OR10G3

Summary

OR10G3 (olfactory receptor family 10 subfamily G member 3, HGNC:8171) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 10G3 (Q8NGC4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26533 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 45 total — 1 pathogenic
• MANE Select transcript: NM_001005465

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8171
Approved symbol	OR10G3
Name	olfactory receptor family 10 subfamily G member 3
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000169208
Ensembl biotype	protein_coding
Entrez	26533

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000641040, ENST00000641185, ENST00000641655

RefSeq mRNA: 1 — MANE Select: NM_001005465 NM_001005465

CCDS: CCDS32046

Canonical transcript exons

ENST00000641040 — 2 exons

Exon	Start	End
ENSE00003811529	21579786	21580076
ENSE00003812410	21568520	21570761

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 79.50.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.50	gold quality
right lung	UBERON:0002167	57.10	gold quality
sural nerve	UBERON:0015488	56.53	gold quality
pituitary gland	UBERON:0000007	56.22	gold quality
adenohypophysis	UBERON:0002196	55.80	gold quality
blood	UBERON:0000178	55.50	gold quality
right lobe of liver	UBERON:0001114	55.27	gold quality
granulocyte	CL:0000094	52.85	gold quality
liver	UBERON:0002107	52.77	gold quality
stromal cell of endometrium	CL:0002255	52.61	silver quality
subcutaneous adipose tissue	UBERON:0002190	51.43	gold quality
calcaneal tendon	UBERON:0003701	51.32	silver quality
skeletal muscle tissue	UBERON:0001134	51.10	gold quality
ventricular zone	UBERON:0003053	50.99	silver quality
vermiform appendix	UBERON:0001154	50.07	gold quality
muscle tissue	UBERON:0002385	49.96	gold quality
upper lobe of left lung	UBERON:0008952	49.81	gold quality
myometrium	UBERON:0001296	49.64	gold quality
adipose tissue	UBERON:0001013	49.45	gold quality
tibial nerve	UBERON:0001323	49.32	gold quality
lung	UBERON:0002048	49.01	gold quality
body of uterus	UBERON:0009853	49.01	gold quality
descending thoracic aorta	UBERON:0002345	48.97	gold quality
bone marrow	UBERON:0002371	48.90	gold quality
heart left ventricle	UBERON:0002084	48.87	gold quality
right atrium auricular region	UBERON:0006631	48.80	gold quality
heart	UBERON:0000948	48.62	gold quality
apex of heart	UBERON:0002098	48.10	gold quality
left coronary artery	UBERON:0001626	48.00	gold quality
monocyte	CL:0000576	47.94	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75688	yes	843.99
E-ANND-3	yes	4.25

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g3	ENSMUSG00000094140
mus_musculus	Or10g3b	ENSMUSG00000095030
rattus_norvegicus	Or10g3c	ENSRNOG00000081762
rattus_norvegicus	Or10g3	ENSRNOG00000082912

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10G3 — Q8NGC4 (reviewed: Q8NGC4)

Alternative names: Olfactory receptor OR14-40

All UniProt accessions (2): Q8NGC4, A0A126GWE3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005465* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC4-F1	87.67	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (2): 5, 85

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr14q11

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

172 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G3	RNF212B	A8MTL3	615
OR10G3	KRTAP12-3	P60328	582
OR10G3	TMEM235	A6NFC5	508
OR10G3	C1QTNF8	P60827	433
OR10G3	TOX4	O94842	408
OR10G3	SPATA31D3	P0C874	391
OR10G3	CNGA2	Q16280	389
OR10G3	GNG8	Q9UK08	376
OR10G3	RNF212	Q495C1	374
OR10G3	DAD1	P46966	353
OR10G3	SPATA31D4	Q6ZUB0	348
OR10G3	LHFPL6	Q9Y693	336
OR10G3	GNAL	P38405	335
OR10G3	RAB2B	Q8WUD1	334
OR10G3	ANO2	Q9NQ90	327

IntAct

107 interactions, top by confidence:

A	B	Type	Score
OR10G3	PATJ	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	MAGI3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	MAGI2	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	DLG1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	APBA1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	HTRA4	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	ARHGAP21	psi-mi:“MI:0407”(direct interaction)	0.440
PDZD2	OR10G3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	MAGI1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	APBA3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	MAST1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	PDZRN4	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	LDB3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	PCLO	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	LNX1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	MPP2	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	LNX2	psi-mi:“MI:0407”(direct interaction)	0.440
PATJ	OR10G3	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	NHERF2	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	GRID2IP	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	GOPC	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	FRMPD1	psi-mi:“MI:0407”(direct interaction)	0.440
OR10G3	SNTB1	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (1): OR10G3 (Affinity Capture-Luminescence)

