OR10H2

Summary

OR10H2 (olfactory receptor family 10 subfamily H member 2, HGNC:8173) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 10H2 (O60403). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26538 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total
• MANE Select transcript: NM_013939

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8173
Approved symbol	OR10H2
Name	olfactory receptor family 10 subfamily H member 2
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000171942
Ensembl biotype	protein_coding
Entrez	26538

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000305899

RefSeq mRNA: 1 — MANE Select: NM_013939 NM_013939

CCDS: CCDS12333

Canonical transcript exons

ENST00000305899 — 1 exons

Exon	Start	End
ENSE00001132645	15728024	15729052

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 42.09.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	42.09	gold quality
bone marrow cell	CL:0002092	38.58	gold quality
granulocyte	CL:0000094	37.15	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.99	gold quality
muscle tissue	UBERON:0002385	33.46	gold quality
bone marrow	UBERON:0002371	32.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.38	gold quality
tonsil	UBERON:0002372	28.80	gold quality
leukocyte	CL:0000738	28.62	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	28.09	gold quality
smooth muscle tissue	UBERON:0001135	27.94	gold quality
placenta	UBERON:0001987	27.65	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.12	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.40	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
muscle of leg	UBERON:0001383	25.14	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
skin of abdomen	UBERON:0001416	24.47	gold quality
frontal cortex	UBERON:0001870	24.16	gold quality
uterine cervix	UBERON:0000002	24.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10h1	ENSMUSG00000093884
mus_musculus	Or10h1b	ENSMUSG00000094891
mus_musculus	Or10h5	ENSMUSG00000096169
rattus_norvegicus	Olr1092	ENSRNOG00000073810
rattus_norvegicus	Or10h1	ENSRNOG00000074063
rattus_norvegicus	Olr1090	ENSRNOG00000082788
rattus_norvegicus	Olr1093	ENSRNOG00000090741
rattus_norvegicus	Or10h1d	ENSRNOG00000091234

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10H2 — O60403 (reviewed: O60403)

Alternative names: Olfactory receptor OR19-23

All UniProt accessions (2): O60403, A0A126GWJ7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_039227* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60403-F1	88.12	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 28 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN, PDGF_UP.V1_DN

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

224 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10H2	ZNF212	Q9UDV6	508
OR10H2	ZNF182	P17025	506
OR10H2	TRMT9B	Q9P272	474
OR10H2	MTMR11	A4FU01	447
OR10H2	VN1R4	Q7Z5H5	392
OR10H2	VN1R2	Q8NFZ6	364
OR10H2	VN1R1	Q9GZP7	305
OR10H2	OMP	P47874	271
OR10H2	TAS2R13	Q9NYV9	270
OR10H2	TAS2R5	Q9NYW4	246
OR10H2	TAS2R31	P59538	246
OR10H2	TAS2R50	P59544	246
OR10H2	TAS2R10	Q9NYW0	242
OR10H2	ADCY3	O60266	240
OR10H2	TAS2R4	Q9NYW5	223

IntAct

3 interactions, top by confidence:

A	B	Type	Score
OR10H2	ABCD4	psi-mi:“MI:0914”(association)	0.350
OR10H2	LRATD2	psi-mi:“MI:0914”(association)	0.350

BioGRID (71): ABHD6 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), LCLAT1 (Affinity Capture-MS), ATG9A (Affinity Capture-MS), SARAF (Affinity Capture-MS), ATP13A3 (Affinity Capture-MS), PTRH2 (Affinity Capture-MS), TRPM4 (Affinity Capture-MS), NRP2 (Affinity Capture-MS), FADS3 (Affinity Capture-MS), AGPAT3 (Affinity Capture-MS), SLC29A1 (Affinity Capture-MS), SLC12A7 (Affinity Capture-MS), RAB6B (Affinity Capture-MS), CLCN3 (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

