OR10H3

Summary

OR10H3 (olfactory receptor family 10 subfamily H member 3, HGNC:8174) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 10H3 (O60404). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26532 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_013938

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8174
Approved symbol	OR10H3
Name	olfactory receptor family 10 subfamily H member 3
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000171936
Ensembl biotype	protein_coding
Entrez	26532

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641646

RefSeq mRNA: 1 — MANE Select: NM_013938 NM_013938

CCDS: CCDS12334

Canonical transcript exons

ENST00000641646 — 2 exons

Exon	Start	End
ENSE00003811708	15741382	15742343
ENSE00003812183	15737985	15738051

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 71.22.

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	71.22	silver quality
ileal mucosa	UBERON:0000331	69.35	silver quality
tibialis anterior	UBERON:0001385	65.42	silver quality
decidua	UBERON:0002450	56.55	gold quality
deltoid	UBERON:0001476	55.00	silver quality
epithelial cell of pancreas	CL:0000083	53.14	silver quality
hair follicle	UBERON:0002073	52.43	gold quality
cranial nerve II	UBERON:0000941	51.11	gold quality
quadriceps femoris	UBERON:0001377	51.08	gold quality
vastus lateralis	UBERON:0001379	49.87	gold quality
oocyte	CL:0000023	49.68	gold quality
thymus	UBERON:0002370	49.54	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.30	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
layer of synovial tissue	UBERON:0007616	49.07	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality
upper arm skin	UBERON:0004263	48.06	gold quality
cervix epithelium	UBERON:0004801	48.04	gold quality
oviduct epithelium	UBERON:0004804	48.00	gold quality
skin of hip	UBERON:0001554	47.93	gold quality
tongue squamous epithelium	UBERON:0006919	47.92	gold quality
cardia of stomach	UBERON:0001162	47.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10h28	ENSMUSG00000054666
rattus_norvegicus		ENSRNOG00000077038
rattus_norvegicus		ENSRNOG00000089697

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 10H3 — O60404 (reviewed: O60404)

Alternative names: Olfactory receptor OR19-24

All UniProt accessions (2): O60404, A0A126GW93

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_039226* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60404-F1	86.84	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 55 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, MORF_RAD51L3, MODULE_289, MORF_IL4, MORF_PRKCA, KEGG_OLFACTORY_TRANSDUCTION, MORF_THPO, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, MORF_ATF2, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, MORF_MAP2K7, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

284 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10H3	ADGRF3	Q8IZF5	446
OR10H3	MINDY4	Q4G0A6	404
OR10H3	GJC3	Q8NFK1	356
OR10H3	TAAR5	O14804	348
OR10H3	GPR31	O00270	330
OR10H3	GPRC5D	Q9NZD1	324
OR10H3	MINDY3	Q9H8M7	323
OR10H3	GPR37L1	O60883	323
OR10H3	SORCS2	Q96PQ0	311
OR10H3	COL21A1	Q96P44	305
OR10H3	GJA3	Q9Y6H8	276
OR10H3	ADGRB3	O60242	270
OR10H3	AQP12B	A6NM10	270
OR10H3	EXOC3	O60645	258
OR10H3	GJA8	P48165	256

IntAct

4 interactions, top by confidence:

A	B	Type	Score
OR10H3	HMGCS1	psi-mi:“MI:0914”(association)	0.530
OR10H3	NME2	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (17): CYB5A (Affinity Capture-MS), LASP1 (Affinity Capture-MS), PAK2 (Affinity Capture-MS), FAHD1 (Affinity Capture-MS), HMGCS1 (Affinity Capture-MS), FAHD1 (Affinity Capture-MS), PAK2 (Affinity Capture-MS), HMGCS1 (Affinity Capture-MS), IRGQ (Affinity Capture-MS), LASP1 (Affinity Capture-MS), PLS1 (Affinity Capture-MS), LASP1 (Affinity Capture-MS), IRGQ (Affinity Capture-MS), PLS1 (Affinity Capture-MS), PAK2 (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O60404, O76001, O76002, O95371, P23266, P23267, P30953, P34984, P58173, Q13607, Q5JQS5, Q60885, Q7Z3T1, Q8N148, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGF6, Q8NGN1, Q8NGQ2, Q8NGQ4, Q8NGT2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY1, Q8NGY5, Q8NGZ5, Q8NGZ6, Q8NHB1, Q8VGD6, Q96KK4, Q96R30, Q96R45, Q96R47, Q96R48

