OR10G6

Summary

OR10G6 (olfactory receptor family 10 subfamily G member 6, HGNC:14836) is a protein-coding gene on chromosome 11q24.1, encoding Olfactory receptor 10G6 (Q8NH81). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 79490 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001355219

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14836
Approved symbol	OR10G6
Name	olfactory receptor family 10 subfamily G member 6
Location	11q24.1
Locus type	gene with protein product
Status	Approved
Aliases	OR10G6Q
Ensembl gene	ENSG00000198674
Ensembl biotype	protein_coding
Entrez	79490

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000307002

RefSeq mRNA: 1 — MANE Select: NM_001355219 NM_001355219

CCDS: CCDS86256

Canonical transcript exons

ENST00000307002 — 1 exons

Exon	Start	End
ENSE00001133915	123994163	123995161

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.89.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	41.89	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.46	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
tonsil	UBERON:0002372	28.85	gold quality
liver	UBERON:0002107	28.64	gold quality
corpus callosum	UBERON:0002336	28.46	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
leukocyte	CL:0000738	26.20	gold quality
monocyte	CL:0000576	26.07	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
blood	UBERON:0000178	25.90	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
calcaneal tendon	UBERON:0003701	25.00	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
kidney	UBERON:0002113	24.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.13

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g6	ENSMUSG00000046678
rattus_norvegicus	Or10g6	ENSRNOG00000064020

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10G6 — Q8NH81 (reviewed: Q8NH81)

Alternative names: Olfactory receptor OR11-280

All UniProt accessions (2): Q8NH81, A0A126GVD6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001342148* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH81-F1	85.43	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 118–210

Glycosylation sites (1): 26

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, DACH1_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

92 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G6	CCDC198	Q9NVL8	615
OR10G6	SLC35F4	A4IF30	575
OR10G6	UBXN10	Q96LJ8	517
OR10G6	JADE2	Q9NQC1	454
OR10G6	PPM1H	Q9ULR3	418
OR10G6	SEC24A	O95486	390
OR10G6	HPSE2	Q8WWQ2	376
OR10G6	SAR1B	Q9Y6B6	355
OR10G6	JAML	Q86YT9	346
OR10G6	CTSW	P56202	339
OR10G6	CTSF	Q9UBX1	325
OR10G6	ZNF613	Q6PF04	323
OR10G6	UBE2B	P23567	301
OR10G6	STARD3NL	O95772	272
OR10G6	TCERG1L	Q5VWI1	246

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

230 predictions. Top by Δscore:

Variant	Effect	Δscore
11:123994833:C:CT	donor_gain	0.8000
11:123994834:T:TT	donor_gain	0.8000
11:123994605:C:T	acceptor_gain	0.6800
11:123994836:C:A	donor_gain	0.6800
11:123994591:C:CT	acceptor_gain	0.6700
11:123995028:C:CA	donor_gain	0.6600
11:123994605:C:CT	acceptor_gain	0.6500
11:123994831:TAC:T	donor_gain	0.6500
11:123994832:A:AC	donor_gain	0.6300
11:123995100:T:TA	donor_gain	0.6200
11:123994444:C:CT	acceptor_gain	0.5800
11:123994835:A:AA	donor_gain	0.5700
11:123995147:AACAC:A	donor_gain	0.5700
11:123995032:G:C	donor_gain	0.5500
11:123994533:CAGG:C	acceptor_gain	0.5400
11:123994552:C:CT	acceptor_gain	0.5400
11:123994445:A:C	acceptor_gain	0.5100
11:123994432:C:CC	acceptor_gain	0.5000
11:123994285:C:CT	donor_gain	0.4900
11:123994343:A:C	acceptor_gain	0.4900
11:123994429:CAG:C	acceptor_gain	0.4900
11:123995088:C:CT	donor_gain	0.4900
11:123994602:A:T	acceptor_gain	0.4800
11:123994833:CTA:C	donor_gain	0.4800
11:123994832:ACTAC:A	donor_gain	0.4700
11:123994833:CTACC:C	donor_gain	0.4700
11:123994923:A:C	donor_gain	0.4700
11:123995145:TCAA:T	donor_gain	0.4700
11:123995146:CAAC:C	donor_gain	0.4700
11:123995147:AACA:A	donor_gain	0.4700

AlphaMissense

2152 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:123994595:G:C	F189L	0.918
11:123994595:G:T	F189L	0.918
11:123994597:A:G	F189L	0.918
11:123995063:G:C	F33L	0.903
11:123995063:G:T	F33L	0.903
11:123995065:A:G	F33L	0.903
11:123994607:G:C	F185L	0.876
11:123994607:G:T	F185L	0.876
11:123994609:A:G	F185L	0.876
11:123994565:G:C	F199L	0.859
11:123994565:G:T	F199L	0.859
11:123994567:A:G	F199L	0.859
11:123994730:G:C	F144L	0.854
11:123994730:G:T	F144L	0.854
11:123994732:A:G	F144L	0.854
11:123994793:A:C	F123L	0.829
11:123994793:A:T	F123L	0.829
11:123994795:A:G	F123L	0.829
11:123994787:G:C	F125L	0.826
11:123994787:G:T	F125L	0.826
11:123994789:A:G	F125L	0.826
11:123994385:G:C	F259L	0.813
11:123994385:G:T	F259L	0.813
11:123994387:A:G	F259L	0.813
11:123995006:G:C	F52L	0.810
11:123995006:G:T	F52L	0.810
11:123995008:A:G	F52L	0.810
11:123994817:A:C	F115L	0.805
11:123994817:A:T	F115L	0.805
11:123994819:A:G	F115L	0.805

dbSNP variants (sampled 300 via entrez): RS1001427191 (11:123993908 A>G), RS1001466177 (11:123996395 CTG>C), RS1001559445 (11:123996133 A>C,G), RS1001893085 (11:123994794 A>G,T), RS1002869934 (11:123996457 T>G), RS1003183740 (11:123995275 T>A), RS1003426322 (11:123995457 A>T), RS1004939856 (11:123996687 A>C,T), RS1005133964 (11:123997049 A>G), RS1005678793 (11:123995504 A>G), RS1006402669 (11:123995657 A>C), RS1006702600 (11:123994201 G>C), RS1006777438 (11:123995355 C>G), RS1006938828 (11:123994306 G>A), RS1007339903 (11:123994542 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.