OR10G8

Summary

OR10G8 (olfactory receptor family 10 subfamily G member 8, HGNC:14845) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 10G8 (Q8NGN5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219869 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total
• MANE Select transcript: NM_001004464

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14845
Approved symbol	OR10G8
Name	olfactory receptor family 10 subfamily G member 8
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000234560
Ensembl biotype	protein_coding
Entrez	219869

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000431524, ENST00000641224

RefSeq mRNA: 1 — MANE Select: NM_001004464 NM_001004464

CCDS: CCDS31704

Canonical transcript exons

ENST00000641224 — 2 exons

Exon	Start	End
ENSE00003811645	124026798	124026867
ENSE00003813213	124029596	124030634

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 54.64.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.64	gold quality
sural nerve	UBERON:0015488	38.01	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.39	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
pancreas	UBERON:0001264	28.09	gold quality
monocyte	CL:0000576	28.03	gold quality
leukocyte	CL:0000738	27.99	gold quality
urinary bladder	UBERON:0001255	27.90	gold quality
rectum	UBERON:0001052	27.67	silver quality
lymph node	UBERON:0000029	27.57	gold quality
body of pancreas	UBERON:0001150	27.32	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.28	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g7	ENSMUSG00000044292
mus_musculus	Or10g9	ENSMUSG00000059473
mus_musculus	Or10g9b	ENSMUSG00000060254
rattus_norvegicus	Or10g9	ENSRNOG00000058082
rattus_norvegicus	Or10g9b	ENSRNOG00000059229

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10G8 — Q8NGN5 (reviewed: Q8NGN5)

Alternative names: Olfactory receptor OR11-282

All UniProt accessions (2): Q8NGN5, A0A126GVX3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004464* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN5-F1	88.30	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, BPTF_TARGET_GENES, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

238 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G8	TAS2R13	Q9NYV9	520
OR10G8	VN1R4	Q7Z5H5	507
OR10G8	TAS2R5	Q9NYW4	480
OR10G8	TAS2R50	P59544	480
OR10G8	TAS2R10	Q9NYW0	477
OR10G8	VN1R2	Q8NFZ6	475
OR10G8	TAS2R14	Q9NYV8	444
OR10G8	VN1R1	Q9GZP7	400
OR10G8	ZNF232	Q9UNY5	377
OR10G8	TAS2R38	P59533	376
OR10G8	ZNF804B	A4D1E1	369
OR10G8	APCDD1L	Q8NCL9	359
OR10G8	CHRM4	P08173	351
OR10G8	CHRM1	P11229	349
OR10G8	TAS2R31	P59538	348

IntAct

0 interactions, top by confidence:

BioGRID (1): OR10G8 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: O60403, O76001, O76002, O95222, O95918, P23266, P23267, P23275, P34984, P58173, Q13607, Q5TZ20, Q60885, Q60890, Q60894, Q7Z3T1, Q8N148, Q8N628, Q8NGA6, Q8NGC3, Q8NGC4, Q8NGI7, Q8NGJ0, Q8NGN1, Q8NGN4, Q8NGN5, Q8NGN6, Q8NGN7, Q8NGQ2, Q8NGQ4, Q8NGT9, Q8NGX0, Q8NGX9, Q8NGY1, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NH04, Q8NHB1

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	13
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

277 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124029831:G:GA	donor_gain	0.9900
11:124029815:T:TA	donor_gain	0.9600
11:124029830:T:TA	donor_gain	0.9400
11:124029796:C:CG	donor_gain	0.9300
11:124029761:A:AG	donor_gain	0.9200
11:124029766:G:GT	donor_gain	0.9200
11:124029792:T:G	donor_gain	0.9200
11:124029769:G:GA	donor_gain	0.8900
11:124029849:TGCCC:T	donor_gain	0.8900
11:124029715:G:GA	donor_gain	0.8800
11:124029768:T:TA	donor_gain	0.8400
11:124029714:T:TA	donor_gain	0.8100
11:124029852:C:G	donor_gain	0.8000
11:124029771:A:G	donor_gain	0.7700
11:124029851:C:CG	donor_gain	0.7700
11:124029762:T:G	donor_gain	0.7600
11:124029759:TGATC:T	donor_gain	0.7300
11:124029846:C:CA	donor_gain	0.7100
11:124029767:G:T	donor_gain	0.7000
11:124029793:G:GG	donor_gain	0.6900
11:124029828:T:G	donor_gain	0.6900
11:124029756:T:A	donor_gain	0.6700
11:124029850:G:A	donor_gain	0.6500
11:124029845:AC:A	donor_gain	0.6400
11:124029794:T:TA	donor_gain	0.6300
11:124029795:A:AA	donor_gain	0.6300
11:124030126:T:TA	acceptor_gain	0.6100
11:124029832:G:GG	donor_gain	0.6000
11:124029765:GG:G	donor_gain	0.5900
11:124029875:TTCCC:T	donor_gain	0.5900

AlphaMissense

2015 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124029650:T:C	F10L	0.829
11:124029652:C:A	F10L	0.829
11:124029652:C:G	F10L	0.829
11:124030331:T:C	F237L	0.750
11:124030333:T:A	F237L	0.750
11:124030333:T:G	F237L	0.750
11:124030373:T:C	F251L	0.725
11:124030375:T:A	F251L	0.725
11:124030375:T:G	F251L	0.725
11:124029707:T:C	F29L	0.711
11:124029709:C:A	F29L	0.711
11:124029709:C:G	F29L	0.711
11:124030109:T:C	F163L	0.710
11:124030111:C:A	F163L	0.710
11:124030111:C:G	F163L	0.710
11:124030370:T:C	F250L	0.703
11:124030372:C:A	F250L	0.703
11:124030372:C:G	F250L	0.703
11:124030442:T:C	F274L	0.696
11:124030444:C:A	F274L	0.696
11:124030444:C:G	F274L	0.696
11:124029899:T:C	F93L	0.673
11:124029901:C:A	F93L	0.673
11:124029901:C:G	F93L	0.673
11:124029833:T:C	F71L	0.644
11:124029835:C:A	F71L	0.644
11:124029835:C:G	F71L	0.644
11:124029698:T:C	F26L	0.629
11:124029700:T:A	F26L	0.629
11:124029700:T:G	F26L	0.629

dbSNP variants (sampled 300 via entrez): RS1000562822 (11:124025728 A>G), RS1000617513 (11:124030745 T>C), RS1000626493 (11:124027142 C>T), RS1000997850 (11:124026980 A>C), RS1001272165 (11:124025186 G>T), RS1001336834 (11:124026617 C>A), RS1001724979 (11:124025428 ATTATG>A), RS1003037726 (11:124028868 G>T), RS1003073798 (11:124028623 A>C,G), RS1003407526 (11:124027416 T>C), RS1004173454 (11:124027406 CATAG>C,CATAGATAG), RS1005105280 (11:124028875 A>C,G), RS1005485450 (11:124029169 G>A), RS1005795695 (11:124025519 G>A), RS1005800293 (11:124030354 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
tebuconazole	decreases expression	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.