a protein-coding gene on chromosome 12q13.11, encoding Olfactory receptor 10AD1 (Q8NGE0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 121275 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001004134

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14819
Approved symbol	OR10AD1
Name	olfactory receptor family 10 subfamily AD member 1
Location	12q13.11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172640
Ensembl biotype	protein_coding
Entrez	121275

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000310248

RefSeq mRNA: 1 — MANE Select: NM_001004134 NM_001004134

CCDS: CCDS31787

Canonical transcript exons

ENST00000310248 — 1 exons

Exon	Start	End
ENSE00004001349	48202339	48203292

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 56.47.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	56.47	gold quality
granulocyte	CL:0000094	54.74	gold quality
pituitary gland	UBERON:0000007	54.74	gold quality
right uterine tube	UBERON:0001302	52.68	gold quality
tonsil	UBERON:0002372	52.53	gold quality
adenohypophysis	UBERON:0002196	52.19	gold quality
bone marrow cell	CL:0002092	52.06	gold quality
right adrenal gland cortex	UBERON:0035827	51.80	gold quality
adrenal tissue	UBERON:0018303	51.08	gold quality
calcaneal tendon	UBERON:0003701	51.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.81	gold quality
vermiform appendix	UBERON:0001154	50.62	gold quality
skeletal muscle tissue	UBERON:0001134	50.61	silver quality
cerebellum	UBERON:0002037	49.83	gold quality
cerebellar cortex	UBERON:0002129	49.77	gold quality
urinary bladder	UBERON:0001255	49.72	gold quality
cerebellar hemisphere	UBERON:0002245	49.70	gold quality
right lobe of thyroid gland	UBERON:0001119	49.58	gold quality
adrenal gland	UBERON:0002369	49.01	gold quality
left ovary	UBERON:0002119	48.97	gold quality
lymph node	UBERON:0000029	48.95	gold quality
ovary	UBERON:0000992	48.65	gold quality
left adrenal gland	UBERON:0001234	48.37	gold quality
muscle tissue	UBERON:0002385	48.34	silver quality
mucosa of transverse colon	UBERON:0004991	48.13	gold quality
left adrenal gland cortex	UBERON:0035825	48.06	gold quality
thyroid gland	UBERON:0002046	47.53	gold quality
colonic epithelium	UBERON:0000397	47.22	gold quality
fundus of stomach	UBERON:0001160	47.01	gold quality
hindlimb stylopod muscle	UBERON:0004252	46.91	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10ad1b	ENSMUSG00000059460
mus_musculus	Or10ad1c	ENSMUSG00000075427
mus_musculus	Or10ad1	ENSMUSG00000090129
rattus_norvegicus	Or10ad1	ENSRNOG00000064488
rattus_norvegicus	Olr1102	ENSRNOG00000066134
rattus_norvegicus	Olr1877	ENSRNOG00000070612

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10AD1 — Q8NGE0 (reviewed: Q8NGE0)

Alternative names: Olfactory receptor OR12-1

All UniProt accessions (1): Q8NGE0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004134* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGE0-F1	80.35	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 28 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE14350_TREG_VS_TEFF_DN, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GSE27786_LSK_VS_ERYTHROBLAST_DN, GSE27786_LIN_NEG_VS_NKCELL_UP

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10AD1	OTOL1	A6NHN0	435
OR10AD1	MRGPRG	Q86SM5	419
OR10AD1	CBLL2	Q8N7E2	398
OR10AD1	TAS2R60	P59551	395
OR10AD1	SEC22C	Q9BRL7	372
OR10AD1	SPEM1	Q8N4L4	340
OR10AD1	NRSN1	Q8IZ57	334
OR10AD1	MRPL30	Q8TCC3	325
OR10AD1	TRIM58	Q8NG06	303
OR10AD1	GPSM1	Q86YR5	302
OR10AD1	OSCP1	Q8WVF1	298
OR10AD1	KRT6C	P48666	255
OR10AD1	OPN3	Q9H1Y3	249
OR10AD1	G5EA03	G5EA03	247
OR10AD1	TDRD6	O60522	244

