OR10H5

Summary

OR10H5 (olfactory receptor family 10 subfamily H member 5, HGNC:15389) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 10H5 (Q8NGA6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 284433 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• MANE Select transcript: NM_001004466

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15389
Approved symbol	OR10H5
Name	olfactory receptor family 10 subfamily H member 5
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172519
Ensembl biotype	protein_coding
Entrez	284433

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000308940, ENST00000642092

RefSeq mRNA: 1 — MANE Select: NM_001004466 NM_001004466

CCDS: CCDS32940

Canonical transcript exons

ENST00000642092 — 2 exons

Exon	Start	End
ENSE00003814111	15794038	15800357
ENSE00003814221	15787661	15787716

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 56.77.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	56.77	gold quality
skeletal muscle tissue	UBERON:0001134	48.63	gold quality
stromal cell of endometrium	CL:0002255	47.49	gold quality
muscle tissue	UBERON:0002385	47.04	gold quality
ventricular zone	UBERON:0003053	46.60	gold quality
cortical plate	UBERON:0005343	46.48	gold quality
ganglionic eminence	UBERON:0004023	45.41	gold quality
duodenum	UBERON:0002114	45.40	gold quality
hindlimb stylopod muscle	UBERON:0004252	45.38	gold quality
monocyte	CL:0000576	44.82	gold quality
leukocyte	CL:0000738	44.42	gold quality
bone marrow	UBERON:0002371	43.40	gold quality
liver	UBERON:0002107	42.04	gold quality
blood	UBERON:0000178	42.03	gold quality
calcaneal tendon	UBERON:0003701	41.79	gold quality
islet of Langerhans	UBERON:0000006	41.42	silver quality
superior frontal gyrus	UBERON:0002661	40.97	gold quality
muscle of leg	UBERON:0001383	40.61	gold quality
bone marrow cell	CL:0002092	39.96	gold quality
gastrocnemius	UBERON:0001388	39.31	gold quality
tonsil	UBERON:0002372	39.29	gold quality
right lobe of liver	UBERON:0001114	38.99	gold quality
endometrium	UBERON:0001295	38.97	gold quality
lymph node	UBERON:0000029	38.72	gold quality
pancreas	UBERON:0001264	38.48	silver quality
prefrontal cortex	UBERON:0000451	38.44	gold quality
smooth muscle tissue	UBERON:0001135	38.41	gold quality
primary visual cortex	UBERON:0002436	38.18	gold quality
gall bladder	UBERON:0002110	38.10	gold quality
vermiform appendix	UBERON:0001154	37.68	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-86618	yes	41.27
E-ANND-3	yes	5.23

Regulation

Is transcription factor: no

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or10h1	ENSMUSG00000093884
mus_musculus	Or10h1b	ENSMUSG00000094891
mus_musculus	Or10h5	ENSMUSG00000096169
rattus_norvegicus	Olr1092	ENSRNOG00000073810
rattus_norvegicus	Or10h1	ENSRNOG00000074063
rattus_norvegicus	Olr1090	ENSRNOG00000082788
rattus_norvegicus	Olr1093	ENSRNOG00000090741
rattus_norvegicus	Or10h1d	ENSRNOG00000091234

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 10H5 — Q8NGA6 (reviewed: Q8NGA6)

Alternative names: Olfactory receptor OR19-25, Olfactory receptor OR19-26

All UniProt accessions (2): A0A126GWE9, Q8NGA6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004466* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGA6-F1	88.13	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, NOTCH3_TARGET_GENES, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

160 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR10H5	NPIPB8	E9PQR5	605
OR10H5	NPIPB9	F8W1W9	577
OR10H5	CPXCR1	Q8N123	507
OR10H5	DUSP21	Q9H596	480
OR10H5	EFCAB13	Q8IY85	464
OR10H5	AMMECR1	Q9Y4X0	447
OR10H5	APOL4	Q9BPW4	422
OR10H5	RABEP2	Q9H5N1	408
OR10H5	APOBR	Q0VD83	400
OR10H5	ITPRIP	Q8IWB1	399
OR10H5	MRPL52	Q86TS9	397
OR10H5	KICS2	Q96MD2	394
OR10H5	GFRA4	Q9GZZ7	370
OR10H5	SPHKAP	Q2M3C7	370
OR10H5	B4GALT4	O60513	357

