OR10G4

Summary

OR10G4 (olfactory receptor family 10 subfamily G member 4, HGNC:14809) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 10G4 (Q8NGN3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390264 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001004462

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14809
Approved symbol	OR10G4
Name	olfactory receptor family 10 subfamily G member 4
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000254737
Ensembl biotype	protein_coding
Entrez	390264

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641521, ENST00000641722

RefSeq mRNA: 1 — MANE Select: NM_001004462 NM_001004462

CCDS: CCDS31702

Canonical transcript exons

ENST00000641722 — 2 exons

Exon	Start	End
ENSE00003811948	124015548	124018732
ENSE00003814053	124012997	124013112

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 70.58.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	70.58	gold quality
body of pancreas	UBERON:0001150	49.89	gold quality
pancreas	UBERON:0001264	43.65	gold quality
colonic epithelium	UBERON:0000397	41.39	gold quality
mucosa of transverse colon	UBERON:0004991	40.95	silver quality
placenta	UBERON:0001987	40.58	gold quality
ventricular zone	UBERON:0003053	39.94	gold quality
rectum	UBERON:0001052	39.24	silver quality
stromal cell of endometrium	CL:0002255	38.89	gold quality
granulocyte	CL:0000094	37.72	gold quality
ganglionic eminence	UBERON:0004023	37.11	gold quality
lower esophagus mucosa	UBERON:0035834	37.04	gold quality
skeletal muscle tissue	UBERON:0001134	36.55	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.33	gold quality
muscle tissue	UBERON:0002385	34.46	gold quality
mucosa of stomach	UBERON:0001199	34.01	gold quality
superior frontal gyrus	UBERON:0002661	33.36	gold quality
bone marrow	UBERON:0002371	32.84	gold quality
leukocyte	CL:0000738	32.35	gold quality
monocyte	CL:0000576	31.64	gold quality
liver	UBERON:0002107	31.53	gold quality
prefrontal cortex	UBERON:0000451	31.13	gold quality
adrenal tissue	UBERON:0018303	30.98	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
tonsil	UBERON:0002372	30.27	gold quality
vermiform appendix	UBERON:0001154	29.23	gold quality
lymph node	UBERON:0000029	28.72	gold quality
right uterine tube	UBERON:0001302	28.65	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.93
E-GEOD-124858	no	44.75
E-MTAB-7249	no	11.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study verified that variations in OR10G4 genotype explain over 15% of the observed variation in perceived intensity and over 10% of the observed variation in perceived valence for the high-affinity in vitro agonist guaiacol. (PMID:24316890)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g7	ENSMUSG00000044292
mus_musculus	Or10g9	ENSMUSG00000059473
mus_musculus	Or10g9b	ENSMUSG00000060254
rattus_norvegicus	Or10g9	ENSRNOG00000058082
rattus_norvegicus	Or10g9b	ENSRNOG00000059229

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10G4 — Q8NGN3 (reviewed: Q8NGN3)

Alternative names: Olfactory receptor OR11-278

All UniProt accessions (2): A0A126GWS5, Q8NGN3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004462* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (29 total): sequence variant 11, topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN3-F1	87.95	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

164 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G4	GAL3ST3	Q96A11	400
OR10G4	PLEKHG4B	Q96PX9	400
OR10G4	RTP2	Q5QGT7	397
OR10G4	SPATA17	Q96L03	367
OR10G4	RTP1	P59025	357
OR10G4	ATP13A5	Q4VNC0	348
OR10G4	NAA30	Q147X3	336
OR10G4	RABL6	Q3YEC7	300
OR10G4	INPP5B	P32019	272
OR10G4	ADPGK	Q9BRR6	269
OR10G4	TELO2	Q9Y4R8	266
OR10G4	EIF3L	Q9Y262	256
OR10G4	EPPK1	P58107	253
OR10G4	PDIA2	Q13087	248
OR10G4	BCAS3	Q9H6U6	248

IntAct

7 interactions, top by confidence:

A	B	Type	Score
RPL12	OR10G4	psi-mi:“MI:0915”(physical association)	0.560
B4GALT1	OR10G4	psi-mi:“MI:0915”(physical association)	0.560
OR10G4	RPL12	psi-mi:“MI:0915”(physical association)	0.000
OR10G4	B4GALT1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): OR10G4 (Two-hybrid), OR10G4 (Two-hybrid), RIMKLB (Cross-Linking-MS (XL-MS)), DNAJC7 (Cross-Linking-MS (XL-MS)), MIPOL1 (Cross-Linking-MS (XL-MS)), OR10G4 (Cross-Linking-MS (XL-MS)), OR10G4 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A096LPK9, O95918, P0C623, P0C645, P0DN82, P23266, P58180, P58182, Q15615, Q60878, Q60881, Q60882, Q6IF00, Q6IF82, Q6UXT6, Q8IXE1, Q8N0Y3, Q8NGB4, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD5, Q8NGE5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGM1, Q8NGN0, Q8NGN3, Q8NGN4, Q8NGN5, Q8NGN6, Q8NGN8, Q8NGX2

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	11
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

216 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124016078:T:TA	acceptor_gain	0.8500
11:124015713:A:AG	donor_gain	0.7800
11:124016074:ACTGT:A	acceptor_gain	0.7000
11:124015744:T:G	donor_gain	0.6900
11:124015748:C:CG	donor_gain	0.6800
11:124015859:C:G	donor_gain	0.6800
11:124016076:T:A	acceptor_gain	0.6500
11:124016079:G:A	acceptor_gain	0.6500
11:124016451:G:GT	donor_gain	0.6500
11:124015977:A:G	donor_gain	0.6400
11:124015959:CTCAG:C	donor_loss	0.5900
11:124015960:TCAGG:T	donor_loss	0.5900
11:124015962:AGG:A	donor_loss	0.5900
11:124015963:GG:G	donor_loss	0.5900
11:124015964:G:C	donor_loss	0.5900
11:124015965:T:A	donor_loss	0.5900
11:124015966:A:C	donor_loss	0.5600
11:124016251:G:A	acceptor_gain	0.5600
11:124015667:G:GA	donor_gain	0.5500
11:124015783:G:GA	donor_gain	0.5400
11:124015894:G:T	donor_gain	0.5400
11:124016250:C:CA	acceptor_gain	0.5400
11:124016348:TCTG:T	acceptor_gain	0.5200
11:124016488:T:TA	donor_gain	0.5100
11:124016489:A:AA	donor_gain	0.5100
11:124015958:GCTCA:G	donor_loss	0.5000
11:124016305:G:GG	donor_gain	0.4900
11:124015891:T:A	acceptor_gain	0.4800
11:124016165:C:A	donor_gain	0.4800
11:124016245:T:G	acceptor_gain	0.4800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000144342 (11:124011253 A>G), RS1000181650 (11:124011127 C>A), RS1000393936 (11:124016430 G>A,T), RS1000580941 (11:124016149 C>A,G), RS1000650767 (11:124017126 C>A), RS1002400411 (11:124014567 A>T), RS1002665301 (11:124018212 A>G,T), RS1003056131 (11:124018724 G>A,T), RS1003107003 (11:124018962 A>G), RS1003377363 (11:124017435 C>T), RS1003442578 (11:124017743 G>A,T), RS1003448551 (11:124012917 C>T), RS1004308781 (11:124014828 A>G), RS1005240167 (11:124018587 T>A,C), RS1005384482 (11:124015295 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
hydroxyhydroquinone	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.