OR10G2

Summary

OR10G2 (olfactory receptor family 10 subfamily G member 2, HGNC:8170) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 10G2 (Q8NGC3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26534 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001005466

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8170
Approved symbol	OR10G2
Name	olfactory receptor family 10 subfamily G member 2
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000255582
Ensembl biotype	protein_coding
Entrez	26534

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000542433

RefSeq mRNA: 1 — MANE Select: NM_001005466 NM_001005466

CCDS: CCDS32047

Canonical transcript exons

ENST00000542433 — 1 exons

Exon	Start	End
ENSE00002272088	21633836	21634940

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 39.99.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	39.99	gold quality
lymph node	UBERON:0000029	37.86	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
vermiform appendix	UBERON:0001154	36.29	silver quality
bone marrow cell	CL:0002092	36.16	gold quality
mucosa of transverse colon	UBERON:0004991	35.96	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	33.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
cortex of kidney	UBERON:0001225	31.07	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
spleen	UBERON:0002106	30.26	silver quality
leukocyte	CL:0000738	30.03	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.89	gold quality
gall bladder	UBERON:0002110	28.81	gold quality
duodenum	UBERON:0002114	28.14	gold quality
right coronary artery	UBERON:0001625	27.43	gold quality
urinary bladder	UBERON:0001255	26.79	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
endometrium	UBERON:0001295	25.70	gold quality
ectocervix	UBERON:0012249	25.53	gold quality
kidney	UBERON:0002113	25.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Expression of miR-135b, LZTS1, LATS2 and nuclear TAZ predicts poor outcomes of non-small-cell lung cancer. (PMID:23695671)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g1	ENSMUSG00000063106
mus_musculus	Or10g1b	ENSMUSG00000063867
rattus_norvegicus	Or10g1	ENSRNOG00000076863
rattus_norvegicus	Or10g1b	ENSRNOG00000079004

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10G2 — Q8NGC3 (reviewed: Q8NGC3)

All UniProt accessions (1): Q8NGC3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005466* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (25 total): topological domain 8, transmembrane region 7, sequence variant 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC3-F1	87.57	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZNF22_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

158 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G2	RNF212B	A8MTL3	613
OR10G2	STARD3NL	O95772	527
OR10G2	DAD1	P46966	473
OR10G2	ZNF17	P17021	447
OR10G2	TRDV1	A0A1B0GX56	425
OR10G2	TOX4	O94842	406
OR10G2	MAMDC4	Q6UXC1	397
OR10G2	ABHD1	Q96SE0	396
OR10G2	RNF212	Q495C1	370
OR10G2	A0A0B4J2G0	A0A0B4J2G0	370
OR10G2	CNIH3	Q8TBE1	360
OR10G2	EPHB6	O15197	355
OR10G2	HOGA1	Q86XE5	351
OR10G2	FAM111B	Q6SJ93	340
OR10G2	HNRNPCL1	O60812	339

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR10G2	ATP12A	psi-mi:“MI:0915”(physical association)	0.400

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

241 predictions. Top by Δscore:

Variant	Effect	Δscore
14:21633980:A:T	acceptor_gain	0.7800
14:21634146:T:C	donor_gain	0.7100
14:21634164:C:CC	acceptor_gain	0.7000
14:21634046:C:CC	acceptor_gain	0.6900
14:21634043:GCCC:G	acceptor_loss	0.6600
14:21634045:CCTAA:C	acceptor_loss	0.6600
14:21634046:C:CG	acceptor_loss	0.6600
14:21634047:T:C	acceptor_loss	0.6600
14:21634174:A:C	acceptor_gain	0.6600
14:21633957:TCA:T	acceptor_gain	0.6500
14:21634041:CAGCC:C	acceptor_gain	0.6500
14:21634166:A:AC	acceptor_gain	0.6300
14:21634044:CC:C	acceptor_gain	0.6200
14:21634045:CC:C	acceptor_gain	0.6200
14:21634129:C:A	donor_gain	0.6200
14:21634174:A:AC	acceptor_gain	0.6100
14:21634637:C:CA	donor_gain	0.6000
14:21634043:GCC:G	acceptor_gain	0.5900
14:21634044:CCC:C	acceptor_gain	0.5900
14:21634166:A:C	acceptor_gain	0.5900
14:21634160:TGGA:T	acceptor_gain	0.5800
14:21634048:A:C	acceptor_loss	0.5700
14:21633958:C:A	acceptor_gain	0.5600
14:21634215:C:A	donor_gain	0.5600
14:21633956:CTCAG:C	acceptor_gain	0.5500
14:21633979:C:CT	acceptor_gain	0.5500
14:21634051:G:GC	acceptor_gain	0.5400
14:21634086:C:CT	donor_gain	0.5400
14:21634173:CA:C	acceptor_gain	0.5400
14:21634083:TG:T	donor_gain	0.5100

AlphaMissense

1994 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000731336 (14:21633348 A>G), RS1003154311 (14:21634773 G>C,T), RS1003173702 (14:21635871 T>C), RS1003836627 (14:21636355 A>G), RS1004817035 (14:21635507 G>A), RS1005310406 (14:21636924 T>C), RS1005776514 (14:21636875 G>C), RS1007748421 (14:21635230 A>G), RS1009668000 (14:21633379 T>G), RS1009777346 (14:21633743 G>T), RS1011668812 (14:21636006 G>A), RS1011700879 (14:21633494 G>A), RS1011983858 (14:21636375 G>C), RS1012036287 (14:21635930 T>C), RS1012128197 (14:21634945 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	increases expression	1
Benzo(a)pyrene	increases methylation	1
Endosulfan	increases expression	1
Estradiol	affects expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.