OR10G7

Summary

OR10G7 (olfactory receptor family 10 subfamily G member 7, HGNC:14842) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 10G7 (Q8NGN6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390265 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_001004463

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14842
Approved symbol	OR10G7
Name	olfactory receptor family 10 subfamily G member 7
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000182634
Ensembl biotype	protein_coding
Entrez	390265

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641585

RefSeq mRNA: 1 — MANE Select: NM_001004463 NM_001004463

CCDS: CCDS31705

Canonical transcript exons

ENST00000641585 — 2 exons

Exon	Start	End
ENSE00003812448	124036013	124039021
ENSE00003813089	124040886	124041325

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.06.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	41.06	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	34.23	gold quality
mucosa of transverse colon	UBERON:0004991	33.98	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
body of pancreas	UBERON:0001150	32.87	gold quality
prefrontal cortex	UBERON:0000451	32.68	gold quality
leukocyte	CL:0000738	32.46	gold quality
monocyte	CL:0000576	32.43	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
pancreas	UBERON:0001264	32.01	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
placenta	UBERON:0001987	30.77	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	28.53	gold quality
liver	UBERON:0002107	28.51	gold quality
islet of Langerhans	UBERON:0000006	28.22	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
frontal cortex	UBERON:0001870	26.89	gold quality
rectum	UBERON:0001052	26.88	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.35	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• OR10G7 is expressed at significantly greater levels in undifferentiated keratinocytes from patients with atopic dermatitis compared with healthy control subjects (PMID:30445058)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g7	ENSMUSG00000044292
mus_musculus	Or10g9	ENSMUSG00000059473
mus_musculus	Or10g9b	ENSMUSG00000060254
rattus_norvegicus	Or10g9	ENSRNOG00000058082
rattus_norvegicus	Or10g9b	ENSRNOG00000059229

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10G7 — Q8NGN6 (reviewed: Q8NGN6)

Alternative names: Olfactory receptor OR11-283

All UniProt accessions (2): Q8NGN6, A0A126GWF3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004463* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (25 total): topological domain 8, transmembrane region 7, sequence variant 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN6-F1	87.32	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

166 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G7	TAS2R60	P59551	418
OR10G7	TMEM248	Q9NWD8	417
OR10G7	RTP1	P59025	357
OR10G7	CHRM4	P08173	351
OR10G7	ATP1B4	Q9UN42	349
OR10G7	CHRM1	P11229	349
OR10G7	STX10	O60499	316
OR10G7	CSHL1	Q14406	312
OR10G7	NXNL1	Q96CM4	306
OR10G7	INHBC	P55103	288
OR10G7	TNP2	Q05952	286
OR10G7	OR1D2	P34982	282
OR10G7	TAS2R38	P59533	268
OR10G7	NHLH2	Q02577	258
OR10G7	EIF2B1	Q14232	250

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10G7 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A6NH00, O43749, O60403, O76001, O76002, O95371, O95918, P23266, P23267, P23275, P34984, P58173, Q13607, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60890, Q60894, Q7Z3T1, Q8N148, Q8N628, Q8NG76, Q8NG97, Q8NGA6, Q8NGC3, Q8NGN4, Q8NGN6, Q8NGQ4, Q8NGT9, Q8NGX0, Q8NGY1, Q8NGY5, Q8NGZ4, Q8NGZ6, Q8NHB1, Q8VGD6, Q95156, Q96KK4, Q96R30

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

220 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124038497:C:CT	acceptor_gain	0.8400
11:124038124:T:TA	donor_gain	0.6800
11:124038121:ACCT:A	donor_gain	0.5900
11:124038122:CCTC:C	donor_gain	0.5900
11:124038607:GTGTA:G	donor_loss	0.5700
11:124038608:TGTA:T	donor_loss	0.5700
11:124038609:GTACC:G	donor_loss	0.5700
11:124038610:TACCT:T	donor_loss	0.5700
11:124038611:A:AT	donor_loss	0.5700
11:124038612:CC:C	donor_loss	0.5700
11:124038500:A:T	acceptor_gain	0.5600
11:124038613:C:A	donor_loss	0.5600
11:124038242:C:CT	acceptor_gain	0.5500
11:124038497:C:T	acceptor_gain	0.5500
11:124038717:G:C	donor_gain	0.5300
11:124038135:CAGGG:C	acceptor_gain	0.5100
11:124038141:G:C	acceptor_gain	0.5100
11:124038307:C:A	donor_gain	0.5100
11:124038392:G:A	donor_gain	0.5100
11:124038154:T:TC	acceptor_gain	0.4900
11:124038411:G:T	donor_gain	0.4800
11:124038606:GGTGT:G	donor_loss	0.4800
11:124038832:A:C	donor_gain	0.4800
11:124038306:C:A	donor_gain	0.4700
11:124038325:C:CT	acceptor_gain	0.4700
11:124038325:C:T	acceptor_gain	0.4700
11:124038305:T:TA	donor_gain	0.4600
11:124038614:T:C	donor_loss	0.4600
11:124038224:TCAG:T	acceptor_gain	0.4500
11:124038136:A:T	acceptor_gain	0.4400

AlphaMissense

2014 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124038651:C:A	M117I	0.967
11:124038651:C:G	M117I	0.967
11:124038651:C:T	M117I	0.967
11:124038640:C:G	R121P	0.966
11:124038678:G:C	S108R	0.962
11:124038678:G:T	S108R	0.962
11:124038680:T:G	S108R	0.962
11:124038972:G:C	F10L	0.942
11:124038972:G:T	F10L	0.942
11:124038974:A:G	F10L	0.942
11:124038257:A:G	C249R	0.933
11:124038643:T:G	D120A	0.931
11:124038628:A:T	I125N	0.930
11:124038643:T:A	D120V	0.930
11:124038882:G:C	N40K	0.923
11:124038882:G:T	N40K	0.923
11:124038513:G:C	F163L	0.921
11:124038513:G:T	F163L	0.921
11:124038515:A:G	F163L	0.921
11:124038649:G:A	S118F	0.919
11:124038377:A:G	C209R	0.917
11:124038642:A:C	D120E	0.917
11:124038642:A:T	D120E	0.917
11:124038272:A:G	C244R	0.916
11:124038641:G:T	R121S	0.913
11:124038628:A:C	I125S	0.908
11:124038628:A:G	I125T	0.905
11:124038808:G:T	S65Y	0.905
11:124038560:A:G	W148R	0.904
11:124038560:A:T	W148R	0.904

dbSNP variants (sampled 300 via entrez): RS1000884294 (11:124041237 C>T), RS1001050967 (11:124038961 C>A,T), RS1001233592 (11:124035936 G>A,T), RS1001250530 (11:124040239 T>G), RS1002025822 (11:124037298 T>A), RS1002899562 (11:124038897 G>A), RS1003231592 (11:124037980 C>T), RS1004364588 (11:124039131 T>C), RS1004646192 (11:124038010 G>A,T), RS1005392232 (11:124039281 T>A), RS1005922852 (11:124042009 T>C), RS1006094232 (11:124038030 A>C,G), RS1006261756 (11:124042304 G>A), RS1006542003 (11:124040426 T>C), RS1007397384 (11:124037112 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001540_2	Male fertility	9.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004803	male fertility
EFO:0004804	birth rate

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.