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10AD1 (Positive Genetic)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A2R8YED5, A6NH00, A6NM03, O43749, O43869, O76000, O76001, O76002, O95006, O95007, O95222, O95918, P0C629, P0C7N1, P0C7N5, P0C7T2, P0DN82, P23266, P23270, P34984, P34986, P47881, P58173, P58181, P59922, Q13607, Q15619, Q5TZ20, Q60890, Q6IEZ7, Q6IF00, Q6IF42, Q6UXT6, Q7TR96, Q7Z3T1, Q8N127, Q8NG77, Q8NG83, Q8NG84, Q8NG97

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

261 predictions. Top by Δscore:

Variant	Effect	Δscore
12:48202630:G:C	acceptor_gain	0.7300
12:48202532:G:GC	acceptor_gain	0.6700
12:48202585:C:A	donor_gain	0.6500
12:48202584:T:TA	donor_gain	0.6000
12:48202418:C:CC	acceptor_gain	0.5600
12:48202546:G:T	donor_gain	0.5600
12:48202636:A:C	acceptor_gain	0.5600
12:48202510:CA:C	acceptor_gain	0.5500
12:48202924:A:C	donor_gain	0.5300
12:48202460:A:T	acceptor_gain	0.5100
12:48202526:G:C	donor_gain	0.5100
12:48202624:CAGGA:C	acceptor_gain	0.5100
12:48202522:CATAG:C	acceptor_gain	0.5000
12:48202456:G:C	acceptor_gain	0.4900
12:48202524:TAG:T	acceptor_gain	0.4900
12:48202399:AATTT:A	donor_gain	0.4800
12:48202511:A:C	acceptor_gain	0.4800
12:48202403:T:A	donor_gain	0.4700
12:48203114:A:C	donor_gain	0.4700
12:48202456:G:GC	acceptor_gain	0.4600
12:48203029:G:T	donor_gain	0.4500
12:48203283:T:TA	donor_gain	0.4500
12:48202417:A:C	acceptor_gain	0.4300
12:48202511:A:AC	acceptor_gain	0.4300
12:48202630:G:GC	acceptor_gain	0.4300
12:48202499:C:CC	acceptor_gain	0.4200
12:48202549:C:CT	donor_gain	0.4200
12:48202670:A:C	donor_gain	0.4200
12:48203025:C:A	donor_gain	0.4200
12:48202527:C:CC	acceptor_gain	0.4100

AlphaMissense

2109 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:48202936:C:A	M119I	0.934
12:48202936:C:G	M119I	0.934
12:48202936:C:T	M119I	0.934
12:48203260:A:C	F11L	0.930
12:48203260:A:T	F11L	0.930
12:48203262:A:G	F11L	0.930
12:48202417:A:C	S292R	0.920
12:48202417:A:T	S292R	0.920
12:48202419:T:G	S292R	0.920
12:48203185:G:C	S36R	0.913
12:48203185:G:T	S36R	0.913
12:48203187:T:G	S36R	0.913
12:48202663:G:C	S210R	0.907
12:48202663:G:T	S210R	0.907
12:48202665:T:G	S210R	0.907
12:48203076:A:G	C73R	0.900
12:48203245:A:C	F16L	0.884
12:48203245:A:T	F16L	0.884
12:48203247:A:G	F16L	0.884
12:48202925:C:G	R123P	0.876
12:48202437:A:G	C286R	0.863
12:48203107:G:C	F62L	0.862
12:48203107:G:T	F62L	0.862
12:48203109:A:G	F62L	0.862
12:48202759:G:C	F178L	0.860
12:48202759:G:T	F178L	0.860
12:48202761:A:G	F178L	0.860
12:48202928:T:G	D122A	0.856
12:48202413:G:T	R294S	0.850
12:48202786:G:C	F169L	0.844

dbSNP variants (sampled 300 via entrez): RS1000855240 (12:48202384 C>T), RS1001804158 (12:48203939 G>C), RS1002276237 (12:48203487 G>C), RS1002860392 (12:48204904 C>T), RS1004119663 (12:48203969 C>T), RS1004173585 (12:48203694 G>A), RS1004728293 (12:48205175 G>A,C), RS1008657223 (12:48204338 T>C), RS1009859640 (12:48204532 C>G), RS1011044574 (12:48203997 C>T), RS1012076964 (12:48205270 G>A), RS1012730751 (12:48202524 T>A,C), RS1014508293 (12:48204009 A>C,G), RS1014855378 (12:48204871 C>T), RS1015420891 (12:48203706 T>A,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	decreases methylation	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.