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

341 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15741797:GCTAA:G	donor_gain	0.7800
19:15741712:T:G	donor_gain	0.7600
19:15741849:G:GA	donor_gain	0.7600
19:15741798:C:G	donor_gain	0.7500
19:15741801:A:AG	donor_gain	0.7500
19:15741695:G:GT	donor_gain	0.7400
19:15741848:T:TA	donor_gain	0.7400
19:15742063:T:TA	acceptor_gain	0.7000
19:15741935:T:G	acceptor_gain	0.6900
19:15741761:C:CG	donor_gain	0.6600
19:15741682:C:T	donor_gain	0.6500
19:15741571:T:G	donor_gain	0.6400
19:15741695:GAT:G	donor_gain	0.6400
19:15741747:A:AG	donor_gain	0.6400
19:15741745:TC:T	donor_gain	0.6200
19:15741572:G:GG	donor_gain	0.6100
19:15741746:C:A	donor_gain	0.6100
19:15741801:A:G	donor_gain	0.6100
19:15741953:GTT:G	acceptor_gain	0.6000
19:15742059:ATTGT:A	acceptor_gain	0.5900
19:15741539:A:AG	donor_gain	0.5800
19:15741540:G:GG	donor_gain	0.5800
19:15741750:GGC:G	donor_gain	0.5800
19:15741751:GC:G	donor_gain	0.5800
19:15741873:A:AG	donor_gain	0.5800
19:15742064:G:A	acceptor_gain	0.5800
19:15741752:C:G	donor_gain	0.5600
19:15741952:AGTT:A	acceptor_gain	0.5600
19:15741953:GTTG:G	acceptor_gain	0.5600
19:15741742:T:TA	acceptor_gain	0.5500

AlphaMissense

2110 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15741426:T:C	F12L	0.877
19:15741428:T:A	F12L	0.877
19:15741428:T:G	F12L	0.877
19:15741897:T:C	F169L	0.867
19:15741899:C:A	F169L	0.867
19:15741899:C:G	F169L	0.867
19:15741441:T:C	F17L	0.847
19:15741443:C:A	F17L	0.847
19:15741443:C:G	F17L	0.847
19:15741885:T:C	F165L	0.839
19:15741887:T:A	F165L	0.839
19:15741887:T:G	F165L	0.839
19:15741924:T:C	F178L	0.780
19:15741926:T:A	F178L	0.780
19:15741926:T:G	F178L	0.780
19:15742266:T:C	F292L	0.776
19:15742268:C:A	F292L	0.776
19:15742268:C:G	F292L	0.776
19:15741477:T:C	F29L	0.737
19:15741479:C:A	F29L	0.737
19:15741479:C:G	F29L	0.737
19:15741699:T:C	F103L	0.724
19:15741701:C:A	F103L	0.724
19:15741701:C:G	F103L	0.724
19:15741498:T:C	F36L	0.717
19:15741500:C:A	F36L	0.717
19:15741500:C:G	F36L	0.717
19:15741612:T:C	F74L	0.715
19:15741614:C:A	F74L	0.715
19:15741614:C:G	F74L	0.715

dbSNP variants (sampled 300 via entrez): RS1000236121 (19:15741976 C>G), RS1000833902 (19:15738173 TTG>T), RS1001069507 (19:15737946 G>A,C), RS1001461725 (19:15737862 C>T), RS1001514495 (19:15742575 G>A), RS1001904422 (19:15738236 G>A,T), RS1002622740 (19:15739686 G>A), RS1002965783 (19:15740864 G>A,C), RS1003241877 (19:15736326 C>T), RS1004201002 (19:15736556 A>G), RS1004489279 (19:15741198 A>C,G), RS1005252318 (19:15738885 T>C), RS1005366312 (19:15737501 G>T), RS1005649224 (19:15738599 A>C,G), RS1006142866 (19:15740525 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium	increases abundance, decreases expression	2
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.