268 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15728782:ATTGT:A	acceptor_gain	0.7000
19:15728786:T:TA	acceptor_gain	0.6800
19:15728700:T:G	acceptor_gain	0.6700
19:15728707:ATCGT:A	acceptor_gain	0.6300
19:15728852:A:T	donor_gain	0.6300
19:15728851:G:GT	donor_gain	0.6200
19:15728825:TCAAG:T	acceptor_gain	0.6100
19:15728826:CAAGC:C	acceptor_gain	0.6100
19:15728711:T:TA	acceptor_gain	0.6000
19:15728787:G:GA	donor_gain	0.5900
19:15728830:CCCAA:C	acceptor_gain	0.5900
19:15728409:C:G	donor_gain	0.5800
19:15728700:T:TA	acceptor_gain	0.5800
19:15728707:ATC:A	acceptor_gain	0.5800
19:15728709:C:A	acceptor_gain	0.5700
19:15728699:AT:A	acceptor_gain	0.5600
19:15728707:A:AG	acceptor_gain	0.5600
19:15728715:C:CA	acceptor_gain	0.5600
19:15728720:T:G	acceptor_gain	0.5500
19:15728916:CAG:C	acceptor_gain	0.5500
19:15728858:A:AG	donor_gain	0.5100
19:15728900:TCAGC:T	acceptor_gain	0.5100
19:15728901:CAGCC:C	acceptor_gain	0.5100
19:15728712:G:A	acceptor_gain	0.5000
19:15728899:CTCAG:C	acceptor_gain	0.5000
19:15728926:A:T	donor_gain	0.5000
19:15728708:T:G	acceptor_gain	0.4900
19:15728918:G:T	acceptor_gain	0.4900
19:15728925:G:GT	donor_gain	0.4900
19:15728699:A:AG	acceptor_gain	0.4800

AlphaMissense

2053 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15728914:T:C	F291L	0.953
19:15728916:C:A	F291L	0.953
19:15728916:C:G	F291L	0.953
19:15728092:T:C	F17L	0.936
19:15728094:C:A	F17L	0.936
19:15728094:C:G	F17L	0.936
19:15728077:T:C	F12L	0.931
19:15728079:C:A	F12L	0.931
19:15728079:C:G	F12L	0.931
19:15728545:T:C	F168L	0.923
19:15728547:C:A	F168L	0.923
19:15728547:C:G	F168L	0.923
19:15728917:A:C	S292R	0.917
19:15728919:C:A	S292R	0.917
19:15728919:C:G	S292R	0.917
19:15728359:A:C	S106R	0.904
19:15728361:C:A	S106R	0.904
19:15728361:C:G	S106R	0.904
19:15728902:A:C	S287R	0.904
19:15728904:C:A	S287R	0.904
19:15728904:C:G	S287R	0.904
19:15728533:T:C	F164L	0.903
19:15728535:C:A	F164L	0.903
19:15728535:C:G	F164L	0.903
19:15728488:T:A	W149R	0.897
19:15728488:T:C	W149R	0.897
19:15728572:T:C	F177L	0.894
19:15728574:T:A	F177L	0.894
19:15728574:T:G	F177L	0.894
19:15728509:G:A	G156R	0.890

dbSNP variants (sampled 300 via entrez): RS1002258663 (19:15727717 A>G), RS1002311012 (19:15727946 C>A,T), RS1003930335 (19:15727026 G>A), RS1004157536 (19:15726488 G>A), RS1004282360 (19:15726746 G>A), RS1005555627 (19:15727980 G>C), RS1005897494 (19:15727702 A>G), RS1006260949 (19:15727479 G>C), RS1008103617 (19:15727073 G>C,T), RS1010014991 (19:15728446 C>T), RS1011229782 (19:15729149 C>T), RS1012401177 (19:15727744 G>A,T), RS1013363071 (19:15726138 C>T), RS1014279164 (19:15726411 C>T), RS1014331345 (19:15726703 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Asbestos, Crocidolite	affects expression	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.