OR10G9

Summary

OR10G9 (olfactory receptor family 10 subfamily G member 9, HGNC:15129) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 10G9 (Q8NGN4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219870 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001001953

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15129
Approved symbol	OR10G9
Name	olfactory receptor family 10 subfamily G member 9
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000236981
Ensembl biotype	protein_coding
Entrez	219870

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000375024

RefSeq mRNA: 1 — MANE Select: NM_001001953 NM_001001953

CCDS: CCDS31703

Canonical transcript exons

ENST00000375024 — 1 exons

Exon	Start	End
ENSE00002438214	124023013	124023948

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 43.64.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	43.64	silver quality
granulocyte	CL:0000094	37.72	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
liver	UBERON:0002107	29.12	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
pancreas	UBERON:0001264	27.28	gold quality
tonsil	UBERON:0002372	27.05	gold quality
superior frontal gyrus	UBERON:0002661	26.73	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
body of pancreas	UBERON:0001150	26.53	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.07	gold quality
leukocyte	CL:0000738	26.01	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
monocyte	CL:0000576	25.19	gold quality
muscle of leg	UBERON:0001383	25.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10g7	ENSMUSG00000044292
mus_musculus	Or10g9	ENSMUSG00000059473
mus_musculus	Or10g9b	ENSMUSG00000060254
rattus_norvegicus	Or10g9	ENSRNOG00000058082
rattus_norvegicus	Or10g9b	ENSRNOG00000059229

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 10G9 — Q8NGN4 (reviewed: Q8NGN4)

Alternative names: Olfactory receptor 10G10

All UniProt accessions (1): Q8NGN4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001953* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN4-F1	87.39	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10G9	SPATA3	Q8NHX4	401
OR10G9	VCX2	Q9H322	397
OR10G9	SPAG8	Q99932	374
OR10G9	CCDC136	Q96JN2	350
OR10G9	PITPNB	P48739	349
OR10G9	MAP3K15	Q6ZN16	324
OR10G9	SPEG	Q15772	323
OR10G9	MGARP	Q8TDB4	306
OR10G9	CNTNAP4	Q9C0A0	306
OR10G9	GRAMD1B	Q3KR37	302
OR10G9	KCTD11	Q693B1	300
OR10G9	SCUBE1	Q8IWY4	277
OR10G9	ASB4	Q9Y574	270
OR10G9	TRIM58	Q8NG06	270
OR10G9	RTP1	P59025	262

IntAct

0 interactions, top by confidence:

BioGRID (5): RIMKLB (Cross-Linking-MS (XL-MS)), DNAJC7 (Cross-Linking-MS (XL-MS)), MIPOL1 (Cross-Linking-MS (XL-MS)), OR10G9 (Cross-Linking-MS (XL-MS)), OR10G9 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A6NH00, O43749, O60403, O76001, O76002, O95371, O95918, P23266, P23267, P23275, P34984, P58173, Q13607, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60890, Q60894, Q7Z3T1, Q8N148, Q8N628, Q8NG76, Q8NG97, Q8NGA6, Q8NGC3, Q8NGN4, Q8NGN6, Q8NGQ4, Q8NGT9, Q8NGX0, Q8NGY1, Q8NGY5, Q8NGZ4, Q8NGZ6, Q8NHB1, Q8VGD6, Q95156, Q96KK4, Q96R30

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

239 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124023151:A:AG	donor_gain	0.7300
11:124023516:T:TA	acceptor_gain	0.7300
11:124023297:C:G	donor_gain	0.6600
11:124023186:C:CG	donor_gain	0.6300
11:124023889:G:GT	donor_gain	0.6300
11:124023689:G:A	acceptor_gain	0.6200
11:124023182:T:G	donor_gain	0.6000
11:124023772:T:TA	acceptor_gain	0.5900
11:124023786:CCTG:C	acceptor_gain	0.5900
11:124023415:A:G	donor_gain	0.5800
11:124023512:ACTGT:A	acceptor_gain	0.5700
11:124023707:G:T	donor_gain	0.5700
11:124023105:G:GA	donor_gain	0.5600
11:124023805:G:T	donor_gain	0.5400
11:124023926:T:TA	donor_gain	0.5300
11:124023927:A:AA	donor_gain	0.5300
11:124023332:G:T	donor_gain	0.5200
11:124023397:CTCAG:C	donor_loss	0.5200
11:124023398:TCAG:T	donor_loss	0.5200
11:124023399:CAGGT:C	donor_loss	0.5200
11:124023400:AGG:A	donor_loss	0.5200
11:124023401:G:GA	donor_loss	0.5200
11:124023402:GT:G	donor_loss	0.5200
11:124023403:T:G	donor_loss	0.5200
11:124023683:T:G	acceptor_gain	0.5200
11:124023688:C:CA	acceptor_gain	0.5200
11:124023708:G:T	donor_gain	0.5200
11:124023708:G:GT	donor_gain	0.5100
11:124023774:T:TA	acceptor_gain	0.5100
11:124023514:T:A	acceptor_gain	0.5000

AlphaMissense

2025 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124023374:G:C	R121P	0.954
11:124023363:G:A	M117I	0.942
11:124023363:G:C	M117I	0.942
11:124023363:G:T	M117I	0.942
11:124023334:A:C	S108R	0.940
11:124023336:C:A	S108R	0.940
11:124023336:C:G	S108R	0.940
11:124023040:T:C	F10L	0.936
11:124023042:C:A	F10L	0.936
11:124023042:C:G	F10L	0.936
11:124023757:T:C	C249R	0.935
11:124023861:C:A	N283K	0.932
11:124023861:C:G	N283K	0.932
11:124023371:A:C	D120A	0.924
11:124023132:C:A	N40K	0.921
11:124023132:C:G	N40K	0.921
11:124023371:A:T	D120V	0.917
11:124023372:T:A	D120E	0.915
11:124023372:T:G	D120E	0.915
11:124023454:T:A	W148R	0.915
11:124023454:T:C	W148R	0.915
11:124023763:T:C	F251L	0.912
11:124023765:T:A	F251L	0.912
11:124023765:T:G	F251L	0.912
11:124023637:T:C	C209R	0.910
11:124023544:T:A	C178S	0.908
11:124023545:G:C	C178S	0.908
11:124023499:T:C	F163L	0.907
11:124023501:C:A	F163L	0.907
11:124023501:C:G	F163L	0.907

dbSNP variants (sampled 300 via entrez): RS1000330750 (11:124022438 A>G), RS1000364818 (11:124022020 G>T), RS1001041164 (11:124021180 A>G), RS1002994072 (11:124024239 T>C,G), RS1003729902 (11:124023294 C>T), RS1005348139 (11:124021646 C>A,T), RS1006532546 (11:124024301 A>G), RS1006575006 (11:124021939 A>T), RS1008483056 (11:124022689 T>C), RS1009498939 (11:124024258 A>G), RS1009731864 (11:124021158 C>T), RS1011409931 (11:124023684 C>A,T), RS1011984409 (11:124022783 G>A,C,T), RS1012854369 (11:124022497 A>C), RS1013085131 (11:124022714 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.