OR10H4

Summary

OR10H4 (olfactory receptor family 10 subfamily H member 4, HGNC:15388) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 10H4 (Q8NGA5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 126541 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 64 total
• MANE Select transcript: NM_001004465

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15388
Approved symbol	OR10H4
Name	olfactory receptor family 10 subfamily H member 4
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176231
Ensembl biotype	protein_coding
Entrez	126541

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000322107, ENST00000641275

RefSeq mRNA: 1 — MANE Select: NM_001004465 NM_001004465

CCDS: CCDS32941

Canonical transcript exons

ENST00000322107 — 1 exons

Exon	Start	End
ENSE00001761967	15949008	15949958

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 40.92.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	40.92	gold quality
lower esophagus mucosa	UBERON:0035834	39.46	gold quality
sural nerve	UBERON:0015488	37.49	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.22	gold quality
muscle tissue	UBERON:0002385	32.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
leukocyte	CL:0000738	31.96	silver quality
bone marrow	UBERON:0002371	31.74	gold quality
monocyte	CL:0000576	31.61	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality
right coronary artery	UBERON:0001625	27.76	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
blood	UBERON:0000178	26.90	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
ectocervix	UBERON:0012249	26.09	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.18	gold quality
calcaneal tendon	UBERON:0003701	24.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10h28	ENSMUSG00000054666
rattus_norvegicus		ENSRNOG00000077038
rattus_norvegicus		ENSRNOG00000089697

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 10H4 — Q8NGA5 (reviewed: Q8NGA5)

Alternative names: Olfactory receptor OR19-28

All UniProt accessions (3): A0A126GVV2, A0A2R8Y5B6, Q8NGA5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004465* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGA5-F1	86.92	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZNF507_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10H4	TVP23A	A6NH52	507
OR10H4	LANCL3	Q6ZV70	477
OR10H4	NUDT18	Q6ZVK8	411
OR10H4	SNAPC3	Q92966	370
OR10H4	KCNV1	Q6PIU1	348
OR10H4	SZT2	Q5T011	324
OR10H4	ADAMTSL3	P82987	318
OR10H4	FBN3	Q75N90	311
OR10H4	XPO6	Q96QU8	310
OR10H4	GLYATL3	Q5SZD4	310
OR10H4	G3V325	G3V325	305
OR10H4	CDK11B	P21127	303
OR10H4	CILP2	Q8IUL8	300
OR10H4	USP46	P62068	294
OR10H4	BAG5	Q9UL15	289

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O60404, O76001, O76002, O76100, O95007, O95047, P0DMU2, P23269, P23271, P23272, P23274, P30953, P47884, P58170, P70526, Q15622, Q6IEZ7, Q6IF42, Q8N148, Q8NGA5, Q8NGA6, Q8NGC8, Q8NGI7, Q8NGS2, Q8NGS4, Q8NGX0, Q8NGX3, Q8NGX8, Q8NGZ5, Q8NH02, Q8NH04, Q8NH80, Q8NHA6, Q8VBW9, Q96R30, Q96R45, Q9GZK6, Q9GZM6

Diamond homologs: A4D2G3, O43749, O60403, O60404, O76099, P0C629, P0DN81, P23270, P30953, P30954, P34984, P34986, P58173, P58181, P70526, Q13606, Q5JRS4, Q60880, Q60890, Q62007, Q6IF99, Q6IFH4, Q6UXT6, Q7TR96, Q8N127, Q8NG75, Q8NGA5, Q8NGA6, Q8NGC0, Q8NGC3, Q8NGC5, Q8NGE3, Q8NGE5, Q8NGF4, Q8NGG3, Q8NGI7, Q8NGI9, Q8NGJ0, Q8NGN3, Q8NGN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

244 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15949429:ACT:A	donor_gain	0.8800
19:15949464:GGCTC:G	donor_gain	0.8700
19:15949430:C:G	donor_gain	0.8300
19:15949463:T:TA	donor_gain	0.7500
19:15949376:C:G	donor_gain	0.7200
19:15949667:T:G	acceptor_gain	0.6700
19:15949186:T:G	donor_gain	0.6400
19:15949488:A:AG	donor_gain	0.6400
19:15949489:C:G	donor_gain	0.6400
19:15949550:T:G	acceptor_gain	0.6300
19:15949679:G:A	acceptor_gain	0.6300
19:15949678:T:TA	acceptor_gain	0.6200
19:15949310:G:GT	donor_gain	0.6100
19:15949409:T:G	donor_gain	0.6100
19:15949568:GTT:G	acceptor_gain	0.5800
19:15949413:C:CG	donor_gain	0.5600
19:15949462:GTGGC:G	donor_gain	0.5600
19:15949567:A:AC	acceptor_loss	0.5500
19:15949567:A:AG	acceptor_gain	0.5500
19:15949568:G:GG	acceptor_gain	0.5500
19:15949568:G:GT	acceptor_loss	0.5500
19:15949676:T:TA	acceptor_gain	0.5500
19:15949366:GC:G	donor_gain	0.5400
19:15949666:A:AG	acceptor_gain	0.5400
19:15949674:ATTGT:A	acceptor_gain	0.5400
19:15949566:AAG:A	acceptor_gain	0.5300
19:15949567:AGTT:A	acceptor_gain	0.5300
19:15949568:GTTG:G	acceptor_gain	0.5300
19:15949454:C:G	donor_gain	0.5200
19:15949486:TGACA:T	donor_gain	0.5200

AlphaMissense

2107 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15949881:T:C	F292L	0.972
19:15949883:C:A	F292L	0.972
19:15949883:C:G	F292L	0.972
19:15949869:A:C	S288R	0.952
19:15949871:C:A	S288R	0.952
19:15949871:C:G	S288R	0.952
19:15949884:A:C	S293R	0.946
19:15949886:C:A	S293R	0.946
19:15949886:C:G	S293R	0.946
19:15949500:T:C	F165L	0.927
19:15949502:C:A	F165L	0.927
19:15949502:C:G	F165L	0.927
19:15949770:A:C	S255R	0.922
19:15949772:T:A	S255R	0.922
19:15949772:T:G	S255R	0.922
19:15949041:T:C	F12L	0.921
19:15949043:T:A	F12L	0.921
19:15949043:T:G	F12L	0.921
19:15949512:T:C	F169L	0.921
19:15949514:C:A	F169L	0.921
19:15949514:C:G	F169L	0.921
19:15949056:T:C	F17L	0.915
19:15949058:C:A	F17L	0.915
19:15949058:C:G	F17L	0.915
19:15949375:G:C	R123P	0.905
19:15949882:T:C	F292S	0.903
19:15949892:G:C	R295S	0.902
19:15949892:G:T	R295S	0.902
19:15949364:G:A	M119I	0.895
19:15949364:G:C	M119I	0.895

dbSNP variants (sampled 300 via entrez): RS1000277481 (19:15949097 G>A,T), RS1000496488 (19:15949991 G>C), RS1000538554 (19:15947069 T>G), RS1000565641 (19:15948882 A>G), RS1001015465 (19:15950206 G>A), RS1002399001 (19:15947694 T>C), RS1003006968 (19:15947237 T>A), RS1004516825 (19:15948220 C>T), RS1004821030 (19:15947885 T>A,C), RS1006810043 (19:15947988 G>T), RS1006829257 (19:15950235 G>A), RS1009170576 (19:15949132 G>A,T), RS1009347469 (19:15947084 A>G), RS1010301278 (19:15948854 A>C), RS1011025708 (19:15948350 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.