OR10AG1

Summary

OR10AG1 (olfactory receptor family 10 subfamily AG member 1, HGNC:19607) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 10AG1 (Q8NH19). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 282770 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 36 total
• MANE Select transcript: NM_001005491

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19607
Approved symbol	OR10AG1
Name	olfactory receptor family 10 subfamily AG member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000174970
Ensembl biotype	protein_coding
Entrez	282770

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000312345, ENST00000641071

RefSeq mRNA: 1 — MANE Select: NM_001005491 NM_001005491

CCDS: CCDS31514

Canonical transcript exons

ENST00000641071 — 2 exons

Exon	Start	End
ENSE00003813508	55965755	55968507
ENSE00003813939	55969892	55969945

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.00	gold quality
monocyte	CL:0000576	34.25	silver quality
leukocyte	CL:0000738	33.65	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.65	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.94	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.36	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.32	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.86	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.26	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	24.01	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	130.00
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10ag2	ENSMUSG00000043274
mus_musculus	Or10ag57	ENSMUSG00000047594
mus_musculus	Or10ag54	ENSMUSG00000070855
mus_musculus	Or10ag56	ENSMUSG00000083706
mus_musculus	Or10ag55	ENSMUSG00000089732
rattus_norvegicus	Or10ag57	ENSRNOG00000037837
rattus_norvegicus	Or10ag54	ENSRNOG00000066294
rattus_norvegicus	Or10ag54b	ENSRNOG00000066948
rattus_norvegicus		ENSRNOG00000089112

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10AG1 — Q8NH19 (reviewed: Q8NH19)

Alternative names: Olfactory receptor OR11-160

All UniProt accessions (3): Q8NH19, A0A126GVM8, A0A2U3TZR9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005491* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH19-F1	91.38	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 88–180

Glycosylation sites (1): 82

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11q12

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

226 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10AG1	TSGA10IP	Q3SY00	601
OR10AG1	ABCC12	Q96J65	551
OR10AG1	PIGZ	Q86VD9	432
OR10AG1	AK9	Q5TCS8	400
OR10AG1	NPAP1	Q9NZP6	376
OR10AG1	PLBD1	Q6P4A8	348
OR10AG1	MMAB	Q96EY8	348
OR10AG1	SLX4	Q8IY92	347
OR10AG1	DEGS2	Q6QHC5	315
OR10AG1	EPCIP	Q9NYP8	312
OR10AG1	FXYD3	Q14802	304
OR10AG1	IQGAP3	Q86VI3	299
OR10AG1	KIF26B	Q2KJY2	296
OR10AG1	ZNF420	Q8TAQ5	291
OR10AG1	FAM149B1	Q96BN6	290

IntAct

16 interactions, top by confidence:

A	B	Type	Score
OR10AG1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
AQP2	OR10AG1	psi-mi:“MI:0915”(physical association)	0.560
FFAR2	OR10AG1	psi-mi:“MI:0915”(physical association)	0.560
MUC1	OR10AG1	psi-mi:“MI:0915”(physical association)	0.560
EBAG9	OR10AG1	psi-mi:“MI:0915”(physical association)	0.560
OR10AG1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.000
OR10AG1	AQP2	psi-mi:“MI:0915”(physical association)	0.000
OR10AG1	MUC1	psi-mi:“MI:0915”(physical association)	0.000
OR10AG1	FFAR2	psi-mi:“MI:0915”(physical association)	0.000
OR10AG1	EBAG9	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): OR10AG1 (Two-hybrid), OR10AG1 (Two-hybrid), OR10AG1 (Two-hybrid), OR10AG1 (Two-hybrid), MUC1 (Two-hybrid)

ESM2 similar proteins: A6NF89, A6NJZ3, O76000, O95007, P0C626, P0C628, P23269, P23273, P34986, P37067, P37069, P37070, P37071, P58181, Q13606, Q60884, Q60895, Q8N162, Q8NG80, Q8NGC8, Q8NGE1, Q8NGE2, Q8NGG4, Q8NGQ6, Q8NGS4, Q8NGT1, Q8NGV7, Q8NGZ3, Q8NGZ9, Q8NH19, Q8NH51, Q8VEW5, Q8VEW6, Q8VEX5, Q8VEZ0, Q8VF66, Q8VF76, Q8VFB9, Q8VFD0, Q8VFK2

