OR10D3

Summary

OR10D3 (olfactory receptor family 10 subfamily D member 3, HGNC:8168) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 10D3 (Q8NH80). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26497 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001355213

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8168
Approved symbol	OR10D3
Name	olfactory receptor family 10 subfamily D member 3
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Aliases	HTPCRX09
Ensembl gene	ENSG00000197309
Ensembl biotype	protein_coding
Entrez	26497

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000318666, ENST00000641351, ENST00000641546

RefSeq mRNA: 1 — MANE Select: NM_001355213 NM_001355213

CCDS: CCDS86257

Canonical transcript exons

ENST00000641351 — 2 exons

Exon	Start	End
ENSE00003813056	124185259	124188780
ENSE00003978178	124183345	124183383

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 80.04.

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.04	gold quality
endothelial cell	CL:0000115	66.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	63.80	gold quality
myocardium	UBERON:0002349	57.25	gold quality
heart right ventricle	UBERON:0002080	54.79	gold quality
parotid gland	UBERON:0001831	52.09	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.96	gold quality
colonic epithelium	UBERON:0000397	46.37	gold quality
amniotic fluid	UBERON:0000173	44.60	gold quality
vastus lateralis	UBERON:0001379	43.80	gold quality
quadriceps femoris	UBERON:0001377	43.71	gold quality
trigeminal ganglion	UBERON:0001675	43.60	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
inferior vagus X ganglion	UBERON:0005363	42.74	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
layer of synovial tissue	UBERON:0007616	42.39	gold quality
skeletal muscle tissue	UBERON:0001134	42.29	gold quality
superior vestibular nucleus	UBERON:0007227	42.18	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
dorsal root ganglion	UBERON:0000044	41.24	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
ventral tegmental area	UBERON:0002691	40.93	gold quality
sperm	CL:0000019	40.86	gold quality
subthalamic nucleus	UBERON:0001906	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
medulla oblongata	UBERON:0001896	40.56	gold quality
Brodmann (1909) area 23	UBERON:0013554	40.48	gold quality
testis	UBERON:0000473	40.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.77

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10d3	ENSMUSG00000050853
rattus_norvegicus	Or10d3	ENSRNOG00000039236

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10D3 — Q8NH80 (reviewed: Q8NH80)

Alternative names: HTPCRX09, Olfactory receptor OR11-293

All UniProt accessions (1): Q8NH80

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001342142* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, sequence conflict 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH80-F1	89.04	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_UP, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

76 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10D3	DCHS2	Q6V1P9	269
OR10D3	SUPT3H	O75486	248
OR10D3	FUCA2	Q9BTY2	221
OR10D3	COL23A1	Q86Y22	213
OR10D3	SLC24A5	Q71RS6	207
OR10D3	OR52E5	Q8NH55	202
OR10D3	ANO2	Q9NQ90	200
OR10D3	PCDH7	O60245	174
OR10D3	RHO	P08100	168
OR10D3	LIMS1	P48059	160
OR10D3	EDAR	Q9UNE0	156
OR10D3	SLC45A2	Q9UMX9	155
OR10D3	FABP7	O15540	155
OR10D3	AGO3	Q9H9G7	155
OR10D3	OR51E1	Q8TCB6	149

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

315 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124185906:C:G	donor_gain	0.7400
11:124185592:G:GT	donor_gain	0.6900
11:124185391:G:T	donor_gain	0.6700
11:124185857:GAGG:G	donor_gain	0.6700
11:124185859:GG:G	donor_gain	0.6600
11:124185860:GG:G	donor_gain	0.6600
11:124185861:G:GG	donor_gain	0.6500
11:124185927:A:AG	acceptor_gain	0.6400
11:124185928:G:GG	acceptor_gain	0.6400
11:124185858:AGGGT:A	donor_loss	0.6300
11:124185859:GGGT:G	donor_loss	0.6300
11:124185861:G:GC	donor_loss	0.6300
11:124185862:T:TG	donor_loss	0.6300
11:124185863:GAGC:G	donor_loss	0.6300
11:124185928:GA:G	acceptor_gain	0.6300
11:124185961:CTG:C	acceptor_gain	0.6300
11:124185391:G:GT	donor_gain	0.6200
11:124185864:A:AC	donor_loss	0.6200
11:124185865:G:C	donor_loss	0.6200
11:124185273:G:GT	donor_gain	0.5800
11:124185392:A:T	donor_gain	0.5600
11:124185875:C:G	donor_gain	0.5600
11:124185316:G:T	donor_gain	0.5500
11:124185415:T:G	donor_gain	0.5500
11:124185963:G:GC	acceptor_gain	0.5500
11:124185772:ACTGT:A	acceptor_gain	0.5400
11:124185786:G:GT	donor_gain	0.5400
11:124185776:T:TA	acceptor_gain	0.5300
11:124185342:A:G	donor_gain	0.5200
11:124186149:G:GT	donor_gain	0.5200

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000304811 (11:124181911 C>G), RS1000427848 (11:124187954 A>T), RS1000824202 (11:124186789 T>C), RS1001151727 (11:124186455 T>C), RS1001286655 (11:124189142 G>C), RS1002801166 (11:124184316 G>A,C), RS1002901467 (11:124185471 G>A,T), RS1003043061 (11:124181502 A>G), RS1004776903 (11:124184577 G>A,C), RS1005269308 (11:124183428 TTCTC>T,TTC), RS1005391617 (11:124188828 A>T), RS1006543579 (11:124181475 T>C), RS1006618313 (11:124187647 T>C), RS1006946123 (11:124182015 C>T), RS1006992186 (11:124181614 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Hydrogen Peroxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.