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	7
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

176 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15794787:ACTGT:A	acceptor_gain	0.6300
19:15794795:G:GA	donor_gain	0.6100
19:15794856:G:GT	donor_gain	0.6000
19:15794712:ATCGT:A	acceptor_gain	0.5900
19:15794716:T:TA	acceptor_gain	0.5900
19:15794712:ATC:A	acceptor_gain	0.5800
19:15794791:T:TA	acceptor_gain	0.5800
19:15794705:T:G	acceptor_gain	0.5600
19:15794705:T:TA	acceptor_gain	0.5600
19:15794714:C:A	acceptor_gain	0.5600
19:15794830:TGAAG:T	acceptor_gain	0.5500
19:15794717:G:A	acceptor_gain	0.5400
19:15794797:T:TA	donor_gain	0.5300
19:15794704:AT:A	acceptor_gain	0.5200
19:15794712:A:AG	acceptor_gain	0.5200
19:15794843:TCCC:T	donor_gain	0.5200
19:15794844:CCCC:C	donor_gain	0.5200
19:15794792:G:GA	donor_gain	0.5100
19:15794414:C:G	donor_gain	0.5000
19:15794555:T:TA	acceptor_gain	0.4900
19:15794720:C:A	acceptor_gain	0.4800
19:15794860:G:GT	donor_gain	0.4800
19:15794857:A:T	donor_gain	0.4600
19:15794831:G:GT	donor_gain	0.4400
19:15794921:CAG:C	acceptor_gain	0.4400
19:15794923:G:T	acceptor_gain	0.4300
19:15794829:CTGAA:C	acceptor_gain	0.4200
19:15794713:T:G	acceptor_gain	0.4100
19:15794746:A:C	acceptor_gain	0.4000
19:15794796:GTC:G	donor_gain	0.4000

AlphaMissense

2065 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15794919:T:C	F291L	0.908
19:15794921:C:A	F291L	0.908
19:15794921:C:G	F291L	0.908
19:15794082:T:C	F12L	0.896
19:15794084:C:A	F12L	0.896
19:15794084:C:G	F12L	0.896
19:15794550:T:C	F168L	0.887
19:15794552:C:A	F168L	0.887
19:15794552:C:G	F168L	0.887
19:15794097:T:C	F17L	0.876
19:15794099:C:A	F17L	0.876
19:15794099:C:G	F17L	0.876
19:15794907:A:C	S287R	0.853
19:15794909:C:A	S287R	0.853
19:15794909:C:G	S287R	0.853
19:15794538:T:C	F164L	0.830
19:15794540:C:A	F164L	0.830
19:15794540:C:G	F164L	0.830
19:15794763:T:C	F239L	0.830
19:15794765:C:A	F239L	0.830
19:15794765:C:G	F239L	0.830
19:15794130:T:C	F28L	0.822
19:15794132:C:A	F28L	0.822
19:15794132:C:G	F28L	0.822
19:15794577:T:C	F177L	0.809
19:15794579:C:A	F177L	0.809
19:15794579:C:G	F177L	0.809
19:15794922:A:C	S292R	0.805
19:15794924:C:A	S292R	0.805
19:15794924:C:G	S292R	0.805

dbSNP variants (sampled 300 via entrez): RS1000127611 (19:15788636 C>T), RS1000242578 (19:15788994 G>A), RS1000420407 (19:15787858 C>T), RS1000572536 (19:15797060 G>T), RS1000625131 (19:15794126 G>C), RS1000641102 (19:15795753 G>A,C), RS1000702891 (19:15789335 C>T), RS1000718919 (19:15796847 C>T), RS1001030062 (19:15790494 G>A), RS1001295006 (19:15791745 T>G), RS1001352764 (19:15793877 TCAAAAA>T), RS1001593028 (19:15788395 C>G,T), RS1001646351 (19:15798520 C>T), RS1001740849 (19:15800369 T>C,G), RS1001773422 (19:15800114 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
CGP 52608	increases reaction, affects binding	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.