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 71 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neurexins and neuroligins	8	36.6×	6e-09
Assembly and cell surface presentation of NMDA receptors	6	35.4×	1e-06
Protein-protein interactions at synapses	5	30.9×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	9	76.9×	7e-13
protein localization to synapse	6	67.6×	5e-08
receptor clustering	6	55.1×	1e-07
regulation of postsynaptic membrane neurotransmitter receptor levels	6	43.7×	4e-07
protein-containing complex assembly	9	15.1×	6e-07
cell-cell adhesion	9	13.4×	1e-06
protein localization to plasma membrane	5	8.0×	6e-03
chemical synaptic transmission	7	8.0×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	38
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2580329	GRCh37/hg19 14q11.2(chr14:21851693-22089506)x1	Pathogenic

SpliceAI

114 predictions. Top by Δscore:

Variant	Effect	Δscore
14:21570677:AG:A	donor_gain	0.9500
14:21570678:G:C	donor_gain	0.8800
14:21570145:CG:C	donor_gain	0.7500
14:21570146:G:GC	donor_gain	0.6900
14:21570147:TC:T	donor_gain	0.6600
14:21570219:C:CT	donor_gain	0.6500
14:21570672:T:TA	donor_gain	0.6500
14:21570078:TGAT:T	acceptor_gain	0.6400
14:21570080:ATC:A	acceptor_loss	0.6400
14:21570081:TCTG:T	acceptor_loss	0.6400
14:21570082:C:G	acceptor_loss	0.6400
14:21570083:T:C	acceptor_loss	0.6400
14:21570220:C:CT	donor_gain	0.6300
14:21570082:C:CC	acceptor_gain	0.6100
14:21570218:T:C	donor_gain	0.6000
14:21570080:AT:A	acceptor_gain	0.5500
14:21570086:A:AC	acceptor_gain	0.5500
14:21570077:ATGAT:A	acceptor_gain	0.5400
14:21570697:T:TA	donor_gain	0.5400
14:21570694:AATT:A	donor_gain	0.5100
14:21569870:C:CT	acceptor_gain	0.4900
14:21570080:ATCTG:A	acceptor_gain	0.4800
14:21570081:TCTGT:T	acceptor_gain	0.4800
14:21570086:A:C	acceptor_gain	0.4800
14:21570152:A:T	donor_gain	0.4800
14:21570082:CT:C	acceptor_gain	0.4600
14:21570084:G:C	acceptor_gain	0.4600
14:21570018:C:CT	acceptor_gain	0.4500
14:21570088:G:C	acceptor_gain	0.4500
14:21570678:G:A	donor_gain	0.4500

AlphaMissense

2019 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:21570365:A:T	I127K	0.954
14:21570709:A:C	F12L	0.951
14:21570709:A:T	F12L	0.951
14:21570711:A:G	F12L	0.951
14:21570388:C:A	M119I	0.949
14:21570388:C:G	M119I	0.949
14:21570388:C:T	M119I	0.949
14:21570415:G:C	S110R	0.949
14:21570415:G:T	S110R	0.949
14:21570417:T:G	S110R	0.949
14:21570115:A:C	S210R	0.946
14:21570115:A:T	S210R	0.946
14:21570117:T:G	S210R	0.946
14:21569890:G:C	N285K	0.928
14:21569890:G:T	N285K	0.928
14:21570377:C:A	R123M	0.917
14:21570297:A:G	W150R	0.911
14:21570297:A:T	W150R	0.911
14:21570028:A:C	F239L	0.904
14:21570028:A:T	F239L	0.904
14:21570030:A:G	F239L	0.904
14:21570526:G:C	S73R	0.904
14:21570526:G:T	S73R	0.904
14:21570528:T:G	S73R	0.904
14:21570380:T:G	D122A	0.898
14:21570365:A:C	I127R	0.897
14:21570380:T:A	D122V	0.893
14:21570114:A:G	C211R	0.892
14:21570250:G:C	F165L	0.891
14:21570250:G:T	F165L	0.891

dbSNP variants (sampled 300 via entrez): RS1000351598 (14:21581440 A>G), RS1000668873 (14:21572379 A>G), RS1000669249 (14:21570946 C>G,T), RS1000722064 (14:21577332 C>T), RS1001039680 (14:21571341 T>C), RS1001920182 (14:21578793 A>G), RS1001975475 (14:21579178 T>C), RS1002192641 (14:21572878 C>CTG), RS1002308161 (14:21572826 A>G), RS1002455688 (14:21568251 T>C), RS1002527054 (14:21568343 C>A,G,T), RS1002571983 (14:21568435 C>A), RS1002671227 (14:21573972 A>T), RS1002921828 (14:21580076 C>T), RS1002975516 (14:21580509 A>G)

Disease associations

OMIM: gene `` | disease phenotypes: MIM:615032

GenCC curated gene-disease

Mondo (1): intellectual developmental disorder with autism and macrocephaly (MONDO:0014017)

Orphanet (1): CHD8 overgrowth syndrome (Orphanet:642675)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010136_27	Fruit consumption	5.000000e-19

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation, increases expression	2

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.