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

280 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55967955:C:CT	acceptor_gain	0.7800
11:55967953:C:CT	acceptor_gain	0.7200
11:55968408:A:AC	donor_gain	0.7200
11:55968408:AAAAG:A	donor_gain	0.7200
11:55967836:C:CT	acceptor_gain	0.6900
11:55968409:A:C	donor_gain	0.6900
11:55968393:A:C	donor_gain	0.6800
11:55967837:A:C	acceptor_gain	0.6700
11:55967813:CAAAA:C	acceptor_gain	0.6500
11:55968221:T:A	donor_gain	0.6400
11:55967949:A:C	acceptor_gain	0.6200
11:55968169:C:CT	acceptor_gain	0.6200
11:55968170:A:T	acceptor_gain	0.6000
11:55968459:T:TA	donor_gain	0.6000
11:55968404:A:AC	donor_gain	0.5900
11:55968405:C:CC	donor_gain	0.5900
11:55967902:T:C	donor_gain	0.5800
11:55968169:C:T	acceptor_gain	0.5800
11:55967836:C:T	acceptor_gain	0.5700
11:55968110:A:AC	donor_gain	0.5600
11:55968111:C:CC	donor_gain	0.5600
11:55967734:C:CT	acceptor_gain	0.5500
11:55967735:A:T	acceptor_gain	0.5500
11:55968025:C:CT	donor_gain	0.5500
11:55968026:T:TT	donor_gain	0.5500
11:55968125:G:C	donor_gain	0.5500
11:55968174:A:C	acceptor_gain	0.5400
11:55967723:AGTAC:A	acceptor_loss	0.5300
11:55967725:TACC:T	acceptor_loss	0.5300
11:55967726:ACCT:A	acceptor_loss	0.5300

AlphaMissense

2124 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55968455:A:C	F3L	0.895
11:55968455:A:T	F3L	0.895
11:55968457:A:G	F3L	0.895
11:55967987:A:C	F159L	0.828
11:55967987:A:T	F159L	0.828
11:55967989:A:G	F159L	0.828
11:55968440:A:C	F8L	0.824
11:55968440:A:T	F8L	0.824
11:55968442:A:G	F8L	0.824
11:55968126:C:G	R113P	0.822
11:55968137:C:A	M109I	0.787
11:55968137:C:G	M109I	0.787
11:55968137:C:T	M109I	0.787
11:55967738:G:C	F242L	0.780
11:55967738:G:T	F242L	0.780
11:55967740:A:G	F242L	0.780
11:55967999:G:C	F155L	0.772
11:55967999:G:T	F155L	0.772
11:55968001:A:G	F155L	0.772
11:55967960:G:C	F168L	0.768
11:55967960:G:T	F168L	0.768
11:55967962:A:G	F168L	0.768
11:55968046:A:G	W140R	0.767
11:55968046:A:T	W140R	0.767
11:55967735:A:C	F243L	0.760
11:55967735:A:T	F243L	0.760
11:55967737:A:G	F243L	0.760
11:55967777:G:C	F229L	0.746
11:55967777:G:T	F229L	0.746
11:55967779:A:G	F229L	0.746

dbSNP variants (sampled 300 via entrez): RS1000131384 (11:55968862 T>C), RS1000903424 (11:55969073 A>G), RS1000935165 (11:55968972 C>A), RS1001640466 (11:55966052 ATTATC>A), RS1001880008 (11:55968198 G>A), RS1001932121 (11:55968535 T>C), RS1002592960 (11:55967569 A>G), RS1002601571 (11:55966169 C>T), RS1002827204 (11:55971257 C>T), RS1002957034 (11:55971464 G>A,T), RS1003323246 (11:55967559 C>T), RS1004344366 (11:55970821 C>T), RS1004829178 (11:55966919 C>T), RS1004890157 (11:55965771 C>T), RS1005569536 (11:55969387 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.